make_noisy_spectra: Creates spectra with technical replicates and noise

In hadexversum/powerHDX: Efficient Simulation of HDX-MS Data and Tools for the Statistical Analysis

Creates spectra with technical replicates and noise

Description

Creates spectra with technical replicates and noise

Usage

make_noisy_spectra(
  spectra,
  n_experiments = 100,
  undeuterated_mass,
  mass_deviations = 50,
  intensity_deviations = NULL
)

Arguments

spectra	a list of spectra obtained via make_experimental_design.
n_experiments	number of replicates of an experiment for power calculation.
undeuterated_mass	the value of mass of an undeuterated peptide computed by get_undeuterated_mass.
mass_deviations	mass deviation in parts per million. Either a single number (then the error at each time point will be the same) or a vector of the same length as number of unique time points in the experiment. The error will be sampled from normal distribution with standard deviation equal to mass_deviations * undeuterated_mass/1e6 Default to 50.
intensity_deviations	optional, standard deviations of random noise that will be added to intensities. Either a single number (then the error at each time point will be the same) or a vector of the same length as number of unique time points in the experiment. The error will be sampled from normal distribution with these standard deviations.Default NULL.

Details

This function uses add_noise_to_one_spectrum.

Value

list of lists of data.tables

hadexversum/powerHDX documentation built on Aug. 31, 2022, 7:47 p.m.