tests/testthat/_snaps/independent-test-print.nSurvival.md

In keaven/gsDesign: Group Sequential Design

Test: checking entry set to "unif"

Fixed design, two-arm trial with time-to-event
outcome (Lachin and Foulkes, 1986).
Study duration (fixed):          Ts=2
Accrual duration (fixed):        Tr=0.5
Uniform accrual:              entry="unif"
Control median:      log(2)/lambda1=3.5
Experimental median: log(2)/lambda2=6.9
Censoring median:        log(2)/eta=6.9
Control failure rate:       lambda1=0.2
Experimental failure rate:  lambda2=0.1
Censoring rate:                 eta=0.1
Power:                 100*(1-beta)=90%
Type I error (1-sided):   100*alpha=2.5%
Equal randomization:          ratio=1
Sample size based on hazard ratio=0.5 (type="rr")
Sample size (computed):           n=430
Events required (computed): nEvents=91

Test: checking entry set to "expo"

Fixed design, two-arm trial with time-to-event
outcome (Lachin and Foulkes, 1986).
Study duration (fixed):          Ts=2
Accrual duration (fixed):        Tr=0.5
Exponential accrual:          entry="expo"
Accrual shape parameter:      gamma=1
Control median:      log(2)/lambda1=3.5
Experimental median: log(2)/lambda2=6.9
Censoring median:        log(2)/eta=6.9
Control failure rate:       lambda1=0.2
Experimental failure rate:  lambda2=0.1
Censoring rate:                 eta=0.1
Power:                 100*(1-beta)=90%
Type I error (1-sided):   100*alpha=2.5%
Equal randomization:          ratio=1
Sample size based on hazard ratio=0.5 (type="rr")
Sample size (computed):           n=426
Events required (computed): nEvents=91

Test: checking entry - "expo", eta = 0 and ratio set

Fixed design, two-arm trial with time-to-event
outcome (Lachin and Foulkes, 1986).
Study duration (fixed):          Ts=2
Accrual duration (fixed):        Tr=0.5
Exponential accrual:          entry="expo"
Accrual shape parameter:      gamma=1
Control median:      log(2)/lambda1=3.5
Experimental median: log(2)/lambda2=6.9
Censoring only at study end (eta=0)
Control failure rate:       lambda1=0.2
Experimental failure rate:  lambda2=0.1
Censoring rate:                 eta=0
Power:                 100*(1-beta)=90%
Type I error (1-sided):   100*alpha=2.5%
Randomization (Exp/Control):  ratio=1.25
Sample size based on hazard ratio=0.5 (type="rr")
Sample size (computed):           n=400
Events required (computed): nEvents=89

Test: checking entry set to "expo",eta = 0,ratio != 1

Fixed design, two-arm trial with time-to-event
outcome (Lachin and Foulkes, 1986).
Study duration (fixed):          Ts=2
Accrual duration (fixed):        Tr=0.5
Exponential accrual:          entry="expo"
Accrual shape parameter:      gamma=1
Control median:      log(2)/lambda1=3.5
Experimental median: log(2)/lambda2=6.9
Censoring only at study end (eta=0)
Control failure rate:       lambda1=0.2
Experimental failure rate:  lambda2=0.1
Censoring rate:                 eta=0
Power:                 100*(1-beta)=90%
Type I error (1-sided):   100*alpha=2.5%
Randomization (Exp/Control):  ratio=0.8
Sample size based on hazard ratio=0.5 (type="rr")
Sample size (computed):           n=396
Events required (computed): nEvents=94

Test: checking type of sample size calculation:

                risk ratio (type = rr) with approximate computation

Fixed design, two-arm trial with time-to-event
outcome (Lachin and Foulkes, 1986).
Study duration (fixed):          Ts=2
Accrual duration (fixed):        Tr=0.5
Uniform accrual:              entry="unif"
Control median:      log(2)/lambda1=3.5
Experimental median: log(2)/lambda2=6.9
Censoring median:        log(2)/eta=0.1
Control failure rate:       lambda1=0.2
Experimental failure rate:  lambda2=0.1
Censoring rate:                 eta=6.9
Power:                 100*(1-beta)=90%
Type I error (1-sided):   100*alpha=2.5%
Equal randomization:          ratio=1
Sample size based on hazard ratio=0.5 (type="rr")
Sample size (computed):           n=4308
Events required (computed): nEvents=92

Test: checking type of sample size calculation:

                risk difference (type = rd) with approximate computation

Fixed design, two-arm trial with time-to-event
outcome (Lachin and Foulkes, 1986).
Study duration (fixed):          Ts=2
Accrual duration (fixed):        Tr=0.5
Uniform accrual:              entry="unif"
Control median:      log(2)/lambda1=3.5
Experimental median: log(2)/lambda2=6.9
Censoring only at study end (eta=0)
Control failure rate:       lambda1=0.2
Experimental failure rate:  lambda2=0.1
Censoring rate:                 eta=0
Power:                 100*(1-beta)=90%
Type I error (1-sided):   100*alpha=2.5%
Equal randomization:          ratio=1
Sample size based on risk difference=0.1 (type="rd")
Sample size based on H1 variance only:  approx=TRUE
Sample size (computed):           n=416
Events required (computed): nEvents=95

Test: checking type of sample size calculation:

                risk difference (type = rd) with approx set to FALSE

Fixed design, two-arm trial with time-to-event
outcome (Lachin and Foulkes, 1986).
Study duration (fixed):          Ts=2
Accrual duration (fixed):        Tr=0.5
Uniform accrual:              entry="unif"
Control median:      log(2)/lambda1=3.5
Experimental median: log(2)/lambda2=6.9
Censoring only at study end (eta=0)
Control failure rate:       lambda1=0.2
Experimental failure rate:  lambda2=0.1
Censoring rate:                 eta=0
Power:                 100*(1-beta)=90%
Type I error (1-sided):   100*alpha=2.5%
Equal randomization:          ratio=1
Sample size based on risk difference=0.1 (type="rd")
Sample size based on H0 and H1 variance: approx=FALSE
Sample size (computed):           n=414
Events required (computed): nEvents=94

keaven/gsDesign documentation built on April 10, 2024, 6:21 a.m.