Adaptive Subgroup Selection in Group Sequential Trials

ASSISTant | Three stage group sequential adaptive design with subgroup... |

ASSISTant-internal | Is a scalar quantity is a specified range? |

ASSISTDesign | A class to encapsulate the adaptive clinical trial design of... |

ASSISTDesignB | A fixed sample design to compare against the adaptive... |

ASSISTDesignC | A fixed sample RCT design to compare against the adaptive... |

colNamesForStage | Return a vector of column names for statistics for a given... |

computeMeanAndSD | Compute the mean and sd of a discrete Rankin distribution |

computeMHPBoundaries | Compute the three modified Haybittle-Peto boundaries |

computeMHPBoundaryITT | Compute the three modified Haybittle-Peto boundaries and... |

DEFUSE3Design | The DEFUSE3 design |

generateDiscreteData | A data generation function using a discrete distribution for... |

generateNormalData | A data generation function along the lines of what was used... |

groupSampleSize | Compute the sample size for any group at a stage assuming a... |

LLL.SETTINGS | Design and trial settings used in the Lai, Lavori, Liao paper... |

mHP.b | Compute the efficacy boundary (modified Haybittle-Peto) for... |

mHP.btilde | Compute the futility boundary (modified Haybittle-Peto) for... |

mHP.c | Compute the efficacy boundary (modified Haybittle-Peto) for... |

wilcoxon | Compute the standardized Wilcoxon test statistic for two... |

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