boost | R Documentation |
This package provides functions to detect genes with spatial expression pattern, also known as spatially variable (SV) genes, in spatial transcriptomics (ST) data. Two major and novel Bayesian models are implemented via a Gaussian process or Ising model. In addition, it also provides other standard statistical tools such as SPARK, binSpect, etc. Utilities are available to normalize count data, dichotomise expression levels, get spatial neighbors, and view the results of the procedures.
See Jiang et al. (2021) and Li et al. (2020) for details and illustrations of how the Bayesian models are fitted and their applications.
Jiang, X., Li, Q., & Xiao, G. (2021). Bayesian Modeling of Spatial Transcriptomics Data via a Modified Ising Model. arXiv preprint arXiv:2104.13957.
Li, Q., Zhang M., Xie Y., & Xiao, G. (2020). Bayesian Modeling of Spatial Molecular Profiling Data via Gaussian Process. arXiv preprint arXiv:2012.03326.
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