sd_iv_rich_pkpd: One-compartment single IV bolus PKPD

In dpastoor/PKPDdatasets: data sets for pharmacometric analysis and visualization

Description

A dataset containing simulated PKPD data. A single IV bolus dose was given and rich pharmacokinetic and pharmacodynamic measurements were taken. Demographic data of Age, Weight, Gender, and Race were collected.

Usage

data(sd_iv_rich_pkpd)

Format

A data frame with 480 rows and 10 variables

Details

The model used is a one-compartment PK model with allometric model of weight on CL (exp 0.75) and volume (exp 1) with direct PD effect (Emax model).

• ID. Numerical ID (1-100)

• TIME Time in hours (0-12)

• COBS. Plasma concentration in

• EOBS.

• WEIGHT. Weight in kg

• AGE. Age in years

• DOSE. Three dose levels: 1, 10, and 100 mg

• SEX. Male or Female gender identification

• RACE. AfricanAmerican, Caucasian, Others, and Asian races

• AMT. Amount of drug given, time dependent, in milligrams

Parameters used to simulate data:

Parameter	Mean	Variance (BSV)
CL (L/hr)	1	0.16 (40%)
V (L)	10	0.09 (30%)
Residual error: Proportional	0	10%
Emax	10	sd = 1.4 units
EC50 (mg/L)	2	0.09 (30%)
Residual Error on Effect	0	sd = 0.5 units

dpastoor/PKPDdatasets documentation built on May 15, 2019, 10:45 a.m.