Description Usage Arguments Details

Function to obtain TLP effect size estimates given summary statistics and a reference panel

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`cors` |
A vector of correlations, representing the univariate SNP-phenotype associations from the summary statistic data. |

`bfile` |
The stem of a PLINK binary file to be used as a reference panel. |

`lambdas` |
Vector of values of lambda. |

`taus` |
Vector of values of tau. |

`s` |
Vector of values for s. |

`thr` |
Convergence threshold. |

`init` |
Initial values for |

`maxIter` |
Maximum number of iterations. |

`extract` |
Vector of the indices of SNPs to keep. If null, will keep all SNPs. |

`ldBlocks` |
Location of file specifying independent LD Blocks to be used. File should be in the BED file format. If null, estimation is done by chromosome. |

`corBim` |
Optional PLINK formatted '.bim' file that specifies SNP labels and locations for 'cors' vector. If non-null, will check for SNPs missing in the reference panel and handle ensuing estimation. |

Function finds the minimum of the TLP objective function

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