FittingSingleDrug: Fitting single drug dose-response curve
In google/synergyfinderengineered: Calculate and Visualize Synergy Scores for Drug Combinations

A function to fit single drug dose-response curve with observed response data

1 2	FittingSingleDrug(response.mat, fixed = c(NA, NA, NA, NA), nan.handle = c("LL4", "L4"))

`response.mat`	a matrix with first column as the drug concentrations and second column as the observed responses
`fixed`	a parameter to specify which parameters are fixed and at what value they are fixed. NAs for parameter that are not fixed.
`nan.handle`	a parameter to specify if L.4 function or LL.4 function is used when fitting with LL.4 produces NaNs.

Single drug dose-response curve is fitted with a commonly used 4-paramter log-losistic (4PL) function.

Fitted responses and fitted models are returned.

Seber, G. A. F. and Wild, C. J (1989) Nonlinear Regression, New York: Wiley \& Sons (p. 330).

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data("mathews_screening_data")
data <- ReshapeData(mathews_screening_data)
single.drug.fitted <- FittingSingleDrug(data$dose.response.mats[[1]])

google/synergyfinderengineered documentation built on May 16, 2019, 2:31 a.m.

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