trisomy21: Function to compute the trisomy21 risk based on 3 biomarkers...

In hoehleatsu/trisomy21risk: Risk Calculation for T21 from a First Trimester Combined Test

Description

Function to compute the trisomy21 risk based on 3 biomarkers (NT, PAPP-A, betahCG) and visibility of the nasal bone on the ultrasound. Several covariates (age of mother, weight of mother, CRL at measurement) are taken into account.

Usage

trisomy21(age, weight, crlbe, crl, nt, pappa, betahCG, nasalbone, background)

Arguments

age	Age of the mother (in years)
weight	Weight of the mother (in kg)
crlbe	Crown-rump-length (in mm) at the time of the PAPP-A and betahCG measurements
crl	Crown-rump-length (in mm) at the time of the NT measurement
nt	nuchal translucency of the fetus (in mm)
pappa	Measured value of PAPP-A in maternal serum (in miU/ml)
betahCG	Measured value of betahCG in maternal serum (in miU/ml)
nasalbone	Visibility of a nasal bone on the ultrasound (0/1 or "Unknown")
background	Background probability for T21

Value

Posterior risk of T21.

References

Merz, E., C. Thode, B. Eiben, and S. Wellek. 2016. "Prenatal Risk Calculation (PRC) 3.0: An Extended Doe-Based First-Trimester Screening Algorithm Allowing for Early Blood Sampling." Ultrasound International Open 2: E19–E26. doi:10.1055/s-0035-1569403.

hoehleatsu/trisomy21risk documentation built on Sept. 19, 2020, 8:44 p.m.