mac: MAC randomized trial

In dave-harrington/eventtimedata: Event time data for teaching

Description

The data come from a three Phase III randomized, double-blind study comparing rifabutin, clarithromycin, and the combination of rifabutin and clarithromycin for prevention of MAC disease in HIV-infected patients with CD4 lymphocyte counts less than 100 cells/mm3. The treatments were rifabutin, clarithomycin (the experimental arm), or the combination of the two drugs.

Usage

data("mac")

Format

A data frame with 1177 observations on the following 20 variables.

patid

patient id

age

age in years

agecat

Binary variable for age 0: <= 35, 1:> 35

sex

0=male, 1=female

karnof

Karnofsky score, a measure of general health, lower indicates poor health

ivdrug

IV Drug Use: 0=Never, 1=Previous/Current)

antiret

Antiretroviral use: 0=never/unk, 1=prev/curr

cd4

cd4 cell count

cd4cat

0 if cd4 <= 25, 1 if cd4 > 25

ctg

clinical trials group

dthstat

death status: 1 = died, 0 = censored

dthtime

time to death in days

macstat

Status of MAC: 1 = yes, 0 = censored

mactime

time to MAC diseasd

swdrstat

study wide dose reduction status

swdrtime

study wide does reduction time

rif

1 = rifabutin treatment arm; 0 = otherwise

clari

1 if treated on clarithromycin arm, 0 = otherwise

toxstat

status for permanent discontinuation of treatment due to toxicity, 1 = discontinued, 0 = censored

toxtime

time to permanent discontinuation due of treatment due to toxicity

Source

Personal communication, Professor Rui Wang

References

Benson CA, Williams PL, Cohn DL, et al and the ACTG 196/CPCRA 009 Protocol Team. Clarithromycin or rifabutin alone or in combination for primary prophylaxis of mycobacterium avium complex disease in patients with AIDS: A randomized, double-blind, placebo-controlled trial. Journal of Infectious Disease 2000; 181:1289-1297.

Examples

data(mac)
## maybe str(mac) ; plot(mac) ...

dave-harrington/eventtimedata documentation built on May 7, 2020, 2 p.m.