Description Usage Format Details
CTM_Nopain is a novel anti-inflammatory agent under preliminary investigation. A dose-ranging trial was conducted comparing placebo with 3 doses of CTM_Nopain (5mg, 20mg and 80 mg QD). The maximum tolerated dose is 160 mg per day. Plasma concentrations (mg/L) of the drug were measured at 0, 0.5, 1, 1.5, 2, 2.5, 3-8 hours. Pain score (0=no pain, 1=mild, 2=moderate, 3=severe) were obtained at time points when plasma concentration was collected. A pain score of 2 or more is considered as no pain relief. The model used is a one-compartment PK model with allometric model of weight on CL (exp 0.75) and volume (exp 1) with direct PD effect (Emax model).
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A data frame with 1920 rows and 7 variables
ARM Factor with 4 levels
ID. Numerical ID (1-160)
TIME Time in hours
CONC Concentration (mg/L)
PAINRELIEF 0 (no relief) or 1 (relief)
PAINSCORE categorical pain score
DOSE Dose Given
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