computeQ: Compute the conditional Q-statistic for assessing instrument...
In jingshuw/GRAPPLE-beta-: R Package for MR Framework GRAPPLE
computeQ R Documentation
Compute the conditional Q-statistic for assessing instrument strength
Description
Compute the conditional Q-statistic for assessing instrument strength
Usage
computeQ(dat.list, p.thres = NULL)
Arguments
dat.list
Object returned from getInput
p.thres
The p-value threshold for SNP selection. The SNPs whose selection_pvals are less than p.thres are selected.
The default value is NULL, which is to include all SNPs in data. If it is not NULL, then data should have a column selection_pvals
that stores the selection p-value of each SNP.
Value
The conditional Q-statistics, degrees of freedom, and the corresponding p-values
References
Eleanor Sanderson, George Davey Smith, Frank Windmeijer, Jack Bowden, An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings, International Journal of Epidemiology, Volume 48, Issue 3, June 2019, Pages 713–727, https://doi.org/10.1093/ije/dyy262.
jingshuw/GRAPPLE-beta- documentation built on March 29, 2024, 1:26 p.m.
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| computeQ | R Documentation |
Compute the conditional Q-statistic for assessing instrument strength
Description
Compute the conditional Q-statistic for assessing instrument strength
Usage
computeQ(dat.list, p.thres = NULL)
Arguments
dat.list |
Object returned from |
p.thres |
The p-value threshold for SNP selection. The SNPs whose |
Value
The conditional Q-statistics, degrees of freedom, and the corresponding p-values
References
Eleanor Sanderson, George Davey Smith, Frank Windmeijer, Jack Bowden, An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings, International Journal of Epidemiology, Volume 48, Issue 3, June 2019, Pages 713–727, https://doi.org/10.1093/ije/dyy262.
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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