PAIRADISE: PAIRADISE Detecting allele-specific alternative splicing from...

In hubentu/PAIRADISE: PAIRADISE: Paired analysis of differential isoform expression

Description

We introduce PAIRADISE (PAIred Replicate analysis of Allelic DIfferential Splicing Events), a method for detecting allele-specific alternative splicing (ASAS) from RNA-seq data. PAIRADISE uses a statistical model that aggregates ASAS signals across multiple individuals in a population. It formulates ASAS detection as a statistical problem for identifying differential alternative splicing from RNA-seq data with paired replicates. The PAIRADISE statistical model is applicable to many forms of allele-specific isoform variation (e.g. RNA editing), and can be used as a generic statistical model for RNA-seq studies involving paired replicates.

See Also

pairadise

hubentu/PAIRADISE documentation built on Oct. 4, 2020, 4:27 a.m.