Added NCA parameter estimation to calc_derived_1cpt()
, calc_derived_2cpt()
and calc_derived_3cpt()
, if dose and other required information (e.g. tinf
, dur
, tau
) is provided.
Added a warning about flip-flop kinetics and their potential effects on derived half-lives to calc_derived_1cpt()
, calc_derived_2cpt()
, and calc_derived_3cpt()
.
Added blq_trans()
and blq_log_trans()
for assistance with visualization of measurements below a limit of quantification.
Added a test for valid XML to read_nm()
.
Small fixes and enhancements to read_nmtable_single()
and read_nm_multi_table()
to ensure that stray text is properly handled while reading in NONMEM output files.
count_na()
now throws a warning if NaN
values are included in the NA
count, and indicates how many of them there are.
Changed the significant digits functionality for 95% confidence intervals for get_theta()
, get_omega()
and get_sigma()
, and all functions that apply these.
Replaced gridExtra
with patchwork
.
Numerous small fixes.
Removed some unnecessary dependencies.
Added many new unit tests, increasing test coverage considerably.
Fixed another error in sample_uncert()
which was still crashing the function.
Added helper functions count_na()
, dgr_table()
, gcv()
, fmt_signif()
.
Added distribution plotting function plot_dist()
.
sample_uncert()
which was crashing the function.Added vignette describing PK curves.
Fixed a systematic error in calc_sd_1cmt_linear_oral_0_lag()
, calc_ss_1cmt_linear_oral_0_lag()
, calc_sd_2cmt_linear_oral_0_lag()
which resulted in incorrect curves being plotted.
Rewrote plot_scm
function to produce tree diagrams via DiagrammeR
.
Fixed a rare bug in get_auc
in which measurements from different individuals could be erroneously mixed.
Amended (or added) read_nm()
, read_nm_all()
, read_nmext()
, read_nmcov()
, read_nmtables()
functions to allow reading of multiple NONMEM estimation steps.
Clarified documentation for calc_derived()
.
Now using xml2
to read NONMEM-generated XML files.
Fixed partial argument match warnings encountered during tests.
Add function for calculting geometric CV.
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