CrcSpinModel-class: Class orchestrating the CRC Spin model

Description Details Fields Methods See Also


This class acts as the entry point and driver for an implementation of the CRC Spin model, described by X et al., which is implemented using a collection of classes.


It orchestrates the modeling on a population represented as a study_group of PersonWithColon class objects. And models the development of Adenomas, and ultimately CRC, within the subjects' Colon.

Users of the model should only call this class's new (initialize), set_adenoma_modeling_parameters, set_crcrisk_modeling_parameters, and run methods. And directly access it's study_results field.



A two dimensional matrix containing an 18 column summary of model state at each year of the study. Inherited from GenericModel



Returns the number of columns in the model's study result matrix

@author Luke Domanski [email protected]

initialize(study_group = list(), iterations = 0, iteration_resolution = 1, num_subjects = 0, base_seed = NA, commencement_age = 1, study_results = NA, ...)

Create and initialize a new instance of a GenericModel

This function creates and initializes a new instance of the GenericModel class. Parameters relating to the length of the modelled study and the number of subjects in the study group are passed to this function. See run to run the created model.

@section Model details:

The GenericModel classes present a framework or set of base classes on which to build more complex models. As a place holder the GenericModel implements a simple natural aging model, and and records the number of non-deceased subjects remaining at each iteration.

@param study_group list containing objects of a class derived from Person. Used to specify an existing group you wish to run/continue the model on

@param iterations the number of iterations the model should run to

@param iteration_resolution how many iterations are modelled in one call to the subject model step function updateSubject

@param num_subjects integer indicating number of subjects in the study group. If study_group is not specified, a new random study_group of size sum_subjects, containing objects of class Person, is created. Otherwise, it is taken as the size of the specified study_group and may result in study_group being truncated

@param base_seed integer RNG seed used for model

@param commencement_age integer indicating age at which to start running the model of subjects of the study_group

@param study_results an integer matrix with iterations*2 rows and enough columns to fit the model's iteration results. Used to specify existing results when an existing study_group is specified.

@param ... additional model values/parameters

@return a new object of type GenericModel with specified configuration

@seealso run to run the model

@family model_initializers


@author Luke Domanski [email protected]

@aliases GenericModel$new


Applies a model step to an individual subject

This function applies a model step to an individual subject updating the subject's state. It implements the main, overall, structure and flow of the model.

@param subject an object of class Person on which to apply a model step

@return an integer vector of length equal to the width of the model's study_result matrix, containing the iteration results for the subject


@author Luke Domanski [email protected]

See Also

Other CrcSpinModel_classes: AdenomaParams, AdenomaParams-class; Adenoma, Adenoma-class; CrcRiskParams, CrcRiskParams-class; CrcRisk, CrcRisk-class; Risk, Risk-class

csiro-crc-spin/RCSpin documentation built on May 12, 2017, 12:26 p.m.