THUNDER estimates cell type proportions in bulk Hi-C datasets
1 | run_thunder(path_to_mixture, n_cell_types, itter = 200, out_init_nmf = NULL)
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path_to_mixture |
String. Path to .tsv file of bulk Hi-C samples. |
n_cell_types |
Integer. The number of columns in the basis matrix of the deconvolution. Corresponds to the number of cell types in bulk Hi-C mixture. |
itter |
Integer. Number of itterations for NMF algorithm. Default is 200. |
out_init_nmf |
String. Default is NULL. If character, then saves the initial NMF fit as a .RDS object to specified file path. |
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