Nedelman_1995: Pharmacokinetics of an CPI 975 (an experimental drug)...

In billdenney/PKdata: Pharmacokinetic Data Sets

Pharmacokinetics of an CPI 975 (an experimental drug) reported in Table II of Nedelman 1995

Description

Observed data set of concentration-time data for an experimental compound. These data use sparse PK sampling with a "batch" design where each animal has more than one sample but not the full profile.

Usage

Nedelman_1995_conc

Nedelman_1995_dose

Nedelman_1995_demog

Format

Nedelman_1995_conc is a data frame describing concentration by time with the following variables:

ID

Subject identifier

TIME

Time (in hours)

TIMEU

Units for time, "hr"

CONC

Plasma concentration of the experimental compound (in ug/mL)

CONCU

Units for plasma concentration, "ug/mL"

Nedelman_1995_dose is a data frame describing dosing with the following variables:

ID

Subject identifier

DOSE

Dose (in mg/kg)

DOSEU

Units for nominal dose, "mg/kg"

TIME

Time for the dose (in hours, always 0)

TIMEU

Units for time, "hr"

ROUTE

Route of administration, "oral"

Nedelman_1995_demog is a data frame describing demographics with the following variables:

ID

Subject identifier

SEX

Animal sex

SPECIES

Species of the animal (always "rat")

An object of class data.frame with 60 rows and 5 columns.

An object of class data.frame with 60 rows and 6 columns.

An object of class data.frame with 60 rows and 3 columns.

References

Nedelman JR, Gibiansky E, Lau DT. Applying Bailer’s method for AUC confidence intervals to sparse sampling. Pharm Res. 1995;12(1):124-128. doi:10.1023/a:1016255124336

billdenney/PKdata documentation built on Feb. 23, 2023, 12:01 p.m.