carmonalab/STACAS: STACAS: Sub-Type Anchoring Correction for Alignment in Seurat

This package implements methods for batch correction and integration of scRNA-seq datasets, based on the popular Seurat anchor-based integration framework. In particular, STACAS is optimized for the integration of heterogenous datasets with only limited overlap between cell sub-types (e.g. TIL sets of CD8 from tumor with CD8/CD4 T cells from lymphnode), for which the default Seurat alignment methods would tend to over-correct biological differences. The 2.0 version of our package allows to the users to incorporate explicit information about cell-types in order to assist the integration process.

install.packages("remotes")
remotes::install_github("carmonalab/STACAS")