tissueTreg: Epigenomes and transcriptomes of tissue resident regulatory T...

In cimbusch/tissueTreg: TWGBS and RNA-seq data from tissue T regulatory cells from mice

Epigenomes and transcriptomes of tissue resident regulatory T cells

Description

The package provides ready to use epigenomes (obtained from TWGBS) and transcriptomes (RNA-seq) from various tissues. Regulatory T cells (Treg cells) perform two distinct functions: they maintain self-tolerance, and they support organ homeostasis by differentiating into specialized tissue Treg cells. The underlying dataset characterises the epigenetic and transcriptomic modifications for specialized tissue Treg cells.

Source

Delacher, M, Imbusch, CD, Weichenhan, D, Breiling, A, Hotz-Wagenblatt, A, Träger, U, Hofer, AC, Kägebein, D, Wang, Q, Frauhammer, F, Mallm, JP, Bauer, K, Herrmann, C, Lang, PA, Brors, B, Plass, C, Feuerer, M (2017). Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues. Nat. Immunol., 18, 10:1160-1172.

Examples

eh <- ExperimentHub::ExperimentHub()

# RNA-seq RPKM data:
se_rpkms <- eh[["EH1074"]]

# Whole genome bisulfite sequencing data as bsseq objects:
tregs_per_sample <- eh[["EH1072"]]
tregs_per_tissue <- eh[["EH1073"]]

cimbusch/tissueTreg documentation built on Sept. 28, 2023, 5:20 p.m.