carltonyfakhry/geneticsCRE: geneticsCRE is an R package that performs genome-wide association study pathway analysis (GWASPA) to identify statistically significant associations between variants on gene regulatory pathways and a given phenotype

geneticsCRE is an R package that performs genome-wide association study pathway anaysis (GWASPA) to identify statistically significant associations between variants on gene regulatory pathways and a given phenotype. Unlike Genome-wide association study (GWAS), that seeks to assign statistical significance to associations of variations in single genes to a phenotype, GWASPA accumulates statistical power by examining rare variant along gene-gene interaction pathways. GWASPA uses prior causal information a gene regulatory interactions to infer statistically significant associations between causal pathways and a the phenotype. Given phenotype data with case/control information, geneticsCRE computes GWASPA for all valid pathways as identified by the Homo Sapien STRINGdb causal network. Examples on usage are provided in the vignette.

install.packages("remotes")
remotes::install_github("carltonyfakhry/geneticsCRE")