tests/testthat/_snaps/sensitivity-calculation.md
In esqLABS/esqlabsR: esqLABS utilities package
sensitivityCalculation PK parameters tidy dataframe is as expected
Code
df1_pk
Output
$charColumnSummary
# A tibble: 3 x 6
OutputPath
<chr>
1 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
2 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
3 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
ParameterPath ParameterUnit ParameterPathUserName PKParameter
<chr> <chr> <chr> <chr>
1 Aciclovir|Lipophilicity Log Units <NA> AUC_inf
2 Aciclovir|Lipophilicity Log Units <NA> C_max
3 Aciclovir|Lipophilicity Log Units <NA> t_max
Unit
<chr>
1 µmol*min/l
2 µmol/l
3 h
$numericColumnSummary
# A tibble: 5 x 8
column Min. `1st Qu.` Median Mean
<chr> <table[1d]> <table[1d]> <table[1d]> <table[1d]>
1 ParameterFactor 0.1000 0.7750 1.500000 5.775000
2 ParameterValue -1.9400 -0.6305 -0.145500 -0.560175
3 PKParameterValue 0.1833 0.1833 50.964733 1382.726744
4 PKPercentChange -2.6806 0.0000 0.000000 3.313318
5 SensitivityPKParameter 0.0000 0.0000 0.004299 0.009798
`3rd Qu.` Max. `NA's`
<table[1d]> <table[1d]> <table[1d]>
1 6.50000 20.00000 NA
2 -0.07518 -0.00970 NA
3 4059.14498 4154.58500 NA
4 0.82553 37.60585 NA
5 0.01979 0.02978 3
Code
df2_pk
Output
$charColumnSummary
# A tibble: 3 x 6
OutputPath
<chr>
1 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
2 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
3 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
ParameterPath
<chr>
1 Applications|IV 250mg 10min|Application_1|ProtocolSchemaItem|Dose
2 Applications|IV 250mg 10min|Application_1|ProtocolSchemaItem|Dose
3 Applications|IV 250mg 10min|Application_1|ProtocolSchemaItem|Dose
ParameterUnit ParameterPathUserName PKParameter Unit
<chr> <chr> <chr> <chr>
1 kg <NA> AUC_inf µmol*min/l
2 kg <NA> C_max µmol/l
3 kg <NA> t_max h
$numericColumnSummary
# A tibble: 5 x 8
column Min. `1st Qu.` Median Mean
<chr> <table[1d]> <table[1d]> <table[1d]> <table[1d]>
1 ParameterFactor 0.100000 0.7750000 1.500000 5.775000
2 ParameterValue 0.000025 0.0001937 0.000375 0.001444
3 PKParameterValue 0.183333 0.1833333 75.379087 7936.607132
4 PKPercentChange -90.000112 0.0000000 0.000000 318.333335
5 SensitivityPKParameter 0.000000 0.0000000 1.000000 0.666667
`3rd Qu.` Max. `NA's`
<table[1d]> <table[1d]> <table[1d]>
1 6.500000 20.000 NA
2 0.001625 0.005 NA
3 1771.948050 81452.570 NA
4 100.000006 1900.000 NA
5 1.000000 1.000 3
Code
df3_pk
Output
$charColumnSummary
# A tibble: 3 x 6
OutputPath
<chr>
1 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
2 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
3 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
ParameterPath
<chr>
1 Neighborhoods|Kidney_pls_Kidney_ur|Aciclovir|Glomerular Filtration-GFR|GFR fr~
2 Neighborhoods|Kidney_pls_Kidney_ur|Aciclovir|Glomerular Filtration-GFR|GFR fr~
3 Neighborhoods|Kidney_pls_Kidney_ur|Aciclovir|Glomerular Filtration-GFR|GFR fr~
ParameterUnit ParameterPathUserName PKParameter Unit
<chr> <chr> <chr> <chr>
1 "" <NA> AUC_inf µmol*min/l
2 "" <NA> C_max µmol/l
3 "" <NA> t_max h
$numericColumnSummary
# A tibble: 5 x 8
column Min. `1st Qu.` Median Mean
<chr> <table[1d]> <table[1d]> <table[1d]> <table[1d]>
1 ParameterFactor 0.1000 0.77500 1.50000 5.7750
2 ParameterValue 0.1000 0.77500 1.50000 5.7750
3 PKParameterValue 0.1667 0.18333 49.78161 1210.6412
4 PKPercentChange -52.4018 -9.74787 0.00000 -5.9048
5 SensitivityPKParameter -0.1784 -0.02758 -0.01875 -0.0418
`3rd Qu.` Max. `NA's`
<table[1d]> <table[1d]> <table[1d]>
1 6.500000 20.00 NA
2 6.500000 20.00 NA
3 2352.716300 4726.35 NA
4 0.000000 16.05 NA
5 -0.004785 0.00 3
sensitivityCalculation returns expected results with single custom function
Code
customPKData
Output
# A tibble: 12 x 11
OutputPath
<chr>
1 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
2 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
3 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
4 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
5 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
6 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
7 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
8 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
9 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
10 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
11 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
12 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
ParameterPath
<chr>
1 Aciclovir|Lipophilicity
2 Aciclovir|Lipophilicity
3 Aciclovir|Lipophilicity
4 Aciclovir|Lipophilicity
5 Applications|IV 250mg 10min|Application_1|ProtocolSchemaItem|Dose
6 Applications|IV 250mg 10min|Application_1|ProtocolSchemaItem|Dose
7 Applications|IV 250mg 10min|Application_1|ProtocolSchemaItem|Dose
8 Applications|IV 250mg 10min|Application_1|ProtocolSchemaItem|Dose
9 Neighborhoods|Kidney_pls_Kidney_ur|Aciclovir|Glomerular Filtration-GFR|GFR f~
10 Neighborhoods|Kidney_pls_Kidney_ur|Aciclovir|Glomerular Filtration-GFR|GFR f~
11 Neighborhoods|Kidney_pls_Kidney_ur|Aciclovir|Glomerular Filtration-GFR|GFR f~
12 Neighborhoods|Kidney_pls_Kidney_ur|Aciclovir|Glomerular Filtration-GFR|GFR f~
ParameterFactor ParameterValue ParameterUnit ParameterPathUserName
<dbl> <dbl> <chr> <chr>
1 0.1 -0.0097 "Log Units" <NA>
2 1 -0.097 "Log Units" <NA>
3 2 -0.194 "Log Units" <NA>
4 20 -1.94 "Log Units" <NA>
5 0.1 0.000025 "kg" <NA>
6 1 0.00025 "kg" <NA>
7 2 0.0005 "kg" <NA>
8 20 0.005 "kg" <NA>
9 0.1 0.1 "" <NA>
10 1 1 "" <NA>
11 2 2 "" <NA>
12 20 20 "" <NA>
PKParameter PKParameterValue PKPercentChange Unit SensitivityPKParameter
<chr> <dbl> <dbl> <chr> <dbl>
1 minmax 0.0006992 7.968 <NA> -8.854e-2
2 minmax 0.0006476 0 <NA> NaN
3 minmax 0.0006206 -4.157 <NA> -4.157e-2
4 minmax 0.0008589 32.64 <NA> 1.718e-2
5 minmax 0.0006475 -0.01035 <NA> 1.149e-4
6 minmax 0.0006476 0 <NA> NaN
7 minmax 0.0006476 -0.00002663 <NA> -2.663e-7
8 minmax 0.0006476 -0.00002665 <NA> -1.403e-8
9 minmax 0.001230 89.87 <NA> -9.985e-1
10 minmax 0.0006476 0 <NA> NaN
11 minmax 0.0003805 -41.24 <NA> -4.124e-1
12 minmax 0.00005314 -91.79 <NA> -4.831e-2
sensitivityCalculation returns expected results with multiple custom functions
Code
customPKData
Output
# A tibble: 24 x 11
OutputPath
<chr>
1 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
2 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
3 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
4 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
5 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
6 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
7 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
8 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
9 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
10 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
ParameterPath
<chr>
1 Aciclovir|Lipophilicity
2 Aciclovir|Lipophilicity
3 Aciclovir|Lipophilicity
4 Aciclovir|Lipophilicity
5 Aciclovir|Lipophilicity
6 Aciclovir|Lipophilicity
7 Aciclovir|Lipophilicity
8 Aciclovir|Lipophilicity
9 Applications|IV 250mg 10min|Application_1|ProtocolSchemaItem|Dose
10 Applications|IV 250mg 10min|Application_1|ProtocolSchemaItem|Dose
ParameterFactor ParameterValue ParameterUnit ParameterPathUserName
<dbl> <dbl> <chr> <chr>
1 0.1 -0.0097 Log Units <NA>
2 1 -0.097 Log Units <NA>
3 2 -0.194 Log Units <NA>
4 20 -1.94 Log Units <NA>
5 0.1 -0.0097 Log Units <NA>
6 1 -0.097 Log Units <NA>
7 2 -0.194 Log Units <NA>
8 20 -1.94 Log Units <NA>
9 0.1 0.000025 kg <NA>
10 1 0.00025 kg <NA>
PKParameter PKParameterValue PKPercentChange Unit SensitivityPKParameter
<chr> <dbl> <dbl> <chr> <dbl>
1 max_slope 5.847 -1.167 <NA> 0.01297
2 max_slope 5.916 0 <NA> NaN
3 max_slope 5.979 1.057 <NA> 0.01057
4 max_slope 7.418 25.38 <NA> 0.01336
5 minmax 1430. -7.380 <NA> 0.08200
6 minmax 1544. 0 <NA> NaN
7 minmax 1611. 4.338 <NA> 0.04338
8 minmax 1164. -24.61 <NA> -0.01295
9 max_slope 0.5916 -90.00 <NA> 1.000
10 max_slope 5.916 0 <NA> NaN
# i 14 more rows
sensitivityCalculation applies custom PK function with multiple output paths
Code
customPKDataMultiple
Output
# A tibble: 27 x 11
OutputPath
<chr>
1 Organism|ArterialBlood|Plasma|Aciclovir
2 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
3 Organism|Age
4 Organism|ArterialBlood|Plasma|Aciclovir
5 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
6 Organism|Age
7 Organism|ArterialBlood|Plasma|Aciclovir
8 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
9 Organism|Age
10 Organism|ArterialBlood|Plasma|Aciclovir
ParameterPath
<chr>
1 Aciclovir|Lipophilicity
2 Aciclovir|Lipophilicity
3 Aciclovir|Lipophilicity
4 Aciclovir|Lipophilicity
5 Aciclovir|Lipophilicity
6 Aciclovir|Lipophilicity
7 Aciclovir|Lipophilicity
8 Aciclovir|Lipophilicity
9 Aciclovir|Lipophilicity
10 Applications|IV 250mg 10min|Application_1|ProtocolSchemaItem|Dose
ParameterFactor ParameterValue ParameterUnit ParameterPathUserName
<dbl> <dbl> <chr> <chr>
1 1 -0.097 Log Units <NA>
2 1 -0.097 Log Units <NA>
3 1 -0.097 Log Units <NA>
4 5 -0.485 Log Units <NA>
5 5 -0.485 Log Units <NA>
6 5 -0.485 Log Units <NA>
7 10 -0.97 Log Units <NA>
8 10 -0.97 Log Units <NA>
9 10 -0.97 Log Units <NA>
10 1 0.00025 kg <NA>
PKParameter PKParameterValue PKPercentChange Unit SensitivityPKParameter
<chr> <dbl> <dbl> <chr> <dbl>
1 minmax 0.0003409 0 <NA> NaN
2 minmax 0.0006476 0 <NA> NaN
3 minmax 1 0 <NA> NaN
4 minmax 0.0002932 -14.01 <NA> -0.03501
5 minmax 0.0005992 -7.474 <NA> -0.01868
6 minmax 1 0 <NA> 0
7 minmax 0.0005275 54.72 <NA> 0.06080
8 minmax 0.0009463 46.13 <NA> 0.05126
9 minmax 1 0 <NA> 0
10 minmax 0.0003409 0 <NA> NaN
# i 17 more rows
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sensitivityCalculation PK parameters tidy dataframe is as expected
Code
df1_pk
Output
$charColumnSummary
# A tibble: 3 x 6
OutputPath
<chr>
1 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
2 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
3 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
ParameterPath ParameterUnit ParameterPathUserName PKParameter
<chr> <chr> <chr> <chr>
1 Aciclovir|Lipophilicity Log Units <NA> AUC_inf
2 Aciclovir|Lipophilicity Log Units <NA> C_max
3 Aciclovir|Lipophilicity Log Units <NA> t_max
Unit
<chr>
1 µmol*min/l
2 µmol/l
3 h
$numericColumnSummary
# A tibble: 5 x 8
column Min. `1st Qu.` Median Mean
<chr> <table[1d]> <table[1d]> <table[1d]> <table[1d]>
1 ParameterFactor 0.1000 0.7750 1.500000 5.775000
2 ParameterValue -1.9400 -0.6305 -0.145500 -0.560175
3 PKParameterValue 0.1833 0.1833 50.964733 1382.726744
4 PKPercentChange -2.6806 0.0000 0.000000 3.313318
5 SensitivityPKParameter 0.0000 0.0000 0.004299 0.009798
`3rd Qu.` Max. `NA's`
<table[1d]> <table[1d]> <table[1d]>
1 6.50000 20.00000 NA
2 -0.07518 -0.00970 NA
3 4059.14498 4154.58500 NA
4 0.82553 37.60585 NA
5 0.01979 0.02978 3
Code
df2_pk
Output
$charColumnSummary
# A tibble: 3 x 6
OutputPath
<chr>
1 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
2 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
3 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
ParameterPath
<chr>
1 Applications|IV 250mg 10min|Application_1|ProtocolSchemaItem|Dose
2 Applications|IV 250mg 10min|Application_1|ProtocolSchemaItem|Dose
3 Applications|IV 250mg 10min|Application_1|ProtocolSchemaItem|Dose
ParameterUnit ParameterPathUserName PKParameter Unit
<chr> <chr> <chr> <chr>
1 kg <NA> AUC_inf µmol*min/l
2 kg <NA> C_max µmol/l
3 kg <NA> t_max h
$numericColumnSummary
# A tibble: 5 x 8
column Min. `1st Qu.` Median Mean
<chr> <table[1d]> <table[1d]> <table[1d]> <table[1d]>
1 ParameterFactor 0.100000 0.7750000 1.500000 5.775000
2 ParameterValue 0.000025 0.0001937 0.000375 0.001444
3 PKParameterValue 0.183333 0.1833333 75.379087 7936.607132
4 PKPercentChange -90.000112 0.0000000 0.000000 318.333335
5 SensitivityPKParameter 0.000000 0.0000000 1.000000 0.666667
`3rd Qu.` Max. `NA's`
<table[1d]> <table[1d]> <table[1d]>
1 6.500000 20.000 NA
2 0.001625 0.005 NA
3 1771.948050 81452.570 NA
4 100.000006 1900.000 NA
5 1.000000 1.000 3
Code
df3_pk
Output
$charColumnSummary
# A tibble: 3 x 6
OutputPath
<chr>
1 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
2 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
3 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
ParameterPath
<chr>
1 Neighborhoods|Kidney_pls_Kidney_ur|Aciclovir|Glomerular Filtration-GFR|GFR fr~
2 Neighborhoods|Kidney_pls_Kidney_ur|Aciclovir|Glomerular Filtration-GFR|GFR fr~
3 Neighborhoods|Kidney_pls_Kidney_ur|Aciclovir|Glomerular Filtration-GFR|GFR fr~
ParameterUnit ParameterPathUserName PKParameter Unit
<chr> <chr> <chr> <chr>
1 "" <NA> AUC_inf µmol*min/l
2 "" <NA> C_max µmol/l
3 "" <NA> t_max h
$numericColumnSummary
# A tibble: 5 x 8
column Min. `1st Qu.` Median Mean
<chr> <table[1d]> <table[1d]> <table[1d]> <table[1d]>
1 ParameterFactor 0.1000 0.77500 1.50000 5.7750
2 ParameterValue 0.1000 0.77500 1.50000 5.7750
3 PKParameterValue 0.1667 0.18333 49.78161 1210.6412
4 PKPercentChange -52.4018 -9.74787 0.00000 -5.9048
5 SensitivityPKParameter -0.1784 -0.02758 -0.01875 -0.0418
`3rd Qu.` Max. `NA's`
<table[1d]> <table[1d]> <table[1d]>
1 6.500000 20.00 NA
2 6.500000 20.00 NA
3 2352.716300 4726.35 NA
4 0.000000 16.05 NA
5 -0.004785 0.00 3
sensitivityCalculation returns expected results with single custom function
Code
customPKData
Output
# A tibble: 12 x 11
OutputPath
<chr>
1 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
2 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
3 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
4 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
5 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
6 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
7 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
8 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
9 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
10 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
11 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
12 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
ParameterPath
<chr>
1 Aciclovir|Lipophilicity
2 Aciclovir|Lipophilicity
3 Aciclovir|Lipophilicity
4 Aciclovir|Lipophilicity
5 Applications|IV 250mg 10min|Application_1|ProtocolSchemaItem|Dose
6 Applications|IV 250mg 10min|Application_1|ProtocolSchemaItem|Dose
7 Applications|IV 250mg 10min|Application_1|ProtocolSchemaItem|Dose
8 Applications|IV 250mg 10min|Application_1|ProtocolSchemaItem|Dose
9 Neighborhoods|Kidney_pls_Kidney_ur|Aciclovir|Glomerular Filtration-GFR|GFR f~
10 Neighborhoods|Kidney_pls_Kidney_ur|Aciclovir|Glomerular Filtration-GFR|GFR f~
11 Neighborhoods|Kidney_pls_Kidney_ur|Aciclovir|Glomerular Filtration-GFR|GFR f~
12 Neighborhoods|Kidney_pls_Kidney_ur|Aciclovir|Glomerular Filtration-GFR|GFR f~
ParameterFactor ParameterValue ParameterUnit ParameterPathUserName
<dbl> <dbl> <chr> <chr>
1 0.1 -0.0097 "Log Units" <NA>
2 1 -0.097 "Log Units" <NA>
3 2 -0.194 "Log Units" <NA>
4 20 -1.94 "Log Units" <NA>
5 0.1 0.000025 "kg" <NA>
6 1 0.00025 "kg" <NA>
7 2 0.0005 "kg" <NA>
8 20 0.005 "kg" <NA>
9 0.1 0.1 "" <NA>
10 1 1 "" <NA>
11 2 2 "" <NA>
12 20 20 "" <NA>
PKParameter PKParameterValue PKPercentChange Unit SensitivityPKParameter
<chr> <dbl> <dbl> <chr> <dbl>
1 minmax 0.0006992 7.968 <NA> -8.854e-2
2 minmax 0.0006476 0 <NA> NaN
3 minmax 0.0006206 -4.157 <NA> -4.157e-2
4 minmax 0.0008589 32.64 <NA> 1.718e-2
5 minmax 0.0006475 -0.01035 <NA> 1.149e-4
6 minmax 0.0006476 0 <NA> NaN
7 minmax 0.0006476 -0.00002663 <NA> -2.663e-7
8 minmax 0.0006476 -0.00002665 <NA> -1.403e-8
9 minmax 0.001230 89.87 <NA> -9.985e-1
10 minmax 0.0006476 0 <NA> NaN
11 minmax 0.0003805 -41.24 <NA> -4.124e-1
12 minmax 0.00005314 -91.79 <NA> -4.831e-2
sensitivityCalculation returns expected results with multiple custom functions
Code
customPKData
Output
# A tibble: 24 x 11
OutputPath
<chr>
1 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
2 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
3 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
4 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
5 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
6 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
7 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
8 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
9 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
10 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
ParameterPath
<chr>
1 Aciclovir|Lipophilicity
2 Aciclovir|Lipophilicity
3 Aciclovir|Lipophilicity
4 Aciclovir|Lipophilicity
5 Aciclovir|Lipophilicity
6 Aciclovir|Lipophilicity
7 Aciclovir|Lipophilicity
8 Aciclovir|Lipophilicity
9 Applications|IV 250mg 10min|Application_1|ProtocolSchemaItem|Dose
10 Applications|IV 250mg 10min|Application_1|ProtocolSchemaItem|Dose
ParameterFactor ParameterValue ParameterUnit ParameterPathUserName
<dbl> <dbl> <chr> <chr>
1 0.1 -0.0097 Log Units <NA>
2 1 -0.097 Log Units <NA>
3 2 -0.194 Log Units <NA>
4 20 -1.94 Log Units <NA>
5 0.1 -0.0097 Log Units <NA>
6 1 -0.097 Log Units <NA>
7 2 -0.194 Log Units <NA>
8 20 -1.94 Log Units <NA>
9 0.1 0.000025 kg <NA>
10 1 0.00025 kg <NA>
PKParameter PKParameterValue PKPercentChange Unit SensitivityPKParameter
<chr> <dbl> <dbl> <chr> <dbl>
1 max_slope 5.847 -1.167 <NA> 0.01297
2 max_slope 5.916 0 <NA> NaN
3 max_slope 5.979 1.057 <NA> 0.01057
4 max_slope 7.418 25.38 <NA> 0.01336
5 minmax 1430. -7.380 <NA> 0.08200
6 minmax 1544. 0 <NA> NaN
7 minmax 1611. 4.338 <NA> 0.04338
8 minmax 1164. -24.61 <NA> -0.01295
9 max_slope 0.5916 -90.00 <NA> 1.000
10 max_slope 5.916 0 <NA> NaN
# i 14 more rows
sensitivityCalculation applies custom PK function with multiple output paths
Code
customPKDataMultiple
Output
# A tibble: 27 x 11
OutputPath
<chr>
1 Organism|ArterialBlood|Plasma|Aciclovir
2 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
3 Organism|Age
4 Organism|ArterialBlood|Plasma|Aciclovir
5 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
6 Organism|Age
7 Organism|ArterialBlood|Plasma|Aciclovir
8 Organism|PeripheralVenousBlood|Aciclovir|Plasma (Peripheral Venous Blood)
9 Organism|Age
10 Organism|ArterialBlood|Plasma|Aciclovir
ParameterPath
<chr>
1 Aciclovir|Lipophilicity
2 Aciclovir|Lipophilicity
3 Aciclovir|Lipophilicity
4 Aciclovir|Lipophilicity
5 Aciclovir|Lipophilicity
6 Aciclovir|Lipophilicity
7 Aciclovir|Lipophilicity
8 Aciclovir|Lipophilicity
9 Aciclovir|Lipophilicity
10 Applications|IV 250mg 10min|Application_1|ProtocolSchemaItem|Dose
ParameterFactor ParameterValue ParameterUnit ParameterPathUserName
<dbl> <dbl> <chr> <chr>
1 1 -0.097 Log Units <NA>
2 1 -0.097 Log Units <NA>
3 1 -0.097 Log Units <NA>
4 5 -0.485 Log Units <NA>
5 5 -0.485 Log Units <NA>
6 5 -0.485 Log Units <NA>
7 10 -0.97 Log Units <NA>
8 10 -0.97 Log Units <NA>
9 10 -0.97 Log Units <NA>
10 1 0.00025 kg <NA>
PKParameter PKParameterValue PKPercentChange Unit SensitivityPKParameter
<chr> <dbl> <dbl> <chr> <dbl>
1 minmax 0.0003409 0 <NA> NaN
2 minmax 0.0006476 0 <NA> NaN
3 minmax 1 0 <NA> NaN
4 minmax 0.0002932 -14.01 <NA> -0.03501
5 minmax 0.0005992 -7.474 <NA> -0.01868
6 minmax 1 0 <NA> 0
7 minmax 0.0005275 54.72 <NA> 0.06080
8 minmax 0.0009463 46.13 <NA> 0.05126
9 minmax 1 0 <NA> 0
10 minmax 0.0003409 0 <NA> NaN
# i 17 more rows
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