drugData: CellMiner compound data: NCI-60 activity and metadata

In cannin/rcellminerData: rcellminerData: Molecular Profiles and Drug Response for the NCI-60 Cell Lines

CellMiner compound data: NCI-60 activity and metadata

Description

The drugData object, of rcellminer package class DrugData, organizes data for 20861 compounds screened over the NCI-60 cancer cell lines by the NCI Developmental Therapeutics Program. These include activity profiles, as well as other information such as chemical structure, and where appropriate, name, mechanism of action, clinical testing status, etc.

Usage

data(drugData)

Details

The activity data has two forms. A standardized 'z-score' data set provides a single NCI-60 profile for each compound, possibly averaging data derived from multiple experiments (subject to quality standards described in Reinhold et al.). A repeat activity data set provides data at the level of individual NCI-60 profiling experiments.

Value

the drugData object that contains Cellminer drug information as a DrugData object

Source

CellMiner Website: <URL: http://discover.nci.nih.gov/cellminer/>

References

Reinhold, W.C., et al. (2012) CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set, Cancer Research, 72, 3499-3511

cannin/rcellminerData documentation built on Oct. 21, 2024, 9:51 p.m.