NEWS.md

In kestrel99/occamsPmx: Pharmacometric and Pharmacokinetic Toolkit

pmxTools 1.3

• Added NCA parameter estimation to calc_derived_1cpt(), calc_derived_2cpt() and calc_derived_3cpt(), if dose and other required information (e.g. tinf, dur, tau) is provided.

• Added a warning about flip-flop kinetics and their potential effects on derived half-lives to calc_derived_1cpt(), calc_derived_2cpt(), and calc_derived_3cpt().

• Added blq_trans() and blq_log_trans() for assistance with visualization of measurements below a limit of quantification.

• Added a test for valid XML to read_nm().

• Small fixes and enhancements to read_nmtable_single() and read_nm_multi_table() to ensure that stray text is properly handled while reading in NONMEM output files.

• count_na() now throws a warning if NaN values are included in the NA count, and indicates how many of them there are.

• Changed the significant digits functionality for 95% confidence intervals for get_theta(), get_omega() and get_sigma(), and all functions that apply these.

• Replaced gridExtra with patchwork.

• Numerous small fixes.

• Removed some unnecessary dependencies.

• Added many new unit tests, increasing test coverage considerably.

pmxTools 1.2.4

• Fixed some minor documentation issues. Thanks to Julien Grassot for spotting these.

pmxTools 1.2.3

• Fixed another error in sample_uncert() which was still crashing the function.

• Added helper functions count_na(), dgr_table(), gcv(), fmt_signif().

• Added distribution plotting function plot_dist().

pmxTools 1.2.2

• Fixed an error in sample_uncert() which was crashing the function.

pmxTools 1.2.1

• Added vignette describing PK curves.

• Fixed a systematic error in calc_sd_1cmt_linear_oral_0_lag(), calc_ss_1cmt_linear_oral_0_lag(), calc_sd_2cmt_linear_oral_0_lag() which resulted in incorrect curves being plotted.

pmxTools 1.2

• Rewrote plot_scm function to produce tree diagrams via DiagrammeR.

• Fixed a rare bug in get_auc in which measurements from different individuals could be erroneously mixed.

• Amended (or added) read_nm(), read_nm_all(), read_nmext(), read_nmcov(), read_nmtables() functions to allow reading of multiple NONMEM estimation steps.

• Clarified documentation for calc_derived().

• Now using xml2 to read NONMEM-generated XML files.

• Fixed partial argument match warnings encountered during tests.

• Add function for calculting geometric CV.

kestrel99/occamsPmx documentation built on Feb. 25, 2023, 8:39 a.m.