geneticsCRE-package: geneticsCRE is an R package that performs genome-wide...

In carltonyfakhry/geneticsCRE: geneticsCRE is an R package that performs genome-wide association study pathway analysis (GWASPA) to identify statistically significant associations between variants on gene regulatory pathways and a given phenotype

Description

geneticsCRE is an R package that performs genome-wide association study pathway analysis (GWASPA) to identify statistically significant associations between variants on gene regulatory pathways and a given phenotype. Unlike Genome-wide association study (GWAS), that seeks to assign statistical significance to associations of variations in single genes to a phenotype, GWASPA accumulates statistical power by examining rare variant along gene-gene interaction pathways. GWASPA uses prior causal information a gene regulatory interactions to infer statistically significant associations between causal pathways and a the phenotype. Given phenotype data with case/control information, geneticsCRE computes GWASPA for all valid pathways as identified by the Homo Sapien STRINGdb causal network. Examples on usage are provided in the vignette.

Details

Package:	geneticsCRE
Type:	Package
Version:	0.1.0
Date:	2016-06-01
License:	GPL (>= 3)

Author(s)

Carl Tony Fakhry and Kourosh Zarringhalam

Maintainer: Carl Tony Fakhry <[e-mail]>

References

Franceschini, A (2013). STRING v9.1: protein-protein interaction networks, with increased coverage and integration. In:'Nucleic Acids Res. 2013 Jan;41(Database issue):D808-15. doi: 10.1093/nar/gks1094. Epub 2012 Nov 29'.

carltonyfakhry/geneticsCRE documentation built on May 13, 2019, 12:49 p.m.