add.interval.col: Add columns for calculations within PKNCA intervals

In billdenney/pknca: Perform Pharmacokinetic Non-Compartmental Analysis

Add columns for calculations within PKNCA intervals

Description

Add columns for calculations within PKNCA intervals

Usage

add.interval.col(
  name,
  FUN,
  values = c(FALSE, TRUE),
  unit_type,
  pretty_name,
  depends = NULL,
  desc = "",
  sparse = FALSE,
  formalsmap = list(),
  datatype = c("interval", "individual", "population")
)

Arguments

name	The column name as a character string
FUN	The function to run (as a character string) or NA if the parameter is automatically calculated when calculating another parameter.
values	Valid values for the column
unit_type	The type of units to use for assigning and converting units.
pretty_name	The name of the parameter to use for printing in summary tables with units. (If an analysis does not include units, then the normal name is used.)
depends	Character vector of columns that must be run before this column.
desc	A human-readable description of the parameter (<=40 characters to comply with SDTM)
sparse	Is the calculation for sparse PK?
formalsmap	A named list mapping parameter names in the function call to NCA parameter names. See the details for information on use of formalsmap.
datatype	The type of data used for the calculation

Details

The formalsmap argument enables mapping some alternate formal argument names to parameters. It is used to generalize functions that may use multiple similar arguments (such as the variants of mean residence time). The names of the list should correspond to function formal parameter names and the values should be one of the following:

• For the current interval:

  character strings of NCA parameter name

  The value of the parameter calculated for the current interval.

  "conc"

  Concentration measurements for the current interval.

  "time"

  Times associated with concentration measurements for the current interval (values start at 0 at the beginning of the current interval).

  "volume"

  Volume associated with concentration measurements for the current interval (typically applies for excretion parameters like urine).

  "duration.conc"

  Durations associated with concentration measurements for the current interval.

  "dose"

  Dose amounts assocuated with the current interval.

  "time.dose"

  Time of dose start associated with the current interval (values start at 0 at the beginning of the current interval).

  "duration.dose"

  Duration of dose (typically infusion duration) for doses in the current interval.

  "route"

  Route of dosing for the current interval.

  "start"

  Time of interval start.

  "end"

  Time of interval end.

  "options"

  PKNCA.options governing calculations.

• For the current group:

  "conc.group"

  Concentration measurements for the current group.

  "time.group"

  Times associated with concentration measurements for the current group (values start at 0 at the beginning of the current interval).

  "volume.group"

  Volume associated with concentration measurements for the current interval (typically applies for excretion parameters like urine).

  "duration.conc.group"

  Durations assocuated with concentration measurements for the current group.

  "dose.group"

  Dose amounts assocuated with the current group.

  "time.dose.group"

  Time of dose start associated with the current group (values start at 0 at the beginning of the current interval).

  "duration.dose.group"

  Duration of dose (typically infusion duration) for doses in the current group.

  "route.group"

  Route of dosing for the current group.

Value

NULL (Calling this function has a side effect of changing the available intervals for calculations)

See Also

Other Interval specifications: check.interval.deps(), check.interval.specification(), choose.auc.intervals(), get.interval.cols(), get.parameter.deps()

Examples

## Not run: 
add.interval.col("cmax",
                 FUN="pk.calc.cmax",
                 values=c(FALSE, TRUE),
                 unit_type="conc",
                 pretty_name="Cmax",
                 desc="Maximum observed concentration")
add.interval.col("cmax.dn",
                 FUN="pk.calc.dn",
                 values=c(FALSE, TRUE),
                 unit_type="conc_dosenorm",
                 pretty_name="Cmax (dose-normalized)",
                 desc="Maximum observed concentration, dose normalized",
                 formalsmap=list(parameter="cmax"),
                 depends="cmax")

## End(Not run)

billdenney/pknca documentation built on April 1, 2024, 10:45 p.m.