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The Mothers' Stress and Children's Morbidity (MSCM) study is a longitudinal observational study of the causal effect of maternal stress on childhood illness (Zeger and Liang 1986, pp. 125-128).
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A data frame with 5010 observations on 167 mother/child dyads each observed on 30 successive days with the following 14 variables.
idid for dyad
dayday of observation: 1 to 30 for each dyad
stressindicator for maternal stress
illnessindicator for child illness
marrieda factor with levels married other
educationa factor with levels less than high school some high school high school graduate some college college graduate
employedindicator for employment
chlthchild health status at baseline: 1=very poor 2=poor 3=fair 4=good 5=very good
mhlthmother health status at baseline: 1=very poor 2=poor 3=fair 4=good 5=very good
racea factor with levels white non-white
csexa factor with levels male female
housizea factor with levels 2-3 people more than 3 people
bIllnessproportion of child days ill in first 7 days
bStressproportion of maternal days with Stress in first 7 days
The Mothers' Stress and Children's Morbidity (MSCM) study is a longitudinal observational study of the causal effect of maternal stress on childhood illness (Zeger and Liang 1986, pp. 125-128). In the MSCM data, the daily prevalence of childhood illness was 14 questions. How would the prevalence change if an ongoing, fully effective stress-reduction intervention program were instituted? How would prevalence change if conditions worsened and all mothers were subjected to substantial stress on a daily basis? To attempt to answer these questions, we use a formal model for causal effects in longitudinal studies introduced by Robins (1986, 1987a,b). This model extends Neyman's (1923) counterfactual causal model for "point" treatment studies to longitudinal studies with time-varying treatments and confounders. We show that the methods for causal inference developed by Robins provide a better justified basis for answering the foregoing causal questions in longitudinal data in general and in the MSCM study in particular than do methods based on generalized estimating equations (GEE's).
Estimation of the Causal Effect of a Time-Varying Exposure on the Marginal Mean of a Repeated Binary Outcome Journal article by James M. Robins, Sander Greenland, Fu-Chang Hu; Journal of the American Statistical Association, Vol. 94, 1999
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