Fixed design, two-arm trial with time-to-event
outcome (Lachin and Foulkes, 1986).
Solving for: Accrual duration
Hazard ratio H1/H0=0.6/1
Study duration: T=172.197
Accrual duration: 171.997
Min. end-of-study follow-up: minfup=0.2
Expected events (total, H1): 160.6536
Expected sample size (total): 171.997
Accrual rates:
Stratum 1
0-172 1
Control event rates (H1):
Stratum 1
0-Inf 0.1155
Censoring rates:
Stratum 1
0-Inf 0
Power: 100*(1-beta)=90%
Type I error (1-sided): 100*alpha=2.5%
Equal randomization: ratio=1
Fixed design, two-arm trial with time-to-event
outcome (Lachin and Foulkes, 1986).
Solving for: Accrual duration
Hazard ratio H1/H0=0.6/1
Study duration: T=362.7886
Accrual duration: 362.5886
Min. end-of-study follow-up: minfup=0.2
Expected events (total, H1): 223.2728
Expected sample size (total): 362.5886
Accrual rates:
Stratum 1
0-362.59 1
Control event rates (H1):
Stratum 1
0-Inf 0.1155
Control censoring rates:
Stratum 1
0-Inf 0
Experimental censoring rates:
Stratum 1
0-Inf 0.2
Power: 100*(1-beta)=90%
Type I error (1-sided): 100*alpha=2.5%
Equal randomization: ratio=1
Fixed design, two-arm trial with time-to-event
outcome (Lachin and Foulkes, 1986).
Solving for: Accrual duration
Hazard ratio H1/H0=0.6/1
Study duration: T=385.7633
Accrual duration: 385.5633
Min. end-of-study follow-up: minfup=0.2
Expected events (total, H1): 253.2043
Expected sample size (total): 385.5633
Accrual rates:
Stratum 1
0-385.56 1
Control event rates (H1):
Stratum 1
0-Inf 0.1155
Control censoring rates:
Stratum 1
0-Inf 0
Experimental censoring rates:
Stratum 1
0-Inf 0.2
Power: 100*(1-beta)=90%
Type I error (1-sided): 100*alpha=2.5%
Randomization (Exp/Control): ratio= 0.8
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