The basic idea is to determine a significantly expressed gene set based on expression profiles, and match the gene symbols with associated protein ids from popular PPI databases, as the following figure shows:
A Multilayer PPI network consists of several layers, each layer is a PPI network. There are two ways to construct Multilayer PPI:
If you are using this package, please cite the following paper:
Active module identification in intracellular networks using a memetic algorithm with a new binary decoding scheme. BMC Genomics 2017 18(Suppl 2):209. Link
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