Baker2009: Network meta-analysis of pharmacologic treatments for chronic...

In guido-s/netmeta: Network Meta-Analysis using Frequentist Methods

Network meta-analysis of pharmacologic treatments for chronic obstructive pulmonary disease

Description

This data set comes from a systematic review of randomized controlled trials on pharmacologic treatments for chronic obstructive pulmonary disease (COPD) (Baker et al., 2009).

The primary outcome, occurrence of one or more episodes of COPD exacerbation, is binary (yes / no). For this outcome, five drug treatments (fluticasone, budesonide, salmeterol, formoterol, tiotropium) and two combinations (fluticasone + salmeterol, budesonide + formoterol) were compared to placebo. The authors considered the two combinations as separate treatments instead of evaluating the individual components.

Format

A data frame with the following columns:

study	study label
year	year of publication
id	study ID
treatment	treatment
exac	one or more episodes of COPD exacerbation
total	number of individuals in treatment arm

Source

Baker WL, Baker EL, Coleman CI (2009): Pharmacologic Treatments for Chronic Obstructive Pulmonary Disease: A Mixed-Treatment Comparison Meta-analysis. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 29, 891–905

See Also

pairwise, metabin, netmetabin

Examples

data(Baker2009)
Baker2009

## Not run: 
# Transform data from long arm-based format to contrast-based
# format. Argument 'sm' has to be used for odds ratio as summary
# measure; by default the risk ratio is used in the metabin
# function called internally.
#
p1 <- pairwise(treatment, exac, total, studlab = paste(study, year),
  data = Baker2009, sm = "OR")

# Conduct network meta-analysis
#
net1 <- netmeta(p1, ref = "plac")

# Conduct component network meta-analysis
#
cnet1 <- netcomb(net1)
cnet1

## End(Not run)

guido-s/netmeta documentation built on April 8, 2024, 5:31 a.m.