Description Details Author(s) References
geneticsCRE is an R package that performs genome-wide association study pathway analysis (GWASPA) to identify statistically significant associations between variants on gene regulatory pathways and a given phenotype. Unlike Genome-wide association study (GWAS), that seeks to assign statistical significance to associations of variations in single genes to a phenotype, GWASPA accumulates statistical power by examining rare variant along gene-gene interaction pathways. GWASPA uses prior causal information a gene regulatory interactions to infer statistically significant associations between causal pathways and a the phenotype. Given phenotype data with case/control information, geneticsCRE computes GWASPA for all valid pathways as identified by the Homo Sapien STRINGdb causal network. Examples on usage are provided in the vignette.
Package: | geneticsCRE |
Type: | Package |
Version: | 0.1.0 |
Date: | 2016-06-01 |
License: | GPL (>= 3) |
Carl Tony Fakhry and Kourosh Zarringhalam
Maintainer: Carl Tony Fakhry <cfakhry@cs.umb.edu>
Franceschini, A (2013). STRING v9.1: protein-protein interaction networks, with increased coverage and integration. In:'Nucleic Acids Res. 2013 Jan;41(Database issue):D808-15. doi: 10.1093/nar/gks1094. Epub 2012 Nov 29'.
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