In gdorum/relMix: Relationship Inference for DNA Mixtures

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relMix

relMix analyses DNA mixtures involving relatives by computing likelihood ratios that can account for dropout and drop-in, mutations, silent alleles and population substructure. relMix can both be used to make inferences about the relationship between individuals in a DNA mixture such as in non-invasive prenatal paternity testing, and to identify contributors to a mixed DNA stain who may be related. Relationships are represented by pedigrees and can include kinship between more than two individuals. The main function is the graphical user interface relMixGUI. A tutorial can be found here: https://gdorum.github.io/relMix/articles/relMix.html

Installation

Install from GitHub as follows:

 # First install devtools if needed
if(!require(devtools)) install.packages("devtools")
devtools::install_github("gdorum/relMix")

To provide pedigree plots, relMix uses the package tkrplot. However, this package has some compatibility issues with MacOS and hence is not included as a hard dependency. Users who wish to see pedigree plots in the results screen have to install the package tkrplot manually with

install.packages("tkrplot")

The tkrplot package will be loaded by relMix automatially, so users do not need to run library("tkrplot") in advance.

gdorum/relMix documentation built on May 3, 2024, 4:29 a.m.