MC_delay_crossover_median: Monte Carlo simulation for treatment switching with delay...
In borealexander/tslrt: Function for treatment switching logrank test

View source: R/MC_delay_crossover_median.R

Runs a Monte Carlo simulation for the treatment switching model with switch after delay

MC_delay_crossover_median(n_c = 100, n_e = 100, median_c_1 = c(5, 10),
  median_c_2 = 10, median_e = 15, delay = 5, end_event = 150,
  rec_period = 12, rec_power = 1, p = 1, HR_fun, alpha = 0.025,
  M = 100)

`n_c`	Number of patients in control
`n_e`	Number of patients in experimental
`median_c_1`	Median in control before switching (and for patients that do not switch)
`median_c_2`	Median in control after switching (for the patients that switches)
`delay`	Delay time for when switching occurs
`end_event`	Number of events in the study
`rec_period`	Time for recruitment
`rec_power`	Variable for recruitment that follows the power model
`p`	Proportion(s) of patients that switches after the delay
`HR_fun`	Pre specified HR function
`alpha`	One-sided significance level
`M`	Number of simulations (for each p)
`median_e_1`	Median in experimental