tests/testthat/_snaps/calc.md
In kestrel99/pmxTools: Pharmacometric and Pharmacokinetic Toolkit
PK curves
Code
pk_curve(t = seq(0, 72, by = 0.1), model = "1cmt_bolus", ii = 12, addl = 5,
params = list(CL = 2.5, V = 25))
Output
t cp
1 0.0 24.000000
2 0.1 23.761196
3 0.2 23.524768
4 0.3 23.290693
5 0.4 23.058947
6 0.5 22.829506
7 0.6 22.602349
8 0.7 22.377452
9 0.8 22.154792
10 0.9 21.934348
11 1.0 21.716098
12 1.1 21.500019
13 1.2 21.286090
14 1.3 21.074290
15 1.4 20.864598
16 1.5 20.656991
17 1.6 20.451451
18 1.7 20.247956
19 1.8 20.046485
20 1.9 19.847019
21 2.0 19.649538
22 2.1 19.454022
23 2.2 19.260451
24 2.3 19.068806
25 2.4 18.879069
26 2.5 18.691219
27 2.6 18.505238
28 2.7 18.321108
29 2.8 18.138810
30 2.9 17.958326
31 3.0 17.779637
32 3.1 17.602727
33 3.2 17.427577
34 3.3 17.254170
35 3.4 17.082488
36 3.5 16.912514
37 3.6 16.744232
38 3.7 16.577624
39 3.8 16.412674
40 3.9 16.249365
41 4.0 16.087681
42 4.1 15.927606
43 4.2 15.769124
44 4.3 15.612218
45 4.4 15.456874
46 4.5 15.303076
47 4.6 15.150807
48 4.7 15.000054
49 4.8 14.850801
50 4.9 14.703033
51 5.0 14.556736
52 5.1 14.411894
53 5.2 14.268493
54 5.3 14.126519
55 5.4 13.985958
56 5.5 13.846795
57 5.6 13.709018
58 5.7 13.572611
59 5.8 13.437561
60 5.9 13.303855
61 6.0 13.171479
62 6.1 13.040421
63 6.2 12.910667
64 6.3 12.782203
65 6.4 12.655018
66 6.5 12.529099
67 6.6 12.404432
68 6.7 12.281006
69 6.8 12.158808
70 6.9 12.037826
71 7.0 11.918047
72 7.1 11.799461
73 7.2 11.682054
74 7.3 11.565816
75 7.4 11.450734
76 7.5 11.336797
77 7.6 11.223994
78 7.7 11.112314
79 7.8 11.001744
80 7.9 10.892275
81 8.0 10.783895
82 8.1 10.676594
83 8.2 10.570360
84 8.3 10.465183
85 8.4 10.361053
86 8.5 10.257958
87 8.6 10.155890
88 8.7 10.054837
89 8.8 9.954790
90 8.9 9.855738
91 9.0 9.757672
92 9.1 9.660581
93 9.2 9.564457
94 9.3 9.469289
95 9.4 9.375068
96 9.5 9.281785
97 9.6 9.189429
98 9.7 9.097993
99 9.8 9.007466
100 9.9 8.917841
101 10.0 8.829107
102 10.1 8.741256
103 10.2 8.654279
104 10.3 8.568167
105 10.4 8.482912
106 10.5 8.398506
107 10.6 8.314939
108 10.7 8.232204
109 10.8 8.150293
110 10.9 8.069196
111 11.0 7.988906
112 11.1 7.909415
113 11.2 7.830715
114 11.3 7.752798
115 11.4 7.675657
116 11.5 7.599282
117 11.6 7.523668
118 11.7 7.448807
119 11.8 7.374690
120 11.9 7.301310
121 12.0 31.228661
122 12.1 30.917931
123 12.2 30.610292
124 12.3 30.305715
125 12.4 30.004168
126 12.5 29.705621
127 12.6 29.410045
128 12.7 29.117411
129 12.8 28.827688
130 12.9 28.540847
131 13.0 28.256861
132 13.1 27.975701
133 13.2 27.697338
134 13.3 27.421745
135 13.4 27.148894
136 13.5 26.878758
137 13.6 26.611310
138 13.7 26.346523
139 13.8 26.084370
140 13.9 25.824827
141 14.0 25.567865
142 14.1 25.313461
143 14.2 25.061588
144 14.3 24.812221
145 14.4 24.565335
146 14.5 24.320906
147 14.6 24.078909
148 14.7 23.839320
149 14.8 23.602114
150 14.9 23.367269
151 15.0 23.134761
152 15.1 22.904566
153 15.2 22.676662
154 15.3 22.451026
155 15.4 22.227634
156 15.5 22.006466
157 15.6 21.787498
158 15.7 21.570708
159 15.8 21.356076
160 15.9 21.143580
161 16.0 20.933198
162 16.1 20.724909
163 16.2 20.518692
164 16.3 20.314528
165 16.4 20.112395
166 16.5 19.912273
167 16.6 19.714143
168 16.7 19.517984
169 16.8 19.323777
170 16.9 19.131502
171 17.0 18.941140
172 17.1 18.752673
173 17.2 18.566081
174 17.3 18.381345
175 17.4 18.198448
176 17.5 18.017370
177 17.6 17.838094
178 17.7 17.660602
179 17.8 17.484876
180 17.9 17.310899
181 18.0 17.138653
182 18.1 16.968120
183 18.2 16.799285
184 18.3 16.632129
185 18.4 16.466636
186 18.5 16.302791
187 18.6 16.140575
188 18.7 15.979974
189 18.8 15.820970
190 18.9 15.663549
191 19.0 15.507694
192 19.1 15.353390
193 19.2 15.200621
194 19.3 15.049373
195 19.4 14.899629
196 19.5 14.751375
197 19.6 14.604596
198 19.7 14.459278
199 19.8 14.315406
200 19.9 14.172965
201 20.0 14.031942
202 20.1 13.892322
203 20.2 13.754091
204 20.3 13.617235
205 20.4 13.481742
206 20.5 13.347596
207 20.6 13.214785
208 20.7 13.083296
209 20.8 12.953115
210 20.9 12.824229
211 21.0 12.696626
212 21.1 12.570293
213 21.2 12.445216
214 21.3 12.321384
215 21.4 12.198784
216 21.5 12.077404
217 21.6 11.957232
218 21.7 11.838256
219 21.8 11.720463
220 21.9 11.603843
221 22.0 11.488382
222 22.1 11.374071
223 22.2 11.260897
224 22.3 11.148849
225 22.4 11.037916
226 22.5 10.928087
227 22.6 10.819351
228 22.7 10.711697
229 22.8 10.605114
230 22.9 10.499591
231 23.0 10.395118
232 23.1 10.291685
233 23.2 10.189281
234 23.3 10.087896
235 23.4 9.987520
236 23.5 9.888142
237 23.6 9.789754
238 23.7 9.692344
239 23.8 9.595904
240 23.9 9.500423
241 24.0 33.405892
242 24.1 33.073498
243 24.2 32.744411
244 24.3 32.418599
245 24.4 32.096028
246 24.5 31.776667
247 24.6 31.460484
248 24.7 31.147447
249 24.8 30.837525
250 24.9 30.530686
251 25.0 30.226901
252 25.1 29.926138
253 25.2 29.628368
254 25.3 29.333561
255 25.4 29.041687
256 25.5 28.752718
257 25.6 28.466623
258 25.7 28.183376
259 25.8 27.902946
260 25.9 27.625307
261 26.0 27.350431
262 26.1 27.078290
263 26.2 26.808856
264 26.3 26.542104
265 26.4 26.278005
266 26.5 26.016535
267 26.6 25.757666
268 26.7 25.501373
269 26.8 25.247630
270 26.9 24.996412
271 27.0 24.747693
272 27.1 24.501450
273 27.2 24.257656
274 27.3 24.016289
275 27.4 23.777323
276 27.5 23.540734
277 27.6 23.306500
278 27.7 23.074596
279 27.8 22.845000
280 27.9 22.617689
281 28.0 22.392639
282 28.1 22.169829
283 28.2 21.949235
284 28.3 21.730837
285 28.4 21.514611
286 28.5 21.300537
287 28.6 21.088593
288 28.7 20.878758
289 28.8 20.671011
290 28.9 20.465331
291 29.0 20.261698
292 29.1 20.060090
293 29.2 19.860489
294 29.3 19.662874
295 29.4 19.467225
296 29.5 19.273523
297 29.6 19.081748
298 29.7 18.891882
299 29.8 18.703904
300 29.9 18.517797
301 30.0 18.333542
302 30.1 18.151120
303 30.2 17.970514
304 30.3 17.791704
305 30.4 17.614674
306 30.5 17.439405
307 30.6 17.265880
308 30.7 17.094081
309 30.8 16.923993
310 30.9 16.755596
311 31.0 16.588875
312 31.1 16.423813
313 31.2 16.260393
314 31.3 16.098600
315 31.4 15.938416
316 31.5 15.779826
317 31.6 15.622814
318 31.7 15.467365
319 31.8 15.313462
320 31.9 15.161090
321 32.0 15.010235
322 32.1 14.860880
323 32.2 14.713012
324 32.3 14.566615
325 32.4 14.421675
326 32.5 14.278177
327 32.6 14.136107
328 32.7 13.995450
329 32.8 13.856193
330 32.9 13.718322
331 33.0 13.581822
332 33.1 13.446681
333 33.2 13.312884
334 33.3 13.180419
335 33.4 13.049271
336 33.5 12.919429
337 33.6 12.790878
338 33.7 12.663607
339 33.8 12.537602
340 33.9 12.412851
341 34.0 12.289341
342 34.1 12.167060
343 34.2 12.045996
344 34.3 11.926136
345 34.4 11.807469
346 34.5 11.689983
347 34.6 11.573665
348 34.7 11.458505
349 34.8 11.344491
350 34.9 11.231612
351 35.0 11.119855
352 35.1 11.009211
353 35.2 10.899668
354 35.3 10.791214
355 35.4 10.683840
356 35.5 10.577534
357 35.6 10.472285
358 35.7 10.368085
359 35.8 10.264920
360 35.9 10.162783
361 36.0 34.061661
362 36.1 33.722742
363 36.2 33.387195
364 36.3 33.054987
365 36.4 32.726084
366 36.5 32.400454
367 36.6 32.078065
368 36.7 31.758882
369 36.8 31.442876
370 36.9 31.130014
371 37.0 30.820266
372 37.1 30.513599
373 37.2 30.209984
374 37.3 29.909389
375 37.4 29.611786
376 37.5 29.317144
377 37.6 29.025433
378 37.7 28.736625
379 37.8 28.450691
380 37.9 28.167602
381 38.0 27.887330
382 38.1 27.609846
383 38.2 27.335123
384 38.3 27.063134
385 38.4 26.793852
386 38.5 26.527248
387 38.6 26.263298
388 38.7 26.001974
389 38.8 25.743250
390 38.9 25.487100
391 39.0 25.233499
392 39.1 24.982422
393 39.2 24.733843
394 39.3 24.487737
395 39.4 24.244080
396 39.5 24.002847
397 39.6 23.764015
398 39.7 23.527559
399 39.8 23.293456
400 39.9 23.061682
401 40.0 22.832214
402 40.1 22.605030
403 40.2 22.380106
404 40.3 22.157420
405 40.4 21.936950
406 40.5 21.718674
407 40.6 21.502570
408 40.7 21.288616
409 40.8 21.076790
410 40.9 20.867073
411 41.0 20.659442
412 41.1 20.453877
413 41.2 20.250358
414 41.3 20.048863
415 41.4 19.849374
416 41.5 19.651869
417 41.6 19.456330
418 41.7 19.262736
419 41.8 19.071069
420 41.9 18.881308
421 42.0 18.693436
422 42.1 18.507433
423 42.2 18.323281
424 42.3 18.140962
425 42.4 17.960456
426 42.5 17.781746
427 42.6 17.604815
428 42.7 17.429644
429 42.8 17.256216
430 42.9 17.084514
431 43.0 16.914520
432 43.1 16.746218
433 43.2 16.579590
434 43.3 16.414621
435 43.4 16.251293
436 43.5 16.089590
437 43.6 15.929495
438 43.7 15.770994
439 43.8 15.614070
440 43.9 15.458708
441 44.0 15.304891
442 44.1 15.152605
443 44.2 15.001834
444 44.3 14.852563
445 44.4 14.704778
446 44.5 14.558463
447 44.6 14.413604
448 44.7 14.270186
449 44.8 14.128195
450 44.9 13.987617
451 45.0 13.848438
452 45.1 13.710644
453 45.2 13.574221
454 45.3 13.439155
455 45.4 13.305433
456 45.5 13.173042
457 45.6 13.041968
458 45.7 12.912198
459 45.8 12.783720
460 45.9 12.656519
461 46.0 12.530585
462 46.1 12.405904
463 46.2 12.282463
464 46.3 12.160250
465 46.4 12.039254
466 46.5 11.919461
467 46.6 11.800860
468 46.7 11.683440
469 46.8 11.567188
470 46.9 11.452092
471 47.0 11.338142
472 47.1 11.225326
473 47.2 11.113632
474 47.3 11.003049
475 47.4 10.893567
476 47.5 10.785174
477 47.6 10.677860
478 47.7 10.571614
479 47.8 10.466424
480 47.9 10.362282
481 48.0 34.259175
482 48.1 33.918291
483 48.2 33.580798
484 48.3 33.246664
485 48.4 32.915854
486 48.5 32.588336
487 48.6 32.264076
488 48.7 31.943043
489 48.8 31.625205
490 48.9 31.310529
491 49.0 30.998984
492 49.1 30.690539
493 49.2 30.385163
494 49.3 30.082825
495 49.4 29.783496
496 49.5 29.487145
497 49.6 29.193743
498 49.7 28.903261
499 49.8 28.615669
500 49.9 28.330938
501 50.0 28.049040
502 50.1 27.769948
503 50.2 27.493632
504 50.3 27.220066
505 50.4 26.949222
506 50.5 26.681072
507 50.6 26.415591
508 50.7 26.152752
509 50.8 25.892528
510 50.9 25.634893
511 51.0 25.379821
512 51.1 25.127288
513 51.2 24.877267
514 51.3 24.629734
515 51.4 24.384664
516 51.5 24.142033
517 51.6 23.901816
518 51.7 23.663988
519 51.8 23.428528
520 51.9 23.195410
521 52.0 22.964612
522 52.1 22.736110
523 52.2 22.509882
524 52.3 22.285905
525 52.4 22.064157
526 52.5 21.844615
527 52.6 21.627257
528 52.7 21.412062
529 52.8 21.199009
530 52.9 20.988075
531 53.0 20.779240
532 53.1 20.572483
533 53.2 20.367784
534 53.3 20.165121
535 53.4 19.964474
536 53.5 19.765825
537 53.6 19.569151
538 53.7 19.374435
539 53.8 19.181656
540 53.9 18.990796
541 54.0 18.801834
542 54.1 18.614753
543 54.2 18.429533
544 54.3 18.246156
545 54.4 18.064604
546 54.5 17.884858
547 54.6 17.706900
548 54.7 17.530714
549 54.8 17.356280
550 54.9 17.183582
551 55.0 17.012603
552 55.1 16.843325
553 55.2 16.675731
554 55.3 16.509805
555 55.4 16.345529
556 55.5 16.182889
557 55.6 16.021866
558 55.7 15.862446
559 55.8 15.704612
560 55.9 15.548348
561 56.0 15.393640
562 56.1 15.240470
563 56.2 15.088825
564 56.3 14.938689
565 56.4 14.790046
566 56.5 14.642883
567 56.6 14.497184
568 56.7 14.352935
569 56.8 14.210120
570 56.9 14.068727
571 57.0 13.928741
572 57.1 13.790148
573 57.2 13.652934
574 57.3 13.517085
575 57.4 13.382587
576 57.5 13.249428
577 57.6 13.117594
578 57.7 12.987072
579 57.8 12.857849
580 57.9 12.729911
581 58.0 12.603246
582 58.1 12.477842
583 58.2 12.353685
584 58.3 12.230764
585 58.4 12.109066
586 58.5 11.988579
587 58.6 11.869290
588 58.7 11.751189
589 58.8 11.634263
590 58.9 11.518500
591 59.0 11.403889
592 59.1 11.290418
593 59.2 11.178077
594 59.3 11.066853
595 59.4 10.956736
596 59.5 10.847715
597 59.6 10.739778
598 59.7 10.632915
599 59.8 10.527116
600 59.9 10.422370
601 60.0 34.318665
602 60.1 33.977189
603 60.2 33.639110
604 60.3 33.304395
605 60.4 32.973011
606 60.5 32.644924
607 60.6 32.320102
608 60.7 31.998511
609 60.8 31.680121
610 60.9 31.364898
611 61.0 31.052812
612 61.1 30.743832
613 61.2 30.437926
614 61.3 30.135063
615 61.4 29.835214
616 61.5 29.538349
617 61.6 29.244437
618 61.7 28.953450
619 61.8 28.665359
620 61.9 28.380134
621 62.0 28.097747
622 62.1 27.818169
623 62.2 27.541374
624 62.3 27.267333
625 62.4 26.996018
626 62.5 26.727403
627 62.6 26.461461
628 62.7 26.198165
629 62.8 25.937489
630 62.9 25.679407
631 63.0 25.423893
632 63.1 25.170921
633 63.2 24.920466
634 63.3 24.672503
635 63.4 24.427007
636 63.5 24.183955
637 63.6 23.943320
638 63.7 23.705080
639 63.8 23.469211
640 63.9 23.235688
641 64.0 23.004489
642 64.1 22.775591
643 64.2 22.548970
644 64.3 22.324604
645 64.4 22.102470
646 64.5 21.882547
647 64.6 21.664812
648 64.7 21.449244
649 64.8 21.235820
650 64.9 21.024520
651 65.0 20.815323
652 65.1 20.608207
653 65.2 20.403152
654 65.3 20.200137
655 65.4 19.999142
656 65.5 19.800147
657 65.6 19.603133
658 65.7 19.408078
659 65.8 19.214965
660 65.9 19.023773
661 66.0 18.834483
662 66.1 18.647077
663 66.2 18.461535
664 66.3 18.277840
665 66.4 18.095972
666 66.5 17.915914
667 66.6 17.737648
668 66.7 17.561155
669 66.8 17.386419
670 66.9 17.213421
671 67.0 17.042145
672 67.1 16.872573
673 67.2 16.704688
674 67.3 16.538473
675 67.4 16.373913
676 67.5 16.210990
677 67.6 16.049688
678 67.7 15.889991
679 67.8 15.731882
680 67.9 15.575348
681 68.0 15.420370
682 68.1 15.266935
683 68.2 15.115027
684 68.3 14.964630
685 68.4 14.815729
686 68.5 14.668310
687 68.6 14.522358
688 68.7 14.377858
689 68.8 14.234796
690 68.9 14.093157
691 69.0 13.952928
692 69.1 13.814094
693 69.2 13.676642
694 69.3 13.540557
695 69.4 13.405826
696 69.5 13.272436
697 69.6 13.140373
698 69.7 13.009624
699 69.8 12.880176
700 69.9 12.752016
701 70.0 12.625131
702 70.1 12.499509
703 70.2 12.375137
704 70.3 12.252002
705 70.4 12.130093
706 70.5 12.009396
707 70.6 11.889901
708 70.7 11.771594
709 70.8 11.654465
710 70.9 11.538501
711 71.0 11.423691
712 71.1 11.310024
713 71.2 11.197487
714 71.3 11.086070
715 71.4 10.975762
716 71.5 10.866551
717 71.6 10.758427
718 71.7 10.651379
719 71.8 10.545396
720 71.9 10.440468
721 72.0 10.336583
Code
pk_curve(t = seq(0, 72, by = 0.1), model = "1cmt_oral", ii = 12, addl = 5,
params = list(CL = 2.5, V = 25, ka = 1))
Output
t cp
1 0.0 0.000000
2 0.1 2.272331
3 0.2 4.305811
4 0.3 6.123395
5 0.4 7.745850
6 0.5 9.191967
7 0.6 10.478744
8 0.7 11.621560
9 0.8 12.634330
10 0.9 13.529641
11 1.0 14.318879
12 1.1 15.012348
13 1.2 15.619366
14 1.3 16.148364
15 1.4 16.606967
16 1.5 17.002075
17 1.6 17.339927
18 1.7 17.626168
19 1.8 17.865902
20 1.9 18.063747
21 2.0 18.223879
22 2.1 18.350075
23 2.2 18.445750
24 2.3 18.513994
25 2.4 18.557598
26 2.5 18.579088
27 2.6 18.580747
28 2.7 18.564640
29 2.8 18.532631
30 2.9 18.486409
31 3.0 18.427497
32 3.1 18.357273
33 3.2 18.276982
34 3.3 18.187748
35 3.4 18.090588
36 3.5 17.986419
37 3.6 17.876069
38 3.7 17.760288
39 3.8 17.639750
40 3.9 17.515066
41 4.0 17.386784
42 4.1 17.255402
43 4.2 17.121366
44 4.3 16.985081
45 4.4 16.846909
46 4.5 16.707177
47 4.6 16.566182
48 4.7 16.424186
49 4.8 16.281431
50 4.9 16.138128
51 5.0 15.994472
52 5.1 15.850636
53 5.2 15.706773
54 5.3 15.563023
55 5.4 15.419511
56 5.5 15.276348
57 5.6 15.133632
58 5.7 14.991453
59 5.8 14.849888
60 5.9 14.709009
61 6.0 14.568877
62 6.1 14.429547
63 6.2 14.291067
64 6.3 14.153480
65 6.4 14.016823
66 6.5 13.881129
67 6.6 13.746426
68 6.7 13.612738
69 6.8 13.480086
70 6.9 13.348488
71 7.0 13.217958
72 7.1 13.088509
73 7.2 12.960151
74 7.3 12.832892
75 7.4 12.706738
76 7.5 12.581692
77 7.6 12.457759
78 7.7 12.334940
79 7.8 12.213234
80 7.9 12.092641
81 8.0 11.973160
82 8.1 11.854787
83 8.2 11.737520
84 8.3 11.621354
85 8.4 11.506284
86 8.5 11.392306
87 8.6 11.279413
88 8.7 11.167599
89 8.8 11.056858
90 8.9 10.947183
91 9.0 10.838567
92 9.1 10.731002
93 9.2 10.624480
94 9.3 10.518994
95 9.4 10.414536
96 9.5 10.311098
97 9.6 10.208671
98 9.7 10.107247
99 9.8 10.006817
100 9.9 9.907374
101 10.0 9.808908
102 10.1 9.711411
103 10.2 9.614874
104 10.3 9.519289
105 10.4 9.424647
106 10.5 9.330939
107 10.6 9.238157
108 10.7 9.146293
109 10.8 9.055337
110 10.9 8.965281
111 11.0 8.876117
112 11.1 8.787836
113 11.2 8.700430
114 11.3 8.613890
115 11.4 8.528209
116 11.5 8.443377
117 11.6 8.359387
118 11.7 8.276231
119 11.8 8.193900
120 11.9 8.112386
121 12.0 8.031682
122 12.1 10.224110
123 12.2 12.178482
124 12.3 13.917742
125 12.4 15.462653
126 12.5 16.831996
127 12.6 18.042761
128 12.7 19.110322
129 12.8 20.048585
130 12.9 20.870128
131 13.0 21.586334
132 13.1 22.207495
133 13.2 22.742925
134 13.3 23.201046
135 13.4 23.589478
136 13.5 23.915112
137 13.6 24.184182
138 13.7 24.402323
139 13.8 24.574636
140 13.9 24.705731
141 14.0 24.799776
142 14.1 24.860543
143 14.2 24.891439
144 14.3 24.895548
145 14.4 24.875656
146 14.5 24.834282
147 14.6 24.773702
148 14.7 24.695975
149 14.8 24.602960
150 14.9 24.496338
151 15.0 24.377627
152 15.1 24.248199
153 15.2 24.109293
154 15.3 23.962027
155 15.4 23.807412
156 15.5 23.646360
157 15.6 23.479694
158 15.7 23.308156
159 15.8 23.132416
160 15.9 22.953079
161 16.0 22.770688
162 16.1 22.585736
163 16.2 22.398663
164 16.3 22.209867
165 16.4 22.019708
166 16.5 21.828507
167 16.6 21.636553
168 16.7 21.444107
169 16.8 21.251402
170 16.9 21.058648
171 17.0 20.866032
172 17.1 20.673722
173 17.2 20.481869
174 17.3 20.290607
175 17.4 20.100055
176 17.5 19.910319
177 17.6 19.721494
178 17.7 19.533665
179 17.8 19.346905
180 17.9 19.161280
181 18.0 18.976847
182 18.1 18.793657
183 18.2 18.611753
184 18.3 18.431175
185 18.4 18.251954
186 18.5 18.074120
187 18.6 17.897696
188 18.7 17.722702
189 18.8 17.549155
190 18.9 17.377069
191 19.0 17.206454
192 19.1 17.037319
193 19.2 16.869670
194 19.3 16.703511
195 19.4 16.538843
196 19.5 16.375668
197 19.6 16.213984
198 19.7 16.053789
199 19.8 15.895080
200 19.9 15.737853
201 20.0 15.582101
202 20.1 15.427819
203 20.2 15.274999
204 20.3 15.123634
205 20.4 14.973716
206 20.5 14.825236
207 20.6 14.678185
208 20.7 14.532553
209 20.8 14.388330
210 20.9 14.245507
211 21.0 14.104071
212 21.1 13.964014
213 21.2 13.825323
214 21.3 13.687989
215 21.4 13.551999
216 21.5 13.417342
217 21.6 13.284007
218 21.7 13.151983
219 21.8 13.021258
220 21.9 12.891820
221 22.0 12.763659
222 22.1 12.636761
223 22.2 12.511117
224 22.3 12.386714
225 22.4 12.263540
226 22.5 12.141585
227 22.6 12.020837
228 22.7 11.901284
229 22.8 11.782916
230 22.9 11.665720
231 23.0 11.549686
232 23.1 11.434803
233 23.2 11.321059
234 23.3 11.208443
235 23.4 11.096946
236 23.5 10.986555
237 23.6 10.877260
238 23.7 10.769050
239 23.8 10.661915
240 23.9 10.555844
241 24.0 10.450827
242 24.1 12.619185
243 24.2 14.549725
244 24.3 16.265391
245 24.4 17.786943
246 24.5 19.133158
247 24.6 20.321027
248 24.7 21.365919
249 24.8 22.281737
250 24.9 23.081061
251 25.0 23.775267
252 25.1 24.374648
253 25.2 24.888514
254 25.3 25.325287
255 25.4 25.692582
256 25.5 25.997290
257 25.6 26.245641
258 25.7 26.443271
259 25.8 26.595276
260 25.9 26.706265
261 26.0 26.780405
262 26.1 26.821464
263 26.2 26.832849
264 26.3 26.817641
265 26.4 26.778623
266 26.5 26.718314
267 26.6 26.638988
268 26.7 26.542701
269 26.8 26.431311
270 26.9 26.306496
271 27.0 26.169774
272 27.1 26.022514
273 27.2 25.865953
274 27.3 25.701208
275 27.4 25.529288
276 27.5 25.351103
277 27.6 25.167474
278 27.7 24.979142
279 27.8 24.786776
280 27.9 24.590978
281 28.0 24.392290
282 28.1 24.191202
283 28.2 23.988154
284 28.3 23.783543
285 28.4 23.577726
286 28.5 23.371022
287 28.6 23.163720
288 28.7 22.956078
289 28.8 22.748329
290 28.9 22.540680
291 29.0 22.333318
292 29.1 22.126408
293 29.2 21.920101
294 29.3 21.714528
295 29.4 21.509807
296 29.5 21.306044
297 29.6 21.103332
298 29.7 20.901753
299 29.8 20.701381
300 29.9 20.502278
301 30.0 20.304502
302 30.1 20.108101
303 30.2 19.913119
304 30.3 19.719592
305 30.4 19.527551
306 30.5 19.337025
307 30.6 19.148034
308 30.7 18.960599
309 30.8 18.774735
310 30.9 18.590454
311 31.0 18.407766
312 31.1 18.226678
313 31.2 18.047195
314 31.3 17.869318
315 31.4 17.693051
316 31.5 17.518391
317 31.6 17.345337
318 31.7 17.173885
319 31.8 17.004031
320 31.9 16.835769
321 32.0 16.669093
322 32.1 16.503995
323 32.2 16.340467
324 32.3 16.178501
325 32.4 16.018087
326 32.5 15.859215
327 32.6 15.701876
328 32.7 15.546058
329 32.8 15.391751
330 32.9 15.238943
331 33.0 15.087623
332 33.1 14.937779
333 33.2 14.789399
334 33.3 14.642472
335 33.4 14.496984
336 33.5 14.352925
337 33.6 14.210281
338 33.7 14.069040
339 33.8 13.929190
340 33.9 13.790718
341 34.0 13.653613
342 34.1 13.517860
343 34.2 13.383448
344 34.3 13.250365
345 34.4 13.118598
346 34.5 12.988135
347 34.6 12.858964
348 34.7 12.731072
349 34.8 12.604447
350 34.9 12.479077
351 35.0 12.354950
352 35.1 12.232054
353 35.2 12.110377
354 35.3 11.989908
355 35.4 11.870634
356 35.5 11.752545
357 35.6 11.635628
358 35.7 11.519873
359 35.8 11.405267
360 35.9 11.291800
361 36.0 11.179460
362 36.1 13.340567
363 36.2 15.263929
364 36.3 16.972489
365 36.4 18.487005
366 36.5 19.826255
367 36.6 21.007227
368 36.7 22.045291
369 36.8 22.954350
370 36.9 23.746981
371 37.0 24.434561
372 37.1 25.027382
373 37.2 25.534753
374 37.3 25.965095
375 37.4 26.326025
376 37.5 26.624430
377 37.6 26.866541
378 37.7 27.057993
379 37.8 27.203881
380 37.9 27.308814
381 38.0 27.376959
382 38.1 27.412082
383 38.2 27.417590
384 38.3 27.396564
385 38.4 27.351786
386 38.5 27.285774
387 38.6 27.200801
388 38.7 27.098924
389 38.8 26.981999
390 38.9 26.851705
391 39.0 26.709558
392 39.1 26.556927
393 39.2 26.395049
394 39.3 26.225039
395 39.4 26.047907
396 39.5 25.864562
397 39.6 25.675824
398 39.7 25.482434
399 39.8 25.285060
400 39.9 25.084303
401 40.0 24.880707
402 40.1 24.674759
403 40.2 24.466900
404 40.3 24.257526
405 40.4 24.046992
406 40.5 23.835618
407 40.6 23.623694
408 40.7 23.411475
409 40.8 23.199195
410 40.9 22.987060
411 41.0 22.775256
412 41.1 22.563949
413 41.2 22.353288
414 41.3 22.143405
415 41.4 21.934417
416 41.5 21.726429
417 41.6 21.519534
418 41.7 21.313814
419 41.8 21.109341
420 41.9 20.906179
421 42.0 20.704384
422 42.1 20.504005
423 42.2 20.305083
424 42.3 20.107656
425 42.4 19.911754
426 42.5 19.717404
427 42.6 19.524629
428 42.7 19.333447
429 42.8 19.143873
430 42.9 18.955919
431 43.0 18.769595
432 43.1 18.584906
433 43.2 18.401858
434 43.3 18.220453
435 43.4 18.040692
436 43.5 17.862573
437 43.6 17.686094
438 43.7 17.511252
439 43.8 17.338041
440 43.9 17.166455
441 44.0 16.996489
442 44.1 16.828133
443 44.2 16.661380
444 44.3 16.496221
445 44.4 16.332645
446 44.5 16.170644
447 44.6 16.010206
448 44.7 15.851320
449 44.8 15.693975
450 44.9 15.538160
451 45.0 15.383862
452 45.1 15.231071
453 45.2 15.079773
454 45.3 14.929956
455 45.4 14.781608
456 45.5 14.634717
457 45.6 14.489269
458 45.7 14.345252
459 45.8 14.202654
460 45.9 14.061461
461 46.0 13.921661
462 46.1 13.783242
463 46.2 13.646190
464 46.3 13.510492
465 46.4 13.376137
466 46.5 13.243111
467 46.6 13.111403
468 46.7 12.980999
469 46.8 12.851887
470 46.9 12.724055
471 47.0 12.597490
472 47.1 12.472181
473 47.2 12.348115
474 47.3 12.225280
475 47.4 12.103665
476 47.5 11.983257
477 47.6 11.864045
478 47.7 11.746016
479 47.8 11.629160
480 47.9 11.513465
481 48.0 11.398920
482 48.1 13.557844
483 48.2 15.479044
484 48.3 17.185463
485 48.4 18.697860
486 48.5 20.035011
487 48.6 21.213907
488 48.7 22.249914
489 48.8 23.156937
490 48.9 23.947552
491 49.0 24.633136
492 49.1 25.223982
493 49.2 25.729397
494 49.3 26.157802
495 49.4 26.516814
496 49.5 26.813321
497 49.6 27.053552
498 49.7 27.243144
499 49.8 27.387190
500 49.9 27.490299
501 50.0 27.556637
502 50.1 27.589973
503 50.2 27.593711
504 50.3 27.570932
505 50.4 27.524419
506 50.5 27.456689
507 50.6 27.370016
508 50.7 27.266455
509 50.8 27.147864
510 50.9 27.015919
511 51.0 26.872138
512 51.1 26.717889
513 51.2 26.554409
514 51.3 26.382814
515 51.4 26.204112
516 51.5 26.019212
517 51.6 25.828936
518 51.7 25.634022
519 51.8 25.435140
520 51.9 25.232890
521 52.0 25.027815
522 52.1 24.820404
523 52.2 24.611096
524 52.3 24.400286
525 52.4 24.188332
526 52.5 23.975552
527 52.6 23.762235
528 52.7 23.548638
529 52.8 23.334993
530 52.9 23.121507
531 53.0 22.908365
532 53.1 22.695734
533 53.2 22.483761
534 53.3 22.272580
535 53.4 22.062307
536 53.5 21.853046
537 53.6 21.644891
538 53.7 21.437924
539 53.8 21.232216
540 53.9 21.027832
541 54.0 20.824826
542 54.1 20.623248
543 54.2 20.423140
544 54.3 20.224538
545 54.4 20.027473
546 54.5 19.831972
547 54.6 19.638057
548 54.7 19.445746
549 54.8 19.255055
550 54.9 19.065995
551 55.0 18.878575
552 55.1 18.692802
553 55.2 18.508681
554 55.3 18.326213
555 55.4 18.145399
556 55.5 17.966238
557 55.6 17.788728
558 55.7 17.612864
559 55.8 17.438642
560 55.9 17.266056
561 56.0 17.095098
562 56.1 16.925762
563 56.2 16.758037
564 56.3 16.591916
565 56.4 16.427388
566 56.5 16.264444
567 56.6 16.103073
568 56.7 15.943263
569 56.8 15.785003
570 56.9 15.628282
571 57.0 15.473088
572 57.1 15.319409
573 57.2 15.167232
574 57.3 15.016545
575 57.4 14.867336
576 57.5 14.719591
577 57.6 14.573299
578 57.7 14.428446
579 57.8 14.285020
580 57.9 14.143008
581 58.0 14.002396
582 58.1 13.863173
583 58.2 13.725326
584 58.3 13.588841
585 58.4 13.453706
586 58.5 13.319909
587 58.6 13.187436
588 58.7 13.056275
589 58.8 12.926414
590 58.9 12.797841
591 59.0 12.670542
592 59.1 12.544506
593 59.2 12.419721
594 59.3 12.296173
595 59.4 12.173852
596 59.5 12.052746
597 59.6 11.932842
598 59.7 11.814129
599 59.8 11.696596
600 59.9 11.580230
601 60.0 11.465020
602 60.1 13.623286
603 60.2 15.543835
604 60.3 17.249610
605 60.4 18.761368
606 60.5 20.097888
607 60.6 21.276157
608 60.7 22.311545
609 60.8 23.217955
610 60.9 24.007963
611 61.0 24.692946
612 61.1 25.283196
613 61.2 25.788022
614 61.3 26.215844
615 61.4 26.574279
616 61.5 26.870214
617 61.6 27.109879
618 61.7 27.298910
619 61.8 27.442401
620 61.9 27.544961
621 62.0 27.610755
622 62.1 27.643552
623 62.2 27.646758
624 62.3 27.623451
625 62.4 27.576416
626 62.5 27.508168
627 62.6 27.420983
628 62.7 27.316915
629 62.8 27.197821
630 62.9 27.065379
631 63.0 26.921106
632 63.1 26.766370
633 63.2 26.602408
634 63.3 26.430335
635 63.4 26.251160
636 63.5 26.065792
637 63.6 25.875052
638 63.7 25.679680
639 63.8 25.480343
640 63.9 25.277644
641 64.0 25.072124
642 64.1 24.864271
643 64.2 24.654526
644 64.3 24.443285
645 64.4 24.230903
646 64.5 24.017700
647 64.6 23.803963
648 64.7 23.589951
649 64.8 23.375894
650 64.9 23.162001
651 65.0 22.948457
652 65.1 22.735427
653 65.2 22.523059
654 65.3 22.311487
655 65.4 22.100826
656 65.5 21.891183
657 65.6 21.682648
658 65.7 21.475305
659 65.8 21.269225
660 65.9 21.064473
661 66.0 20.861103
662 66.1 20.659164
663 66.2 20.458698
664 66.3 20.259742
665 66.4 20.062327
666 66.5 19.866479
667 66.6 19.672221
668 66.7 19.479570
669 66.8 19.288542
670 66.9 19.099149
671 67.0 18.911399
672 67.1 18.725300
673 67.2 18.540855
674 67.3 18.358067
675 67.4 18.176936
676 67.5 17.997462
677 67.6 17.819641
678 67.7 17.643470
679 67.8 17.468943
680 67.9 17.296055
681 68.0 17.124799
682 68.1 16.955167
683 68.2 16.787150
684 68.3 16.620739
685 68.4 16.455925
686 68.5 16.292696
687 68.6 16.131044
688 68.7 15.970955
689 68.8 15.812420
690 68.9 15.655427
691 69.0 15.499962
692 69.1 15.346016
693 69.2 15.193574
694 69.3 15.042625
695 69.4 14.893156
696 69.5 14.745155
697 69.6 14.598608
698 69.7 14.453503
699 69.8 14.309828
700 69.9 14.167569
701 70.0 14.026713
702 70.1 13.887248
703 70.2 13.749161
704 70.3 13.612439
705 70.4 13.477069
706 70.5 13.343040
707 70.6 13.210337
708 70.7 13.078948
709 70.8 12.948862
710 70.9 12.820065
711 71.0 12.692545
712 71.1 12.566290
713 71.2 12.441288
714 71.3 12.317526
715 71.4 12.194993
716 71.5 12.073676
717 71.6 11.953564
718 71.7 11.834645
719 71.8 11.716907
720 71.9 11.600339
721 72.0 11.484929
Code
pk_curve(t = seq(0, 72, by = 0.1), model = "1cmt_infusion", ii = 12, addl = 5,
params = list(CL = 2.5, V = 25, tinf = 3))
Output
t cp
1 0.0 0.0000000
2 0.1 0.7960133
3 0.2 1.5841061
4 0.3 2.3643573
5 0.4 3.1368449
6 0.5 3.9016460
7 0.6 4.6588373
8 0.7 5.4084944
9 0.8 6.1506923
10 0.9 6.8855052
11 1.0 7.6130066
12 1.1 8.3332692
13 1.2 9.0463651
14 1.3 9.7523655
15 1.4 10.4513412
16 1.5 11.1433619
17 1.6 11.8284969
18 1.7 12.5068147
19 1.8 13.1783831
20 1.9 13.8432693
21 2.0 14.5015398
22 2.1 15.1532603
23 2.2 15.7984962
24 2.3 16.4373118
25 2.4 17.0697711
26 2.5 17.6959374
27 2.6 18.3158731
28 2.7 18.9296405
29 2.8 19.5373007
30 2.9 20.1389146
31 3.0 20.7345423
32 3.1 20.5282302
33 3.2 20.3239709
34 3.3 20.1217440
35 3.4 19.9215293
36 3.5 19.7233068
37 3.6 19.5270566
38 3.7 19.3327591
39 3.8 19.1403950
40 3.9 18.9499449
41 4.0 18.7613898
42 4.1 18.5747108
43 4.2 18.3898894
44 4.3 18.2069069
45 4.4 18.0257451
46 4.5 17.8463860
47 4.6 17.6688115
48 4.7 17.4930039
49 4.8 17.3189456
50 4.9 17.1466192
51 5.0 16.9760075
52 5.1 16.8070934
53 5.2 16.6398600
54 5.3 16.4742906
55 5.4 16.3103687
56 5.5 16.1480778
57 5.6 15.9874018
58 5.7 15.8283245
59 5.8 15.6708300
60 5.9 15.5149026
61 6.0 15.3605268
62 6.1 15.2076870
63 6.2 15.0563680
64 6.3 14.9065546
65 6.4 14.7582319
66 6.5 14.6113850
67 6.6 14.4659993
68 6.7 14.3220602
69 6.8 14.1795533
70 6.9 14.0384644
71 7.0 13.8987794
72 7.1 13.7604842
73 7.2 13.6235651
74 7.3 13.4880084
75 7.4 13.3538004
76 7.5 13.2209279
77 7.6 13.0893775
78 7.7 12.9591360
79 7.8 12.8301904
80 7.9 12.7025279
81 8.0 12.5761356
82 8.1 12.4510010
83 8.2 12.3271115
84 8.3 12.2044547
85 8.4 12.0830183
86 8.5 11.9627903
87 8.6 11.8437585
88 8.7 11.7259112
89 8.8 11.6092364
90 8.9 11.4937226
91 9.0 11.3793581
92 9.1 11.2661316
93 9.2 11.1540317
94 9.3 11.0430473
95 9.4 10.9331671
96 9.5 10.8243803
97 9.6 10.7166759
98 9.7 10.6100432
99 9.8 10.5044715
100 9.9 10.3999502
101 10.0 10.2964690
102 10.1 10.1940174
103 10.2 10.0925853
104 10.3 9.9921624
105 10.4 9.8927387
106 10.5 9.7943043
107 10.6 9.6968493
108 10.7 9.6003641
109 10.8 9.5048389
110 10.9 9.4102641
111 11.0 9.3166304
112 11.1 9.2239284
113 11.2 9.1321488
114 11.3 9.0412824
115 11.4 8.9513201
116 11.5 8.8622530
117 11.6 8.7740721
118 11.7 8.6867686
119 11.8 8.6003338
120 11.9 8.5147591
121 12.0 8.4300358
122 12.1 9.1421689
123 12.2 9.8472161
124 12.3 10.5452479
125 12.4 11.2363343
126 12.5 11.9205442
127 12.6 12.5979461
128 12.7 13.2686077
129 12.8 13.9325962
130 12.9 14.5899778
131 13.0 15.2408184
132 13.1 15.8851830
133 13.2 16.5231361
134 13.3 17.1547415
135 13.4 17.7800622
136 13.5 18.3991610
137 13.6 19.0120996
138 13.7 19.6189393
139 13.8 20.2197409
140 13.9 20.8145644
141 14.0 21.4034693
142 14.1 21.9865146
143 14.2 22.5637584
144 14.3 23.1352585
145 14.4 23.7010722
146 14.5 24.2612559
147 14.6 24.8158656
148 14.7 25.3649569
149 14.8 25.9085847
150 14.9 26.4468033
151 15.0 26.9796665
152 15.1 26.7112143
153 15.2 26.4454333
154 15.3 26.1822968
155 15.4 25.9217786
156 15.5 25.6638526
157 15.6 25.4084930
158 15.7 25.1556743
159 15.8 24.9053712
160 15.9 24.6575586
161 16.0 24.4122118
162 16.1 24.1693062
163 16.2 23.9288176
164 16.3 23.6907219
165 16.4 23.4549952
166 16.5 23.2216141
167 16.6 22.9905552
168 16.7 22.7617954
169 16.8 22.5353117
170 16.9 22.3110816
171 17.0 22.0890827
172 17.1 21.8692926
173 17.2 21.6516895
174 17.3 21.4362516
175 17.4 21.2229573
176 17.5 21.0117854
177 17.6 20.8027146
178 17.7 20.5957242
179 17.8 20.3907933
180 17.9 20.1879015
181 18.0 19.9870285
182 18.1 19.7881543
183 18.2 19.5912588
184 18.3 19.3963226
185 18.4 19.2033259
186 18.5 19.0122496
187 18.6 18.8230746
188 18.7 18.6357819
189 18.8 18.4503527
190 18.9 18.2667687
191 19.0 18.0850113
192 19.1 17.9050624
193 19.2 17.7269041
194 19.3 17.5505184
195 19.4 17.3758878
196 19.5 17.2029949
197 19.6 17.0318222
198 19.7 16.8623528
199 19.8 16.6945695
200 19.9 16.5284558
201 20.0 16.3639949
202 20.1 16.2011704
203 20.2 16.0399661
204 20.3 15.8803658
205 20.4 15.7223535
206 20.5 15.5659135
207 20.6 15.4110300
208 20.7 15.2576877
209 20.8 15.1058712
210 20.9 14.9555653
211 21.0 14.8067549
212 21.1 14.6594252
213 21.2 14.5135615
214 21.3 14.3691492
215 21.4 14.2261737
216 21.5 14.0846209
217 21.6 13.9444766
218 21.7 13.8057268
219 21.8 13.6683575
220 21.9 13.5323551
221 22.0 13.3977059
222 22.1 13.2643965
223 22.2 13.1324135
224 22.3 13.0017438
225 22.4 12.8723743
226 22.5 12.7442921
227 22.6 12.6174842
228 22.7 12.4919382
229 22.8 12.3676413
230 22.9 12.2445812
231 23.0 12.1227456
232 23.1 12.0021223
233 23.2 11.8826991
234 23.3 11.7644643
235 23.4 11.6474059
236 23.5 11.5315123
237 23.6 11.4167719
238 23.7 11.3031731
239 23.8 11.1907046
240 23.9 11.0793553
241 24.0 10.9691138
242 24.1 11.6559826
243 24.2 12.3360170
244 24.3 13.0092848
245 24.4 13.6758536
246 24.5 14.3357899
247 24.6 14.9891597
248 24.7 15.6360283
249 24.8 16.2764606
250 24.9 16.9105204
251 25.0 17.5382712
252 25.1 18.1597758
253 25.2 18.7750963
254 25.3 19.3842943
255 25.4 19.9874306
256 25.5 20.5845656
257 25.6 21.1757591
258 25.7 21.7610701
259 25.8 22.3405571
260 25.9 22.9142782
261 26.0 23.4822906
262 26.1 24.0446512
263 26.2 24.6014162
264 26.3 25.1526413
265 26.4 25.6983817
266 26.5 26.2386918
267 26.6 26.7736257
268 26.7 27.3032370
269 26.8 27.8275786
270 26.9 28.3467028
271 27.0 28.8606617
272 27.1 28.5734933
273 27.2 28.2891823
274 27.3 28.0077003
275 27.4 27.7290190
276 27.5 27.4531106
277 27.6 27.1799476
278 27.7 26.9095026
279 27.8 26.6417486
280 27.9 26.3766588
281 28.0 26.1142066
282 28.1 25.8543659
283 28.2 25.5971107
284 28.3 25.3424152
285 28.4 25.0902540
286 28.5 24.8406018
287 28.6 24.5934336
288 28.7 24.3487249
289 28.8 24.1064510
290 28.9 23.8665878
291 29.0 23.6291113
292 29.1 23.3939977
293 29.2 23.1612236
294 29.3 22.9307655
295 29.4 22.7026006
296 29.5 22.4767060
297 29.6 22.2530590
298 29.7 22.0316374
299 29.8 21.8124189
300 29.9 21.5953817
301 30.0 21.3805041
302 30.1 21.1677645
303 30.2 20.9571417
304 30.3 20.7486147
305 30.4 20.5421625
306 30.5 20.3377646
307 30.6 20.1354004
308 30.7 19.9350499
309 30.8 19.7366928
310 30.9 19.5403094
311 31.0 19.3458801
312 31.1 19.1533854
313 31.2 18.9628060
314 31.3 18.7741229
315 31.4 18.5873173
316 31.5 18.4023704
317 31.6 18.2192637
318 31.7 18.0379790
319 31.8 17.8584982
320 31.9 17.6808031
321 32.0 17.5048762
322 32.1 17.3306998
323 32.2 17.1582564
324 32.3 16.9875289
325 32.4 16.8185002
326 32.5 16.6511533
327 32.6 16.4854716
328 32.7 16.3214384
329 32.8 16.1590374
330 32.9 15.9982523
331 33.0 15.8390670
332 33.1 15.6814656
333 33.2 15.5254324
334 33.3 15.3709518
335 33.4 15.2180083
336 33.5 15.0665866
337 33.6 14.9166715
338 33.7 14.7682482
339 33.8 14.6213016
340 33.9 14.4758173
341 34.0 14.3317805
342 34.1 14.1891769
343 34.2 14.0479922
344 34.3 13.9082123
345 34.4 13.7698233
346 34.5 13.6328113
347 34.6 13.4971626
348 34.7 13.3628635
349 34.8 13.2299008
350 34.9 13.0982611
351 35.0 12.9679312
352 35.1 12.8388982
353 35.2 12.7111490
354 35.3 12.5846710
355 35.4 12.4594514
356 35.5 12.3354778
357 35.6 12.2127377
358 35.7 12.0912189
359 35.8 11.9709093
360 35.9 11.8517968
361 36.0 11.7338694
362 36.1 12.4131288
363 36.2 13.0856294
364 36.3 13.7514385
365 36.4 14.4106227
366 36.5 15.0632479
367 36.6 15.7093794
368 36.7 16.3490817
369 36.8 16.9824190
370 36.9 17.6094544
371 37.0 18.2302507
372 37.1 18.8448699
373 37.2 19.4533737
374 37.3 20.0558227
375 37.4 20.6522772
376 37.5 21.2427969
377 37.6 21.8274408
378 37.7 22.4062675
379 37.8 22.9793347
380 37.9 23.5466998
381 38.0 24.1084195
382 38.1 24.6645500
383 38.2 25.2151469
384 38.3 25.7602653
385 38.4 26.2999597
386 38.5 26.8342840
387 38.6 27.3632918
388 38.7 27.8870358
389 38.8 28.4055684
390 38.9 28.9189416
391 39.0 29.4272066
392 39.1 29.1344010
393 39.2 28.8445089
394 39.3 28.5575012
395 39.4 28.2733493
396 39.5 27.9920248
397 39.6 27.7134995
398 39.7 27.4377456
399 39.8 27.1647355
400 39.9 26.8944418
401 40.0 26.6268376
402 40.1 26.3618962
403 40.2 26.0995909
404 40.3 25.8398957
405 40.4 25.5827844
406 40.5 25.3282315
407 40.6 25.0762113
408 40.7 24.8266989
409 40.8 24.5796691
410 40.9 24.3350973
411 41.0 24.0929590
412 41.1 23.8532301
413 41.2 23.6158865
414 41.3 23.3809045
415 41.4 23.1482606
416 41.5 22.9179316
417 41.6 22.6898943
418 41.7 22.4641261
419 41.8 22.2406043
420 41.9 22.0193066
421 42.0 21.8002108
422 42.1 21.5832951
423 42.2 21.3685377
424 42.3 21.1559172
425 42.4 20.9454123
426 42.5 20.7370020
427 42.6 20.5306654
428 42.7 20.3263819
429 42.8 20.1241310
430 42.9 19.9238925
431 43.0 19.7256465
432 43.1 19.5293730
433 43.2 19.3350525
434 43.3 19.1426655
435 43.4 18.9521928
436 43.5 18.7636154
437 43.6 18.5769143
438 43.7 18.3920709
439 43.8 18.2090667
440 43.9 18.0278835
441 44.0 17.8485030
442 44.1 17.6709075
443 44.2 17.4950790
444 44.3 17.3210001
445 44.4 17.1486532
446 44.5 16.9780213
447 44.6 16.8090871
448 44.7 16.6418339
449 44.8 16.4762449
450 44.9 16.3123035
451 45.0 16.1499934
452 45.1 15.9892983
453 45.2 15.8302021
454 45.3 15.6726890
455 45.4 15.5167431
456 45.5 15.3623489
457 45.6 15.2094910
458 45.7 15.0581540
459 45.8 14.9083229
460 45.9 14.7599826
461 46.0 14.6131183
462 46.1 14.4677154
463 46.2 14.3237592
464 46.3 14.1812354
465 46.4 14.0401298
466 46.5 13.9004281
467 46.6 13.7621166
468 46.7 13.6251812
469 46.8 13.4896084
470 46.9 13.3553846
471 47.0 13.2224963
472 47.1 13.0909302
473 47.2 12.9606733
474 47.3 12.8317124
475 47.4 12.7040348
476 47.5 12.5776275
477 47.6 12.4524780
478 47.7 12.3285738
479 47.8 12.2059024
480 47.9 12.0844517
481 48.0 11.9642094
482 48.1 12.6411768
483 48.2 13.3114083
484 48.3 13.9749709
485 48.4 14.6319309
486 48.5 15.2823540
487 48.6 15.9263054
488 48.7 16.5638493
489 48.8 17.1950495
490 48.9 17.8199692
491 49.0 18.4386709
492 49.1 19.0512163
493 49.2 19.6576669
494 49.3 20.2580831
495 49.4 20.8525251
496 49.5 21.4410523
497 49.6 22.0237236
498 49.7 22.6005972
499 49.8 23.1717308
500 49.9 23.7371815
501 50.0 24.2970059
502 50.1 24.8512600
503 50.2 25.3999991
504 50.3 25.9432782
505 50.4 26.4811515
506 50.5 27.0136730
507 50.6 27.5408958
508 50.7 28.0628726
509 50.8 28.5796556
510 50.9 29.0912966
511 51.0 29.5978466
512 51.1 29.3033432
513 51.2 29.0117700
514 51.3 28.7230981
515 51.4 28.4372985
516 51.5 28.1543426
517 51.6 27.8742022
518 51.7 27.5968493
519 51.8 27.3222561
520 51.9 27.0503951
521 52.0 26.7812391
522 52.1 26.5147614
523 52.2 26.2509351
524 52.3 25.9897339
525 52.4 25.7311317
526 52.5 25.4751027
527 52.6 25.2216212
528 52.7 24.9706619
529 52.8 24.7221996
530 52.9 24.4762096
531 53.0 24.2326673
532 53.1 23.9915482
533 53.2 23.7528283
534 53.3 23.5164837
535 53.4 23.2824908
536 53.5 23.0508261
537 53.6 22.8214666
538 53.7 22.5943892
539 53.8 22.3695713
540 53.9 22.1469903
541 54.0 21.9266241
542 54.1 21.7084505
543 54.2 21.4924478
544 54.3 21.2785944
545 54.4 21.0668689
546 54.5 20.8572500
547 54.6 20.6497169
548 54.7 20.4442488
549 54.8 20.2408251
550 54.9 20.0394255
551 55.0 19.8400299
552 55.1 19.6426183
553 55.2 19.4471710
554 55.3 19.2536684
555 55.4 19.0620912
556 55.5 18.8724203
557 55.6 18.6846365
558 55.7 18.4987213
559 55.8 18.3146559
560 55.9 18.1324221
561 56.0 17.9520015
562 56.1 17.7733761
563 56.2 17.5965280
564 56.3 17.4214396
565 56.4 17.2480934
566 56.5 17.0764720
567 56.6 16.9065583
568 56.7 16.7383352
569 56.8 16.5717860
570 56.9 16.4068940
571 57.0 16.2436426
572 57.1 16.0820157
573 57.2 15.9219970
574 57.3 15.7635705
575 57.4 15.6067203
576 57.5 15.4514308
577 57.6 15.2976865
578 57.7 15.1454720
579 57.8 14.9947720
580 57.9 14.8455716
581 58.0 14.6978557
582 58.1 14.5516096
583 58.2 14.4068186
584 58.3 14.2634684
585 58.4 14.1215445
586 58.5 13.9810328
587 58.6 13.8419192
588 58.7 13.7041898
589 58.8 13.5678308
590 58.9 13.4328287
591 59.0 13.2991698
592 59.1 13.1668408
593 59.2 13.0358286
594 59.3 12.9061199
595 59.4 12.7777019
596 59.5 12.6505616
597 59.6 12.5246864
598 59.7 12.4000637
599 59.8 12.2766810
600 59.9 12.1545260
601 60.0 12.0335864
602 60.1 12.7098636
603 60.2 13.3794116
604 60.3 14.0422975
605 60.4 14.6985876
606 60.5 15.3483475
607 60.6 15.9916422
608 60.7 16.6285360
609 60.8 17.2590926
610 60.9 17.8833751
611 61.0 18.5014458
612 61.1 19.1133667
613 61.2 19.7191988
614 61.3 20.3190028
615 61.4 20.9128386
616 61.5 21.5007657
617 61.6 22.0828428
618 61.7 22.6591282
619 61.8 23.2296794
620 61.9 23.7945535
621 62.0 24.3538070
622 62.1 24.9074959
623 62.2 25.4556755
624 62.3 25.9984006
625 62.4 26.5357255
626 62.5 27.0677039
627 62.6 27.5943890
628 62.7 28.1158336
629 62.8 28.6320897
630 62.9 29.1432089
631 63.0 29.6492424
632 63.1 29.3542275
633 63.2 29.0621481
634 63.3 28.7729749
635 63.4 28.4866790
636 63.5 28.2032318
637 63.6 27.9226050
638 63.7 27.6447704
639 63.8 27.3697004
640 63.9 27.0973673
641 64.0 26.8277440
642 64.1 26.5608035
643 64.2 26.2965191
644 64.3 26.0348643
645 64.4 25.7758131
646 64.5 25.5193395
647 64.6 25.2654178
648 64.7 25.0140227
649 64.8 24.7651290
650 64.9 24.5187119
651 65.0 24.2747466
652 65.1 24.0332088
653 65.2 23.7940744
654 65.3 23.5573194
655 65.4 23.3229202
656 65.5 23.0908532
657 65.6 22.8610954
658 65.7 22.6336237
659 65.8 22.4084154
660 65.9 22.1854479
661 66.0 21.9646990
662 66.1 21.7461466
663 66.2 21.5297688
664 66.3 21.3155441
665 66.4 21.1034509
666 66.5 20.8934680
667 66.6 20.6855745
668 66.7 20.4797496
669 66.8 20.2759727
670 66.9 20.0742234
671 67.0 19.8744816
672 67.1 19.6767272
673 67.2 19.4809405
674 67.3 19.2871019
675 67.4 19.0951920
676 67.5 18.9051917
677 67.6 18.7170819
678 67.7 18.5308438
679 67.8 18.3464588
680 67.9 18.1639085
681 68.0 17.9831746
682 68.1 17.8042390
683 68.2 17.6270839
684 68.3 17.4516914
685 68.4 17.2780442
686 68.5 17.1061248
687 68.6 16.9359160
688 68.7 16.7674008
689 68.8 16.6005624
690 68.9 16.4353841
691 69.0 16.2718493
692 69.1 16.1099416
693 69.2 15.9496451
694 69.3 15.7909434
695 69.4 15.6338209
696 69.5 15.4782618
697 69.6 15.3242505
698 69.7 15.1717717
699 69.8 15.0208100
700 69.9 14.8713505
701 70.0 14.7233781
702 70.1 14.5768780
703 70.2 14.4318356
704 70.3 14.2882365
705 70.4 14.1460662
706 70.5 14.0053104
707 70.6 13.8659553
708 70.7 13.7279867
709 70.8 13.5913910
710 70.9 13.4561544
711 71.0 13.3222634
712 71.1 13.1897047
713 71.2 13.0584649
714 71.3 12.9285310
715 71.4 12.7998900
716 71.5 12.6725289
717 71.6 12.5464352
718 71.7 12.4215961
719 71.8 12.2979991
720 71.9 12.1756320
721 72.0 12.0544824
Code
pk_curve(t = seq(0, 72, by = 0.1), model = "2cmt_bolus", ii = 24, addl = 5,
params = list(CL = 2.5, V1 = 25, V2 = 50, Q = 5))
Output
t cp
1 0.0 24.000000
2 0.1 23.293038
3 0.2 22.611512
4 0.3 21.954493
5 0.4 21.321084
6 0.5 20.710422
7 0.6 20.121673
8 0.7 19.554038
9 0.8 19.006743
10 0.9 18.479044
11 1.0 17.970225
12 1.1 17.479596
13 1.2 17.006492
14 1.3 16.550271
15 1.4 16.110316
16 1.5 15.686033
17 1.6 15.276849
18 1.7 14.882211
19 1.8 14.501589
20 1.9 14.134469
21 2.0 13.780359
22 2.1 13.438783
23 2.2 13.109283
24 2.3 12.791418
25 2.4 12.484763
26 2.5 12.188907
27 2.6 11.903458
28 2.7 11.628035
29 2.8 11.362271
30 2.9 11.105814
31 3.0 10.858324
32 3.1 10.619475
33 3.2 10.388949
34 3.3 10.166444
35 3.4 9.951668
36 3.5 9.744337
37 3.6 9.544180
38 3.7 9.350937
39 3.8 9.164353
40 3.9 8.984188
41 4.0 8.810206
42 4.1 8.642183
43 4.2 8.479900
44 4.3 8.323150
45 4.4 8.171730
46 4.5 8.025446
47 4.6 7.884111
48 4.7 7.747546
49 4.8 7.615575
50 4.9 7.488033
51 5.0 7.364758
52 5.1 7.245594
53 5.2 7.130393
54 5.3 7.019010
55 5.4 6.911306
56 5.5 6.807148
57 5.6 6.706407
58 5.7 6.608958
59 5.8 6.514683
60 5.9 6.423465
61 6.0 6.335195
62 6.1 6.249765
63 6.2 6.167072
64 6.3 6.087016
65 6.4 6.009504
66 6.5 5.934441
67 6.6 5.861740
68 6.7 5.791315
69 6.8 5.723083
70 6.9 5.656966
71 7.0 5.592887
72 7.1 5.530772
73 7.2 5.470551
74 7.3 5.412155
75 7.4 5.355518
76 7.5 5.300577
77 7.6 5.247270
78 7.7 5.195539
79 7.8 5.145328
80 7.9 5.096580
81 8.0 5.049245
82 8.1 5.003271
83 8.2 4.958609
84 8.3 4.915212
85 8.4 4.873035
86 8.5 4.832034
87 8.6 4.792167
88 8.7 4.753393
89 8.8 4.715674
90 8.9 4.678972
91 9.0 4.643250
92 9.1 4.608473
93 9.2 4.574609
94 9.3 4.541623
95 9.4 4.509486
96 9.5 4.478167
97 9.6 4.447638
98 9.7 4.417869
99 9.8 4.388834
100 9.9 4.360508
101 10.0 4.332865
102 10.1 4.305881
103 10.2 4.279533
104 10.3 4.253799
105 10.4 4.228656
106 10.5 4.204085
107 10.6 4.180066
108 10.7 4.156578
109 10.8 4.133604
110 10.9 4.111126
111 11.0 4.089126
112 11.1 4.067588
113 11.2 4.046495
114 11.3 4.025833
115 11.4 4.005587
116 11.5 3.985741
117 11.6 3.966284
118 11.7 3.947200
119 11.8 3.928478
120 11.9 3.910104
121 12.0 3.892068
122 12.1 3.874358
123 12.2 3.856962
124 12.3 3.839870
125 12.4 3.823072
126 12.5 3.806558
127 12.6 3.790318
128 12.7 3.774344
129 12.8 3.758626
130 12.9 3.743155
131 13.0 3.727925
132 13.1 3.712926
133 13.2 3.698151
134 13.3 3.683593
135 13.4 3.669245
136 13.5 3.655100
137 13.6 3.641151
138 13.7 3.627392
139 13.8 3.613817
140 13.9 3.600421
141 14.0 3.587196
142 14.1 3.574138
143 14.2 3.561242
144 14.3 3.548503
145 14.4 3.535915
146 14.5 3.523475
147 14.6 3.511176
148 14.7 3.499016
149 14.8 3.486989
150 14.9 3.475093
151 15.0 3.463322
152 15.1 3.451673
153 15.2 3.440142
154 15.3 3.428727
155 15.4 3.417423
156 15.5 3.406227
157 15.6 3.395136
158 15.7 3.384148
159 15.8 3.373258
160 15.9 3.362465
161 16.0 3.351765
162 16.1 3.341157
163 16.2 3.330636
164 16.3 3.320202
165 16.4 3.309852
166 16.5 3.299583
167 16.6 3.289393
168 16.7 3.279280
169 16.8 3.269242
170 16.9 3.259278
171 17.0 3.249384
172 17.1 3.239560
173 17.2 3.229804
174 17.3 3.220114
175 17.4 3.210488
176 17.5 3.200924
177 17.6 3.191422
178 17.7 3.181980
179 17.8 3.172596
180 17.9 3.163269
181 18.0 3.153997
182 18.1 3.144780
183 18.2 3.135616
184 18.3 3.126504
185 18.4 3.117443
186 18.5 3.108432
187 18.6 3.099469
188 18.7 3.090554
189 18.8 3.081685
190 18.9 3.072862
191 19.0 3.064084
192 19.1 3.055349
193 19.2 3.046658
194 19.3 3.038009
195 19.4 3.029401
196 19.5 3.020834
197 19.6 3.012306
198 19.7 3.003818
199 19.8 2.995367
200 19.9 2.986955
201 20.0 2.978580
202 20.1 2.970241
203 20.2 2.961938
204 20.3 2.953670
205 20.4 2.945437
206 20.5 2.937238
207 20.6 2.929072
208 20.7 2.920940
209 20.8 2.912840
210 20.9 2.904772
211 21.0 2.896736
212 21.1 2.888731
213 21.2 2.880756
214 21.3 2.872812
215 21.4 2.864898
216 21.5 2.857013
217 21.6 2.849158
218 21.7 2.841331
219 21.8 2.833532
220 21.9 2.825762
221 22.0 2.818019
222 22.1 2.810303
223 22.2 2.802615
224 22.3 2.794953
225 22.4 2.787318
226 22.5 2.779709
227 22.6 2.772126
228 22.7 2.764568
229 22.8 2.757036
230 22.9 2.749529
231 23.0 2.742047
232 23.1 2.734589
233 23.2 2.727155
234 23.3 2.719746
235 23.4 2.712361
236 23.5 2.704999
237 23.6 2.697661
238 23.7 2.690346
239 23.8 2.683055
240 23.9 2.675786
241 24.0 26.668540
242 24.1 25.954354
243 24.2 25.265627
244 24.3 24.601429
245 24.4 23.960863
246 24.5 23.343065
247 24.6 22.747204
248 24.7 22.172476
249 24.8 21.618111
250 24.9 21.083363
251 25.0 20.567516
252 25.1 20.069880
253 25.2 19.589789
254 25.3 19.126602
255 25.4 18.679703
256 25.5 18.248495
257 25.6 17.832407
258 25.7 17.430885
259 25.8 17.043399
260 25.9 16.669435
261 26.0 16.308501
262 26.1 15.960121
263 26.2 15.623836
264 26.3 15.299206
265 26.4 14.985805
266 26.5 14.683223
267 26.6 14.391067
268 26.7 14.108955
269 26.8 13.836523
270 26.9 13.573416
271 27.0 13.319295
272 27.1 13.073833
273 27.2 12.836714
274 27.3 12.607634
275 27.4 12.386301
276 27.5 12.172432
277 27.6 11.965755
278 27.7 11.766010
279 27.8 11.572944
280 27.9 11.386313
281 28.0 11.205884
282 28.1 11.031431
283 28.2 10.862737
284 28.3 10.699594
285 28.4 10.541798
286 28.5 10.389156
287 28.6 10.241481
288 28.7 10.098592
289 28.8 9.960316
290 28.9 9.826486
291 29.0 9.696940
292 29.1 9.571523
293 29.2 9.450085
294 29.3 9.332483
295 29.4 9.218577
296 29.5 9.108234
297 29.6 9.001325
298 29.7 8.897725
299 29.8 8.797315
300 29.9 8.699980
301 30.0 8.605609
302 30.1 8.514094
303 30.2 8.425333
304 30.3 8.339227
305 30.4 8.255680
306 30.5 8.174599
307 30.6 8.095896
308 30.7 8.019485
309 30.8 7.945285
310 30.9 7.873215
311 31.0 7.803199
312 31.1 7.735164
313 31.2 7.669038
314 31.3 7.604753
315 31.4 7.542243
316 31.5 7.481445
317 31.6 7.422298
318 31.7 7.364742
319 31.8 7.308721
320 31.9 7.254180
321 32.0 7.201067
322 32.1 7.149331
323 32.2 7.098922
324 32.3 7.049794
325 32.4 7.001901
326 32.5 6.955200
327 32.6 6.909648
328 32.7 6.865205
329 32.8 6.821831
330 32.9 6.779490
331 33.0 6.738144
332 33.1 6.697759
333 33.2 6.658301
334 33.3 6.619738
335 33.4 6.582037
336 33.5 6.545170
337 33.6 6.509106
338 33.7 6.473819
339 33.8 6.439281
340 33.9 6.405465
341 34.0 6.372348
342 34.1 6.339905
343 34.2 6.308112
344 34.3 6.276948
345 34.4 6.246390
346 34.5 6.216418
347 34.6 6.187012
348 34.7 6.158152
349 34.8 6.129821
350 34.9 6.101999
351 35.0 6.074670
352 35.1 6.047818
353 35.2 6.021425
354 35.3 5.995477
355 35.4 5.969959
356 35.5 5.944856
357 35.6 5.920155
358 35.7 5.895841
359 35.8 5.871904
360 35.9 5.848329
361 36.0 5.825105
362 36.1 5.802221
363 36.2 5.779666
364 36.3 5.757428
365 36.4 5.735498
366 36.5 5.713866
367 36.6 5.692521
368 36.7 5.671456
369 36.8 5.650661
370 36.9 5.630127
371 37.0 5.609846
372 37.1 5.589811
373 37.2 5.570013
374 37.3 5.550446
375 37.4 5.531102
376 37.5 5.511974
377 37.6 5.493055
378 37.7 5.474341
379 37.8 5.455823
380 37.9 5.437496
381 38.0 5.419356
382 38.1 5.401395
383 38.2 5.383609
384 38.3 5.365993
385 38.4 5.348541
386 38.5 5.331249
387 38.6 5.314113
388 38.7 5.297128
389 38.8 5.280290
390 38.9 5.263594
391 39.0 5.247037
392 39.1 5.230615
393 39.2 5.214324
394 39.3 5.198160
395 39.4 5.182121
396 39.5 5.166203
397 39.6 5.150402
398 39.7 5.134716
399 39.8 5.119142
400 39.9 5.103677
401 40.0 5.088318
402 40.1 5.073062
403 40.2 5.057907
404 40.3 5.042851
405 40.4 5.027891
406 40.5 5.013024
407 40.6 4.998249
408 40.7 4.983563
409 40.8 4.968965
410 40.9 4.954452
411 41.0 4.940022
412 41.1 4.925674
413 41.2 4.911406
414 41.3 4.897216
415 41.4 4.883102
416 41.5 4.869063
417 41.6 4.855097
418 41.7 4.841202
419 41.8 4.827378
420 41.9 4.813623
421 42.0 4.799935
422 42.1 4.786314
423 42.2 4.772757
424 42.3 4.759264
425 42.4 4.745834
426 42.5 4.732465
427 42.6 4.719156
428 42.7 4.705907
429 42.8 4.692715
430 42.9 4.679581
431 43.0 4.666504
432 43.1 4.653481
433 43.2 4.640513
434 43.3 4.627599
435 43.4 4.614737
436 43.5 4.601928
437 43.6 4.589169
438 43.7 4.576461
439 43.8 4.563803
440 43.9 4.551194
441 44.0 4.538632
442 44.1 4.526119
443 44.2 4.513653
444 44.3 4.501232
445 44.4 4.488858
446 44.5 4.476529
447 44.6 4.464244
448 44.7 4.452004
449 44.8 4.439807
450 44.9 4.427653
451 45.0 4.415542
452 45.1 4.403472
453 45.2 4.391445
454 45.3 4.379458
455 45.4 4.367512
456 45.5 4.355606
457 45.6 4.343741
458 45.7 4.331914
459 45.8 4.320127
460 45.9 4.308379
461 46.0 4.296669
462 46.1 4.284996
463 46.2 4.273362
464 46.3 4.261765
465 46.4 4.250204
466 46.5 4.238681
467 46.6 4.227193
468 46.7 4.215742
469 46.8 4.204327
470 46.9 4.192947
471 47.0 4.181602
472 47.1 4.170292
473 47.2 4.159017
474 47.3 4.147776
475 47.4 4.136569
476 47.5 4.125397
477 47.6 4.114258
478 47.7 4.103152
479 47.8 4.092080
480 47.9 4.081041
481 48.0 28.070034
482 48.1 27.352098
483 48.2 26.659631
484 48.3 25.991703
485 48.4 25.347417
486 48.5 24.725909
487 48.6 24.126347
488 48.7 23.547929
489 48.8 22.989882
490 48.9 22.451464
491 49.0 21.931956
492 49.1 21.430669
493 49.2 20.946937
494 49.3 20.480119
495 49.4 20.029597
496 49.5 19.594777
497 49.6 19.175086
498 49.7 18.769972
499 49.8 18.378902
500 49.9 18.001365
501 50.0 17.636867
502 50.1 17.284932
503 50.2 16.945102
504 50.3 16.616936
505 50.4 16.300009
506 50.5 15.993911
507 50.6 15.698247
508 50.7 15.412638
509 50.8 15.136717
510 50.9 14.870130
511 51.0 14.612540
512 51.1 14.363617
513 51.2 14.123046
514 51.3 13.890525
515 51.4 13.665758
516 51.5 13.448466
517 51.6 13.238375
518 51.7 13.035224
519 51.8 12.838761
520 51.9 12.648743
521 52.0 12.464936
522 52.1 12.287114
523 52.2 12.115061
524 52.3 11.948566
525 52.4 11.787428
526 52.5 11.631453
527 52.6 11.480453
528 52.7 11.334249
529 52.8 11.192667
530 52.9 11.055539
531 53.0 10.922704
532 53.1 10.794007
533 53.2 10.669298
534 53.3 10.548433
535 53.4 10.431274
536 53.5 10.317686
537 53.6 10.207540
538 53.7 10.100712
539 53.8 9.997083
540 53.9 9.896538
541 54.0 9.798965
542 54.1 9.704257
543 54.2 9.612311
544 54.3 9.523029
545 54.4 9.436314
546 54.5 9.352073
547 54.6 9.270220
548 54.7 9.190667
549 54.8 9.113332
550 54.9 9.038137
551 55.0 8.965004
552 55.1 8.893859
553 55.2 8.824633
554 55.3 8.757256
555 55.4 8.691662
556 55.5 8.627789
557 55.6 8.565574
558 55.7 8.504959
559 55.8 8.445887
560 55.9 8.388303
561 56.0 8.332155
562 56.1 8.277392
563 56.2 8.223964
564 56.3 8.171826
565 56.4 8.120930
566 56.5 8.071235
567 56.6 8.022697
568 56.7 7.975275
569 56.8 7.928931
570 56.9 7.883627
571 57.0 7.839327
572 57.1 7.795995
573 57.2 7.753598
574 57.3 7.712104
575 57.4 7.671480
576 57.5 7.631698
577 57.6 7.592727
578 57.7 7.554540
579 57.8 7.517110
580 57.9 7.480410
581 58.0 7.444417
582 58.1 7.409104
583 58.2 7.374451
584 58.3 7.340433
585 58.4 7.307029
586 58.5 7.274219
587 58.6 7.241982
588 58.7 7.210300
589 58.8 7.179153
590 58.9 7.148523
591 59.0 7.118394
592 59.1 7.088749
593 59.2 7.059571
594 59.3 7.030845
595 59.4 7.002556
596 59.5 6.974690
597 59.6 6.947233
598 59.7 6.920171
599 59.8 6.893492
600 59.9 6.867184
601 60.0 6.841234
602 60.1 6.815631
603 60.2 6.790364
604 60.3 6.765421
605 60.4 6.740794
606 60.5 6.716472
607 60.6 6.692444
608 60.7 6.668703
609 60.8 6.645239
610 60.9 6.622044
611 61.0 6.599109
612 61.1 6.576427
613 61.2 6.553989
614 61.3 6.531789
615 61.4 6.509818
616 61.5 6.488072
617 61.6 6.466541
618 61.7 6.445222
619 61.8 6.424106
620 61.9 6.403188
621 62.0 6.382464
622 62.1 6.361926
623 62.2 6.341569
624 62.3 6.321390
625 62.4 6.301381
626 62.5 6.281540
627 62.6 6.261861
628 62.7 6.242340
629 62.8 6.222972
630 62.9 6.203754
631 63.0 6.184681
632 63.1 6.165750
633 63.2 6.146956
634 63.3 6.128297
635 63.4 6.109769
636 63.5 6.091369
637 63.6 6.073093
638 63.7 6.054938
639 63.8 6.036901
640 63.9 6.018980
641 64.0 6.001172
642 64.1 5.983473
643 64.2 5.965882
644 64.3 5.948396
645 64.4 5.931013
646 64.5 5.913730
647 64.6 5.896544
648 64.7 5.879455
649 64.8 5.862459
650 64.9 5.845555
651 65.0 5.828741
652 65.1 5.812015
653 65.2 5.795375
654 65.3 5.778819
655 65.4 5.762346
656 65.5 5.745954
657 65.6 5.729642
658 65.7 5.713407
659 65.8 5.697249
660 65.9 5.681166
661 66.0 5.665157
662 66.1 5.649220
663 66.2 5.633354
664 66.3 5.617559
665 66.4 5.601831
666 66.5 5.586172
667 66.6 5.570579
668 66.7 5.555051
669 66.8 5.539588
670 66.9 5.524187
671 67.0 5.508850
672 67.1 5.493573
673 67.2 5.478357
674 67.3 5.463201
675 67.4 5.448103
676 67.5 5.433064
677 67.6 5.418081
678 67.7 5.403155
679 67.8 5.388285
680 67.9 5.373469
681 68.0 5.358708
682 68.1 5.344000
683 68.2 5.329345
684 68.3 5.314742
685 68.4 5.300190
686 68.5 5.285690
687 68.6 5.271240
688 68.7 5.256841
689 68.8 5.242490
690 68.9 5.228188
691 69.0 5.213935
692 69.1 5.199729
693 69.2 5.185570
694 69.3 5.171459
695 69.4 5.157394
696 69.5 5.143374
697 69.6 5.129401
698 69.7 5.115472
699 69.8 5.101588
700 69.9 5.087748
701 70.0 5.073953
702 70.1 5.060201
703 70.2 5.046492
704 70.3 5.032826
705 70.4 5.019202
706 70.5 5.005621
707 70.6 4.992081
708 70.7 4.978583
709 70.8 4.965126
710 70.9 4.951711
711 71.0 4.938335
712 71.1 4.925001
713 71.2 4.911706
714 71.3 4.898451
715 71.4 4.885236
716 71.5 4.872060
717 71.6 4.858923
718 71.7 4.845824
719 71.8 4.832765
720 71.9 4.819744
721 72.0 28.806760
Code
pk_curve(t = seq(0, 72, by = 0.1), model = "2cmt_oral", ii = 24, addl = 5,
params = list(CL = 2.5, V1 = 25, V2 = 50, Q = 5, ka = 1))
Output
t cp
1 0.0 0.000000
2 0.1 2.249498
3 0.2 4.218889
4 0.3 5.937205
5 0.4 7.430627
6 0.5 8.722762
7 0.6 9.834888
8 0.7 10.786182
9 0.8 11.593920
10 0.9 12.273664
11 1.0 12.839423
12 1.1 13.303808
13 1.2 13.678165
14 1.3 13.972696
15 1.4 14.196576
16 1.5 14.358046
17 1.6 14.464509
18 1.7 14.522610
19 1.8 14.538309
20 1.9 14.516951
21 2.0 14.463322
22 2.1 14.381708
23 2.2 14.275944
24 2.3 14.149454
25 2.4 14.005299
26 2.5 13.846205
27 2.6 13.674603
28 2.7 13.492655
29 2.8 13.302281
30 2.9 13.105187
31 3.0 12.902879
32 3.1 12.696693
33 3.2 12.487803
34 3.3 12.277245
35 3.4 12.065926
36 3.5 11.854640
37 3.6 11.644080
38 3.7 11.434846
39 3.8 11.227458
40 3.9 11.022363
41 4.0 10.819940
42 4.1 10.620514
43 4.2 10.424356
44 4.3 10.231691
45 4.4 10.042703
46 4.5 9.857540
47 4.6 9.676318
48 4.7 9.499123
49 4.8 9.326019
50 4.9 9.157045
51 5.0 8.992221
52 5.1 8.831551
53 5.2 8.675023
54 5.3 8.522615
55 5.4 8.374289
56 5.5 8.230002
57 5.6 8.089699
58 5.7 7.953322
59 5.8 7.820804
60 5.9 7.692073
61 6.0 7.567057
62 6.1 7.445675
63 6.2 7.327847
64 6.3 7.213492
65 6.4 7.102524
66 6.5 6.994859
67 6.6 6.890412
68 6.7 6.789096
69 6.8 6.690827
70 6.9 6.595519
71 7.0 6.503089
72 7.1 6.413451
73 7.2 6.326525
74 7.3 6.242230
75 7.4 6.160484
76 7.5 6.081211
77 7.6 6.004332
78 7.7 5.929773
79 7.8 5.857461
80 7.9 5.787323
81 8.0 5.719289
82 8.1 5.653292
83 8.2 5.589263
84 8.3 5.527139
85 8.4 5.466857
86 8.5 5.408355
87 8.6 5.351573
88 8.7 5.296455
89 8.8 5.242943
90 8.9 5.190983
91 9.0 5.140523
92 9.1 5.091512
93 9.2 5.043899
94 9.3 4.997638
95 9.4 4.952681
96 9.5 4.908984
97 9.6 4.866503
98 9.7 4.825197
99 9.8 4.785024
100 9.9 4.745946
101 10.0 4.707924
102 10.1 4.670922
103 10.2 4.634904
104 10.3 4.599837
105 10.4 4.565686
106 10.5 4.532420
107 10.6 4.500009
108 10.7 4.468422
109 10.8 4.437631
110 10.9 4.407608
111 11.0 4.378326
112 11.1 4.349759
113 11.2 4.321883
114 11.3 4.294674
115 11.4 4.268108
116 11.5 4.242162
117 11.6 4.216816
118 11.7 4.192049
119 11.8 4.167840
120 11.9 4.144170
121 12.0 4.121021
122 12.1 4.098374
123 12.2 4.076212
124 12.3 4.054518
125 12.4 4.033277
126 12.5 4.012472
127 12.6 3.992089
128 12.7 3.972113
129 12.8 3.952531
130 12.9 3.933328
131 13.0 3.914492
132 13.1 3.896010
133 13.2 3.877871
134 13.3 3.860063
135 13.4 3.842574
136 13.5 3.825393
137 13.6 3.808512
138 13.7 3.791918
139 13.8 3.775603
140 13.9 3.759558
141 14.0 3.743773
142 14.1 3.728240
143 14.2 3.712950
144 14.3 3.697896
145 14.4 3.683069
146 14.5 3.668462
147 14.6 3.654069
148 14.7 3.639882
149 14.8 3.625894
150 14.9 3.612099
151 15.0 3.598490
152 15.1 3.585063
153 15.2 3.571810
154 15.3 3.558727
155 15.4 3.545809
156 15.5 3.533049
157 15.6 3.520443
158 15.7 3.507986
159 15.8 3.495673
160 15.9 3.483501
161 16.0 3.471465
162 16.1 3.459560
163 16.2 3.447783
164 16.3 3.436129
165 16.4 3.424596
166 16.5 3.413179
167 16.6 3.401876
168 16.7 3.390682
169 16.8 3.379594
170 16.9 3.368610
171 17.0 3.357727
172 17.1 3.346941
173 17.2 3.336250
174 17.3 3.325651
175 17.4 3.315142
176 17.5 3.304719
177 17.6 3.294382
178 17.7 3.284127
179 17.8 3.273952
180 17.9 3.263855
181 18.0 3.253834
182 18.1 3.243887
183 18.2 3.234012
184 18.3 3.224207
185 18.4 3.214471
186 18.5 3.204801
187 18.6 3.195196
188 18.7 3.185655
189 18.8 3.176176
190 18.9 3.166756
191 19.0 3.157396
192 19.1 3.148093
193 19.2 3.138847
194 19.3 3.129655
195 19.4 3.120517
196 19.5 3.111432
197 19.6 3.102397
198 19.7 3.093413
199 19.8 3.084478
200 19.9 3.075591
201 20.0 3.066750
202 20.1 3.057956
203 20.2 3.049207
204 20.3 3.040502
205 20.4 3.031840
206 20.5 3.023221
207 20.6 3.014643
208 20.7 3.006107
209 20.8 2.997610
210 20.9 2.989152
211 21.0 2.980733
212 21.1 2.972353
213 21.2 2.964009
214 21.3 2.955702
215 21.4 2.947431
216 21.5 2.939195
217 21.6 2.930994
218 21.7 2.922828
219 21.8 2.914695
220 21.9 2.906595
221 22.0 2.898528
222 22.1 2.890493
223 22.2 2.882490
224 22.3 2.874518
225 22.4 2.866577
226 22.5 2.858666
227 22.6 2.850785
228 22.7 2.842934
229 22.8 2.835112
230 22.9 2.827319
231 23.0 2.819554
232 23.1 2.811817
233 23.2 2.804108
234 23.3 2.796426
235 23.4 2.788772
236 23.5 2.781144
237 23.6 2.773543
238 23.7 2.765968
239 23.8 2.758419
240 23.9 2.750895
241 24.0 2.743397
242 24.1 4.985421
243 24.2 6.947364
244 24.3 8.658257
245 24.4 10.144279
246 24.5 11.429038
247 24.6 12.533813
248 24.7 13.477779
249 24.8 14.278214
250 24.9 14.950676
251 25.0 15.509178
252 25.1 15.966328
253 25.2 16.333472
254 25.3 16.620814
255 25.4 16.837526
256 25.5 16.991851
257 25.6 17.091191
258 25.7 17.142190
259 25.8 17.150810
260 25.9 17.122393
261 26.0 17.061727
262 26.1 16.973098
263 26.2 16.860338
264 26.3 16.726875
265 26.4 16.575767
266 26.5 16.409740
267 26.6 16.231227
268 26.7 16.042387
269 26.8 15.845143
270 26.9 15.641197
271 27.0 15.432059
272 27.1 15.219062
273 27.2 15.003381
274 27.3 14.786051
275 27.4 14.567980
276 27.5 14.349962
277 27.6 14.132689
278 27.7 13.916761
279 27.8 13.702699
280 27.9 13.490948
281 28.0 13.281889
282 28.1 13.075845
283 28.2 12.873088
284 28.3 12.673843
285 28.4 12.478293
286 28.5 12.286587
287 28.6 12.098841
288 28.7 11.915140
289 28.8 11.735548
290 28.9 11.560104
291 29.0 11.388828
292 29.1 11.221725
293 29.2 11.058782
294 29.3 10.899975
295 29.4 10.745270
296 29.5 10.594620
297 29.6 10.447974
298 29.7 10.305269
299 29.8 10.166442
300 29.9 10.031420
301 30.0 9.900128
302 30.1 9.772489
303 30.2 9.648422
304 30.3 9.527844
305 30.4 9.410670
306 30.5 9.296817
307 30.6 9.186198
308 30.7 9.078728
309 30.8 8.974321
310 30.9 8.872893
311 31.0 8.774358
312 31.1 8.678633
313 31.2 8.585636
314 31.3 8.495287
315 31.4 8.407503
316 31.5 8.322209
317 31.6 8.239325
318 31.7 8.158778
319 31.8 8.080494
320 31.9 8.004400
321 32.0 7.930427
322 32.1 7.858506
323 32.2 7.788570
324 32.3 7.720555
325 32.4 7.654397
326 32.5 7.590035
327 32.6 7.527410
328 32.7 7.466464
329 32.8 7.407140
330 32.9 7.349384
331 33.0 7.293144
332 33.1 7.238368
333 33.2 7.185006
334 33.3 7.133011
335 33.4 7.082336
336 33.5 7.032936
337 33.6 6.984768
338 33.7 6.937790
339 33.8 6.891961
340 33.9 6.847241
341 34.0 6.803593
342 34.1 6.760980
343 34.2 6.719367
344 34.3 6.678718
345 34.4 6.639002
346 34.5 6.600185
347 34.6 6.562238
348 34.7 6.525130
349 34.8 6.488833
350 34.9 6.453319
351 35.0 6.418560
352 35.1 6.384532
353 35.2 6.351209
354 35.3 6.318568
355 35.4 6.286584
356 35.5 6.255235
357 35.6 6.224501
358 35.7 6.194359
359 35.8 6.164791
360 35.9 6.135775
361 36.0 6.107295
362 36.1 6.079332
363 36.2 6.051867
364 36.3 6.024886
365 36.4 5.998371
366 36.5 5.972306
367 36.6 5.946677
368 36.7 5.921470
369 36.8 5.896670
370 36.9 5.872264
371 37.0 5.848238
372 37.1 5.824581
373 37.2 5.801280
374 37.3 5.778324
375 37.4 5.755701
376 37.5 5.733401
377 37.6 5.711412
378 37.7 5.689726
379 37.8 5.668332
380 37.9 5.647221
381 38.0 5.626384
382 38.1 5.605813
383 38.2 5.585498
384 38.3 5.565432
385 38.4 5.545607
386 38.5 5.526016
387 38.6 5.506652
388 38.7 5.487506
389 38.8 5.468574
390 38.9 5.449847
391 39.0 5.431321
392 39.1 5.412989
393 39.2 5.394844
394 39.3 5.376883
395 39.4 5.359098
396 39.5 5.341486
397 39.6 5.324040
398 39.7 5.306756
399 39.8 5.289630
400 39.9 5.272657
401 40.0 5.255833
402 40.1 5.239153
403 40.2 5.222613
404 40.3 5.206211
405 40.4 5.189940
406 40.5 5.173799
407 40.6 5.157784
408 40.7 5.141891
409 40.8 5.126118
410 40.9 5.110460
411 41.0 5.094915
412 41.1 5.079480
413 41.2 5.064153
414 41.3 5.048930
415 41.4 5.033809
416 41.5 5.018788
417 41.6 5.003863
418 41.7 4.989034
419 41.8 4.974296
420 41.9 4.959649
421 42.0 4.945090
422 42.1 4.930618
423 42.2 4.916229
424 42.3 4.901923
425 42.4 4.887697
426 42.5 4.873549
427 42.6 4.859479
428 42.7 4.845484
429 42.8 4.831563
430 42.9 4.817714
431 43.0 4.803936
432 43.1 4.790227
433 43.2 4.776586
434 43.3 4.763012
435 43.4 4.749503
436 43.5 4.736059
437 43.6 4.722677
438 43.7 4.709357
439 43.8 4.696097
440 43.9 4.682898
441 44.0 4.669756
442 44.1 4.656672
443 44.2 4.643645
444 44.3 4.630674
445 44.4 4.617757
446 44.5 4.604894
447 44.6 4.592083
448 44.7 4.579325
449 44.8 4.566619
450 44.9 4.553963
451 45.0 4.541357
452 45.1 4.528800
453 45.2 4.516291
454 45.3 4.503830
455 45.4 4.491416
456 45.5 4.479049
457 45.6 4.466728
458 45.7 4.454451
459 45.8 4.442220
460 45.9 4.430033
461 46.0 4.417889
462 46.1 4.405788
463 46.2 4.393730
464 46.3 4.381715
465 46.4 4.369740
466 46.5 4.357807
467 46.6 4.345915
468 46.7 4.334063
469 46.8 4.322251
470 46.9 4.310478
471 47.0 4.298744
472 47.1 4.287049
473 47.2 4.275393
474 47.3 4.263774
475 47.4 4.252193
476 47.5 4.240649
477 47.6 4.229142
478 47.7 4.217672
479 47.8 4.206238
480 47.9 4.194840
481 48.0 4.183478
482 48.1 6.421649
483 48.2 8.379749
484 48.3 10.086808
485 48.4 11.569009
486 48.5 12.849955
487 48.6 13.950928
488 48.7 14.891102
489 48.8 15.687754
490 48.9 16.356445
491 49.0 16.911185
492 49.1 17.364583
493 49.2 17.727986
494 49.3 18.011596
495 49.4 18.224587
496 49.5 18.375200
497 49.6 18.470838
498 49.7 18.518146
499 49.8 18.523083
500 49.9 18.490994
501 50.0 18.426666
502 50.1 18.334384
503 50.2 18.217982
504 50.3 18.080886
505 50.4 17.926154
506 50.5 17.756515
507 50.6 17.574397
508 50.7 17.381963
509 50.8 17.181135
510 50.9 16.973614
511 51.0 16.760910
512 51.1 16.544357
513 51.2 16.325130
514 51.3 16.104263
515 51.4 15.882665
516 51.5 15.661129
517 51.6 15.440347
518 51.7 15.220920
519 51.8 15.003368
520 51.9 14.788136
521 52.0 14.575606
522 52.1 14.366101
523 52.2 14.159891
524 52.3 13.957203
525 52.4 13.758219
526 52.5 13.563088
527 52.6 13.371925
528 52.7 13.184818
529 52.8 13.001828
530 52.9 12.822996
531 53.0 12.648341
532 53.1 12.477867
533 53.2 12.311563
534 53.3 12.149404
535 53.4 11.991355
536 53.5 11.837371
537 53.6 11.687399
538 53.7 11.541378
539 53.8 11.399243
540 53.9 11.260922
541 54.0 11.126341
542 54.1 10.995420
543 54.2 10.868081
544 54.3 10.744239
545 54.4 10.623810
546 54.5 10.506711
547 54.6 10.392854
548 54.7 10.282155
549 54.8 10.174528
550 54.9 10.069888
551 55.0 9.968150
552 55.1 9.869231
553 55.2 9.773048
554 55.3 9.679521
555 55.4 9.588569
556 55.5 9.500114
557 55.6 9.414079
558 55.7 9.330388
559 55.8 9.248968
560 55.9 9.169748
561 56.0 9.092656
562 56.1 9.017625
563 56.2 8.944588
564 56.3 8.873479
565 56.4 8.804236
566 56.5 8.736798
567 56.6 8.671104
568 56.7 8.607097
569 56.8 8.544721
570 56.9 8.483921
571 57.0 8.424645
572 57.1 8.366841
573 57.2 8.310460
574 57.3 8.255453
575 57.4 8.201775
576 57.5 8.149379
577 57.6 8.098224
578 57.7 8.048266
579 57.8 7.999465
580 57.9 7.951782
581 58.0 7.905179
582 58.1 7.859618
583 58.2 7.815064
584 58.3 7.771484
585 58.4 7.728843
586 58.5 7.687110
587 58.6 7.646255
588 58.7 7.606246
589 58.8 7.567056
590 58.9 7.528657
591 59.0 7.491021
592 59.1 7.454123
593 59.2 7.417938
594 59.3 7.382441
595 59.4 7.347611
596 59.5 7.313423
597 59.6 7.279857
598 59.7 7.246891
599 59.8 7.214506
600 59.9 7.182682
601 60.0 7.151401
602 60.1 7.120643
603 60.2 7.090392
604 60.3 7.060632
605 60.4 7.031345
606 60.5 7.002516
607 60.6 6.974131
608 60.7 6.946174
609 60.8 6.918632
610 60.9 6.891491
611 61.0 6.864739
612 61.1 6.838361
613 61.2 6.812348
614 61.3 6.786686
615 61.4 6.761365
616 61.5 6.736373
617 61.6 6.711701
618 61.7 6.687338
619 61.8 6.663274
620 61.9 6.639501
621 62.0 6.616009
622 62.1 6.592789
623 62.2 6.569833
624 62.3 6.547134
625 62.4 6.524682
626 62.5 6.502471
627 62.6 6.480494
628 62.7 6.458742
629 62.8 6.437211
630 62.9 6.415892
631 63.0 6.394781
632 63.1 6.373871
633 63.2 6.353155
634 63.3 6.332629
635 63.4 6.312287
636 63.5 6.292124
637 63.6 6.272134
638 63.7 6.252314
639 63.8 6.232658
640 63.9 6.213161
641 64.0 6.193820
642 64.1 6.174630
643 64.2 6.155587
644 64.3 6.136688
645 64.4 6.117928
646 64.5 6.099304
647 64.6 6.080812
648 64.7 6.062449
649 64.8 6.044212
650 64.9 6.026097
651 65.0 6.008102
652 65.1 5.990224
653 65.2 5.972460
654 65.3 5.954806
655 65.4 5.937261
656 65.5 5.919822
657 65.6 5.902487
658 65.7 5.885253
659 65.8 5.868117
660 65.9 5.851078
661 66.0 5.834134
662 66.1 5.817282
663 66.2 5.800521
664 66.3 5.783848
665 66.4 5.767262
666 66.5 5.750761
667 66.6 5.734344
668 66.7 5.718008
669 66.8 5.701752
670 66.9 5.685575
671 67.0 5.669474
672 67.1 5.653449
673 67.2 5.637498
674 67.3 5.621620
675 67.4 5.605814
676 67.5 5.590078
677 67.6 5.574411
678 67.7 5.558812
679 67.8 5.543279
680 67.9 5.527812
681 68.0 5.512410
682 68.1 5.497072
683 68.2 5.481795
684 68.3 5.466581
685 68.4 5.451427
686 68.5 5.436333
687 68.6 5.421298
688 68.7 5.406322
689 68.8 5.391402
690 68.9 5.376539
691 69.0 5.361732
692 69.1 5.346979
693 69.2 5.332281
694 69.3 5.317637
695 69.4 5.303045
696 69.5 5.288506
697 69.6 5.274019
698 69.7 5.259582
699 69.8 5.245197
700 69.9 5.230861
701 70.0 5.216574
702 70.1 5.202336
703 70.2 5.188147
704 70.3 5.174005
705 70.4 5.159911
706 70.5 5.145863
707 70.6 5.131862
708 70.7 5.117907
709 70.8 5.103997
710 70.9 5.090133
711 71.0 5.076313
712 71.1 5.062537
713 71.2 5.048805
714 71.3 5.035117
715 71.4 5.021472
716 71.5 5.007870
717 71.6 4.994310
718 71.7 4.980792
719 71.8 4.967316
720 71.9 4.953882
721 72.0 4.940488
Code
pk_curve(t = seq(0, 72, by = 0.1), model = "2cmt_infusion", ii = 24, addl = 5,
params = list(CL = 2.5, V1 = 25, V2 = 50, Q = 5, tinf = 3))
Output
t cp
1 0.0 0.0000000
2 0.1 0.7881453
3 0.2 1.5531518
4 0.3 2.2958517
5 0.4 3.0170470
6 0.5 3.7175101
7 0.6 4.3979852
8 0.7 5.0591895
9 0.8 5.7018138
10 0.9 6.3265234
11 1.0 6.9339598
12 1.1 7.5247406
13 1.2 8.0994609
14 1.3 8.6586943
15 1.4 9.2029930
16 1.5 9.7328894
17 1.6 10.2488963
18 1.7 10.7515076
19 1.8 11.2411994
20 1.9 11.7184302
21 2.0 12.1836419
22 2.1 12.6372601
23 2.2 13.0796950
24 2.3 13.5113416
25 2.4 13.9325807
26 2.5 14.3437791
27 2.6 14.7452901
28 2.7 15.1374544
29 2.8 15.5205998
30 2.9 15.8950425
31 3.0 16.2610870
32 3.1 15.8308815
33 3.2 15.4159927
34 3.3 15.0158608
35 3.4 14.6299463
36 3.5 14.2577297
37 3.6 13.8987102
38 3.7 13.5524057
39 3.8 13.2183515
40 3.9 12.8961000
41 4.0 12.5852200
42 4.1 12.2852961
43 4.2 11.9959282
44 4.3 11.7167306
45 4.4 11.4473319
46 4.5 11.1873744
47 4.6 10.9365134
48 4.7 10.6944166
49 4.8 10.4607643
50 4.9 10.2352483
51 5.0 10.0175715
52 5.1 9.8074479
53 5.2 9.6046021
54 5.3 9.4087684
55 5.4 9.2196912
56 5.5 9.0371241
57 5.6 8.8608296
58 5.7 8.6905792
59 5.8 8.5261524
60 5.9 8.3673372
61 6.0 8.2139290
62 6.1 8.0657308
63 6.2 7.9225529
64 6.3 7.7842125
65 6.4 7.6505334
66 6.5 7.5213461
67 6.6 7.3964869
68 6.7 7.2757985
69 6.8 7.1591291
70 6.9 7.0463327
71 7.0 6.9372683
72 7.1 6.8318004
73 7.2 6.7297982
74 7.3 6.6311359
75 7.4 6.5356922
76 7.5 6.4433502
77 7.6 6.3539974
78 7.7 6.2675254
79 7.8 6.1838295
80 7.9 6.1028093
81 8.0 6.0243676
82 8.1 5.9484112
83 8.2 5.8748499
84 8.3 5.8035972
85 8.4 5.7345694
86 8.5 5.6676861
87 8.6 5.6028697
88 8.7 5.5400456
89 8.8 5.4791418
90 8.9 5.4200890
91 9.0 5.3628204
92 9.1 5.3072716
93 9.2 5.2533807
94 9.3 5.2010879
95 9.4 5.1503357
96 9.5 5.1010686
97 9.6 5.0532333
98 9.7 5.0067783
99 9.8 4.9616540
100 9.9 4.9178127
101 10.0 4.8752084
102 10.1 4.8337967
103 10.2 4.7935350
104 10.3 4.7543821
105 10.4 4.7162983
106 10.5 4.6792455
107 10.6 4.6431868
108 10.7 4.6080869
109 10.8 4.5739116
110 10.9 4.5406279
111 11.0 4.5082042
112 11.1 4.4766100
113 11.2 4.4458157
114 11.3 4.4157931
115 11.4 4.3865149
116 11.5 4.3579547
117 11.6 4.3300871
118 11.7 4.3028878
119 11.8 4.2763332
120 11.9 4.2504006
121 12.0 4.2250682
122 12.1 4.2003150
123 12.2 4.1761206
124 12.3 4.1524655
125 12.4 4.1293309
126 12.5 4.1066986
127 12.6 4.0845512
128 12.7 4.0628718
129 12.8 4.0416442
130 12.9 4.0208528
131 13.0 4.0004824
132 13.1 3.9805187
133 13.2 3.9609475
134 13.3 3.9417555
135 13.4 3.9229296
136 13.5 3.9044573
137 13.6 3.8863266
138 13.7 3.8685259
139 13.8 3.8510439
140 13.9 3.8338699
141 14.0 3.8169935
142 14.1 3.8004046
143 14.2 3.7840937
144 14.3 3.7680514
145 14.4 3.7522688
146 14.5 3.7367372
147 14.6 3.7214483
148 14.7 3.7063940
149 14.8 3.6915668
150 14.9 3.6769590
151 15.0 3.6625637
152 15.1 3.6483737
153 15.2 3.6343825
154 15.3 3.6205836
155 15.4 3.6069709
156 15.5 3.5935384
157 15.6 3.5802803
158 15.7 3.5671911
159 15.8 3.5542655
160 15.9 3.5414982
161 16.0 3.5288845
162 16.1 3.5164194
163 16.2 3.5040983
164 16.3 3.4919169
165 16.4 3.4798709
166 16.5 3.4679560
167 16.6 3.4561684
168 16.7 3.4445042
169 16.8 3.4329597
170 16.9 3.4215314
171 17.0 3.4102157
172 17.1 3.3990095
173 17.2 3.3879095
174 17.3 3.3769126
175 17.4 3.3660159
176 17.5 3.3552165
177 17.6 3.3445117
178 17.7 3.3338987
179 17.8 3.3233751
180 17.9 3.3129383
181 18.0 3.3025861
182 18.1 3.2923160
183 18.2 3.2821258
184 18.3 3.2720135
185 18.4 3.2619770
186 18.5 3.2520142
187 18.6 3.2421234
188 18.7 3.2323025
189 18.8 3.2225498
190 18.9 3.2128637
191 19.0 3.2032425
192 19.1 3.1936844
193 19.2 3.1841881
194 19.3 3.1747521
195 19.4 3.1653748
196 19.5 3.1560549
197 19.6 3.1467910
198 19.7 3.1375820
199 19.8 3.1284265
200 19.9 3.1193233
201 20.0 3.1102712
202 20.1 3.1012693
203 20.2 3.0923163
204 20.3 3.0834112
205 20.4 3.0745530
206 20.5 3.0657408
207 20.6 3.0569736
208 20.7 3.0482505
209 20.8 3.0395706
210 20.9 3.0309331
211 21.0 3.0223372
212 21.1 3.0137821
213 21.2 3.0052670
214 21.3 2.9967912
215 21.4 2.9883540
216 21.5 2.9799546
217 21.6 2.9715925
218 21.7 2.9632670
219 21.8 2.9549774
220 21.9 2.9467233
221 22.0 2.9385039
222 22.1 2.9303188
223 22.2 2.9221673
224 22.3 2.9140490
225 22.4 2.9059635
226 22.5 2.8979100
227 22.6 2.8898883
228 22.7 2.8818979
229 22.8 2.8739382
230 22.9 2.8660090
231 23.0 2.8581097
232 23.1 2.8502400
233 23.2 2.8423994
234 23.3 2.8345877
235 23.4 2.8268044
236 23.5 2.8190492
237 23.6 2.8113217
238 23.7 2.8036217
239 23.8 2.7959487
240 23.9 2.7883026
241 24.0 2.7806829
242 24.1 3.5612347
243 24.2 4.3186736
244 24.3 5.0538316
245 24.4 5.7675103
246 24.5 6.4604820
247 24.6 7.1334905
248 24.7 7.7872529
249 24.8 8.4224595
250 24.9 9.0397757
251 25.0 9.6398426
252 25.1 10.2232776
253 25.2 10.7906757
254 25.3 11.3426100
255 25.4 11.8796329
256 25.5 12.4022764
257 25.6 12.9110530
258 25.7 13.4064567
259 25.8 13.8889631
260 25.9 14.3590308
261 26.0 14.8171014
262 26.1 15.2636003
263 26.2 15.6989376
264 26.3 16.1235083
265 26.4 16.5376928
266 26.5 16.9418578
267 26.6 17.3363566
268 26.7 17.7215295
269 26.8 18.0977045
270 26.9 18.4651974
271 27.0 18.8243127
272 27.1 18.3871984
273 27.2 17.9654212
274 27.3 17.5584210
275 27.4 17.1656583
276 27.5 16.7866134
277 27.6 16.4207856
278 27.7 16.0676924
279 27.8 15.7268692
280 27.9 15.3978682
281 28.0 15.0802581
282 28.1 14.7736234
283 28.2 14.4775639
284 28.3 14.1916938
285 28.4 13.9156417
286 28.5 13.6490497
287 28.6 13.3915730
288 28.7 13.1428793
289 28.8 12.9026488
290 28.9 12.6705730
291 29.0 12.4463550
292 29.1 12.2297086
293 29.2 12.0203583
294 29.3 11.8180384
295 29.4 11.6224931
296 29.5 11.4334759
297 29.6 11.2507494
298 29.7 11.0740849
299 29.8 10.9032620
300 29.9 10.7380683
301 30.0 10.5782993
302 30.1 10.4237580
303 30.2 10.2742546
304 30.3 10.1296062
305 30.4 9.9896365
306 30.5 9.8541759
307 30.6 9.7230609
308 30.7 9.5961338
309 30.8 9.4732429
310 30.9 9.3542420
311 31.0 9.2389903
312 31.1 9.1273520
313 31.2 9.0191963
314 31.3 8.9143974
315 31.4 8.8128339
316 31.5 8.7143889
317 31.6 8.6189497
318 31.7 8.5264079
319 31.8 8.4366589
320 31.9 8.3496019
321 32.0 8.2651401
322 32.1 8.1831798
323 32.2 8.1036311
324 32.3 8.0264072
325 32.4 7.9514245
326 32.5 7.8786025
327 32.6 7.8078635
328 32.7 7.7391329
329 32.8 7.6723386
330 32.9 7.6074113
331 33.0 7.5442841
332 33.1 7.4828926
333 33.2 7.4231748
334 33.3 7.3650709
335 33.4 7.3085233
336 33.5 7.2534766
337 33.6 7.1998773
338 33.7 7.1476738
339 33.8 7.0968166
340 33.9 7.0472579
341 34.0 6.9989516
342 34.1 6.9518533
343 34.2 6.9059203
344 34.3 6.8611115
345 34.4 6.8173870
346 34.5 6.7747087
347 34.6 6.7330398
348 34.7 6.6923447
349 34.8 6.6525893
350 34.9 6.6137406
351 35.0 6.5757668
352 35.1 6.5386375
353 35.2 6.5023230
354 35.3 6.4667950
355 35.4 6.4320263
356 35.5 6.3979903
357 35.6 6.3646617
358 35.7 6.3320160
359 35.8 6.3000297
360 35.9 6.2686801
361 36.0 6.2379452
362 36.1 6.2078039
363 36.2 6.1782360
364 36.3 6.1492218
365 36.4 6.1207425
366 36.5 6.0927799
367 36.6 6.0653165
368 36.7 6.0383354
369 36.8 6.0118203
370 36.9 5.9857556
371 37.0 5.9601261
372 37.1 5.9349174
373 37.2 5.9101153
374 37.3 5.8857063
375 37.4 5.8616775
376 37.5 5.8380163
377 37.6 5.8147106
378 37.7 5.7917488
379 37.8 5.7691195
380 37.9 5.7468120
381 38.0 5.7248159
382 38.1 5.7031211
383 38.2 5.6817179
384 38.3 5.6605970
385 38.4 5.6397493
386 38.5 5.6191663
387 38.6 5.5988395
388 38.7 5.5787609
389 38.8 5.5589227
390 38.9 5.5393175
391 39.0 5.5199380
392 39.1 5.5007773
393 39.2 5.4818287
394 39.3 5.4630858
395 39.4 5.4445422
396 39.5 5.4261920
397 39.6 5.4080294
398 39.7 5.3900489
399 39.8 5.3722450
400 39.9 5.3546127
401 40.0 5.3371468
402 40.1 5.3198425
403 40.2 5.3026953
404 40.3 5.2857007
405 40.4 5.2688543
406 40.5 5.2521520
407 40.6 5.2355897
408 40.7 5.2191636
409 40.8 5.2028700
410 40.9 5.1867052
411 41.0 5.1706659
412 41.1 5.1547486
413 41.2 5.1389501
414 41.3 5.1232674
415 41.4 5.1076974
416 41.5 5.0922372
417 41.6 5.0768840
418 41.7 5.0616352
419 41.8 5.0464881
420 41.9 5.0314402
421 42.0 5.0164892
422 42.1 5.0016327
423 42.2 4.9868684
424 42.3 4.9721942
425 42.4 4.9576080
426 42.5 4.9431077
427 42.6 4.9286915
428 42.7 4.9143574
429 42.8 4.9001036
430 42.9 4.8859283
431 43.0 4.8718300
432 43.1 4.8578068
433 43.2 4.8438574
434 43.3 4.8299801
435 43.4 4.8161734
436 43.5 4.8024360
437 43.6 4.7887666
438 43.7 4.7751636
439 43.8 4.7616260
440 43.9 4.7481524
441 44.0 4.7347417
442 44.1 4.7213927
443 44.2 4.7081043
444 44.3 4.6948755
445 44.4 4.6817051
446 44.5 4.6685922
447 44.6 4.6555358
448 44.7 4.6425351
449 44.8 4.6295890
450 44.9 4.6166967
451 45.0 4.6038574
452 45.1 4.5910702
453 45.2 4.5783344
454 45.3 4.5656491
455 45.4 4.5530137
456 45.5 4.5404274
457 45.6 4.5278896
458 45.7 4.5153995
459 45.8 4.5029566
460 45.9 4.4905601
461 46.0 4.4782095
462 46.1 4.4659042
463 46.2 4.4536437
464 46.3 4.4414273
465 46.4 4.4292545
466 46.5 4.4171249
467 46.6 4.4050379
468 46.7 4.3929930
469 46.8 4.3809898
470 46.9 4.3690278
471 47.0 4.3571065
472 47.1 4.3452256
473 47.2 4.3333846
474 47.3 4.3215831
475 47.4 4.3098207
476 47.5 4.2980971
477 47.6 4.2864118
478 47.7 4.2747645
479 47.8 4.2631549
480 47.9 4.2515826
481 48.0 4.2400473
482 48.1 5.0166940
483 48.2 5.7702382
484 48.3 6.5015120
485 48.4 7.2113168
486 48.5 7.9004249
487 48.6 8.5695803
488 48.7 9.2194998
489 48.8 9.8508739
490 48.9 10.4643678
491 49.0 11.0606226
492 49.1 11.6402557
493 49.2 12.2038620
494 49.3 12.7520148
495 49.4 13.2852663
496 49.5 13.8041484
497 49.6 14.3091737
498 49.7 14.8008361
499 49.8 15.2796114
500 49.9 15.7459578
501 50.0 16.2003170
502 50.1 16.6431146
503 50.2 17.0747605
504 50.3 17.4956495
505 50.4 17.9061623
506 50.5 18.3066654
507 50.6 18.6975121
508 50.7 19.0790427
509 50.8 19.4515851
510 50.9 19.8154552
511 51.0 20.1709573
512 51.1 19.7302395
513 51.2 19.3048684
514 51.3 18.8942840
515 51.4 18.4979467
516 51.5 18.1153367
517 51.6 17.7459533
518 51.7 17.3893141
519 51.8 17.0449543
520 51.9 16.7124262
521 52.0 16.3912985
522 52.1 16.0811556
523 52.2 15.7815972
524 52.3 15.4922377
525 52.4 15.2127055
526 52.5 14.9426427
527 52.6 14.6817044
528 52.7 14.4295585
529 52.8 14.1858849
530 52.9 13.9503753
531 53.0 13.7227326
532 53.1 13.5026708
533 53.2 13.2899141
534 53.3 13.0841970
535 53.4 12.8852636
536 53.5 12.6928673
537 53.6 12.5067709
538 53.7 12.3267453
539 53.8 12.1525704
540 53.9 11.9840337
541 54.0 11.8209306
542 54.1 11.6630642
543 54.2 11.5102445
544 54.3 11.3622887
545 54.4 11.2190205
546 54.5 11.0802702
547 54.6 10.9458742
548 54.7 10.8156749
549 54.8 10.6895207
550 54.9 10.5672652
551 55.0 10.4487675
552 55.1 10.3338919
553 55.2 10.2225077
554 55.3 10.1144889
555 55.4 10.0097140
556 55.5 9.9080662
557 55.6 9.8094329
558 55.7 9.7137054
559 55.8 9.6207793
560 55.9 9.5305538
561 56.0 9.4429318
562 56.1 9.3578199
563 56.2 9.2751280
564 56.3 9.1947693
565 56.4 9.1166601
566 56.5 9.0407200
567 56.6 8.9668714
568 56.7 8.8950394
569 56.8 8.8251520
570 56.9 8.7571399
571 57.0 8.6909361
572 57.1 8.6264763
573 57.2 8.5636983
574 57.3 8.5025425
575 57.4 8.4429512
576 57.5 8.3848688
577 57.6 8.3282420
578 57.7 8.2730191
579 57.8 8.2191506
580 57.9 8.1665886
581 58.0 8.1152871
582 58.1 8.0652016
583 58.2 8.0162894
584 58.3 7.9685093
585 58.4 7.9218215
586 58.5 7.8761879
587 58.6 7.8315715
588 58.7 7.7879369
589 58.8 7.7452497
590 58.9 7.7034772
591 59.0 7.6625874
592 59.1 7.6225498
593 59.2 7.5833349
594 59.3 7.5449143
595 59.4 7.5072605
596 59.5 7.4703473
597 59.6 7.4341492
598 59.7 7.3986417
599 59.8 7.3638012
600 59.9 7.3296050
601 60.0 7.2960312
602 60.1 7.2630586
603 60.2 7.2306669
604 60.3 7.1988365
605 60.4 7.1675485
606 60.5 7.1367848
607 60.6 7.1065277
608 60.7 7.0767604
609 60.8 7.0474666
610 60.9 7.0186306
611 61.0 6.9902372
612 61.1 6.9622720
613 61.2 6.9347208
614 61.3 6.9075701
615 61.4 6.8808069
616 61.5 6.8544186
617 61.6 6.8283931
618 61.7 6.8027187
619 61.8 6.7773842
620 61.9 6.7523787
621 62.0 6.7276918
622 62.1 6.7033134
623 62.2 6.6792337
624 62.3 6.6554436
625 62.4 6.6319338
626 62.5 6.6086958
627 62.6 6.5857211
628 62.7 6.5630017
629 62.8 6.5405298
630 62.9 6.5182979
631 63.0 6.4962988
632 63.1 6.4745254
633 63.2 6.4529712
634 63.3 6.4316295
635 63.4 6.4104942
636 63.5 6.3895592
637 63.6 6.3688188
638 63.7 6.3482672
639 63.8 6.3278993
640 63.9 6.3077097
641 64.0 6.2876934
642 64.1 6.2678456
643 64.2 6.2481616
644 64.3 6.2286370
645 64.4 6.2092674
646 64.5 6.1900486
647 64.6 6.1709766
648 64.7 6.1520475
649 64.8 6.1332576
650 64.9 6.1146032
651 65.0 6.0960809
652 65.1 6.0776873
653 65.2 6.0594191
654 65.3 6.0412733
655 65.4 6.0232468
656 65.5 6.0053366
657 65.6 5.9875401
658 65.7 5.9698544
659 65.8 5.9522770
660 65.9 5.9348054
661 66.0 5.9174371
662 66.1 5.9001697
663 66.2 5.8830010
664 66.3 5.8659288
665 66.4 5.8489511
666 66.5 5.8320656
667 66.6 5.8152706
668 66.7 5.7985641
669 66.8 5.7819443
670 66.9 5.7654093
671 67.0 5.7489575
672 67.1 5.7325873
673 67.2 5.7162970
674 67.3 5.7000851
675 67.4 5.6839502
676 67.5 5.6678907
677 67.6 5.6519053
678 67.7 5.6359927
679 67.8 5.6201516
680 67.9 5.6043807
681 68.0 5.5886788
682 68.1 5.5730447
683 68.2 5.5574774
684 68.3 5.5419757
685 68.4 5.5265386
686 68.5 5.5111650
687 68.6 5.4958540
688 68.7 5.4806046
689 68.8 5.4654159
690 68.9 5.4502871
691 69.0 5.4352171
692 69.1 5.4202053
693 69.2 5.4052508
694 69.3 5.3903528
695 69.4 5.3755105
696 69.5 5.3607233
697 69.6 5.3459905
698 69.7 5.3313112
699 69.8 5.3166850
700 69.9 5.3021111
701 70.0 5.2875889
702 70.1 5.2731177
703 70.2 5.2586972
704 70.3 5.2443265
705 70.4 5.2300053
706 70.5 5.2157329
707 70.6 5.2015089
708 70.7 5.1873328
709 70.8 5.1732040
710 70.9 5.1591220
711 71.0 5.1450866
712 71.1 5.1310971
713 71.2 5.1171532
714 71.3 5.1032544
715 71.4 5.0894003
716 71.5 5.0755906
717 71.6 5.0618248
718 71.7 5.0481026
719 71.8 5.0344236
720 71.9 5.0207875
721 72.0 5.0071939
Code
pk_curve(t = seq(0, 72, by = 0.1), model = "3cmt_bolus", ii = 24, addl = 5,
params = list(CL = 0.25, V1 = 25, V2 = 50, V3 = 100, Q2 = 1, Q3 = 0.1))
Output
t cp
1 0.0 24.000000
2 0.1 23.870845
3 0.2 23.742577
4 0.3 23.615190
5 0.4 23.488676
6 0.5 23.363031
7 0.6 23.238248
8 0.7 23.114321
9 0.8 22.991244
10 0.9 22.869011
11 1.0 22.747617
12 1.1 22.627055
13 1.2 22.507320
14 1.3 22.388405
15 1.4 22.270306
16 1.5 22.153016
17 1.6 22.036530
18 1.7 21.920843
19 1.8 21.805948
20 1.9 21.691840
21 2.0 21.578514
22 2.1 21.465964
23 2.2 21.354185
24 2.3 21.243171
25 2.4 21.132918
26 2.5 21.023419
27 2.6 20.914670
28 2.7 20.806665
29 2.8 20.699399
30 2.9 20.592867
31 3.0 20.487064
32 3.1 20.381985
33 3.2 20.277625
34 3.3 20.173978
35 3.4 20.071040
36 3.5 19.968806
37 3.6 19.867270
38 3.7 19.766429
39 3.8 19.666277
40 3.9 19.566809
41 4.0 19.468021
42 4.1 19.369907
43 4.2 19.272464
44 4.3 19.175686
45 4.4 19.079570
46 4.5 18.984109
47 4.6 18.889300
48 4.7 18.795138
49 4.8 18.701619
50 4.9 18.608738
51 5.0 18.516491
52 5.1 18.424873
53 5.2 18.333880
54 5.3 18.243507
55 5.4 18.153750
56 5.5 18.064606
57 5.6 17.976069
58 5.7 17.888136
59 5.8 17.800801
60 5.9 17.714062
61 6.0 17.627914
62 6.1 17.542352
63 6.2 17.457373
64 6.3 17.372973
65 6.4 17.289147
66 6.5 17.205892
67 6.6 17.123204
68 6.7 17.041078
69 6.8 16.959511
70 6.9 16.878498
71 7.0 16.798037
72 7.1 16.718123
73 7.2 16.638752
74 7.3 16.559920
75 7.4 16.481625
76 7.5 16.403861
77 7.6 16.326626
78 7.7 16.249916
79 7.8 16.173726
80 7.9 16.098054
81 8.0 16.022895
82 8.1 15.948247
83 8.2 15.874105
84 8.3 15.800467
85 8.4 15.727328
86 8.5 15.654685
87 8.6 15.582535
88 8.7 15.510874
89 8.8 15.439699
90 8.9 15.369006
91 9.0 15.298792
92 9.1 15.229054
93 9.2 15.159789
94 9.3 15.090992
95 9.4 15.022662
96 9.5 14.954794
97 9.6 14.887385
98 9.7 14.820433
99 9.8 14.753933
100 9.9 14.687884
101 10.0 14.622281
102 10.1 14.557121
103 10.2 14.492403
104 10.3 14.428121
105 10.4 14.364274
106 10.5 14.300859
107 10.6 14.237872
108 10.7 14.175310
109 10.8 14.113171
110 10.9 14.051451
111 11.0 13.990147
112 11.1 13.929258
113 11.2 13.868779
114 11.3 13.808708
115 11.4 13.749042
116 11.5 13.689778
117 11.6 13.630914
118 11.7 13.572446
119 11.8 13.514373
120 11.9 13.456690
121 12.0 13.399396
122 12.1 13.342488
123 12.2 13.285962
124 12.3 13.229817
125 12.4 13.174050
126 12.5 13.118658
127 12.6 13.063638
128 12.7 13.008989
129 12.8 12.954706
130 12.9 12.900788
131 13.0 12.847233
132 13.1 12.794037
133 13.2 12.741199
134 13.3 12.688715
135 13.4 12.636583
136 13.5 12.584801
137 13.6 12.533367
138 13.7 12.482277
139 13.8 12.431530
140 13.9 12.381123
141 14.0 12.331054
142 14.1 12.281320
143 14.2 12.231919
144 14.3 12.182849
145 14.4 12.134108
146 14.5 12.085693
147 14.6 12.037601
148 14.7 11.989831
149 14.8 11.942381
150 14.9 11.895248
151 15.0 11.848430
152 15.1 11.801924
153 15.2 11.755730
154 15.3 11.709843
155 15.4 11.664263
156 15.5 11.618987
157 15.6 11.574014
158 15.7 11.529340
159 15.8 11.484964
160 15.9 11.440884
161 16.0 11.397097
162 16.1 11.353602
163 16.2 11.310397
164 16.3 11.267480
165 16.4 11.224848
166 16.5 11.182499
167 16.6 11.140433
168 16.7 11.098646
169 16.8 11.057137
170 16.9 11.015904
171 17.0 10.974944
172 17.1 10.934257
173 17.2 10.893840
174 17.3 10.853691
175 17.4 10.813808
176 17.5 10.774190
177 17.6 10.734835
178 17.7 10.695740
179 17.8 10.656905
180 17.9 10.618326
181 18.0 10.580004
182 18.1 10.541934
183 18.2 10.504117
184 18.3 10.466550
185 18.4 10.429231
186 18.5 10.392159
187 18.6 10.355332
188 18.7 10.318748
189 18.8 10.282406
190 18.9 10.246304
191 19.0 10.210439
192 19.1 10.174812
193 19.2 10.139419
194 19.3 10.104260
195 19.4 10.069332
196 19.5 10.034634
197 19.6 10.000165
198 19.7 9.965923
199 19.8 9.931906
200 19.9 9.898112
201 20.0 9.864541
202 20.1 9.831190
203 20.2 9.798059
204 20.3 9.765145
205 20.4 9.732447
206 20.5 9.699964
207 20.6 9.667693
208 20.7 9.635634
209 20.8 9.603786
210 20.9 9.572146
211 21.0 9.540713
212 21.1 9.509486
213 21.2 9.478463
214 21.3 9.447643
215 21.4 9.417025
216 21.5 9.386606
217 21.6 9.356387
218 21.7 9.326364
219 21.8 9.296538
220 21.9 9.266906
221 22.0 9.237468
222 22.1 9.208221
223 22.2 9.179165
224 22.3 9.150298
225 22.4 9.121619
226 22.5 9.093127
227 22.6 9.064820
228 22.7 9.036697
229 22.8 9.008756
230 22.9 8.980997
231 23.0 8.953419
232 23.1 8.926019
233 23.2 8.898797
234 23.3 8.871752
235 23.4 8.844881
236 23.5 8.818185
237 23.6 8.791662
238 23.7 8.765310
239 23.8 8.739129
240 23.9 8.713117
241 24.0 32.687273
242 24.1 32.532441
243 24.2 32.378662
244 24.3 32.225928
245 24.4 32.074231
246 24.5 31.923565
247 24.6 31.773922
248 24.7 31.625295
249 24.8 31.477677
250 24.9 31.331062
251 25.0 31.185441
252 25.1 31.040809
253 25.2 30.897158
254 25.3 30.754481
255 25.4 30.612772
256 25.5 30.472024
257 25.6 30.332230
258 25.7 30.193384
259 25.8 30.055478
260 25.9 29.918507
261 26.0 29.782464
262 26.1 29.647342
263 26.2 29.513135
264 26.3 29.379837
265 26.4 29.247441
266 26.5 29.115941
267 26.6 28.985331
268 26.7 28.855605
269 26.8 28.726756
270 26.9 28.598778
271 27.0 28.471665
272 27.1 28.345412
273 27.2 28.220011
274 27.3 28.095458
275 27.4 27.971747
276 27.5 27.848871
277 27.6 27.726824
278 27.7 27.605602
279 27.8 27.485197
280 27.9 27.365605
281 28.0 27.246820
282 28.1 27.128836
283 28.2 27.011648
284 28.3 26.895250
285 28.4 26.779636
286 28.5 26.664802
287 28.6 26.550741
288 28.7 26.437448
289 28.8 26.324918
290 28.9 26.213146
291 29.0 26.102127
292 29.1 25.991854
293 29.2 25.882323
294 29.3 25.773529
295 29.4 25.665467
296 29.5 25.558131
297 29.6 25.451517
298 29.7 25.345619
299 29.8 25.240432
300 29.9 25.135952
301 30.0 25.032174
302 30.1 24.929092
303 30.2 24.826702
304 30.3 24.724999
305 30.4 24.623978
306 30.5 24.523635
307 30.6 24.423964
308 30.7 24.324962
309 30.8 24.226623
310 30.9 24.128943
311 31.0 24.031917
312 31.1 23.935540
313 31.2 23.839809
314 31.3 23.744719
315 31.4 23.650264
316 31.5 23.556442
317 31.6 23.463246
318 31.7 23.370674
319 31.8 23.278721
320 31.9 23.187381
321 32.0 23.096652
322 32.1 23.006529
323 32.2 22.917007
324 32.3 22.828083
325 32.4 22.739752
326 32.5 22.652010
327 32.6 22.564853
328 32.7 22.478277
329 32.8 22.392278
330 32.9 22.306852
331 33.0 22.221995
332 33.1 22.137703
333 33.2 22.053971
334 33.3 21.970797
335 33.4 21.888176
336 33.5 21.806105
337 33.6 21.724579
338 33.7 21.643595
339 33.8 21.563149
340 33.9 21.483237
341 34.0 21.403856
342 34.1 21.325001
343 34.2 21.246670
344 34.3 21.168858
345 34.4 21.091563
346 34.5 21.014779
347 34.6 20.938505
348 34.7 20.862735
349 34.8 20.787467
350 34.9 20.712698
351 35.0 20.638423
352 35.1 20.564640
353 35.2 20.491344
354 35.3 20.418533
355 35.4 20.346204
356 35.5 20.274351
357 35.6 20.202974
358 35.7 20.132067
359 35.8 20.061629
360 35.9 19.991655
361 36.0 19.922143
362 36.1 19.853088
363 36.2 19.784489
364 36.3 19.716342
365 36.4 19.648643
366 36.5 19.581390
367 36.6 19.514579
368 36.7 19.448208
369 36.8 19.382273
370 36.9 19.316771
371 37.0 19.251700
372 37.1 19.187056
373 37.2 19.122836
374 37.3 19.059038
375 37.4 18.995658
376 37.5 18.932694
377 37.6 18.870143
378 37.7 18.808001
379 37.8 18.746266
380 37.9 18.684935
381 38.0 18.624006
382 38.1 18.563475
383 38.2 18.503340
384 38.3 18.443597
385 38.4 18.384245
386 38.5 18.325281
387 38.6 18.266702
388 38.7 18.208504
389 38.8 18.150686
390 38.9 18.093245
391 39.0 18.036179
392 39.1 17.979484
393 39.2 17.923158
394 39.3 17.867198
395 39.4 17.811603
396 39.5 17.756369
397 39.6 17.701494
398 39.7 17.646975
399 39.8 17.592810
400 39.9 17.538997
401 40.0 17.485533
402 40.1 17.432416
403 40.2 17.379642
404 40.3 17.327211
405 40.4 17.275119
406 40.5 17.223364
407 40.6 17.171944
408 40.7 17.120856
409 40.8 17.070099
410 40.9 17.019669
411 41.0 16.969565
412 41.1 16.919784
413 41.2 16.870324
414 41.3 16.821183
415 41.4 16.772358
416 41.5 16.723848
417 41.6 16.675650
418 41.7 16.627763
419 41.8 16.580183
420 41.9 16.532909
421 42.0 16.485938
422 42.1 16.439269
423 42.2 16.392900
424 42.3 16.346828
425 42.4 16.301051
426 42.5 16.255567
427 42.6 16.210375
428 42.7 16.165471
429 42.8 16.120855
430 42.9 16.076524
431 43.0 16.032477
432 43.1 15.988710
433 43.2 15.945223
434 43.3 15.902013
435 43.4 15.859079
436 43.5 15.816418
437 43.6 15.774029
438 43.7 15.731909
439 43.8 15.690058
440 43.9 15.648472
441 44.0 15.607150
442 44.1 15.566091
443 44.2 15.525293
444 44.3 15.484753
445 44.4 15.444469
446 44.5 15.404441
447 44.6 15.364667
448 44.7 15.325144
449 44.8 15.285871
450 44.9 15.246845
451 45.0 15.208067
452 45.1 15.169533
453 45.2 15.131242
454 45.3 15.093192
455 45.4 15.055382
456 45.5 15.017810
457 45.6 14.980474
458 45.7 14.943373
459 45.8 14.906505
460 45.9 14.869868
461 46.0 14.833461
462 46.1 14.797282
463 46.2 14.761330
464 46.3 14.725603
465 46.4 14.690100
466 46.5 14.654819
467 46.6 14.619758
468 46.7 14.584916
469 46.8 14.550291
470 46.9 14.515882
471 47.0 14.481688
472 47.1 14.447706
473 47.2 14.413936
474 47.3 14.380376
475 47.4 14.347025
476 47.5 14.313880
477 47.6 14.280941
478 47.7 14.248206
479 47.8 14.215675
480 47.9 14.183344
481 48.0 38.151213
482 48.1 37.990127
483 48.2 37.830124
484 48.3 37.671198
485 48.4 37.513340
486 48.5 37.356543
487 48.6 37.200801
488 48.7 37.046105
489 48.8 36.892448
490 48.9 36.739824
491 49.0 36.588224
492 49.1 36.437642
493 49.2 36.288071
494 49.3 36.139503
495 49.4 35.991932
496 49.5 35.845351
497 49.6 35.699753
498 49.7 35.555130
499 49.8 35.411477
500 49.9 35.268786
501 50.0 35.127050
502 50.1 34.986264
503 50.2 34.846420
504 50.3 34.707512
505 50.4 34.569534
506 50.5 34.432478
507 50.6 34.296339
508 50.7 34.161110
509 50.8 34.026785
510 50.9 33.893357
511 51.0 33.760821
512 51.1 33.629169
513 51.2 33.498397
514 51.3 33.368497
515 51.4 33.239463
516 51.5 33.111291
517 51.6 32.983973
518 51.7 32.857504
519 51.8 32.731877
520 51.9 32.607088
521 52.0 32.483129
522 52.1 32.359996
523 52.2 32.237682
524 52.3 32.116183
525 52.4 31.995491
526 52.5 31.875602
527 52.6 31.756510
528 52.7 31.638210
529 52.8 31.520696
530 52.9 31.403961
531 53.0 31.288002
532 53.1 31.172813
533 53.2 31.058388
534 53.3 30.944722
535 53.4 30.831810
536 53.5 30.719646
537 53.6 30.608225
538 53.7 30.497542
539 53.8 30.387593
540 53.9 30.278371
541 54.0 30.169872
542 54.1 30.062091
543 54.2 29.955022
544 54.3 29.848661
545 54.4 29.743003
546 54.5 29.638043
547 54.6 29.533777
548 54.7 29.430198
549 54.8 29.327303
550 54.9 29.225087
551 55.0 29.123545
552 55.1 29.022672
553 55.2 28.922464
554 55.3 28.822916
555 55.4 28.724023
556 55.5 28.625782
557 55.6 28.528187
558 55.7 28.431233
559 55.8 28.334917
560 55.9 28.239235
561 56.0 28.144180
562 56.1 28.049750
563 56.2 27.955940
564 56.3 27.862746
565 56.4 27.770162
566 56.5 27.678186
567 56.6 27.586813
568 56.7 27.496038
569 56.8 27.405858
570 56.9 27.316268
571 57.0 27.227264
572 57.1 27.138843
573 57.2 27.051000
574 57.3 26.963730
575 57.4 26.877031
576 57.5 26.790898
577 57.6 26.705327
578 57.7 26.620315
579 57.8 26.535857
580 57.9 26.451949
581 58.0 26.368589
582 58.1 26.285771
583 58.2 26.203492
584 58.3 26.121749
585 58.4 26.040538
586 58.5 25.959854
587 58.6 25.879695
588 58.7 25.800057
589 58.8 25.720935
590 58.9 25.642327
591 59.0 25.564229
592 59.1 25.486638
593 59.2 25.409549
594 59.3 25.332960
595 59.4 25.256866
596 59.5 25.181265
597 59.6 25.106153
598 59.7 25.031527
599 59.8 24.957383
600 59.9 24.883717
601 60.0 24.810528
602 60.1 24.737810
603 60.2 24.665562
604 60.3 24.593779
605 60.4 24.522459
606 60.5 24.451599
607 60.6 24.381194
608 60.7 24.311242
609 60.8 24.241740
610 60.9 24.172685
611 61.0 24.104073
612 61.1 24.035902
613 61.2 23.968168
614 61.3 23.900869
615 61.4 23.834000
616 61.5 23.767561
617 61.6 23.701546
618 61.7 23.635955
619 61.8 23.570782
620 61.9 23.506027
621 62.0 23.441685
622 62.1 23.377754
623 62.2 23.314230
624 62.3 23.251112
625 62.4 23.188397
626 62.5 23.126081
627 62.6 23.064161
628 62.7 23.002636
629 62.8 22.941502
630 62.9 22.880757
631 63.0 22.820397
632 63.1 22.760421
633 63.2 22.700825
634 63.3 22.641608
635 63.4 22.582765
636 63.5 22.524295
637 63.6 22.466195
638 63.7 22.408463
639 63.8 22.351096
640 63.9 22.294091
641 64.0 22.237446
642 64.1 22.181159
643 64.2 22.125226
644 64.3 22.069646
645 64.4 22.014417
646 64.5 21.959534
647 64.6 21.904997
648 64.7 21.850803
649 64.8 21.796949
650 64.9 21.743434
651 65.0 21.690254
652 65.1 21.637407
653 65.2 21.584892
654 65.3 21.532705
655 65.4 21.480845
656 65.5 21.429309
657 65.6 21.378095
658 65.7 21.327201
659 65.8 21.276625
660 65.9 21.226364
661 66.0 21.176416
662 66.1 21.126779
663 66.2 21.077451
664 66.3 21.028430
665 66.4 20.979713
666 66.5 20.931299
667 66.6 20.883185
668 66.7 20.835370
669 66.8 20.787850
670 66.9 20.740625
671 67.0 20.693692
672 67.1 20.647050
673 67.2 20.600695
674 67.3 20.554626
675 67.4 20.508842
676 67.5 20.463340
677 67.6 20.418118
678 67.7 20.373174
679 67.8 20.328507
680 67.9 20.284114
681 68.0 20.239993
682 68.1 20.196143
683 68.2 20.152563
684 68.3 20.109248
685 68.4 20.066200
686 68.5 20.023414
687 68.6 19.980889
688 68.7 19.938625
689 68.8 19.896618
690 68.9 19.854867
691 69.0 19.813370
692 69.1 19.772126
693 69.2 19.731133
694 69.3 19.690389
695 69.4 19.649892
696 69.5 19.609640
697 69.6 19.569633
698 69.7 19.529867
699 69.8 19.490342
700 69.9 19.451056
701 70.0 19.412007
702 70.1 19.373194
703 70.2 19.334615
704 70.3 19.296268
705 70.4 19.258152
706 70.5 19.220265
707 70.6 19.182605
708 70.7 19.145171
709 70.8 19.107962
710 70.9 19.070976
711 71.0 19.034211
712 71.1 18.997666
713 71.2 18.961339
714 71.3 18.925228
715 71.4 18.889333
716 71.5 18.853652
717 71.6 18.818183
718 71.7 18.782925
719 71.8 18.747876
720 71.9 18.713036
721 72.0 42.678401
Code
pk_curve(t = seq(0, 72, by = 0.1), model = "3cmt_oral", ii = 24, addl = 5,
params = list(CL = 0.25, V1 = 25, V2 = 50, V3 = 100, Q2 = 1, Q3 = 0.1, ka = 1))
Output
t cp
1 0.0 0.000000
2 0.1 2.277647
3 0.2 4.326300
4 0.3 6.167834
5 0.4 7.822042
6 0.5 9.306835
7 0.6 10.638416
8 0.7 11.831446
9 0.8 12.899193
10 0.9 13.853659
11 1.0 14.705705
12 1.1 15.465155
13 1.2 16.140901
14 1.3 16.740987
15 1.4 17.272691
16 1.5 17.742597
17 1.6 18.156662
18 1.7 18.520278
19 1.8 18.838320
20 1.9 19.115201
21 2.0 19.354913
22 2.1 19.561066
23 2.2 19.736927
24 2.3 19.885454
25 2.4 20.009318
26 2.5 20.110940
27 2.6 20.192507
28 2.7 20.256000
29 2.8 20.303208
30 2.9 20.335751
31 3.0 20.355095
32 3.1 20.362565
33 3.2 20.359359
34 3.3 20.346561
35 3.4 20.325153
36 3.5 20.296020
37 3.6 20.259964
38 3.7 20.217710
39 3.8 20.169915
40 3.9 20.117170
41 4.0 20.060012
42 4.1 19.998926
43 4.2 19.934347
44 4.3 19.866674
45 4.4 19.796263
46 4.5 19.723438
47 4.6 19.648490
48 4.7 19.571683
49 4.8 19.493256
50 4.9 19.413424
51 5.0 19.332381
52 5.1 19.250301
53 5.2 19.167345
54 5.3 19.083654
55 5.4 18.999356
56 5.5 18.914569
57 5.6 18.829397
58 5.7 18.743933
59 5.8 18.658264
60 5.9 18.572465
61 6.0 18.486605
62 6.1 18.400746
63 6.2 18.314944
64 6.3 18.229248
65 6.4 18.143703
66 6.5 18.058349
67 6.6 17.973223
68 6.7 17.888356
69 6.8 17.803776
70 6.9 17.719511
71 7.0 17.635581
72 7.1 17.552008
73 7.2 17.468810
74 7.3 17.386001
75 7.4 17.303598
76 7.5 17.221611
77 7.6 17.140051
78 7.7 17.058929
79 7.8 16.978251
80 7.9 16.898026
81 8.0 16.818259
82 8.1 16.738955
83 8.2 16.660118
84 8.3 16.581753
85 8.4 16.503862
86 8.5 16.426447
87 8.6 16.349510
88 8.7 16.273052
89 8.8 16.197075
90 8.9 16.121577
91 9.0 16.046560
92 9.1 15.972023
93 9.2 15.897966
94 9.3 15.824388
95 9.4 15.751287
96 9.5 15.678662
97 9.6 15.606512
98 9.7 15.534836
99 9.8 15.463631
100 9.9 15.392896
101 10.0 15.322628
102 10.1 15.252826
103 10.2 15.183486
104 10.3 15.114608
105 10.4 15.046188
106 10.5 14.978224
107 10.6 14.910714
108 10.7 14.843655
109 10.8 14.777044
110 10.9 14.710879
111 11.0 14.645158
112 11.1 14.579876
113 11.2 14.515033
114 11.3 14.450625
115 11.4 14.386649
116 11.5 14.323102
117 11.6 14.259983
118 11.7 14.197288
119 11.8 14.135014
120 11.9 14.073159
121 12.0 14.011719
122 12.1 13.950693
123 12.2 13.890077
124 12.3 13.829869
125 12.4 13.770066
126 12.5 13.710665
127 12.6 13.651664
128 12.7 13.593059
129 12.8 13.534849
130 12.9 13.477030
131 13.0 13.419600
132 13.1 13.362555
133 13.2 13.305895
134 13.3 13.249615
135 13.4 13.193714
136 13.5 13.138188
137 13.6 13.083036
138 13.7 13.028254
139 13.8 12.973840
140 13.9 12.919791
141 14.0 12.866105
142 14.1 12.812780
143 14.2 12.759812
144 14.3 12.707200
145 14.4 12.654941
146 14.5 12.603033
147 14.6 12.551472
148 14.7 12.500258
149 14.8 12.449386
150 14.9 12.398856
151 15.0 12.348664
152 15.1 12.298808
153 15.2 12.249286
154 15.3 12.200096
155 15.4 12.151235
156 15.5 12.102701
157 15.6 12.054492
158 15.7 12.006605
159 15.8 11.959038
160 15.9 11.911789
161 16.0 11.864856
162 16.1 11.818237
163 16.2 11.771929
164 16.3 11.725930
165 16.4 11.680238
166 16.5 11.634851
167 16.6 11.589767
168 16.7 11.544983
169 16.8 11.500499
170 16.9 11.456310
171 17.0 11.412417
172 17.1 11.368815
173 17.2 11.325504
174 17.3 11.282482
175 17.4 11.239745
176 17.5 11.197294
177 17.6 11.155124
178 17.7 11.113235
179 17.8 11.071625
180 17.9 11.030290
181 18.0 10.989231
182 18.1 10.948444
183 18.2 10.907928
184 18.3 10.867681
185 18.4 10.827702
186 18.5 10.787987
187 18.6 10.748535
188 18.7 10.709346
189 18.8 10.670415
190 18.9 10.631743
191 19.0 10.593327
192 19.1 10.555165
193 19.2 10.517256
194 19.3 10.479597
195 19.4 10.442188
196 19.5 10.405025
197 19.6 10.368109
198 19.7 10.331436
199 19.8 10.295006
200 19.9 10.258816
201 20.0 10.222864
202 20.1 10.187150
203 20.2 10.151672
204 20.3 10.116427
205 20.4 10.081415
206 20.5 10.046633
207 20.6 10.012080
208 20.7 9.977755
209 20.8 9.943656
210 20.9 9.909781
211 21.0 9.876128
212 21.1 9.842697
213 21.2 9.809485
214 21.3 9.776492
215 21.4 9.743715
216 21.5 9.711153
217 21.6 9.678805
218 21.7 9.646669
219 21.8 9.614744
220 21.9 9.583028
221 22.0 9.551519
222 22.1 9.520217
223 22.2 9.489119
224 22.3 9.458225
225 22.4 9.427533
226 22.5 9.397042
227 22.6 9.366750
228 22.7 9.336656
229 22.8 9.306758
230 22.9 9.277055
231 23.0 9.247546
232 23.1 9.218229
233 23.2 9.189103
234 23.3 9.160167
235 23.4 9.131420
236 23.5 9.102859
237 23.6 9.074485
238 23.7 9.046294
239 23.8 9.018287
240 23.9 8.990462
241 24.0 8.962818
242 24.1 11.213000
243 24.2 13.234366
244 24.3 15.048790
245 24.4 16.676064
246 24.5 18.134097
247 24.6 19.439091
248 24.7 20.605708
249 24.8 21.647211
250 24.9 22.575604
251 25.0 23.401744
252 25.1 24.135456
253 25.2 24.785631
254 25.3 25.360310
255 25.4 25.866770
256 25.5 26.311596
257 25.6 26.700743
258 25.7 27.039601
259 25.8 27.333044
260 25.9 27.585485
261 26.0 27.800913
262 26.1 27.982939
263 26.2 28.134828
264 26.3 28.259536
265 26.4 28.359735
266 26.5 28.437843
267 26.6 28.496048
268 26.7 28.536327
269 26.8 28.560470
270 26.9 28.570097
271 27.0 28.566670
272 27.1 28.551515
273 27.2 28.525829
274 27.3 28.490695
275 27.4 28.447092
276 27.5 28.395906
277 27.6 28.337938
278 27.7 28.273913
279 27.8 28.204484
280 27.9 28.130243
281 28.0 28.051725
282 28.1 27.969415
283 28.2 27.883748
284 28.3 27.795120
285 28.4 27.703887
286 28.5 27.610372
287 28.6 27.514865
288 28.7 27.417630
289 28.8 27.318904
290 28.9 27.218901
291 29.0 27.117814
292 29.1 27.015818
293 29.2 26.913071
294 29.3 26.809714
295 29.4 26.705875
296 29.5 26.601669
297 29.6 26.497200
298 29.7 26.392562
299 29.8 26.287838
300 29.9 26.183104
301 30.0 26.078429
302 30.1 25.973873
303 30.2 25.869490
304 30.3 25.765330
305 30.4 25.661438
306 30.5 25.557851
307 30.6 25.454605
308 30.7 25.351733
309 30.8 25.249260
310 30.9 25.147213
311 31.0 25.045613
312 31.1 24.944480
313 31.2 24.843830
314 31.3 24.743680
315 31.4 24.644042
316 31.5 24.544928
317 31.6 24.446348
318 31.7 24.348311
319 31.8 24.250823
320 31.9 24.153892
321 32.0 24.057523
322 32.1 23.961719
323 32.2 23.866486
324 32.3 23.771824
325 32.4 23.677738
326 32.5 23.584228
327 32.6 23.491295
328 32.7 23.398939
329 32.8 23.307162
330 32.9 23.215962
331 33.0 23.125340
332 33.1 23.035293
333 33.2 22.945821
334 33.3 22.856923
335 33.4 22.768595
336 33.5 22.680838
337 33.6 22.593648
338 33.7 22.507023
339 33.8 22.420962
340 33.9 22.335460
341 34.0 22.250516
342 34.1 22.166127
343 34.2 22.082290
344 34.3 21.999002
345 34.4 21.916260
346 34.5 21.834062
347 34.6 21.752403
348 34.7 21.671281
349 34.8 21.590693
350 34.9 21.510635
351 35.0 21.431104
352 35.1 21.352097
353 35.2 21.273612
354 35.3 21.195643
355 35.4 21.118188
356 35.5 21.041245
357 35.6 20.964809
358 35.7 20.888877
359 35.8 20.813446
360 35.9 20.738512
361 36.0 20.664073
362 36.1 20.590125
363 36.2 20.516665
364 36.3 20.443689
365 36.4 20.371194
366 36.5 20.299178
367 36.6 20.227636
368 36.7 20.156565
369 36.8 20.085963
370 36.9 20.015826
371 37.0 19.946151
372 37.1 19.876935
373 37.2 19.808174
374 37.3 19.739866
375 37.4 19.672008
376 37.5 19.604595
377 37.6 19.537626
378 37.7 19.471098
379 37.8 19.405006
380 37.9 19.339349
381 38.0 19.274122
382 38.1 19.209324
383 38.2 19.144951
384 38.3 19.081001
385 38.4 19.017470
386 38.5 18.954355
387 38.6 18.891654
388 38.7 18.829364
389 38.8 18.767481
390 38.9 18.706004
391 39.0 18.644929
392 39.1 18.584253
393 39.2 18.523974
394 39.3 18.464089
395 39.4 18.404595
396 39.5 18.345489
397 39.6 18.286770
398 39.7 18.228433
399 39.8 18.170477
400 39.9 18.112899
401 40.0 18.055696
402 40.1 17.998866
403 40.2 17.942405
404 40.3 17.886312
405 40.4 17.830584
406 40.5 17.775218
407 40.6 17.720212
408 40.7 17.665564
409 40.8 17.611270
410 40.9 17.557329
411 41.0 17.503737
412 41.1 17.450493
413 41.2 17.397595
414 41.3 17.345038
415 41.4 17.292823
416 41.5 17.240945
417 41.6 17.189403
418 41.7 17.138194
419 41.8 17.087316
420 41.9 17.036766
421 42.0 16.986543
422 42.1 16.936645
423 42.2 16.887068
424 42.3 16.837810
425 42.4 16.788870
426 42.5 16.740246
427 42.6 16.691934
428 42.7 16.643933
429 42.8 16.596241
430 42.9 16.548855
431 43.0 16.501774
432 43.1 16.454995
433 43.2 16.408516
434 43.3 16.362336
435 43.4 16.316451
436 43.5 16.270861
437 43.6 16.225562
438 43.7 16.180553
439 43.8 16.135833
440 43.9 16.091398
441 44.0 16.047247
442 44.1 16.003378
443 44.2 15.959789
444 44.3 15.916478
445 44.4 15.873443
446 44.5 15.830683
447 44.6 15.788194
448 44.7 15.745976
449 44.8 15.704027
450 44.9 15.662344
451 45.0 15.620927
452 45.1 15.579772
453 45.2 15.538878
454 45.3 15.498244
455 45.4 15.457867
456 45.5 15.417746
457 45.6 15.377879
458 45.7 15.338265
459 45.8 15.298900
460 45.9 15.259785
461 46.0 15.220916
462 46.1 15.182293
463 46.2 15.143914
464 46.3 15.105776
465 46.4 15.067879
466 46.5 15.030220
467 46.6 14.992798
468 46.7 14.955611
469 46.8 14.918658
470 46.9 14.881937
471 47.0 14.845447
472 47.1 14.809185
473 47.2 14.773150
474 47.3 14.737342
475 47.4 14.701757
476 47.5 14.666395
477 47.6 14.631253
478 47.7 14.596332
479 47.8 14.561628
480 47.9 14.527141
481 48.0 14.492868
482 48.1 16.736456
483 48.2 18.751262
484 48.3 20.559159
485 48.4 22.179940
486 48.5 23.631513
487 48.6 24.930080
488 48.7 26.090302
489 48.8 27.125443
490 48.9 28.047505
491 49.0 28.867347
492 49.1 29.594794
493 49.2 30.238733
494 49.3 30.807209
495 49.4 31.307498
496 49.5 31.746182
497 49.6 32.129218
498 49.7 32.461996
499 49.8 32.749390
500 49.9 32.995811
501 50.0 33.205249
502 50.1 33.381315
503 50.2 33.527273
504 50.3 33.646080
505 50.4 33.740407
506 50.5 33.812671
507 50.6 33.865061
508 50.7 33.899554
509 50.8 33.917939
510 50.9 33.921836
511 51.0 33.912707
512 51.1 33.891878
513 51.2 33.860545
514 51.3 33.819791
515 51.4 33.770596
516 51.5 33.713845
517 51.6 33.650339
518 51.7 33.580801
519 51.8 33.505886
520 51.9 33.426187
521 52.0 33.342236
522 52.1 33.254518
523 52.2 33.163470
524 52.3 33.069486
525 52.4 32.972922
526 52.5 32.874101
527 52.6 32.773314
528 52.7 32.670824
529 52.8 32.566867
530 52.9 32.461657
531 53.0 32.355389
532 53.1 32.248235
533 53.2 32.140354
534 53.3 32.031887
535 53.4 31.922961
536 53.5 31.813693
537 53.6 31.704185
538 53.7 31.594530
539 53.8 31.484814
540 53.9 31.375110
541 54.0 31.265487
542 54.1 31.156006
543 54.2 31.046721
544 54.3 30.937682
545 54.4 30.828931
546 54.5 30.720508
547 54.6 30.612449
548 54.7 30.504784
549 54.8 30.397541
550 54.9 30.290744
551 55.0 30.184416
552 55.1 30.078576
553 55.2 29.973241
554 55.3 29.868425
555 55.4 29.764143
556 55.5 29.660405
557 55.6 29.557221
558 55.7 29.454601
559 55.8 29.352550
560 55.9 29.251076
561 56.0 29.150183
562 56.1 29.049877
563 56.2 28.950159
564 56.3 28.851034
565 56.4 28.752502
566 56.5 28.654566
567 56.6 28.557226
568 56.7 28.460483
569 56.8 28.364337
570 56.9 28.268787
571 57.0 28.173833
572 57.1 28.079473
573 57.2 27.985706
574 57.3 27.892531
575 57.4 27.799946
576 57.5 27.707948
577 57.6 27.616535
578 57.7 27.525705
579 57.8 27.435456
580 57.9 27.345785
581 58.0 27.256688
582 58.1 27.168164
583 58.2 27.080209
584 58.3 26.992819
585 58.4 26.905993
586 58.5 26.819727
587 58.6 26.734018
588 58.7 26.648862
589 58.8 26.564256
590 58.9 26.480196
591 59.0 26.396681
592 59.1 26.313705
593 59.2 26.231266
594 59.3 26.149360
595 59.4 26.067985
596 59.5 25.987136
597 59.6 25.906810
598 59.7 25.827003
599 59.8 25.747713
600 59.9 25.668936
601 60.0 25.590668
602 60.1 25.512907
603 60.2 25.435648
604 60.3 25.358888
605 60.4 25.282625
606 60.5 25.206854
607 60.6 25.131573
608 60.7 25.056777
609 60.8 24.982465
610 60.9 24.908631
611 61.0 24.835274
612 61.1 24.762390
613 61.2 24.689976
614 61.3 24.618027
615 61.4 24.546543
616 61.5 24.475518
617 61.6 24.404950
618 61.7 24.334836
619 61.8 24.265173
620 61.9 24.195957
621 62.0 24.127186
622 62.1 24.058856
623 62.2 23.990964
624 62.3 23.923508
625 62.4 23.856484
626 62.5 23.789890
627 62.6 23.723721
628 62.7 23.657977
629 62.8 23.592652
630 62.9 23.527746
631 63.0 23.463254
632 63.1 23.399173
633 63.2 23.335502
634 63.3 23.272237
635 63.4 23.209375
636 63.5 23.146914
637 63.6 23.084851
638 63.7 23.023182
639 63.8 22.961906
640 63.9 22.901019
641 64.0 22.840519
642 64.1 22.780404
643 64.2 22.720670
644 64.3 22.661314
645 64.4 22.602335
646 64.5 22.543730
647 64.6 22.485495
648 64.7 22.427629
649 64.8 22.370129
650 64.9 22.312992
651 65.0 22.256217
652 65.1 22.199799
653 65.2 22.143737
654 65.3 22.088029
655 65.4 22.032672
656 65.5 21.977663
657 65.6 21.923000
658 65.7 21.868681
659 65.8 21.814703
660 65.9 21.761065
661 66.0 21.707763
662 66.1 21.654795
663 66.2 21.602159
664 66.3 21.549852
665 66.4 21.497873
666 66.5 21.446220
667 66.6 21.394889
668 66.7 21.343878
669 66.8 21.293186
670 66.9 21.242810
671 67.0 21.192748
672 67.1 21.142998
673 67.2 21.093558
674 67.3 21.044425
675 67.4 20.995597
676 67.5 20.947073
677 67.6 20.898850
678 67.7 20.850926
679 67.8 20.803299
680 67.9 20.755967
681 68.0 20.708928
682 68.1 20.662179
683 68.2 20.615720
684 68.3 20.569547
685 68.4 20.523659
686 68.5 20.478055
687 68.6 20.432731
688 68.7 20.387686
689 68.8 20.342918
690 68.9 20.298425
691 69.0 20.254206
692 69.1 20.210257
693 69.2 20.166579
694 69.3 20.123168
695 69.4 20.080022
696 69.5 20.037141
697 69.6 19.994522
698 69.7 19.952162
699 69.8 19.910062
700 69.9 19.868218
701 70.0 19.826629
702 70.1 19.785293
703 70.2 19.744209
704 70.3 19.703374
705 70.4 19.662787
706 70.5 19.622446
707 70.6 19.582350
708 70.7 19.542497
709 70.8 19.502884
710 70.9 19.463512
711 71.0 19.424377
712 71.1 19.385478
713 71.2 19.346814
714 71.3 19.308382
715 71.4 19.270182
716 71.5 19.232212
717 71.6 19.194470
718 71.7 19.156954
719 71.8 19.119663
720 71.9 19.082596
721 72.0 19.045751
Code
pk_curve(t = seq(0, 72, by = 0.1), model = "3cmt_infusion", ii = 24, addl = 5,
params = list(CL = 0.25, V1 = 25, V2 = 50, V3 = 100, Q2 = 1, Q3 = 0.1, tinf = 3))
Output
t cp
1 0.0 0.000000
2 0.1 0.797845
3 0.2 1.591400
4 0.3 2.380693
5 0.4 3.165755
6 0.5 3.946615
7 0.6 4.723300
8 0.7 5.495841
9 0.8 6.264264
10 0.9 7.028600
11 1.0 7.788874
12 1.1 8.545117
13 1.2 9.297354
14 1.3 10.045614
15 1.4 10.789923
16 1.5 11.530310
17 1.6 12.266800
18 1.7 12.999421
19 1.8 13.728198
20 1.9 14.453159
21 2.0 15.174330
22 2.1 15.891736
23 2.2 16.605403
24 2.3 17.315356
25 2.4 18.021622
26 2.5 18.724226
27 2.6 19.423192
28 2.7 20.118546
29 2.8 20.810311
30 2.9 21.498514
31 3.0 22.183177
32 3.1 22.066481
33 3.2 21.950585
34 3.3 21.835482
35 3.4 21.721169
36 3.5 21.607638
37 3.6 21.494885
38 3.7 21.382904
39 3.8 21.271691
40 3.9 21.161238
41 4.0 21.051542
42 4.1 20.942597
43 4.2 20.834397
44 4.3 20.726938
45 4.4 20.620214
46 4.5 20.514221
47 4.6 20.408952
48 4.7 20.304403
49 4.8 20.200570
50 4.9 20.097447
51 5.0 19.995028
52 5.1 19.893310
53 5.2 19.792287
54 5.3 19.691955
55 5.4 19.592308
56 5.5 19.493342
57 5.6 19.395052
58 5.7 19.297434
59 5.8 19.200482
60 5.9 19.104192
61 6.0 19.008560
62 6.1 18.913581
63 6.2 18.819250
64 6.3 18.725562
65 6.4 18.632515
66 6.5 18.540101
67 6.6 18.448319
68 6.7 18.357162
69 6.8 18.266627
70 6.9 18.176710
71 7.0 18.087405
72 7.1 17.998709
73 7.2 17.910618
74 7.3 17.823127
75 7.4 17.736232
76 7.5 17.649929
77 7.6 17.564214
78 7.7 17.479083
79 7.8 17.394532
80 7.9 17.310556
81 8.0 17.227151
82 8.1 17.144315
83 8.2 17.062042
84 8.3 16.980328
85 8.4 16.899171
86 8.5 16.818566
87 8.6 16.738508
88 8.7 16.658995
89 8.8 16.580023
90 8.9 16.501587
91 9.0 16.423685
92 9.1 16.346311
93 9.2 16.269463
94 9.3 16.193138
95 9.4 16.117330
96 9.5 16.042037
97 9.6 15.967256
98 9.7 15.892982
99 9.8 15.819212
100 9.9 15.745942
101 10.0 15.673169
102 10.1 15.600890
103 10.2 15.529102
104 10.3 15.457799
105 10.4 15.386980
106 10.5 15.316642
107 10.6 15.246779
108 10.7 15.177390
109 10.8 15.108471
110 10.9 15.040019
111 11.0 14.972030
112 11.1 14.904501
113 11.2 14.837429
114 11.3 14.770812
115 11.4 14.704644
116 11.5 14.638925
117 11.6 14.573650
118 11.7 14.508816
119 11.8 14.444420
120 11.9 14.380460
121 12.0 14.316931
122 12.1 14.253832
123 12.2 14.191159
124 12.3 14.128910
125 12.4 14.067080
126 12.5 14.005668
127 12.6 13.944670
128 12.7 13.884084
129 12.8 13.823906
130 12.9 13.764134
131 13.0 13.704766
132 13.1 13.645797
133 13.2 13.587226
134 13.3 13.529049
135 13.4 13.471264
136 13.5 13.413869
137 13.6 13.356860
138 13.7 13.300234
139 13.8 13.243990
140 13.9 13.188124
141 14.0 13.132634
142 14.1 13.077517
143 14.2 13.022770
144 14.3 12.968392
145 14.4 12.914379
146 14.5 12.860729
147 14.6 12.807439
148 14.7 12.754507
149 14.8 12.701931
150 14.9 12.649707
151 15.0 12.597834
152 15.1 12.546308
153 15.2 12.495129
154 15.3 12.444292
155 15.4 12.393796
156 15.5 12.343639
157 15.6 12.293817
158 15.7 12.244330
159 15.8 12.195173
160 15.9 12.146346
161 16.0 12.097846
162 16.1 12.049670
163 16.2 12.001816
164 16.3 11.954282
165 16.4 11.907066
166 16.5 11.860166
167 16.6 11.813579
168 16.7 11.767303
169 16.8 11.721336
170 16.9 11.675676
171 17.0 11.630321
172 17.1 11.585268
173 17.2 11.540516
174 17.3 11.496062
175 17.4 11.451904
176 17.5 11.408041
177 17.6 11.364470
178 17.7 11.321189
179 17.8 11.278197
180 17.9 11.235490
181 18.0 11.193068
182 18.1 11.150928
183 18.2 11.109068
184 18.3 11.067486
185 18.4 11.026181
186 18.5 10.985150
187 18.6 10.944392
188 18.7 10.903904
189 18.8 10.863685
190 18.9 10.823733
191 19.0 10.784046
192 19.1 10.744622
193 19.2 10.705459
194 19.3 10.666556
195 19.4 10.627911
196 19.5 10.589521
197 19.6 10.551386
198 19.7 10.513503
199 19.8 10.475870
200 19.9 10.438487
201 20.0 10.401350
202 20.1 10.364459
203 20.2 10.327812
204 20.3 10.291407
205 20.4 10.255242
206 20.5 10.219315
207 20.6 10.183626
208 20.7 10.148172
209 20.8 10.112952
210 20.9 10.077964
211 21.0 10.043206
212 21.1 10.008677
213 21.2 9.974375
214 21.3 9.940299
215 21.4 9.906448
216 21.5 9.872819
217 21.6 9.839410
218 21.7 9.806222
219 21.8 9.773251
220 21.9 9.740497
221 22.0 9.707957
222 22.1 9.675631
223 22.2 9.643517
224 22.3 9.611614
225 22.4 9.579919
226 22.5 9.548433
227 22.6 9.517152
228 22.7 9.486076
229 22.8 9.455203
230 22.9 9.424532
231 23.0 9.394061
232 23.1 9.363790
233 23.2 9.333716
234 23.3 9.303839
235 23.4 9.274156
236 23.5 9.244667
237 23.6 9.215371
238 23.7 9.186265
239 23.8 9.157349
240 23.9 9.128621
241 24.0 9.100080
242 24.1 9.869569
243 24.2 10.634953
244 24.3 11.396258
245 24.4 12.153514
246 24.5 12.906748
247 24.6 13.655987
248 24.7 14.401259
249 24.8 15.142592
250 24.9 15.880011
251 25.0 16.613544
252 25.1 17.343218
253 25.2 18.069059
254 25.3 18.791093
255 25.4 19.509347
256 25.5 20.223845
257 25.6 20.934615
258 25.7 21.641681
259 25.8 22.345069
260 25.9 23.044804
261 26.0 23.740911
262 26.1 24.433416
263 26.2 25.122341
264 26.3 25.807713
265 26.4 26.489555
266 26.5 27.167892
267 26.6 27.842747
268 26.7 28.514144
269 26.8 29.182107
270 26.9 29.846660
271 27.0 30.507826
272 27.1 30.367783
273 27.2 30.228688
274 27.3 30.090537
275 27.4 29.953322
276 27.5 29.817036
277 27.6 29.681673
278 27.7 29.547227
279 27.8 29.413692
280 27.9 29.281060
281 28.0 29.149326
282 28.1 29.018483
283 28.2 28.888525
284 28.3 28.759447
285 28.4 28.631241
286 28.5 28.503902
287 28.6 28.377424
288 28.7 28.251801
289 28.8 28.127027
290 28.9 28.003095
291 29.0 27.880001
292 29.1 27.757737
293 29.2 27.636300
294 29.3 27.515681
295 29.4 27.395877
296 29.5 27.276881
297 29.6 27.158688
298 29.7 27.041292
299 29.8 26.924687
300 29.9 26.808868
301 30.0 26.693830
302 30.1 26.579567
303 30.2 26.466074
304 30.3 26.353345
305 30.4 26.241375
306 30.5 26.130158
307 30.6 26.019691
308 30.7 25.909966
309 30.8 25.800980
310 30.9 25.692726
311 31.0 25.585200
312 31.1 25.478397
313 31.2 25.372312
314 31.3 25.266940
315 31.4 25.162275
316 31.5 25.058313
317 31.6 24.955050
318 31.7 24.852479
319 31.8 24.750596
320 31.9 24.649397
321 32.0 24.548877
322 32.1 24.449031
323 32.2 24.349854
324 32.3 24.251342
325 32.4 24.153489
326 32.5 24.056292
327 32.6 23.959746
328 32.7 23.863847
329 32.8 23.768589
330 32.9 23.673968
331 33.0 23.579981
332 33.1 23.486621
333 33.2 23.393886
334 33.3 23.301771
335 33.4 23.210272
336 33.5 23.119383
337 33.6 23.029102
338 33.7 22.939423
339 33.8 22.850342
340 33.9 22.761856
341 34.0 22.673961
342 34.1 22.586651
343 34.2 22.499923
344 34.3 22.413774
345 34.4 22.328198
346 34.5 22.243192
347 34.6 22.158752
348 34.7 22.074875
349 34.8 21.991555
350 34.9 21.908790
351 35.0 21.826575
352 35.1 21.744907
353 35.2 21.663781
354 35.3 21.583195
355 35.4 21.503143
356 35.5 21.423624
357 35.6 21.344632
358 35.7 21.266164
359 35.8 21.188216
360 35.9 21.110786
361 36.0 21.033869
362 36.1 20.957461
363 36.2 20.881560
364 36.3 20.806161
365 36.4 20.731262
366 36.5 20.656858
367 36.6 20.582946
368 36.7 20.509523
369 36.8 20.436586
370 36.9 20.364131
371 37.0 20.292154
372 37.1 20.220652
373 37.2 20.149623
374 37.3 20.079062
375 37.4 20.008967
376 37.5 19.939334
377 37.6 19.870160
378 37.7 19.801442
379 37.8 19.733177
380 37.9 19.665361
381 38.0 19.597992
382 38.1 19.531066
383 38.2 19.464580
384 38.3 19.398531
385 38.4 19.332916
386 38.5 19.267733
387 38.6 19.202977
388 38.7 19.138647
389 38.8 19.074739
390 38.9 19.011250
391 39.0 18.948177
392 39.1 18.885518
393 39.2 18.823269
394 39.3 18.761428
395 39.4 18.699992
396 39.5 18.638958
397 39.6 18.578323
398 39.7 18.518085
399 39.8 18.458240
400 39.9 18.398786
401 40.0 18.339721
402 40.1 18.281041
403 40.2 18.222744
404 40.3 18.164827
405 40.4 18.107288
406 40.5 18.050124
407 40.6 17.993332
408 40.7 17.936910
409 40.8 17.880855
410 40.9 17.825164
411 41.0 17.769836
412 41.1 17.714867
413 41.2 17.660256
414 41.3 17.605999
415 41.4 17.552094
416 41.5 17.498539
417 41.6 17.445331
418 41.7 17.392468
419 41.8 17.339947
420 41.9 17.287767
421 42.0 17.235924
422 42.1 17.184417
423 42.2 17.133243
424 42.3 17.082399
425 42.4 17.031884
426 42.5 16.981695
427 42.6 16.931830
428 42.7 16.882286
429 42.8 16.833062
430 42.9 16.784155
431 43.0 16.735563
432 43.1 16.687284
433 43.2 16.639315
434 43.3 16.591655
435 43.4 16.544301
436 43.5 16.497252
437 43.6 16.450504
438 43.7 16.404057
439 43.8 16.357907
440 43.9 16.312053
441 44.0 16.266493
442 44.1 16.221225
443 44.2 16.176246
444 44.3 16.131556
445 44.4 16.087150
446 44.5 16.043029
447 44.6 15.999189
448 44.7 15.955629
449 44.8 15.912347
450 44.9 15.869341
451 45.0 15.826609
452 45.1 15.784149
453 45.2 15.741959
454 45.3 15.700038
455 45.4 15.658383
456 45.5 15.616993
457 45.6 15.575865
458 45.7 15.534999
459 45.8 15.494392
460 45.9 15.454042
461 46.0 15.413947
462 46.1 15.374107
463 46.2 15.334518
464 46.3 15.295180
465 46.4 15.256090
466 46.5 15.217247
467 46.6 15.178650
468 46.7 15.140295
469 46.8 15.102183
470 46.9 15.064310
471 47.0 15.026676
472 47.1 14.989279
473 47.2 14.952117
474 47.3 14.915188
475 47.4 14.878491
476 47.5 14.842024
477 47.6 14.805786
478 47.7 14.769776
479 47.8 14.733990
480 47.9 14.698429
481 48.0 14.663090
482 48.1 15.425816
483 48.2 16.184472
484 48.3 16.939084
485 48.4 17.689681
486 48.5 18.436291
487 48.6 19.178939
488 48.7 19.917655
489 48.8 20.652464
490 48.9 21.383393
491 49.0 22.110470
492 49.1 22.833720
493 49.2 23.553169
494 49.3 24.268844
495 49.4 24.980771
496 49.5 25.688975
497 49.6 26.393482
498 49.7 27.094316
499 49.8 27.791504
500 49.9 28.485070
501 50.0 29.175039
502 50.1 29.861436
503 50.2 30.544285
504 50.3 31.223610
505 50.4 31.899435
506 50.5 32.571785
507 50.6 33.240683
508 50.7 33.906153
509 50.8 34.568218
510 50.9 35.226901
511 51.0 35.882226
512 51.1 35.736371
513 51.2 35.591493
514 51.3 35.447587
515 51.4 35.304644
516 51.5 35.162659
517 51.6 35.021625
518 51.7 34.881535
519 51.8 34.742383
520 51.9 34.604162
521 52.0 34.466865
522 52.1 34.330487
523 52.2 34.195020
524 52.3 34.060459
525 52.4 33.926796
526 52.5 33.794027
527 52.6 33.662145
528 52.7 33.531142
529 52.8 33.401014
530 52.9 33.271755
531 53.0 33.143358
532 53.1 33.015816
533 53.2 32.889125
534 53.3 32.763279
535 53.4 32.638271
536 53.5 32.514095
537 53.6 32.390747
538 53.7 32.268219
539 53.8 32.146507
540 53.9 32.025604
541 54.0 31.905506
542 54.1 31.786206
543 54.2 31.667699
544 54.3 31.549979
545 54.4 31.433041
546 54.5 31.316880
547 54.6 31.201490
548 54.7 31.086865
549 54.8 30.973001
550 54.9 30.859892
551 55.0 30.747533
552 55.1 30.635918
553 55.2 30.525043
554 55.3 30.414902
555 55.4 30.305490
556 55.5 30.196802
557 55.6 30.088833
558 55.7 29.981579
559 55.8 29.875033
560 55.9 29.769192
561 56.0 29.664050
562 56.1 29.559602
563 56.2 29.455844
564 56.3 29.352771
565 56.4 29.250377
566 56.5 29.148659
567 56.6 29.047612
568 56.7 28.947230
569 56.8 28.847510
570 56.9 28.748446
571 57.0 28.650035
572 57.1 28.552271
573 57.2 28.455150
574 57.3 28.358668
575 57.4 28.262820
576 57.5 28.167602
577 57.6 28.073009
578 57.7 27.979037
579 57.8 27.885682
580 57.9 27.792939
581 58.0 27.700805
582 58.1 27.609274
583 58.2 27.518343
584 58.3 27.428008
585 58.4 27.338264
586 58.5 27.249108
587 58.6 27.160534
588 58.7 27.072540
589 58.8 26.985121
590 58.9 26.898273
591 59.0 26.811993
592 59.1 26.726275
593 59.2 26.641117
594 59.3 26.556515
595 59.4 26.472464
596 59.5 26.388960
597 59.6 26.306001
598 59.7 26.223582
599 59.8 26.141699
600 59.9 26.060349
601 60.0 25.979528
602 60.1 25.899232
603 60.2 25.819458
604 60.3 25.740201
605 60.4 25.661460
606 60.5 25.583229
607 60.6 25.505505
608 60.7 25.428285
609 60.8 25.351566
610 60.9 25.275343
611 61.0 25.199614
612 61.1 25.124374
613 61.2 25.049621
614 61.3 24.975351
615 61.4 24.901561
616 61.5 24.828248
617 61.6 24.755407
618 61.7 24.683037
619 61.8 24.611133
620 61.9 24.539692
621 62.0 24.468712
622 62.1 24.398188
623 62.2 24.328118
624 62.3 24.258499
625 62.4 24.189328
626 62.5 24.120600
627 62.6 24.052314
628 62.7 23.984466
629 62.8 23.917054
630 62.9 23.850073
631 63.0 23.783522
632 63.1 23.717397
633 63.2 23.651695
634 63.3 23.586414
635 63.4 23.521549
636 63.5 23.457100
637 63.6 23.393062
638 63.7 23.329432
639 63.8 23.266209
640 63.9 23.203388
641 64.0 23.140968
642 64.1 23.078946
643 64.2 23.017318
644 64.3 22.956082
645 64.4 22.895235
646 64.5 22.834775
647 64.6 22.774699
648 64.7 22.715005
649 64.8 22.655688
650 64.9 22.596748
651 65.0 22.538181
652 65.1 22.479985
653 65.2 22.422157
654 65.3 22.364695
655 65.4 22.307596
656 65.5 22.250858
657 65.6 22.194477
658 65.7 22.138452
659 65.8 22.082781
660 65.9 22.027460
661 66.0 21.972487
662 66.1 21.917860
663 66.2 21.863577
664 66.3 21.809634
665 66.4 21.756031
666 66.5 21.702764
667 66.6 21.649830
668 66.7 21.597229
669 66.8 21.544957
670 66.9 21.493012
671 67.0 21.441392
672 67.1 21.390094
673 67.2 21.339117
674 67.3 21.288458
675 67.4 21.238115
676 67.5 21.188085
677 67.6 21.138368
678 67.7 21.088959
679 67.8 21.039858
680 67.9 20.991063
681 68.0 20.942570
682 68.1 20.894378
683 68.2 20.846485
684 68.3 20.798888
685 68.4 20.751587
686 68.5 20.704578
687 68.6 20.657860
688 68.7 20.611430
689 68.8 20.565287
690 68.9 20.519429
691 69.0 20.473854
692 69.1 20.428559
693 69.2 20.383543
694 69.3 20.338804
695 69.4 20.294339
696 69.5 20.250148
697 69.6 20.206228
698 69.7 20.162577
699 69.8 20.119194
700 69.9 20.076076
701 70.0 20.033222
702 70.1 19.990630
703 70.2 19.948298
704 70.3 19.906224
705 70.4 19.864407
706 70.5 19.822844
707 70.6 19.781535
708 70.7 19.740476
709 70.8 19.699667
710 70.9 19.659106
711 71.0 19.618791
712 71.1 19.578720
713 71.2 19.538892
714 71.3 19.499304
715 71.4 19.459956
716 71.5 19.420846
717 71.6 19.381972
718 71.7 19.343332
719 71.8 19.304925
720 71.9 19.266748
721 72.0 19.228802
kestrel99/pmxTools documentation built on Feb. 25, 2023, 1:26 p.m.
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PK curves
Code
pk_curve(t = seq(0, 72, by = 0.1), model = "1cmt_bolus", ii = 12, addl = 5,
params = list(CL = 2.5, V = 25))
Output
t cp
1 0.0 24.000000
2 0.1 23.761196
3 0.2 23.524768
4 0.3 23.290693
5 0.4 23.058947
6 0.5 22.829506
7 0.6 22.602349
8 0.7 22.377452
9 0.8 22.154792
10 0.9 21.934348
11 1.0 21.716098
12 1.1 21.500019
13 1.2 21.286090
14 1.3 21.074290
15 1.4 20.864598
16 1.5 20.656991
17 1.6 20.451451
18 1.7 20.247956
19 1.8 20.046485
20 1.9 19.847019
21 2.0 19.649538
22 2.1 19.454022
23 2.2 19.260451
24 2.3 19.068806
25 2.4 18.879069
26 2.5 18.691219
27 2.6 18.505238
28 2.7 18.321108
29 2.8 18.138810
30 2.9 17.958326
31 3.0 17.779637
32 3.1 17.602727
33 3.2 17.427577
34 3.3 17.254170
35 3.4 17.082488
36 3.5 16.912514
37 3.6 16.744232
38 3.7 16.577624
39 3.8 16.412674
40 3.9 16.249365
41 4.0 16.087681
42 4.1 15.927606
43 4.2 15.769124
44 4.3 15.612218
45 4.4 15.456874
46 4.5 15.303076
47 4.6 15.150807
48 4.7 15.000054
49 4.8 14.850801
50 4.9 14.703033
51 5.0 14.556736
52 5.1 14.411894
53 5.2 14.268493
54 5.3 14.126519
55 5.4 13.985958
56 5.5 13.846795
57 5.6 13.709018
58 5.7 13.572611
59 5.8 13.437561
60 5.9 13.303855
61 6.0 13.171479
62 6.1 13.040421
63 6.2 12.910667
64 6.3 12.782203
65 6.4 12.655018
66 6.5 12.529099
67 6.6 12.404432
68 6.7 12.281006
69 6.8 12.158808
70 6.9 12.037826
71 7.0 11.918047
72 7.1 11.799461
73 7.2 11.682054
74 7.3 11.565816
75 7.4 11.450734
76 7.5 11.336797
77 7.6 11.223994
78 7.7 11.112314
79 7.8 11.001744
80 7.9 10.892275
81 8.0 10.783895
82 8.1 10.676594
83 8.2 10.570360
84 8.3 10.465183
85 8.4 10.361053
86 8.5 10.257958
87 8.6 10.155890
88 8.7 10.054837
89 8.8 9.954790
90 8.9 9.855738
91 9.0 9.757672
92 9.1 9.660581
93 9.2 9.564457
94 9.3 9.469289
95 9.4 9.375068
96 9.5 9.281785
97 9.6 9.189429
98 9.7 9.097993
99 9.8 9.007466
100 9.9 8.917841
101 10.0 8.829107
102 10.1 8.741256
103 10.2 8.654279
104 10.3 8.568167
105 10.4 8.482912
106 10.5 8.398506
107 10.6 8.314939
108 10.7 8.232204
109 10.8 8.150293
110 10.9 8.069196
111 11.0 7.988906
112 11.1 7.909415
113 11.2 7.830715
114 11.3 7.752798
115 11.4 7.675657
116 11.5 7.599282
117 11.6 7.523668
118 11.7 7.448807
119 11.8 7.374690
120 11.9 7.301310
121 12.0 31.228661
122 12.1 30.917931
123 12.2 30.610292
124 12.3 30.305715
125 12.4 30.004168
126 12.5 29.705621
127 12.6 29.410045
128 12.7 29.117411
129 12.8 28.827688
130 12.9 28.540847
131 13.0 28.256861
132 13.1 27.975701
133 13.2 27.697338
134 13.3 27.421745
135 13.4 27.148894
136 13.5 26.878758
137 13.6 26.611310
138 13.7 26.346523
139 13.8 26.084370
140 13.9 25.824827
141 14.0 25.567865
142 14.1 25.313461
143 14.2 25.061588
144 14.3 24.812221
145 14.4 24.565335
146 14.5 24.320906
147 14.6 24.078909
148 14.7 23.839320
149 14.8 23.602114
150 14.9 23.367269
151 15.0 23.134761
152 15.1 22.904566
153 15.2 22.676662
154 15.3 22.451026
155 15.4 22.227634
156 15.5 22.006466
157 15.6 21.787498
158 15.7 21.570708
159 15.8 21.356076
160 15.9 21.143580
161 16.0 20.933198
162 16.1 20.724909
163 16.2 20.518692
164 16.3 20.314528
165 16.4 20.112395
166 16.5 19.912273
167 16.6 19.714143
168 16.7 19.517984
169 16.8 19.323777
170 16.9 19.131502
171 17.0 18.941140
172 17.1 18.752673
173 17.2 18.566081
174 17.3 18.381345
175 17.4 18.198448
176 17.5 18.017370
177 17.6 17.838094
178 17.7 17.660602
179 17.8 17.484876
180 17.9 17.310899
181 18.0 17.138653
182 18.1 16.968120
183 18.2 16.799285
184 18.3 16.632129
185 18.4 16.466636
186 18.5 16.302791
187 18.6 16.140575
188 18.7 15.979974
189 18.8 15.820970
190 18.9 15.663549
191 19.0 15.507694
192 19.1 15.353390
193 19.2 15.200621
194 19.3 15.049373
195 19.4 14.899629
196 19.5 14.751375
197 19.6 14.604596
198 19.7 14.459278
199 19.8 14.315406
200 19.9 14.172965
201 20.0 14.031942
202 20.1 13.892322
203 20.2 13.754091
204 20.3 13.617235
205 20.4 13.481742
206 20.5 13.347596
207 20.6 13.214785
208 20.7 13.083296
209 20.8 12.953115
210 20.9 12.824229
211 21.0 12.696626
212 21.1 12.570293
213 21.2 12.445216
214 21.3 12.321384
215 21.4 12.198784
216 21.5 12.077404
217 21.6 11.957232
218 21.7 11.838256
219 21.8 11.720463
220 21.9 11.603843
221 22.0 11.488382
222 22.1 11.374071
223 22.2 11.260897
224 22.3 11.148849
225 22.4 11.037916
226 22.5 10.928087
227 22.6 10.819351
228 22.7 10.711697
229 22.8 10.605114
230 22.9 10.499591
231 23.0 10.395118
232 23.1 10.291685
233 23.2 10.189281
234 23.3 10.087896
235 23.4 9.987520
236 23.5 9.888142
237 23.6 9.789754
238 23.7 9.692344
239 23.8 9.595904
240 23.9 9.500423
241 24.0 33.405892
242 24.1 33.073498
243 24.2 32.744411
244 24.3 32.418599
245 24.4 32.096028
246 24.5 31.776667
247 24.6 31.460484
248 24.7 31.147447
249 24.8 30.837525
250 24.9 30.530686
251 25.0 30.226901
252 25.1 29.926138
253 25.2 29.628368
254 25.3 29.333561
255 25.4 29.041687
256 25.5 28.752718
257 25.6 28.466623
258 25.7 28.183376
259 25.8 27.902946
260 25.9 27.625307
261 26.0 27.350431
262 26.1 27.078290
263 26.2 26.808856
264 26.3 26.542104
265 26.4 26.278005
266 26.5 26.016535
267 26.6 25.757666
268 26.7 25.501373
269 26.8 25.247630
270 26.9 24.996412
271 27.0 24.747693
272 27.1 24.501450
273 27.2 24.257656
274 27.3 24.016289
275 27.4 23.777323
276 27.5 23.540734
277 27.6 23.306500
278 27.7 23.074596
279 27.8 22.845000
280 27.9 22.617689
281 28.0 22.392639
282 28.1 22.169829
283 28.2 21.949235
284 28.3 21.730837
285 28.4 21.514611
286 28.5 21.300537
287 28.6 21.088593
288 28.7 20.878758
289 28.8 20.671011
290 28.9 20.465331
291 29.0 20.261698
292 29.1 20.060090
293 29.2 19.860489
294 29.3 19.662874
295 29.4 19.467225
296 29.5 19.273523
297 29.6 19.081748
298 29.7 18.891882
299 29.8 18.703904
300 29.9 18.517797
301 30.0 18.333542
302 30.1 18.151120
303 30.2 17.970514
304 30.3 17.791704
305 30.4 17.614674
306 30.5 17.439405
307 30.6 17.265880
308 30.7 17.094081
309 30.8 16.923993
310 30.9 16.755596
311 31.0 16.588875
312 31.1 16.423813
313 31.2 16.260393
314 31.3 16.098600
315 31.4 15.938416
316 31.5 15.779826
317 31.6 15.622814
318 31.7 15.467365
319 31.8 15.313462
320 31.9 15.161090
321 32.0 15.010235
322 32.1 14.860880
323 32.2 14.713012
324 32.3 14.566615
325 32.4 14.421675
326 32.5 14.278177
327 32.6 14.136107
328 32.7 13.995450
329 32.8 13.856193
330 32.9 13.718322
331 33.0 13.581822
332 33.1 13.446681
333 33.2 13.312884
334 33.3 13.180419
335 33.4 13.049271
336 33.5 12.919429
337 33.6 12.790878
338 33.7 12.663607
339 33.8 12.537602
340 33.9 12.412851
341 34.0 12.289341
342 34.1 12.167060
343 34.2 12.045996
344 34.3 11.926136
345 34.4 11.807469
346 34.5 11.689983
347 34.6 11.573665
348 34.7 11.458505
349 34.8 11.344491
350 34.9 11.231612
351 35.0 11.119855
352 35.1 11.009211
353 35.2 10.899668
354 35.3 10.791214
355 35.4 10.683840
356 35.5 10.577534
357 35.6 10.472285
358 35.7 10.368085
359 35.8 10.264920
360 35.9 10.162783
361 36.0 34.061661
362 36.1 33.722742
363 36.2 33.387195
364 36.3 33.054987
365 36.4 32.726084
366 36.5 32.400454
367 36.6 32.078065
368 36.7 31.758882
369 36.8 31.442876
370 36.9 31.130014
371 37.0 30.820266
372 37.1 30.513599
373 37.2 30.209984
374 37.3 29.909389
375 37.4 29.611786
376 37.5 29.317144
377 37.6 29.025433
378 37.7 28.736625
379 37.8 28.450691
380 37.9 28.167602
381 38.0 27.887330
382 38.1 27.609846
383 38.2 27.335123
384 38.3 27.063134
385 38.4 26.793852
386 38.5 26.527248
387 38.6 26.263298
388 38.7 26.001974
389 38.8 25.743250
390 38.9 25.487100
391 39.0 25.233499
392 39.1 24.982422
393 39.2 24.733843
394 39.3 24.487737
395 39.4 24.244080
396 39.5 24.002847
397 39.6 23.764015
398 39.7 23.527559
399 39.8 23.293456
400 39.9 23.061682
401 40.0 22.832214
402 40.1 22.605030
403 40.2 22.380106
404 40.3 22.157420
405 40.4 21.936950
406 40.5 21.718674
407 40.6 21.502570
408 40.7 21.288616
409 40.8 21.076790
410 40.9 20.867073
411 41.0 20.659442
412 41.1 20.453877
413 41.2 20.250358
414 41.3 20.048863
415 41.4 19.849374
416 41.5 19.651869
417 41.6 19.456330
418 41.7 19.262736
419 41.8 19.071069
420 41.9 18.881308
421 42.0 18.693436
422 42.1 18.507433
423 42.2 18.323281
424 42.3 18.140962
425 42.4 17.960456
426 42.5 17.781746
427 42.6 17.604815
428 42.7 17.429644
429 42.8 17.256216
430 42.9 17.084514
431 43.0 16.914520
432 43.1 16.746218
433 43.2 16.579590
434 43.3 16.414621
435 43.4 16.251293
436 43.5 16.089590
437 43.6 15.929495
438 43.7 15.770994
439 43.8 15.614070
440 43.9 15.458708
441 44.0 15.304891
442 44.1 15.152605
443 44.2 15.001834
444 44.3 14.852563
445 44.4 14.704778
446 44.5 14.558463
447 44.6 14.413604
448 44.7 14.270186
449 44.8 14.128195
450 44.9 13.987617
451 45.0 13.848438
452 45.1 13.710644
453 45.2 13.574221
454 45.3 13.439155
455 45.4 13.305433
456 45.5 13.173042
457 45.6 13.041968
458 45.7 12.912198
459 45.8 12.783720
460 45.9 12.656519
461 46.0 12.530585
462 46.1 12.405904
463 46.2 12.282463
464 46.3 12.160250
465 46.4 12.039254
466 46.5 11.919461
467 46.6 11.800860
468 46.7 11.683440
469 46.8 11.567188
470 46.9 11.452092
471 47.0 11.338142
472 47.1 11.225326
473 47.2 11.113632
474 47.3 11.003049
475 47.4 10.893567
476 47.5 10.785174
477 47.6 10.677860
478 47.7 10.571614
479 47.8 10.466424
480 47.9 10.362282
481 48.0 34.259175
482 48.1 33.918291
483 48.2 33.580798
484 48.3 33.246664
485 48.4 32.915854
486 48.5 32.588336
487 48.6 32.264076
488 48.7 31.943043
489 48.8 31.625205
490 48.9 31.310529
491 49.0 30.998984
492 49.1 30.690539
493 49.2 30.385163
494 49.3 30.082825
495 49.4 29.783496
496 49.5 29.487145
497 49.6 29.193743
498 49.7 28.903261
499 49.8 28.615669
500 49.9 28.330938
501 50.0 28.049040
502 50.1 27.769948
503 50.2 27.493632
504 50.3 27.220066
505 50.4 26.949222
506 50.5 26.681072
507 50.6 26.415591
508 50.7 26.152752
509 50.8 25.892528
510 50.9 25.634893
511 51.0 25.379821
512 51.1 25.127288
513 51.2 24.877267
514 51.3 24.629734
515 51.4 24.384664
516 51.5 24.142033
517 51.6 23.901816
518 51.7 23.663988
519 51.8 23.428528
520 51.9 23.195410
521 52.0 22.964612
522 52.1 22.736110
523 52.2 22.509882
524 52.3 22.285905
525 52.4 22.064157
526 52.5 21.844615
527 52.6 21.627257
528 52.7 21.412062
529 52.8 21.199009
530 52.9 20.988075
531 53.0 20.779240
532 53.1 20.572483
533 53.2 20.367784
534 53.3 20.165121
535 53.4 19.964474
536 53.5 19.765825
537 53.6 19.569151
538 53.7 19.374435
539 53.8 19.181656
540 53.9 18.990796
541 54.0 18.801834
542 54.1 18.614753
543 54.2 18.429533
544 54.3 18.246156
545 54.4 18.064604
546 54.5 17.884858
547 54.6 17.706900
548 54.7 17.530714
549 54.8 17.356280
550 54.9 17.183582
551 55.0 17.012603
552 55.1 16.843325
553 55.2 16.675731
554 55.3 16.509805
555 55.4 16.345529
556 55.5 16.182889
557 55.6 16.021866
558 55.7 15.862446
559 55.8 15.704612
560 55.9 15.548348
561 56.0 15.393640
562 56.1 15.240470
563 56.2 15.088825
564 56.3 14.938689
565 56.4 14.790046
566 56.5 14.642883
567 56.6 14.497184
568 56.7 14.352935
569 56.8 14.210120
570 56.9 14.068727
571 57.0 13.928741
572 57.1 13.790148
573 57.2 13.652934
574 57.3 13.517085
575 57.4 13.382587
576 57.5 13.249428
577 57.6 13.117594
578 57.7 12.987072
579 57.8 12.857849
580 57.9 12.729911
581 58.0 12.603246
582 58.1 12.477842
583 58.2 12.353685
584 58.3 12.230764
585 58.4 12.109066
586 58.5 11.988579
587 58.6 11.869290
588 58.7 11.751189
589 58.8 11.634263
590 58.9 11.518500
591 59.0 11.403889
592 59.1 11.290418
593 59.2 11.178077
594 59.3 11.066853
595 59.4 10.956736
596 59.5 10.847715
597 59.6 10.739778
598 59.7 10.632915
599 59.8 10.527116
600 59.9 10.422370
601 60.0 34.318665
602 60.1 33.977189
603 60.2 33.639110
604 60.3 33.304395
605 60.4 32.973011
606 60.5 32.644924
607 60.6 32.320102
608 60.7 31.998511
609 60.8 31.680121
610 60.9 31.364898
611 61.0 31.052812
612 61.1 30.743832
613 61.2 30.437926
614 61.3 30.135063
615 61.4 29.835214
616 61.5 29.538349
617 61.6 29.244437
618 61.7 28.953450
619 61.8 28.665359
620 61.9 28.380134
621 62.0 28.097747
622 62.1 27.818169
623 62.2 27.541374
624 62.3 27.267333
625 62.4 26.996018
626 62.5 26.727403
627 62.6 26.461461
628 62.7 26.198165
629 62.8 25.937489
630 62.9 25.679407
631 63.0 25.423893
632 63.1 25.170921
633 63.2 24.920466
634 63.3 24.672503
635 63.4 24.427007
636 63.5 24.183955
637 63.6 23.943320
638 63.7 23.705080
639 63.8 23.469211
640 63.9 23.235688
641 64.0 23.004489
642 64.1 22.775591
643 64.2 22.548970
644 64.3 22.324604
645 64.4 22.102470
646 64.5 21.882547
647 64.6 21.664812
648 64.7 21.449244
649 64.8 21.235820
650 64.9 21.024520
651 65.0 20.815323
652 65.1 20.608207
653 65.2 20.403152
654 65.3 20.200137
655 65.4 19.999142
656 65.5 19.800147
657 65.6 19.603133
658 65.7 19.408078
659 65.8 19.214965
660 65.9 19.023773
661 66.0 18.834483
662 66.1 18.647077
663 66.2 18.461535
664 66.3 18.277840
665 66.4 18.095972
666 66.5 17.915914
667 66.6 17.737648
668 66.7 17.561155
669 66.8 17.386419
670 66.9 17.213421
671 67.0 17.042145
672 67.1 16.872573
673 67.2 16.704688
674 67.3 16.538473
675 67.4 16.373913
676 67.5 16.210990
677 67.6 16.049688
678 67.7 15.889991
679 67.8 15.731882
680 67.9 15.575348
681 68.0 15.420370
682 68.1 15.266935
683 68.2 15.115027
684 68.3 14.964630
685 68.4 14.815729
686 68.5 14.668310
687 68.6 14.522358
688 68.7 14.377858
689 68.8 14.234796
690 68.9 14.093157
691 69.0 13.952928
692 69.1 13.814094
693 69.2 13.676642
694 69.3 13.540557
695 69.4 13.405826
696 69.5 13.272436
697 69.6 13.140373
698 69.7 13.009624
699 69.8 12.880176
700 69.9 12.752016
701 70.0 12.625131
702 70.1 12.499509
703 70.2 12.375137
704 70.3 12.252002
705 70.4 12.130093
706 70.5 12.009396
707 70.6 11.889901
708 70.7 11.771594
709 70.8 11.654465
710 70.9 11.538501
711 71.0 11.423691
712 71.1 11.310024
713 71.2 11.197487
714 71.3 11.086070
715 71.4 10.975762
716 71.5 10.866551
717 71.6 10.758427
718 71.7 10.651379
719 71.8 10.545396
720 71.9 10.440468
721 72.0 10.336583
Code
pk_curve(t = seq(0, 72, by = 0.1), model = "1cmt_oral", ii = 12, addl = 5,
params = list(CL = 2.5, V = 25, ka = 1))
Output
t cp
1 0.0 0.000000
2 0.1 2.272331
3 0.2 4.305811
4 0.3 6.123395
5 0.4 7.745850
6 0.5 9.191967
7 0.6 10.478744
8 0.7 11.621560
9 0.8 12.634330
10 0.9 13.529641
11 1.0 14.318879
12 1.1 15.012348
13 1.2 15.619366
14 1.3 16.148364
15 1.4 16.606967
16 1.5 17.002075
17 1.6 17.339927
18 1.7 17.626168
19 1.8 17.865902
20 1.9 18.063747
21 2.0 18.223879
22 2.1 18.350075
23 2.2 18.445750
24 2.3 18.513994
25 2.4 18.557598
26 2.5 18.579088
27 2.6 18.580747
28 2.7 18.564640
29 2.8 18.532631
30 2.9 18.486409
31 3.0 18.427497
32 3.1 18.357273
33 3.2 18.276982
34 3.3 18.187748
35 3.4 18.090588
36 3.5 17.986419
37 3.6 17.876069
38 3.7 17.760288
39 3.8 17.639750
40 3.9 17.515066
41 4.0 17.386784
42 4.1 17.255402
43 4.2 17.121366
44 4.3 16.985081
45 4.4 16.846909
46 4.5 16.707177
47 4.6 16.566182
48 4.7 16.424186
49 4.8 16.281431
50 4.9 16.138128
51 5.0 15.994472
52 5.1 15.850636
53 5.2 15.706773
54 5.3 15.563023
55 5.4 15.419511
56 5.5 15.276348
57 5.6 15.133632
58 5.7 14.991453
59 5.8 14.849888
60 5.9 14.709009
61 6.0 14.568877
62 6.1 14.429547
63 6.2 14.291067
64 6.3 14.153480
65 6.4 14.016823
66 6.5 13.881129
67 6.6 13.746426
68 6.7 13.612738
69 6.8 13.480086
70 6.9 13.348488
71 7.0 13.217958
72 7.1 13.088509
73 7.2 12.960151
74 7.3 12.832892
75 7.4 12.706738
76 7.5 12.581692
77 7.6 12.457759
78 7.7 12.334940
79 7.8 12.213234
80 7.9 12.092641
81 8.0 11.973160
82 8.1 11.854787
83 8.2 11.737520
84 8.3 11.621354
85 8.4 11.506284
86 8.5 11.392306
87 8.6 11.279413
88 8.7 11.167599
89 8.8 11.056858
90 8.9 10.947183
91 9.0 10.838567
92 9.1 10.731002
93 9.2 10.624480
94 9.3 10.518994
95 9.4 10.414536
96 9.5 10.311098
97 9.6 10.208671
98 9.7 10.107247
99 9.8 10.006817
100 9.9 9.907374
101 10.0 9.808908
102 10.1 9.711411
103 10.2 9.614874
104 10.3 9.519289
105 10.4 9.424647
106 10.5 9.330939
107 10.6 9.238157
108 10.7 9.146293
109 10.8 9.055337
110 10.9 8.965281
111 11.0 8.876117
112 11.1 8.787836
113 11.2 8.700430
114 11.3 8.613890
115 11.4 8.528209
116 11.5 8.443377
117 11.6 8.359387
118 11.7 8.276231
119 11.8 8.193900
120 11.9 8.112386
121 12.0 8.031682
122 12.1 10.224110
123 12.2 12.178482
124 12.3 13.917742
125 12.4 15.462653
126 12.5 16.831996
127 12.6 18.042761
128 12.7 19.110322
129 12.8 20.048585
130 12.9 20.870128
131 13.0 21.586334
132 13.1 22.207495
133 13.2 22.742925
134 13.3 23.201046
135 13.4 23.589478
136 13.5 23.915112
137 13.6 24.184182
138 13.7 24.402323
139 13.8 24.574636
140 13.9 24.705731
141 14.0 24.799776
142 14.1 24.860543
143 14.2 24.891439
144 14.3 24.895548
145 14.4 24.875656
146 14.5 24.834282
147 14.6 24.773702
148 14.7 24.695975
149 14.8 24.602960
150 14.9 24.496338
151 15.0 24.377627
152 15.1 24.248199
153 15.2 24.109293
154 15.3 23.962027
155 15.4 23.807412
156 15.5 23.646360
157 15.6 23.479694
158 15.7 23.308156
159 15.8 23.132416
160 15.9 22.953079
161 16.0 22.770688
162 16.1 22.585736
163 16.2 22.398663
164 16.3 22.209867
165 16.4 22.019708
166 16.5 21.828507
167 16.6 21.636553
168 16.7 21.444107
169 16.8 21.251402
170 16.9 21.058648
171 17.0 20.866032
172 17.1 20.673722
173 17.2 20.481869
174 17.3 20.290607
175 17.4 20.100055
176 17.5 19.910319
177 17.6 19.721494
178 17.7 19.533665
179 17.8 19.346905
180 17.9 19.161280
181 18.0 18.976847
182 18.1 18.793657
183 18.2 18.611753
184 18.3 18.431175
185 18.4 18.251954
186 18.5 18.074120
187 18.6 17.897696
188 18.7 17.722702
189 18.8 17.549155
190 18.9 17.377069
191 19.0 17.206454
192 19.1 17.037319
193 19.2 16.869670
194 19.3 16.703511
195 19.4 16.538843
196 19.5 16.375668
197 19.6 16.213984
198 19.7 16.053789
199 19.8 15.895080
200 19.9 15.737853
201 20.0 15.582101
202 20.1 15.427819
203 20.2 15.274999
204 20.3 15.123634
205 20.4 14.973716
206 20.5 14.825236
207 20.6 14.678185
208 20.7 14.532553
209 20.8 14.388330
210 20.9 14.245507
211 21.0 14.104071
212 21.1 13.964014
213 21.2 13.825323
214 21.3 13.687989
215 21.4 13.551999
216 21.5 13.417342
217 21.6 13.284007
218 21.7 13.151983
219 21.8 13.021258
220 21.9 12.891820
221 22.0 12.763659
222 22.1 12.636761
223 22.2 12.511117
224 22.3 12.386714
225 22.4 12.263540
226 22.5 12.141585
227 22.6 12.020837
228 22.7 11.901284
229 22.8 11.782916
230 22.9 11.665720
231 23.0 11.549686
232 23.1 11.434803
233 23.2 11.321059
234 23.3 11.208443
235 23.4 11.096946
236 23.5 10.986555
237 23.6 10.877260
238 23.7 10.769050
239 23.8 10.661915
240 23.9 10.555844
241 24.0 10.450827
242 24.1 12.619185
243 24.2 14.549725
244 24.3 16.265391
245 24.4 17.786943
246 24.5 19.133158
247 24.6 20.321027
248 24.7 21.365919
249 24.8 22.281737
250 24.9 23.081061
251 25.0 23.775267
252 25.1 24.374648
253 25.2 24.888514
254 25.3 25.325287
255 25.4 25.692582
256 25.5 25.997290
257 25.6 26.245641
258 25.7 26.443271
259 25.8 26.595276
260 25.9 26.706265
261 26.0 26.780405
262 26.1 26.821464
263 26.2 26.832849
264 26.3 26.817641
265 26.4 26.778623
266 26.5 26.718314
267 26.6 26.638988
268 26.7 26.542701
269 26.8 26.431311
270 26.9 26.306496
271 27.0 26.169774
272 27.1 26.022514
273 27.2 25.865953
274 27.3 25.701208
275 27.4 25.529288
276 27.5 25.351103
277 27.6 25.167474
278 27.7 24.979142
279 27.8 24.786776
280 27.9 24.590978
281 28.0 24.392290
282 28.1 24.191202
283 28.2 23.988154
284 28.3 23.783543
285 28.4 23.577726
286 28.5 23.371022
287 28.6 23.163720
288 28.7 22.956078
289 28.8 22.748329
290 28.9 22.540680
291 29.0 22.333318
292 29.1 22.126408
293 29.2 21.920101
294 29.3 21.714528
295 29.4 21.509807
296 29.5 21.306044
297 29.6 21.103332
298 29.7 20.901753
299 29.8 20.701381
300 29.9 20.502278
301 30.0 20.304502
302 30.1 20.108101
303 30.2 19.913119
304 30.3 19.719592
305 30.4 19.527551
306 30.5 19.337025
307 30.6 19.148034
308 30.7 18.960599
309 30.8 18.774735
310 30.9 18.590454
311 31.0 18.407766
312 31.1 18.226678
313 31.2 18.047195
314 31.3 17.869318
315 31.4 17.693051
316 31.5 17.518391
317 31.6 17.345337
318 31.7 17.173885
319 31.8 17.004031
320 31.9 16.835769
321 32.0 16.669093
322 32.1 16.503995
323 32.2 16.340467
324 32.3 16.178501
325 32.4 16.018087
326 32.5 15.859215
327 32.6 15.701876
328 32.7 15.546058
329 32.8 15.391751
330 32.9 15.238943
331 33.0 15.087623
332 33.1 14.937779
333 33.2 14.789399
334 33.3 14.642472
335 33.4 14.496984
336 33.5 14.352925
337 33.6 14.210281
338 33.7 14.069040
339 33.8 13.929190
340 33.9 13.790718
341 34.0 13.653613
342 34.1 13.517860
343 34.2 13.383448
344 34.3 13.250365
345 34.4 13.118598
346 34.5 12.988135
347 34.6 12.858964
348 34.7 12.731072
349 34.8 12.604447
350 34.9 12.479077
351 35.0 12.354950
352 35.1 12.232054
353 35.2 12.110377
354 35.3 11.989908
355 35.4 11.870634
356 35.5 11.752545
357 35.6 11.635628
358 35.7 11.519873
359 35.8 11.405267
360 35.9 11.291800
361 36.0 11.179460
362 36.1 13.340567
363 36.2 15.263929
364 36.3 16.972489
365 36.4 18.487005
366 36.5 19.826255
367 36.6 21.007227
368 36.7 22.045291
369 36.8 22.954350
370 36.9 23.746981
371 37.0 24.434561
372 37.1 25.027382
373 37.2 25.534753
374 37.3 25.965095
375 37.4 26.326025
376 37.5 26.624430
377 37.6 26.866541
378 37.7 27.057993
379 37.8 27.203881
380 37.9 27.308814
381 38.0 27.376959
382 38.1 27.412082
383 38.2 27.417590
384 38.3 27.396564
385 38.4 27.351786
386 38.5 27.285774
387 38.6 27.200801
388 38.7 27.098924
389 38.8 26.981999
390 38.9 26.851705
391 39.0 26.709558
392 39.1 26.556927
393 39.2 26.395049
394 39.3 26.225039
395 39.4 26.047907
396 39.5 25.864562
397 39.6 25.675824
398 39.7 25.482434
399 39.8 25.285060
400 39.9 25.084303
401 40.0 24.880707
402 40.1 24.674759
403 40.2 24.466900
404 40.3 24.257526
405 40.4 24.046992
406 40.5 23.835618
407 40.6 23.623694
408 40.7 23.411475
409 40.8 23.199195
410 40.9 22.987060
411 41.0 22.775256
412 41.1 22.563949
413 41.2 22.353288
414 41.3 22.143405
415 41.4 21.934417
416 41.5 21.726429
417 41.6 21.519534
418 41.7 21.313814
419 41.8 21.109341
420 41.9 20.906179
421 42.0 20.704384
422 42.1 20.504005
423 42.2 20.305083
424 42.3 20.107656
425 42.4 19.911754
426 42.5 19.717404
427 42.6 19.524629
428 42.7 19.333447
429 42.8 19.143873
430 42.9 18.955919
431 43.0 18.769595
432 43.1 18.584906
433 43.2 18.401858
434 43.3 18.220453
435 43.4 18.040692
436 43.5 17.862573
437 43.6 17.686094
438 43.7 17.511252
439 43.8 17.338041
440 43.9 17.166455
441 44.0 16.996489
442 44.1 16.828133
443 44.2 16.661380
444 44.3 16.496221
445 44.4 16.332645
446 44.5 16.170644
447 44.6 16.010206
448 44.7 15.851320
449 44.8 15.693975
450 44.9 15.538160
451 45.0 15.383862
452 45.1 15.231071
453 45.2 15.079773
454 45.3 14.929956
455 45.4 14.781608
456 45.5 14.634717
457 45.6 14.489269
458 45.7 14.345252
459 45.8 14.202654
460 45.9 14.061461
461 46.0 13.921661
462 46.1 13.783242
463 46.2 13.646190
464 46.3 13.510492
465 46.4 13.376137
466 46.5 13.243111
467 46.6 13.111403
468 46.7 12.980999
469 46.8 12.851887
470 46.9 12.724055
471 47.0 12.597490
472 47.1 12.472181
473 47.2 12.348115
474 47.3 12.225280
475 47.4 12.103665
476 47.5 11.983257
477 47.6 11.864045
478 47.7 11.746016
479 47.8 11.629160
480 47.9 11.513465
481 48.0 11.398920
482 48.1 13.557844
483 48.2 15.479044
484 48.3 17.185463
485 48.4 18.697860
486 48.5 20.035011
487 48.6 21.213907
488 48.7 22.249914
489 48.8 23.156937
490 48.9 23.947552
491 49.0 24.633136
492 49.1 25.223982
493 49.2 25.729397
494 49.3 26.157802
495 49.4 26.516814
496 49.5 26.813321
497 49.6 27.053552
498 49.7 27.243144
499 49.8 27.387190
500 49.9 27.490299
501 50.0 27.556637
502 50.1 27.589973
503 50.2 27.593711
504 50.3 27.570932
505 50.4 27.524419
506 50.5 27.456689
507 50.6 27.370016
508 50.7 27.266455
509 50.8 27.147864
510 50.9 27.015919
511 51.0 26.872138
512 51.1 26.717889
513 51.2 26.554409
514 51.3 26.382814
515 51.4 26.204112
516 51.5 26.019212
517 51.6 25.828936
518 51.7 25.634022
519 51.8 25.435140
520 51.9 25.232890
521 52.0 25.027815
522 52.1 24.820404
523 52.2 24.611096
524 52.3 24.400286
525 52.4 24.188332
526 52.5 23.975552
527 52.6 23.762235
528 52.7 23.548638
529 52.8 23.334993
530 52.9 23.121507
531 53.0 22.908365
532 53.1 22.695734
533 53.2 22.483761
534 53.3 22.272580
535 53.4 22.062307
536 53.5 21.853046
537 53.6 21.644891
538 53.7 21.437924
539 53.8 21.232216
540 53.9 21.027832
541 54.0 20.824826
542 54.1 20.623248
543 54.2 20.423140
544 54.3 20.224538
545 54.4 20.027473
546 54.5 19.831972
547 54.6 19.638057
548 54.7 19.445746
549 54.8 19.255055
550 54.9 19.065995
551 55.0 18.878575
552 55.1 18.692802
553 55.2 18.508681
554 55.3 18.326213
555 55.4 18.145399
556 55.5 17.966238
557 55.6 17.788728
558 55.7 17.612864
559 55.8 17.438642
560 55.9 17.266056
561 56.0 17.095098
562 56.1 16.925762
563 56.2 16.758037
564 56.3 16.591916
565 56.4 16.427388
566 56.5 16.264444
567 56.6 16.103073
568 56.7 15.943263
569 56.8 15.785003
570 56.9 15.628282
571 57.0 15.473088
572 57.1 15.319409
573 57.2 15.167232
574 57.3 15.016545
575 57.4 14.867336
576 57.5 14.719591
577 57.6 14.573299
578 57.7 14.428446
579 57.8 14.285020
580 57.9 14.143008
581 58.0 14.002396
582 58.1 13.863173
583 58.2 13.725326
584 58.3 13.588841
585 58.4 13.453706
586 58.5 13.319909
587 58.6 13.187436
588 58.7 13.056275
589 58.8 12.926414
590 58.9 12.797841
591 59.0 12.670542
592 59.1 12.544506
593 59.2 12.419721
594 59.3 12.296173
595 59.4 12.173852
596 59.5 12.052746
597 59.6 11.932842
598 59.7 11.814129
599 59.8 11.696596
600 59.9 11.580230
601 60.0 11.465020
602 60.1 13.623286
603 60.2 15.543835
604 60.3 17.249610
605 60.4 18.761368
606 60.5 20.097888
607 60.6 21.276157
608 60.7 22.311545
609 60.8 23.217955
610 60.9 24.007963
611 61.0 24.692946
612 61.1 25.283196
613 61.2 25.788022
614 61.3 26.215844
615 61.4 26.574279
616 61.5 26.870214
617 61.6 27.109879
618 61.7 27.298910
619 61.8 27.442401
620 61.9 27.544961
621 62.0 27.610755
622 62.1 27.643552
623 62.2 27.646758
624 62.3 27.623451
625 62.4 27.576416
626 62.5 27.508168
627 62.6 27.420983
628 62.7 27.316915
629 62.8 27.197821
630 62.9 27.065379
631 63.0 26.921106
632 63.1 26.766370
633 63.2 26.602408
634 63.3 26.430335
635 63.4 26.251160
636 63.5 26.065792
637 63.6 25.875052
638 63.7 25.679680
639 63.8 25.480343
640 63.9 25.277644
641 64.0 25.072124
642 64.1 24.864271
643 64.2 24.654526
644 64.3 24.443285
645 64.4 24.230903
646 64.5 24.017700
647 64.6 23.803963
648 64.7 23.589951
649 64.8 23.375894
650 64.9 23.162001
651 65.0 22.948457
652 65.1 22.735427
653 65.2 22.523059
654 65.3 22.311487
655 65.4 22.100826
656 65.5 21.891183
657 65.6 21.682648
658 65.7 21.475305
659 65.8 21.269225
660 65.9 21.064473
661 66.0 20.861103
662 66.1 20.659164
663 66.2 20.458698
664 66.3 20.259742
665 66.4 20.062327
666 66.5 19.866479
667 66.6 19.672221
668 66.7 19.479570
669 66.8 19.288542
670 66.9 19.099149
671 67.0 18.911399
672 67.1 18.725300
673 67.2 18.540855
674 67.3 18.358067
675 67.4 18.176936
676 67.5 17.997462
677 67.6 17.819641
678 67.7 17.643470
679 67.8 17.468943
680 67.9 17.296055
681 68.0 17.124799
682 68.1 16.955167
683 68.2 16.787150
684 68.3 16.620739
685 68.4 16.455925
686 68.5 16.292696
687 68.6 16.131044
688 68.7 15.970955
689 68.8 15.812420
690 68.9 15.655427
691 69.0 15.499962
692 69.1 15.346016
693 69.2 15.193574
694 69.3 15.042625
695 69.4 14.893156
696 69.5 14.745155
697 69.6 14.598608
698 69.7 14.453503
699 69.8 14.309828
700 69.9 14.167569
701 70.0 14.026713
702 70.1 13.887248
703 70.2 13.749161
704 70.3 13.612439
705 70.4 13.477069
706 70.5 13.343040
707 70.6 13.210337
708 70.7 13.078948
709 70.8 12.948862
710 70.9 12.820065
711 71.0 12.692545
712 71.1 12.566290
713 71.2 12.441288
714 71.3 12.317526
715 71.4 12.194993
716 71.5 12.073676
717 71.6 11.953564
718 71.7 11.834645
719 71.8 11.716907
720 71.9 11.600339
721 72.0 11.484929
Code
pk_curve(t = seq(0, 72, by = 0.1), model = "1cmt_infusion", ii = 12, addl = 5,
params = list(CL = 2.5, V = 25, tinf = 3))
Output
t cp
1 0.0 0.0000000
2 0.1 0.7960133
3 0.2 1.5841061
4 0.3 2.3643573
5 0.4 3.1368449
6 0.5 3.9016460
7 0.6 4.6588373
8 0.7 5.4084944
9 0.8 6.1506923
10 0.9 6.8855052
11 1.0 7.6130066
12 1.1 8.3332692
13 1.2 9.0463651
14 1.3 9.7523655
15 1.4 10.4513412
16 1.5 11.1433619
17 1.6 11.8284969
18 1.7 12.5068147
19 1.8 13.1783831
20 1.9 13.8432693
21 2.0 14.5015398
22 2.1 15.1532603
23 2.2 15.7984962
24 2.3 16.4373118
25 2.4 17.0697711
26 2.5 17.6959374
27 2.6 18.3158731
28 2.7 18.9296405
29 2.8 19.5373007
30 2.9 20.1389146
31 3.0 20.7345423
32 3.1 20.5282302
33 3.2 20.3239709
34 3.3 20.1217440
35 3.4 19.9215293
36 3.5 19.7233068
37 3.6 19.5270566
38 3.7 19.3327591
39 3.8 19.1403950
40 3.9 18.9499449
41 4.0 18.7613898
42 4.1 18.5747108
43 4.2 18.3898894
44 4.3 18.2069069
45 4.4 18.0257451
46 4.5 17.8463860
47 4.6 17.6688115
48 4.7 17.4930039
49 4.8 17.3189456
50 4.9 17.1466192
51 5.0 16.9760075
52 5.1 16.8070934
53 5.2 16.6398600
54 5.3 16.4742906
55 5.4 16.3103687
56 5.5 16.1480778
57 5.6 15.9874018
58 5.7 15.8283245
59 5.8 15.6708300
60 5.9 15.5149026
61 6.0 15.3605268
62 6.1 15.2076870
63 6.2 15.0563680
64 6.3 14.9065546
65 6.4 14.7582319
66 6.5 14.6113850
67 6.6 14.4659993
68 6.7 14.3220602
69 6.8 14.1795533
70 6.9 14.0384644
71 7.0 13.8987794
72 7.1 13.7604842
73 7.2 13.6235651
74 7.3 13.4880084
75 7.4 13.3538004
76 7.5 13.2209279
77 7.6 13.0893775
78 7.7 12.9591360
79 7.8 12.8301904
80 7.9 12.7025279
81 8.0 12.5761356
82 8.1 12.4510010
83 8.2 12.3271115
84 8.3 12.2044547
85 8.4 12.0830183
86 8.5 11.9627903
87 8.6 11.8437585
88 8.7 11.7259112
89 8.8 11.6092364
90 8.9 11.4937226
91 9.0 11.3793581
92 9.1 11.2661316
93 9.2 11.1540317
94 9.3 11.0430473
95 9.4 10.9331671
96 9.5 10.8243803
97 9.6 10.7166759
98 9.7 10.6100432
99 9.8 10.5044715
100 9.9 10.3999502
101 10.0 10.2964690
102 10.1 10.1940174
103 10.2 10.0925853
104 10.3 9.9921624
105 10.4 9.8927387
106 10.5 9.7943043
107 10.6 9.6968493
108 10.7 9.6003641
109 10.8 9.5048389
110 10.9 9.4102641
111 11.0 9.3166304
112 11.1 9.2239284
113 11.2 9.1321488
114 11.3 9.0412824
115 11.4 8.9513201
116 11.5 8.8622530
117 11.6 8.7740721
118 11.7 8.6867686
119 11.8 8.6003338
120 11.9 8.5147591
121 12.0 8.4300358
122 12.1 9.1421689
123 12.2 9.8472161
124 12.3 10.5452479
125 12.4 11.2363343
126 12.5 11.9205442
127 12.6 12.5979461
128 12.7 13.2686077
129 12.8 13.9325962
130 12.9 14.5899778
131 13.0 15.2408184
132 13.1 15.8851830
133 13.2 16.5231361
134 13.3 17.1547415
135 13.4 17.7800622
136 13.5 18.3991610
137 13.6 19.0120996
138 13.7 19.6189393
139 13.8 20.2197409
140 13.9 20.8145644
141 14.0 21.4034693
142 14.1 21.9865146
143 14.2 22.5637584
144 14.3 23.1352585
145 14.4 23.7010722
146 14.5 24.2612559
147 14.6 24.8158656
148 14.7 25.3649569
149 14.8 25.9085847
150 14.9 26.4468033
151 15.0 26.9796665
152 15.1 26.7112143
153 15.2 26.4454333
154 15.3 26.1822968
155 15.4 25.9217786
156 15.5 25.6638526
157 15.6 25.4084930
158 15.7 25.1556743
159 15.8 24.9053712
160 15.9 24.6575586
161 16.0 24.4122118
162 16.1 24.1693062
163 16.2 23.9288176
164 16.3 23.6907219
165 16.4 23.4549952
166 16.5 23.2216141
167 16.6 22.9905552
168 16.7 22.7617954
169 16.8 22.5353117
170 16.9 22.3110816
171 17.0 22.0890827
172 17.1 21.8692926
173 17.2 21.6516895
174 17.3 21.4362516
175 17.4 21.2229573
176 17.5 21.0117854
177 17.6 20.8027146
178 17.7 20.5957242
179 17.8 20.3907933
180 17.9 20.1879015
181 18.0 19.9870285
182 18.1 19.7881543
183 18.2 19.5912588
184 18.3 19.3963226
185 18.4 19.2033259
186 18.5 19.0122496
187 18.6 18.8230746
188 18.7 18.6357819
189 18.8 18.4503527
190 18.9 18.2667687
191 19.0 18.0850113
192 19.1 17.9050624
193 19.2 17.7269041
194 19.3 17.5505184
195 19.4 17.3758878
196 19.5 17.2029949
197 19.6 17.0318222
198 19.7 16.8623528
199 19.8 16.6945695
200 19.9 16.5284558
201 20.0 16.3639949
202 20.1 16.2011704
203 20.2 16.0399661
204 20.3 15.8803658
205 20.4 15.7223535
206 20.5 15.5659135
207 20.6 15.4110300
208 20.7 15.2576877
209 20.8 15.1058712
210 20.9 14.9555653
211 21.0 14.8067549
212 21.1 14.6594252
213 21.2 14.5135615
214 21.3 14.3691492
215 21.4 14.2261737
216 21.5 14.0846209
217 21.6 13.9444766
218 21.7 13.8057268
219 21.8 13.6683575
220 21.9 13.5323551
221 22.0 13.3977059
222 22.1 13.2643965
223 22.2 13.1324135
224 22.3 13.0017438
225 22.4 12.8723743
226 22.5 12.7442921
227 22.6 12.6174842
228 22.7 12.4919382
229 22.8 12.3676413
230 22.9 12.2445812
231 23.0 12.1227456
232 23.1 12.0021223
233 23.2 11.8826991
234 23.3 11.7644643
235 23.4 11.6474059
236 23.5 11.5315123
237 23.6 11.4167719
238 23.7 11.3031731
239 23.8 11.1907046
240 23.9 11.0793553
241 24.0 10.9691138
242 24.1 11.6559826
243 24.2 12.3360170
244 24.3 13.0092848
245 24.4 13.6758536
246 24.5 14.3357899
247 24.6 14.9891597
248 24.7 15.6360283
249 24.8 16.2764606
250 24.9 16.9105204
251 25.0 17.5382712
252 25.1 18.1597758
253 25.2 18.7750963
254 25.3 19.3842943
255 25.4 19.9874306
256 25.5 20.5845656
257 25.6 21.1757591
258 25.7 21.7610701
259 25.8 22.3405571
260 25.9 22.9142782
261 26.0 23.4822906
262 26.1 24.0446512
263 26.2 24.6014162
264 26.3 25.1526413
265 26.4 25.6983817
266 26.5 26.2386918
267 26.6 26.7736257
268 26.7 27.3032370
269 26.8 27.8275786
270 26.9 28.3467028
271 27.0 28.8606617
272 27.1 28.5734933
273 27.2 28.2891823
274 27.3 28.0077003
275 27.4 27.7290190
276 27.5 27.4531106
277 27.6 27.1799476
278 27.7 26.9095026
279 27.8 26.6417486
280 27.9 26.3766588
281 28.0 26.1142066
282 28.1 25.8543659
283 28.2 25.5971107
284 28.3 25.3424152
285 28.4 25.0902540
286 28.5 24.8406018
287 28.6 24.5934336
288 28.7 24.3487249
289 28.8 24.1064510
290 28.9 23.8665878
291 29.0 23.6291113
292 29.1 23.3939977
293 29.2 23.1612236
294 29.3 22.9307655
295 29.4 22.7026006
296 29.5 22.4767060
297 29.6 22.2530590
298 29.7 22.0316374
299 29.8 21.8124189
300 29.9 21.5953817
301 30.0 21.3805041
302 30.1 21.1677645
303 30.2 20.9571417
304 30.3 20.7486147
305 30.4 20.5421625
306 30.5 20.3377646
307 30.6 20.1354004
308 30.7 19.9350499
309 30.8 19.7366928
310 30.9 19.5403094
311 31.0 19.3458801
312 31.1 19.1533854
313 31.2 18.9628060
314 31.3 18.7741229
315 31.4 18.5873173
316 31.5 18.4023704
317 31.6 18.2192637
318 31.7 18.0379790
319 31.8 17.8584982
320 31.9 17.6808031
321 32.0 17.5048762
322 32.1 17.3306998
323 32.2 17.1582564
324 32.3 16.9875289
325 32.4 16.8185002
326 32.5 16.6511533
327 32.6 16.4854716
328 32.7 16.3214384
329 32.8 16.1590374
330 32.9 15.9982523
331 33.0 15.8390670
332 33.1 15.6814656
333 33.2 15.5254324
334 33.3 15.3709518
335 33.4 15.2180083
336 33.5 15.0665866
337 33.6 14.9166715
338 33.7 14.7682482
339 33.8 14.6213016
340 33.9 14.4758173
341 34.0 14.3317805
342 34.1 14.1891769
343 34.2 14.0479922
344 34.3 13.9082123
345 34.4 13.7698233
346 34.5 13.6328113
347 34.6 13.4971626
348 34.7 13.3628635
349 34.8 13.2299008
350 34.9 13.0982611
351 35.0 12.9679312
352 35.1 12.8388982
353 35.2 12.7111490
354 35.3 12.5846710
355 35.4 12.4594514
356 35.5 12.3354778
357 35.6 12.2127377
358 35.7 12.0912189
359 35.8 11.9709093
360 35.9 11.8517968
361 36.0 11.7338694
362 36.1 12.4131288
363 36.2 13.0856294
364 36.3 13.7514385
365 36.4 14.4106227
366 36.5 15.0632479
367 36.6 15.7093794
368 36.7 16.3490817
369 36.8 16.9824190
370 36.9 17.6094544
371 37.0 18.2302507
372 37.1 18.8448699
373 37.2 19.4533737
374 37.3 20.0558227
375 37.4 20.6522772
376 37.5 21.2427969
377 37.6 21.8274408
378 37.7 22.4062675
379 37.8 22.9793347
380 37.9 23.5466998
381 38.0 24.1084195
382 38.1 24.6645500
383 38.2 25.2151469
384 38.3 25.7602653
385 38.4 26.2999597
386 38.5 26.8342840
387 38.6 27.3632918
388 38.7 27.8870358
389 38.8 28.4055684
390 38.9 28.9189416
391 39.0 29.4272066
392 39.1 29.1344010
393 39.2 28.8445089
394 39.3 28.5575012
395 39.4 28.2733493
396 39.5 27.9920248
397 39.6 27.7134995
398 39.7 27.4377456
399 39.8 27.1647355
400 39.9 26.8944418
401 40.0 26.6268376
402 40.1 26.3618962
403 40.2 26.0995909
404 40.3 25.8398957
405 40.4 25.5827844
406 40.5 25.3282315
407 40.6 25.0762113
408 40.7 24.8266989
409 40.8 24.5796691
410 40.9 24.3350973
411 41.0 24.0929590
412 41.1 23.8532301
413 41.2 23.6158865
414 41.3 23.3809045
415 41.4 23.1482606
416 41.5 22.9179316
417 41.6 22.6898943
418 41.7 22.4641261
419 41.8 22.2406043
420 41.9 22.0193066
421 42.0 21.8002108
422 42.1 21.5832951
423 42.2 21.3685377
424 42.3 21.1559172
425 42.4 20.9454123
426 42.5 20.7370020
427 42.6 20.5306654
428 42.7 20.3263819
429 42.8 20.1241310
430 42.9 19.9238925
431 43.0 19.7256465
432 43.1 19.5293730
433 43.2 19.3350525
434 43.3 19.1426655
435 43.4 18.9521928
436 43.5 18.7636154
437 43.6 18.5769143
438 43.7 18.3920709
439 43.8 18.2090667
440 43.9 18.0278835
441 44.0 17.8485030
442 44.1 17.6709075
443 44.2 17.4950790
444 44.3 17.3210001
445 44.4 17.1486532
446 44.5 16.9780213
447 44.6 16.8090871
448 44.7 16.6418339
449 44.8 16.4762449
450 44.9 16.3123035
451 45.0 16.1499934
452 45.1 15.9892983
453 45.2 15.8302021
454 45.3 15.6726890
455 45.4 15.5167431
456 45.5 15.3623489
457 45.6 15.2094910
458 45.7 15.0581540
459 45.8 14.9083229
460 45.9 14.7599826
461 46.0 14.6131183
462 46.1 14.4677154
463 46.2 14.3237592
464 46.3 14.1812354
465 46.4 14.0401298
466 46.5 13.9004281
467 46.6 13.7621166
468 46.7 13.6251812
469 46.8 13.4896084
470 46.9 13.3553846
471 47.0 13.2224963
472 47.1 13.0909302
473 47.2 12.9606733
474 47.3 12.8317124
475 47.4 12.7040348
476 47.5 12.5776275
477 47.6 12.4524780
478 47.7 12.3285738
479 47.8 12.2059024
480 47.9 12.0844517
481 48.0 11.9642094
482 48.1 12.6411768
483 48.2 13.3114083
484 48.3 13.9749709
485 48.4 14.6319309
486 48.5 15.2823540
487 48.6 15.9263054
488 48.7 16.5638493
489 48.8 17.1950495
490 48.9 17.8199692
491 49.0 18.4386709
492 49.1 19.0512163
493 49.2 19.6576669
494 49.3 20.2580831
495 49.4 20.8525251
496 49.5 21.4410523
497 49.6 22.0237236
498 49.7 22.6005972
499 49.8 23.1717308
500 49.9 23.7371815
501 50.0 24.2970059
502 50.1 24.8512600
503 50.2 25.3999991
504 50.3 25.9432782
505 50.4 26.4811515
506 50.5 27.0136730
507 50.6 27.5408958
508 50.7 28.0628726
509 50.8 28.5796556
510 50.9 29.0912966
511 51.0 29.5978466
512 51.1 29.3033432
513 51.2 29.0117700
514 51.3 28.7230981
515 51.4 28.4372985
516 51.5 28.1543426
517 51.6 27.8742022
518 51.7 27.5968493
519 51.8 27.3222561
520 51.9 27.0503951
521 52.0 26.7812391
522 52.1 26.5147614
523 52.2 26.2509351
524 52.3 25.9897339
525 52.4 25.7311317
526 52.5 25.4751027
527 52.6 25.2216212
528 52.7 24.9706619
529 52.8 24.7221996
530 52.9 24.4762096
531 53.0 24.2326673
532 53.1 23.9915482
533 53.2 23.7528283
534 53.3 23.5164837
535 53.4 23.2824908
536 53.5 23.0508261
537 53.6 22.8214666
538 53.7 22.5943892
539 53.8 22.3695713
540 53.9 22.1469903
541 54.0 21.9266241
542 54.1 21.7084505
543 54.2 21.4924478
544 54.3 21.2785944
545 54.4 21.0668689
546 54.5 20.8572500
547 54.6 20.6497169
548 54.7 20.4442488
549 54.8 20.2408251
550 54.9 20.0394255
551 55.0 19.8400299
552 55.1 19.6426183
553 55.2 19.4471710
554 55.3 19.2536684
555 55.4 19.0620912
556 55.5 18.8724203
557 55.6 18.6846365
558 55.7 18.4987213
559 55.8 18.3146559
560 55.9 18.1324221
561 56.0 17.9520015
562 56.1 17.7733761
563 56.2 17.5965280
564 56.3 17.4214396
565 56.4 17.2480934
566 56.5 17.0764720
567 56.6 16.9065583
568 56.7 16.7383352
569 56.8 16.5717860
570 56.9 16.4068940
571 57.0 16.2436426
572 57.1 16.0820157
573 57.2 15.9219970
574 57.3 15.7635705
575 57.4 15.6067203
576 57.5 15.4514308
577 57.6 15.2976865
578 57.7 15.1454720
579 57.8 14.9947720
580 57.9 14.8455716
581 58.0 14.6978557
582 58.1 14.5516096
583 58.2 14.4068186
584 58.3 14.2634684
585 58.4 14.1215445
586 58.5 13.9810328
587 58.6 13.8419192
588 58.7 13.7041898
589 58.8 13.5678308
590 58.9 13.4328287
591 59.0 13.2991698
592 59.1 13.1668408
593 59.2 13.0358286
594 59.3 12.9061199
595 59.4 12.7777019
596 59.5 12.6505616
597 59.6 12.5246864
598 59.7 12.4000637
599 59.8 12.2766810
600 59.9 12.1545260
601 60.0 12.0335864
602 60.1 12.7098636
603 60.2 13.3794116
604 60.3 14.0422975
605 60.4 14.6985876
606 60.5 15.3483475
607 60.6 15.9916422
608 60.7 16.6285360
609 60.8 17.2590926
610 60.9 17.8833751
611 61.0 18.5014458
612 61.1 19.1133667
613 61.2 19.7191988
614 61.3 20.3190028
615 61.4 20.9128386
616 61.5 21.5007657
617 61.6 22.0828428
618 61.7 22.6591282
619 61.8 23.2296794
620 61.9 23.7945535
621 62.0 24.3538070
622 62.1 24.9074959
623 62.2 25.4556755
624 62.3 25.9984006
625 62.4 26.5357255
626 62.5 27.0677039
627 62.6 27.5943890
628 62.7 28.1158336
629 62.8 28.6320897
630 62.9 29.1432089
631 63.0 29.6492424
632 63.1 29.3542275
633 63.2 29.0621481
634 63.3 28.7729749
635 63.4 28.4866790
636 63.5 28.2032318
637 63.6 27.9226050
638 63.7 27.6447704
639 63.8 27.3697004
640 63.9 27.0973673
641 64.0 26.8277440
642 64.1 26.5608035
643 64.2 26.2965191
644 64.3 26.0348643
645 64.4 25.7758131
646 64.5 25.5193395
647 64.6 25.2654178
648 64.7 25.0140227
649 64.8 24.7651290
650 64.9 24.5187119
651 65.0 24.2747466
652 65.1 24.0332088
653 65.2 23.7940744
654 65.3 23.5573194
655 65.4 23.3229202
656 65.5 23.0908532
657 65.6 22.8610954
658 65.7 22.6336237
659 65.8 22.4084154
660 65.9 22.1854479
661 66.0 21.9646990
662 66.1 21.7461466
663 66.2 21.5297688
664 66.3 21.3155441
665 66.4 21.1034509
666 66.5 20.8934680
667 66.6 20.6855745
668 66.7 20.4797496
669 66.8 20.2759727
670 66.9 20.0742234
671 67.0 19.8744816
672 67.1 19.6767272
673 67.2 19.4809405
674 67.3 19.2871019
675 67.4 19.0951920
676 67.5 18.9051917
677 67.6 18.7170819
678 67.7 18.5308438
679 67.8 18.3464588
680 67.9 18.1639085
681 68.0 17.9831746
682 68.1 17.8042390
683 68.2 17.6270839
684 68.3 17.4516914
685 68.4 17.2780442
686 68.5 17.1061248
687 68.6 16.9359160
688 68.7 16.7674008
689 68.8 16.6005624
690 68.9 16.4353841
691 69.0 16.2718493
692 69.1 16.1099416
693 69.2 15.9496451
694 69.3 15.7909434
695 69.4 15.6338209
696 69.5 15.4782618
697 69.6 15.3242505
698 69.7 15.1717717
699 69.8 15.0208100
700 69.9 14.8713505
701 70.0 14.7233781
702 70.1 14.5768780
703 70.2 14.4318356
704 70.3 14.2882365
705 70.4 14.1460662
706 70.5 14.0053104
707 70.6 13.8659553
708 70.7 13.7279867
709 70.8 13.5913910
710 70.9 13.4561544
711 71.0 13.3222634
712 71.1 13.1897047
713 71.2 13.0584649
714 71.3 12.9285310
715 71.4 12.7998900
716 71.5 12.6725289
717 71.6 12.5464352
718 71.7 12.4215961
719 71.8 12.2979991
720 71.9 12.1756320
721 72.0 12.0544824
Code
pk_curve(t = seq(0, 72, by = 0.1), model = "2cmt_bolus", ii = 24, addl = 5,
params = list(CL = 2.5, V1 = 25, V2 = 50, Q = 5))
Output
t cp
1 0.0 24.000000
2 0.1 23.293038
3 0.2 22.611512
4 0.3 21.954493
5 0.4 21.321084
6 0.5 20.710422
7 0.6 20.121673
8 0.7 19.554038
9 0.8 19.006743
10 0.9 18.479044
11 1.0 17.970225
12 1.1 17.479596
13 1.2 17.006492
14 1.3 16.550271
15 1.4 16.110316
16 1.5 15.686033
17 1.6 15.276849
18 1.7 14.882211
19 1.8 14.501589
20 1.9 14.134469
21 2.0 13.780359
22 2.1 13.438783
23 2.2 13.109283
24 2.3 12.791418
25 2.4 12.484763
26 2.5 12.188907
27 2.6 11.903458
28 2.7 11.628035
29 2.8 11.362271
30 2.9 11.105814
31 3.0 10.858324
32 3.1 10.619475
33 3.2 10.388949
34 3.3 10.166444
35 3.4 9.951668
36 3.5 9.744337
37 3.6 9.544180
38 3.7 9.350937
39 3.8 9.164353
40 3.9 8.984188
41 4.0 8.810206
42 4.1 8.642183
43 4.2 8.479900
44 4.3 8.323150
45 4.4 8.171730
46 4.5 8.025446
47 4.6 7.884111
48 4.7 7.747546
49 4.8 7.615575
50 4.9 7.488033
51 5.0 7.364758
52 5.1 7.245594
53 5.2 7.130393
54 5.3 7.019010
55 5.4 6.911306
56 5.5 6.807148
57 5.6 6.706407
58 5.7 6.608958
59 5.8 6.514683
60 5.9 6.423465
61 6.0 6.335195
62 6.1 6.249765
63 6.2 6.167072
64 6.3 6.087016
65 6.4 6.009504
66 6.5 5.934441
67 6.6 5.861740
68 6.7 5.791315
69 6.8 5.723083
70 6.9 5.656966
71 7.0 5.592887
72 7.1 5.530772
73 7.2 5.470551
74 7.3 5.412155
75 7.4 5.355518
76 7.5 5.300577
77 7.6 5.247270
78 7.7 5.195539
79 7.8 5.145328
80 7.9 5.096580
81 8.0 5.049245
82 8.1 5.003271
83 8.2 4.958609
84 8.3 4.915212
85 8.4 4.873035
86 8.5 4.832034
87 8.6 4.792167
88 8.7 4.753393
89 8.8 4.715674
90 8.9 4.678972
91 9.0 4.643250
92 9.1 4.608473
93 9.2 4.574609
94 9.3 4.541623
95 9.4 4.509486
96 9.5 4.478167
97 9.6 4.447638
98 9.7 4.417869
99 9.8 4.388834
100 9.9 4.360508
101 10.0 4.332865
102 10.1 4.305881
103 10.2 4.279533
104 10.3 4.253799
105 10.4 4.228656
106 10.5 4.204085
107 10.6 4.180066
108 10.7 4.156578
109 10.8 4.133604
110 10.9 4.111126
111 11.0 4.089126
112 11.1 4.067588
113 11.2 4.046495
114 11.3 4.025833
115 11.4 4.005587
116 11.5 3.985741
117 11.6 3.966284
118 11.7 3.947200
119 11.8 3.928478
120 11.9 3.910104
121 12.0 3.892068
122 12.1 3.874358
123 12.2 3.856962
124 12.3 3.839870
125 12.4 3.823072
126 12.5 3.806558
127 12.6 3.790318
128 12.7 3.774344
129 12.8 3.758626
130 12.9 3.743155
131 13.0 3.727925
132 13.1 3.712926
133 13.2 3.698151
134 13.3 3.683593
135 13.4 3.669245
136 13.5 3.655100
137 13.6 3.641151
138 13.7 3.627392
139 13.8 3.613817
140 13.9 3.600421
141 14.0 3.587196
142 14.1 3.574138
143 14.2 3.561242
144 14.3 3.548503
145 14.4 3.535915
146 14.5 3.523475
147 14.6 3.511176
148 14.7 3.499016
149 14.8 3.486989
150 14.9 3.475093
151 15.0 3.463322
152 15.1 3.451673
153 15.2 3.440142
154 15.3 3.428727
155 15.4 3.417423
156 15.5 3.406227
157 15.6 3.395136
158 15.7 3.384148
159 15.8 3.373258
160 15.9 3.362465
161 16.0 3.351765
162 16.1 3.341157
163 16.2 3.330636
164 16.3 3.320202
165 16.4 3.309852
166 16.5 3.299583
167 16.6 3.289393
168 16.7 3.279280
169 16.8 3.269242
170 16.9 3.259278
171 17.0 3.249384
172 17.1 3.239560
173 17.2 3.229804
174 17.3 3.220114
175 17.4 3.210488
176 17.5 3.200924
177 17.6 3.191422
178 17.7 3.181980
179 17.8 3.172596
180 17.9 3.163269
181 18.0 3.153997
182 18.1 3.144780
183 18.2 3.135616
184 18.3 3.126504
185 18.4 3.117443
186 18.5 3.108432
187 18.6 3.099469
188 18.7 3.090554
189 18.8 3.081685
190 18.9 3.072862
191 19.0 3.064084
192 19.1 3.055349
193 19.2 3.046658
194 19.3 3.038009
195 19.4 3.029401
196 19.5 3.020834
197 19.6 3.012306
198 19.7 3.003818
199 19.8 2.995367
200 19.9 2.986955
201 20.0 2.978580
202 20.1 2.970241
203 20.2 2.961938
204 20.3 2.953670
205 20.4 2.945437
206 20.5 2.937238
207 20.6 2.929072
208 20.7 2.920940
209 20.8 2.912840
210 20.9 2.904772
211 21.0 2.896736
212 21.1 2.888731
213 21.2 2.880756
214 21.3 2.872812
215 21.4 2.864898
216 21.5 2.857013
217 21.6 2.849158
218 21.7 2.841331
219 21.8 2.833532
220 21.9 2.825762
221 22.0 2.818019
222 22.1 2.810303
223 22.2 2.802615
224 22.3 2.794953
225 22.4 2.787318
226 22.5 2.779709
227 22.6 2.772126
228 22.7 2.764568
229 22.8 2.757036
230 22.9 2.749529
231 23.0 2.742047
232 23.1 2.734589
233 23.2 2.727155
234 23.3 2.719746
235 23.4 2.712361
236 23.5 2.704999
237 23.6 2.697661
238 23.7 2.690346
239 23.8 2.683055
240 23.9 2.675786
241 24.0 26.668540
242 24.1 25.954354
243 24.2 25.265627
244 24.3 24.601429
245 24.4 23.960863
246 24.5 23.343065
247 24.6 22.747204
248 24.7 22.172476
249 24.8 21.618111
250 24.9 21.083363
251 25.0 20.567516
252 25.1 20.069880
253 25.2 19.589789
254 25.3 19.126602
255 25.4 18.679703
256 25.5 18.248495
257 25.6 17.832407
258 25.7 17.430885
259 25.8 17.043399
260 25.9 16.669435
261 26.0 16.308501
262 26.1 15.960121
263 26.2 15.623836
264 26.3 15.299206
265 26.4 14.985805
266 26.5 14.683223
267 26.6 14.391067
268 26.7 14.108955
269 26.8 13.836523
270 26.9 13.573416
271 27.0 13.319295
272 27.1 13.073833
273 27.2 12.836714
274 27.3 12.607634
275 27.4 12.386301
276 27.5 12.172432
277 27.6 11.965755
278 27.7 11.766010
279 27.8 11.572944
280 27.9 11.386313
281 28.0 11.205884
282 28.1 11.031431
283 28.2 10.862737
284 28.3 10.699594
285 28.4 10.541798
286 28.5 10.389156
287 28.6 10.241481
288 28.7 10.098592
289 28.8 9.960316
290 28.9 9.826486
291 29.0 9.696940
292 29.1 9.571523
293 29.2 9.450085
294 29.3 9.332483
295 29.4 9.218577
296 29.5 9.108234
297 29.6 9.001325
298 29.7 8.897725
299 29.8 8.797315
300 29.9 8.699980
301 30.0 8.605609
302 30.1 8.514094
303 30.2 8.425333
304 30.3 8.339227
305 30.4 8.255680
306 30.5 8.174599
307 30.6 8.095896
308 30.7 8.019485
309 30.8 7.945285
310 30.9 7.873215
311 31.0 7.803199
312 31.1 7.735164
313 31.2 7.669038
314 31.3 7.604753
315 31.4 7.542243
316 31.5 7.481445
317 31.6 7.422298
318 31.7 7.364742
319 31.8 7.308721
320 31.9 7.254180
321 32.0 7.201067
322 32.1 7.149331
323 32.2 7.098922
324 32.3 7.049794
325 32.4 7.001901
326 32.5 6.955200
327 32.6 6.909648
328 32.7 6.865205
329 32.8 6.821831
330 32.9 6.779490
331 33.0 6.738144
332 33.1 6.697759
333 33.2 6.658301
334 33.3 6.619738
335 33.4 6.582037
336 33.5 6.545170
337 33.6 6.509106
338 33.7 6.473819
339 33.8 6.439281
340 33.9 6.405465
341 34.0 6.372348
342 34.1 6.339905
343 34.2 6.308112
344 34.3 6.276948
345 34.4 6.246390
346 34.5 6.216418
347 34.6 6.187012
348 34.7 6.158152
349 34.8 6.129821
350 34.9 6.101999
351 35.0 6.074670
352 35.1 6.047818
353 35.2 6.021425
354 35.3 5.995477
355 35.4 5.969959
356 35.5 5.944856
357 35.6 5.920155
358 35.7 5.895841
359 35.8 5.871904
360 35.9 5.848329
361 36.0 5.825105
362 36.1 5.802221
363 36.2 5.779666
364 36.3 5.757428
365 36.4 5.735498
366 36.5 5.713866
367 36.6 5.692521
368 36.7 5.671456
369 36.8 5.650661
370 36.9 5.630127
371 37.0 5.609846
372 37.1 5.589811
373 37.2 5.570013
374 37.3 5.550446
375 37.4 5.531102
376 37.5 5.511974
377 37.6 5.493055
378 37.7 5.474341
379 37.8 5.455823
380 37.9 5.437496
381 38.0 5.419356
382 38.1 5.401395
383 38.2 5.383609
384 38.3 5.365993
385 38.4 5.348541
386 38.5 5.331249
387 38.6 5.314113
388 38.7 5.297128
389 38.8 5.280290
390 38.9 5.263594
391 39.0 5.247037
392 39.1 5.230615
393 39.2 5.214324
394 39.3 5.198160
395 39.4 5.182121
396 39.5 5.166203
397 39.6 5.150402
398 39.7 5.134716
399 39.8 5.119142
400 39.9 5.103677
401 40.0 5.088318
402 40.1 5.073062
403 40.2 5.057907
404 40.3 5.042851
405 40.4 5.027891
406 40.5 5.013024
407 40.6 4.998249
408 40.7 4.983563
409 40.8 4.968965
410 40.9 4.954452
411 41.0 4.940022
412 41.1 4.925674
413 41.2 4.911406
414 41.3 4.897216
415 41.4 4.883102
416 41.5 4.869063
417 41.6 4.855097
418 41.7 4.841202
419 41.8 4.827378
420 41.9 4.813623
421 42.0 4.799935
422 42.1 4.786314
423 42.2 4.772757
424 42.3 4.759264
425 42.4 4.745834
426 42.5 4.732465
427 42.6 4.719156
428 42.7 4.705907
429 42.8 4.692715
430 42.9 4.679581
431 43.0 4.666504
432 43.1 4.653481
433 43.2 4.640513
434 43.3 4.627599
435 43.4 4.614737
436 43.5 4.601928
437 43.6 4.589169
438 43.7 4.576461
439 43.8 4.563803
440 43.9 4.551194
441 44.0 4.538632
442 44.1 4.526119
443 44.2 4.513653
444 44.3 4.501232
445 44.4 4.488858
446 44.5 4.476529
447 44.6 4.464244
448 44.7 4.452004
449 44.8 4.439807
450 44.9 4.427653
451 45.0 4.415542
452 45.1 4.403472
453 45.2 4.391445
454 45.3 4.379458
455 45.4 4.367512
456 45.5 4.355606
457 45.6 4.343741
458 45.7 4.331914
459 45.8 4.320127
460 45.9 4.308379
461 46.0 4.296669
462 46.1 4.284996
463 46.2 4.273362
464 46.3 4.261765
465 46.4 4.250204
466 46.5 4.238681
467 46.6 4.227193
468 46.7 4.215742
469 46.8 4.204327
470 46.9 4.192947
471 47.0 4.181602
472 47.1 4.170292
473 47.2 4.159017
474 47.3 4.147776
475 47.4 4.136569
476 47.5 4.125397
477 47.6 4.114258
478 47.7 4.103152
479 47.8 4.092080
480 47.9 4.081041
481 48.0 28.070034
482 48.1 27.352098
483 48.2 26.659631
484 48.3 25.991703
485 48.4 25.347417
486 48.5 24.725909
487 48.6 24.126347
488 48.7 23.547929
489 48.8 22.989882
490 48.9 22.451464
491 49.0 21.931956
492 49.1 21.430669
493 49.2 20.946937
494 49.3 20.480119
495 49.4 20.029597
496 49.5 19.594777
497 49.6 19.175086
498 49.7 18.769972
499 49.8 18.378902
500 49.9 18.001365
501 50.0 17.636867
502 50.1 17.284932
503 50.2 16.945102
504 50.3 16.616936
505 50.4 16.300009
506 50.5 15.993911
507 50.6 15.698247
508 50.7 15.412638
509 50.8 15.136717
510 50.9 14.870130
511 51.0 14.612540
512 51.1 14.363617
513 51.2 14.123046
514 51.3 13.890525
515 51.4 13.665758
516 51.5 13.448466
517 51.6 13.238375
518 51.7 13.035224
519 51.8 12.838761
520 51.9 12.648743
521 52.0 12.464936
522 52.1 12.287114
523 52.2 12.115061
524 52.3 11.948566
525 52.4 11.787428
526 52.5 11.631453
527 52.6 11.480453
528 52.7 11.334249
529 52.8 11.192667
530 52.9 11.055539
531 53.0 10.922704
532 53.1 10.794007
533 53.2 10.669298
534 53.3 10.548433
535 53.4 10.431274
536 53.5 10.317686
537 53.6 10.207540
538 53.7 10.100712
539 53.8 9.997083
540 53.9 9.896538
541 54.0 9.798965
542 54.1 9.704257
543 54.2 9.612311
544 54.3 9.523029
545 54.4 9.436314
546 54.5 9.352073
547 54.6 9.270220
548 54.7 9.190667
549 54.8 9.113332
550 54.9 9.038137
551 55.0 8.965004
552 55.1 8.893859
553 55.2 8.824633
554 55.3 8.757256
555 55.4 8.691662
556 55.5 8.627789
557 55.6 8.565574
558 55.7 8.504959
559 55.8 8.445887
560 55.9 8.388303
561 56.0 8.332155
562 56.1 8.277392
563 56.2 8.223964
564 56.3 8.171826
565 56.4 8.120930
566 56.5 8.071235
567 56.6 8.022697
568 56.7 7.975275
569 56.8 7.928931
570 56.9 7.883627
571 57.0 7.839327
572 57.1 7.795995
573 57.2 7.753598
574 57.3 7.712104
575 57.4 7.671480
576 57.5 7.631698
577 57.6 7.592727
578 57.7 7.554540
579 57.8 7.517110
580 57.9 7.480410
581 58.0 7.444417
582 58.1 7.409104
583 58.2 7.374451
584 58.3 7.340433
585 58.4 7.307029
586 58.5 7.274219
587 58.6 7.241982
588 58.7 7.210300
589 58.8 7.179153
590 58.9 7.148523
591 59.0 7.118394
592 59.1 7.088749
593 59.2 7.059571
594 59.3 7.030845
595 59.4 7.002556
596 59.5 6.974690
597 59.6 6.947233
598 59.7 6.920171
599 59.8 6.893492
600 59.9 6.867184
601 60.0 6.841234
602 60.1 6.815631
603 60.2 6.790364
604 60.3 6.765421
605 60.4 6.740794
606 60.5 6.716472
607 60.6 6.692444
608 60.7 6.668703
609 60.8 6.645239
610 60.9 6.622044
611 61.0 6.599109
612 61.1 6.576427
613 61.2 6.553989
614 61.3 6.531789
615 61.4 6.509818
616 61.5 6.488072
617 61.6 6.466541
618 61.7 6.445222
619 61.8 6.424106
620 61.9 6.403188
621 62.0 6.382464
622 62.1 6.361926
623 62.2 6.341569
624 62.3 6.321390
625 62.4 6.301381
626 62.5 6.281540
627 62.6 6.261861
628 62.7 6.242340
629 62.8 6.222972
630 62.9 6.203754
631 63.0 6.184681
632 63.1 6.165750
633 63.2 6.146956
634 63.3 6.128297
635 63.4 6.109769
636 63.5 6.091369
637 63.6 6.073093
638 63.7 6.054938
639 63.8 6.036901
640 63.9 6.018980
641 64.0 6.001172
642 64.1 5.983473
643 64.2 5.965882
644 64.3 5.948396
645 64.4 5.931013
646 64.5 5.913730
647 64.6 5.896544
648 64.7 5.879455
649 64.8 5.862459
650 64.9 5.845555
651 65.0 5.828741
652 65.1 5.812015
653 65.2 5.795375
654 65.3 5.778819
655 65.4 5.762346
656 65.5 5.745954
657 65.6 5.729642
658 65.7 5.713407
659 65.8 5.697249
660 65.9 5.681166
661 66.0 5.665157
662 66.1 5.649220
663 66.2 5.633354
664 66.3 5.617559
665 66.4 5.601831
666 66.5 5.586172
667 66.6 5.570579
668 66.7 5.555051
669 66.8 5.539588
670 66.9 5.524187
671 67.0 5.508850
672 67.1 5.493573
673 67.2 5.478357
674 67.3 5.463201
675 67.4 5.448103
676 67.5 5.433064
677 67.6 5.418081
678 67.7 5.403155
679 67.8 5.388285
680 67.9 5.373469
681 68.0 5.358708
682 68.1 5.344000
683 68.2 5.329345
684 68.3 5.314742
685 68.4 5.300190
686 68.5 5.285690
687 68.6 5.271240
688 68.7 5.256841
689 68.8 5.242490
690 68.9 5.228188
691 69.0 5.213935
692 69.1 5.199729
693 69.2 5.185570
694 69.3 5.171459
695 69.4 5.157394
696 69.5 5.143374
697 69.6 5.129401
698 69.7 5.115472
699 69.8 5.101588
700 69.9 5.087748
701 70.0 5.073953
702 70.1 5.060201
703 70.2 5.046492
704 70.3 5.032826
705 70.4 5.019202
706 70.5 5.005621
707 70.6 4.992081
708 70.7 4.978583
709 70.8 4.965126
710 70.9 4.951711
711 71.0 4.938335
712 71.1 4.925001
713 71.2 4.911706
714 71.3 4.898451
715 71.4 4.885236
716 71.5 4.872060
717 71.6 4.858923
718 71.7 4.845824
719 71.8 4.832765
720 71.9 4.819744
721 72.0 28.806760
Code
pk_curve(t = seq(0, 72, by = 0.1), model = "2cmt_oral", ii = 24, addl = 5,
params = list(CL = 2.5, V1 = 25, V2 = 50, Q = 5, ka = 1))
Output
t cp
1 0.0 0.000000
2 0.1 2.249498
3 0.2 4.218889
4 0.3 5.937205
5 0.4 7.430627
6 0.5 8.722762
7 0.6 9.834888
8 0.7 10.786182
9 0.8 11.593920
10 0.9 12.273664
11 1.0 12.839423
12 1.1 13.303808
13 1.2 13.678165
14 1.3 13.972696
15 1.4 14.196576
16 1.5 14.358046
17 1.6 14.464509
18 1.7 14.522610
19 1.8 14.538309
20 1.9 14.516951
21 2.0 14.463322
22 2.1 14.381708
23 2.2 14.275944
24 2.3 14.149454
25 2.4 14.005299
26 2.5 13.846205
27 2.6 13.674603
28 2.7 13.492655
29 2.8 13.302281
30 2.9 13.105187
31 3.0 12.902879
32 3.1 12.696693
33 3.2 12.487803
34 3.3 12.277245
35 3.4 12.065926
36 3.5 11.854640
37 3.6 11.644080
38 3.7 11.434846
39 3.8 11.227458
40 3.9 11.022363
41 4.0 10.819940
42 4.1 10.620514
43 4.2 10.424356
44 4.3 10.231691
45 4.4 10.042703
46 4.5 9.857540
47 4.6 9.676318
48 4.7 9.499123
49 4.8 9.326019
50 4.9 9.157045
51 5.0 8.992221
52 5.1 8.831551
53 5.2 8.675023
54 5.3 8.522615
55 5.4 8.374289
56 5.5 8.230002
57 5.6 8.089699
58 5.7 7.953322
59 5.8 7.820804
60 5.9 7.692073
61 6.0 7.567057
62 6.1 7.445675
63 6.2 7.327847
64 6.3 7.213492
65 6.4 7.102524
66 6.5 6.994859
67 6.6 6.890412
68 6.7 6.789096
69 6.8 6.690827
70 6.9 6.595519
71 7.0 6.503089
72 7.1 6.413451
73 7.2 6.326525
74 7.3 6.242230
75 7.4 6.160484
76 7.5 6.081211
77 7.6 6.004332
78 7.7 5.929773
79 7.8 5.857461
80 7.9 5.787323
81 8.0 5.719289
82 8.1 5.653292
83 8.2 5.589263
84 8.3 5.527139
85 8.4 5.466857
86 8.5 5.408355
87 8.6 5.351573
88 8.7 5.296455
89 8.8 5.242943
90 8.9 5.190983
91 9.0 5.140523
92 9.1 5.091512
93 9.2 5.043899
94 9.3 4.997638
95 9.4 4.952681
96 9.5 4.908984
97 9.6 4.866503
98 9.7 4.825197
99 9.8 4.785024
100 9.9 4.745946
101 10.0 4.707924
102 10.1 4.670922
103 10.2 4.634904
104 10.3 4.599837
105 10.4 4.565686
106 10.5 4.532420
107 10.6 4.500009
108 10.7 4.468422
109 10.8 4.437631
110 10.9 4.407608
111 11.0 4.378326
112 11.1 4.349759
113 11.2 4.321883
114 11.3 4.294674
115 11.4 4.268108
116 11.5 4.242162
117 11.6 4.216816
118 11.7 4.192049
119 11.8 4.167840
120 11.9 4.144170
121 12.0 4.121021
122 12.1 4.098374
123 12.2 4.076212
124 12.3 4.054518
125 12.4 4.033277
126 12.5 4.012472
127 12.6 3.992089
128 12.7 3.972113
129 12.8 3.952531
130 12.9 3.933328
131 13.0 3.914492
132 13.1 3.896010
133 13.2 3.877871
134 13.3 3.860063
135 13.4 3.842574
136 13.5 3.825393
137 13.6 3.808512
138 13.7 3.791918
139 13.8 3.775603
140 13.9 3.759558
141 14.0 3.743773
142 14.1 3.728240
143 14.2 3.712950
144 14.3 3.697896
145 14.4 3.683069
146 14.5 3.668462
147 14.6 3.654069
148 14.7 3.639882
149 14.8 3.625894
150 14.9 3.612099
151 15.0 3.598490
152 15.1 3.585063
153 15.2 3.571810
154 15.3 3.558727
155 15.4 3.545809
156 15.5 3.533049
157 15.6 3.520443
158 15.7 3.507986
159 15.8 3.495673
160 15.9 3.483501
161 16.0 3.471465
162 16.1 3.459560
163 16.2 3.447783
164 16.3 3.436129
165 16.4 3.424596
166 16.5 3.413179
167 16.6 3.401876
168 16.7 3.390682
169 16.8 3.379594
170 16.9 3.368610
171 17.0 3.357727
172 17.1 3.346941
173 17.2 3.336250
174 17.3 3.325651
175 17.4 3.315142
176 17.5 3.304719
177 17.6 3.294382
178 17.7 3.284127
179 17.8 3.273952
180 17.9 3.263855
181 18.0 3.253834
182 18.1 3.243887
183 18.2 3.234012
184 18.3 3.224207
185 18.4 3.214471
186 18.5 3.204801
187 18.6 3.195196
188 18.7 3.185655
189 18.8 3.176176
190 18.9 3.166756
191 19.0 3.157396
192 19.1 3.148093
193 19.2 3.138847
194 19.3 3.129655
195 19.4 3.120517
196 19.5 3.111432
197 19.6 3.102397
198 19.7 3.093413
199 19.8 3.084478
200 19.9 3.075591
201 20.0 3.066750
202 20.1 3.057956
203 20.2 3.049207
204 20.3 3.040502
205 20.4 3.031840
206 20.5 3.023221
207 20.6 3.014643
208 20.7 3.006107
209 20.8 2.997610
210 20.9 2.989152
211 21.0 2.980733
212 21.1 2.972353
213 21.2 2.964009
214 21.3 2.955702
215 21.4 2.947431
216 21.5 2.939195
217 21.6 2.930994
218 21.7 2.922828
219 21.8 2.914695
220 21.9 2.906595
221 22.0 2.898528
222 22.1 2.890493
223 22.2 2.882490
224 22.3 2.874518
225 22.4 2.866577
226 22.5 2.858666
227 22.6 2.850785
228 22.7 2.842934
229 22.8 2.835112
230 22.9 2.827319
231 23.0 2.819554
232 23.1 2.811817
233 23.2 2.804108
234 23.3 2.796426
235 23.4 2.788772
236 23.5 2.781144
237 23.6 2.773543
238 23.7 2.765968
239 23.8 2.758419
240 23.9 2.750895
241 24.0 2.743397
242 24.1 4.985421
243 24.2 6.947364
244 24.3 8.658257
245 24.4 10.144279
246 24.5 11.429038
247 24.6 12.533813
248 24.7 13.477779
249 24.8 14.278214
250 24.9 14.950676
251 25.0 15.509178
252 25.1 15.966328
253 25.2 16.333472
254 25.3 16.620814
255 25.4 16.837526
256 25.5 16.991851
257 25.6 17.091191
258 25.7 17.142190
259 25.8 17.150810
260 25.9 17.122393
261 26.0 17.061727
262 26.1 16.973098
263 26.2 16.860338
264 26.3 16.726875
265 26.4 16.575767
266 26.5 16.409740
267 26.6 16.231227
268 26.7 16.042387
269 26.8 15.845143
270 26.9 15.641197
271 27.0 15.432059
272 27.1 15.219062
273 27.2 15.003381
274 27.3 14.786051
275 27.4 14.567980
276 27.5 14.349962
277 27.6 14.132689
278 27.7 13.916761
279 27.8 13.702699
280 27.9 13.490948
281 28.0 13.281889
282 28.1 13.075845
283 28.2 12.873088
284 28.3 12.673843
285 28.4 12.478293
286 28.5 12.286587
287 28.6 12.098841
288 28.7 11.915140
289 28.8 11.735548
290 28.9 11.560104
291 29.0 11.388828
292 29.1 11.221725
293 29.2 11.058782
294 29.3 10.899975
295 29.4 10.745270
296 29.5 10.594620
297 29.6 10.447974
298 29.7 10.305269
299 29.8 10.166442
300 29.9 10.031420
301 30.0 9.900128
302 30.1 9.772489
303 30.2 9.648422
304 30.3 9.527844
305 30.4 9.410670
306 30.5 9.296817
307 30.6 9.186198
308 30.7 9.078728
309 30.8 8.974321
310 30.9 8.872893
311 31.0 8.774358
312 31.1 8.678633
313 31.2 8.585636
314 31.3 8.495287
315 31.4 8.407503
316 31.5 8.322209
317 31.6 8.239325
318 31.7 8.158778
319 31.8 8.080494
320 31.9 8.004400
321 32.0 7.930427
322 32.1 7.858506
323 32.2 7.788570
324 32.3 7.720555
325 32.4 7.654397
326 32.5 7.590035
327 32.6 7.527410
328 32.7 7.466464
329 32.8 7.407140
330 32.9 7.349384
331 33.0 7.293144
332 33.1 7.238368
333 33.2 7.185006
334 33.3 7.133011
335 33.4 7.082336
336 33.5 7.032936
337 33.6 6.984768
338 33.7 6.937790
339 33.8 6.891961
340 33.9 6.847241
341 34.0 6.803593
342 34.1 6.760980
343 34.2 6.719367
344 34.3 6.678718
345 34.4 6.639002
346 34.5 6.600185
347 34.6 6.562238
348 34.7 6.525130
349 34.8 6.488833
350 34.9 6.453319
351 35.0 6.418560
352 35.1 6.384532
353 35.2 6.351209
354 35.3 6.318568
355 35.4 6.286584
356 35.5 6.255235
357 35.6 6.224501
358 35.7 6.194359
359 35.8 6.164791
360 35.9 6.135775
361 36.0 6.107295
362 36.1 6.079332
363 36.2 6.051867
364 36.3 6.024886
365 36.4 5.998371
366 36.5 5.972306
367 36.6 5.946677
368 36.7 5.921470
369 36.8 5.896670
370 36.9 5.872264
371 37.0 5.848238
372 37.1 5.824581
373 37.2 5.801280
374 37.3 5.778324
375 37.4 5.755701
376 37.5 5.733401
377 37.6 5.711412
378 37.7 5.689726
379 37.8 5.668332
380 37.9 5.647221
381 38.0 5.626384
382 38.1 5.605813
383 38.2 5.585498
384 38.3 5.565432
385 38.4 5.545607
386 38.5 5.526016
387 38.6 5.506652
388 38.7 5.487506
389 38.8 5.468574
390 38.9 5.449847
391 39.0 5.431321
392 39.1 5.412989
393 39.2 5.394844
394 39.3 5.376883
395 39.4 5.359098
396 39.5 5.341486
397 39.6 5.324040
398 39.7 5.306756
399 39.8 5.289630
400 39.9 5.272657
401 40.0 5.255833
402 40.1 5.239153
403 40.2 5.222613
404 40.3 5.206211
405 40.4 5.189940
406 40.5 5.173799
407 40.6 5.157784
408 40.7 5.141891
409 40.8 5.126118
410 40.9 5.110460
411 41.0 5.094915
412 41.1 5.079480
413 41.2 5.064153
414 41.3 5.048930
415 41.4 5.033809
416 41.5 5.018788
417 41.6 5.003863
418 41.7 4.989034
419 41.8 4.974296
420 41.9 4.959649
421 42.0 4.945090
422 42.1 4.930618
423 42.2 4.916229
424 42.3 4.901923
425 42.4 4.887697
426 42.5 4.873549
427 42.6 4.859479
428 42.7 4.845484
429 42.8 4.831563
430 42.9 4.817714
431 43.0 4.803936
432 43.1 4.790227
433 43.2 4.776586
434 43.3 4.763012
435 43.4 4.749503
436 43.5 4.736059
437 43.6 4.722677
438 43.7 4.709357
439 43.8 4.696097
440 43.9 4.682898
441 44.0 4.669756
442 44.1 4.656672
443 44.2 4.643645
444 44.3 4.630674
445 44.4 4.617757
446 44.5 4.604894
447 44.6 4.592083
448 44.7 4.579325
449 44.8 4.566619
450 44.9 4.553963
451 45.0 4.541357
452 45.1 4.528800
453 45.2 4.516291
454 45.3 4.503830
455 45.4 4.491416
456 45.5 4.479049
457 45.6 4.466728
458 45.7 4.454451
459 45.8 4.442220
460 45.9 4.430033
461 46.0 4.417889
462 46.1 4.405788
463 46.2 4.393730
464 46.3 4.381715
465 46.4 4.369740
466 46.5 4.357807
467 46.6 4.345915
468 46.7 4.334063
469 46.8 4.322251
470 46.9 4.310478
471 47.0 4.298744
472 47.1 4.287049
473 47.2 4.275393
474 47.3 4.263774
475 47.4 4.252193
476 47.5 4.240649
477 47.6 4.229142
478 47.7 4.217672
479 47.8 4.206238
480 47.9 4.194840
481 48.0 4.183478
482 48.1 6.421649
483 48.2 8.379749
484 48.3 10.086808
485 48.4 11.569009
486 48.5 12.849955
487 48.6 13.950928
488 48.7 14.891102
489 48.8 15.687754
490 48.9 16.356445
491 49.0 16.911185
492 49.1 17.364583
493 49.2 17.727986
494 49.3 18.011596
495 49.4 18.224587
496 49.5 18.375200
497 49.6 18.470838
498 49.7 18.518146
499 49.8 18.523083
500 49.9 18.490994
501 50.0 18.426666
502 50.1 18.334384
503 50.2 18.217982
504 50.3 18.080886
505 50.4 17.926154
506 50.5 17.756515
507 50.6 17.574397
508 50.7 17.381963
509 50.8 17.181135
510 50.9 16.973614
511 51.0 16.760910
512 51.1 16.544357
513 51.2 16.325130
514 51.3 16.104263
515 51.4 15.882665
516 51.5 15.661129
517 51.6 15.440347
518 51.7 15.220920
519 51.8 15.003368
520 51.9 14.788136
521 52.0 14.575606
522 52.1 14.366101
523 52.2 14.159891
524 52.3 13.957203
525 52.4 13.758219
526 52.5 13.563088
527 52.6 13.371925
528 52.7 13.184818
529 52.8 13.001828
530 52.9 12.822996
531 53.0 12.648341
532 53.1 12.477867
533 53.2 12.311563
534 53.3 12.149404
535 53.4 11.991355
536 53.5 11.837371
537 53.6 11.687399
538 53.7 11.541378
539 53.8 11.399243
540 53.9 11.260922
541 54.0 11.126341
542 54.1 10.995420
543 54.2 10.868081
544 54.3 10.744239
545 54.4 10.623810
546 54.5 10.506711
547 54.6 10.392854
548 54.7 10.282155
549 54.8 10.174528
550 54.9 10.069888
551 55.0 9.968150
552 55.1 9.869231
553 55.2 9.773048
554 55.3 9.679521
555 55.4 9.588569
556 55.5 9.500114
557 55.6 9.414079
558 55.7 9.330388
559 55.8 9.248968
560 55.9 9.169748
561 56.0 9.092656
562 56.1 9.017625
563 56.2 8.944588
564 56.3 8.873479
565 56.4 8.804236
566 56.5 8.736798
567 56.6 8.671104
568 56.7 8.607097
569 56.8 8.544721
570 56.9 8.483921
571 57.0 8.424645
572 57.1 8.366841
573 57.2 8.310460
574 57.3 8.255453
575 57.4 8.201775
576 57.5 8.149379
577 57.6 8.098224
578 57.7 8.048266
579 57.8 7.999465
580 57.9 7.951782
581 58.0 7.905179
582 58.1 7.859618
583 58.2 7.815064
584 58.3 7.771484
585 58.4 7.728843
586 58.5 7.687110
587 58.6 7.646255
588 58.7 7.606246
589 58.8 7.567056
590 58.9 7.528657
591 59.0 7.491021
592 59.1 7.454123
593 59.2 7.417938
594 59.3 7.382441
595 59.4 7.347611
596 59.5 7.313423
597 59.6 7.279857
598 59.7 7.246891
599 59.8 7.214506
600 59.9 7.182682
601 60.0 7.151401
602 60.1 7.120643
603 60.2 7.090392
604 60.3 7.060632
605 60.4 7.031345
606 60.5 7.002516
607 60.6 6.974131
608 60.7 6.946174
609 60.8 6.918632
610 60.9 6.891491
611 61.0 6.864739
612 61.1 6.838361
613 61.2 6.812348
614 61.3 6.786686
615 61.4 6.761365
616 61.5 6.736373
617 61.6 6.711701
618 61.7 6.687338
619 61.8 6.663274
620 61.9 6.639501
621 62.0 6.616009
622 62.1 6.592789
623 62.2 6.569833
624 62.3 6.547134
625 62.4 6.524682
626 62.5 6.502471
627 62.6 6.480494
628 62.7 6.458742
629 62.8 6.437211
630 62.9 6.415892
631 63.0 6.394781
632 63.1 6.373871
633 63.2 6.353155
634 63.3 6.332629
635 63.4 6.312287
636 63.5 6.292124
637 63.6 6.272134
638 63.7 6.252314
639 63.8 6.232658
640 63.9 6.213161
641 64.0 6.193820
642 64.1 6.174630
643 64.2 6.155587
644 64.3 6.136688
645 64.4 6.117928
646 64.5 6.099304
647 64.6 6.080812
648 64.7 6.062449
649 64.8 6.044212
650 64.9 6.026097
651 65.0 6.008102
652 65.1 5.990224
653 65.2 5.972460
654 65.3 5.954806
655 65.4 5.937261
656 65.5 5.919822
657 65.6 5.902487
658 65.7 5.885253
659 65.8 5.868117
660 65.9 5.851078
661 66.0 5.834134
662 66.1 5.817282
663 66.2 5.800521
664 66.3 5.783848
665 66.4 5.767262
666 66.5 5.750761
667 66.6 5.734344
668 66.7 5.718008
669 66.8 5.701752
670 66.9 5.685575
671 67.0 5.669474
672 67.1 5.653449
673 67.2 5.637498
674 67.3 5.621620
675 67.4 5.605814
676 67.5 5.590078
677 67.6 5.574411
678 67.7 5.558812
679 67.8 5.543279
680 67.9 5.527812
681 68.0 5.512410
682 68.1 5.497072
683 68.2 5.481795
684 68.3 5.466581
685 68.4 5.451427
686 68.5 5.436333
687 68.6 5.421298
688 68.7 5.406322
689 68.8 5.391402
690 68.9 5.376539
691 69.0 5.361732
692 69.1 5.346979
693 69.2 5.332281
694 69.3 5.317637
695 69.4 5.303045
696 69.5 5.288506
697 69.6 5.274019
698 69.7 5.259582
699 69.8 5.245197
700 69.9 5.230861
701 70.0 5.216574
702 70.1 5.202336
703 70.2 5.188147
704 70.3 5.174005
705 70.4 5.159911
706 70.5 5.145863
707 70.6 5.131862
708 70.7 5.117907
709 70.8 5.103997
710 70.9 5.090133
711 71.0 5.076313
712 71.1 5.062537
713 71.2 5.048805
714 71.3 5.035117
715 71.4 5.021472
716 71.5 5.007870
717 71.6 4.994310
718 71.7 4.980792
719 71.8 4.967316
720 71.9 4.953882
721 72.0 4.940488
Code
pk_curve(t = seq(0, 72, by = 0.1), model = "2cmt_infusion", ii = 24, addl = 5,
params = list(CL = 2.5, V1 = 25, V2 = 50, Q = 5, tinf = 3))
Output
t cp
1 0.0 0.0000000
2 0.1 0.7881453
3 0.2 1.5531518
4 0.3 2.2958517
5 0.4 3.0170470
6 0.5 3.7175101
7 0.6 4.3979852
8 0.7 5.0591895
9 0.8 5.7018138
10 0.9 6.3265234
11 1.0 6.9339598
12 1.1 7.5247406
13 1.2 8.0994609
14 1.3 8.6586943
15 1.4 9.2029930
16 1.5 9.7328894
17 1.6 10.2488963
18 1.7 10.7515076
19 1.8 11.2411994
20 1.9 11.7184302
21 2.0 12.1836419
22 2.1 12.6372601
23 2.2 13.0796950
24 2.3 13.5113416
25 2.4 13.9325807
26 2.5 14.3437791
27 2.6 14.7452901
28 2.7 15.1374544
29 2.8 15.5205998
30 2.9 15.8950425
31 3.0 16.2610870
32 3.1 15.8308815
33 3.2 15.4159927
34 3.3 15.0158608
35 3.4 14.6299463
36 3.5 14.2577297
37 3.6 13.8987102
38 3.7 13.5524057
39 3.8 13.2183515
40 3.9 12.8961000
41 4.0 12.5852200
42 4.1 12.2852961
43 4.2 11.9959282
44 4.3 11.7167306
45 4.4 11.4473319
46 4.5 11.1873744
47 4.6 10.9365134
48 4.7 10.6944166
49 4.8 10.4607643
50 4.9 10.2352483
51 5.0 10.0175715
52 5.1 9.8074479
53 5.2 9.6046021
54 5.3 9.4087684
55 5.4 9.2196912
56 5.5 9.0371241
57 5.6 8.8608296
58 5.7 8.6905792
59 5.8 8.5261524
60 5.9 8.3673372
61 6.0 8.2139290
62 6.1 8.0657308
63 6.2 7.9225529
64 6.3 7.7842125
65 6.4 7.6505334
66 6.5 7.5213461
67 6.6 7.3964869
68 6.7 7.2757985
69 6.8 7.1591291
70 6.9 7.0463327
71 7.0 6.9372683
72 7.1 6.8318004
73 7.2 6.7297982
74 7.3 6.6311359
75 7.4 6.5356922
76 7.5 6.4433502
77 7.6 6.3539974
78 7.7 6.2675254
79 7.8 6.1838295
80 7.9 6.1028093
81 8.0 6.0243676
82 8.1 5.9484112
83 8.2 5.8748499
84 8.3 5.8035972
85 8.4 5.7345694
86 8.5 5.6676861
87 8.6 5.6028697
88 8.7 5.5400456
89 8.8 5.4791418
90 8.9 5.4200890
91 9.0 5.3628204
92 9.1 5.3072716
93 9.2 5.2533807
94 9.3 5.2010879
95 9.4 5.1503357
96 9.5 5.1010686
97 9.6 5.0532333
98 9.7 5.0067783
99 9.8 4.9616540
100 9.9 4.9178127
101 10.0 4.8752084
102 10.1 4.8337967
103 10.2 4.7935350
104 10.3 4.7543821
105 10.4 4.7162983
106 10.5 4.6792455
107 10.6 4.6431868
108 10.7 4.6080869
109 10.8 4.5739116
110 10.9 4.5406279
111 11.0 4.5082042
112 11.1 4.4766100
113 11.2 4.4458157
114 11.3 4.4157931
115 11.4 4.3865149
116 11.5 4.3579547
117 11.6 4.3300871
118 11.7 4.3028878
119 11.8 4.2763332
120 11.9 4.2504006
121 12.0 4.2250682
122 12.1 4.2003150
123 12.2 4.1761206
124 12.3 4.1524655
125 12.4 4.1293309
126 12.5 4.1066986
127 12.6 4.0845512
128 12.7 4.0628718
129 12.8 4.0416442
130 12.9 4.0208528
131 13.0 4.0004824
132 13.1 3.9805187
133 13.2 3.9609475
134 13.3 3.9417555
135 13.4 3.9229296
136 13.5 3.9044573
137 13.6 3.8863266
138 13.7 3.8685259
139 13.8 3.8510439
140 13.9 3.8338699
141 14.0 3.8169935
142 14.1 3.8004046
143 14.2 3.7840937
144 14.3 3.7680514
145 14.4 3.7522688
146 14.5 3.7367372
147 14.6 3.7214483
148 14.7 3.7063940
149 14.8 3.6915668
150 14.9 3.6769590
151 15.0 3.6625637
152 15.1 3.6483737
153 15.2 3.6343825
154 15.3 3.6205836
155 15.4 3.6069709
156 15.5 3.5935384
157 15.6 3.5802803
158 15.7 3.5671911
159 15.8 3.5542655
160 15.9 3.5414982
161 16.0 3.5288845
162 16.1 3.5164194
163 16.2 3.5040983
164 16.3 3.4919169
165 16.4 3.4798709
166 16.5 3.4679560
167 16.6 3.4561684
168 16.7 3.4445042
169 16.8 3.4329597
170 16.9 3.4215314
171 17.0 3.4102157
172 17.1 3.3990095
173 17.2 3.3879095
174 17.3 3.3769126
175 17.4 3.3660159
176 17.5 3.3552165
177 17.6 3.3445117
178 17.7 3.3338987
179 17.8 3.3233751
180 17.9 3.3129383
181 18.0 3.3025861
182 18.1 3.2923160
183 18.2 3.2821258
184 18.3 3.2720135
185 18.4 3.2619770
186 18.5 3.2520142
187 18.6 3.2421234
188 18.7 3.2323025
189 18.8 3.2225498
190 18.9 3.2128637
191 19.0 3.2032425
192 19.1 3.1936844
193 19.2 3.1841881
194 19.3 3.1747521
195 19.4 3.1653748
196 19.5 3.1560549
197 19.6 3.1467910
198 19.7 3.1375820
199 19.8 3.1284265
200 19.9 3.1193233
201 20.0 3.1102712
202 20.1 3.1012693
203 20.2 3.0923163
204 20.3 3.0834112
205 20.4 3.0745530
206 20.5 3.0657408
207 20.6 3.0569736
208 20.7 3.0482505
209 20.8 3.0395706
210 20.9 3.0309331
211 21.0 3.0223372
212 21.1 3.0137821
213 21.2 3.0052670
214 21.3 2.9967912
215 21.4 2.9883540
216 21.5 2.9799546
217 21.6 2.9715925
218 21.7 2.9632670
219 21.8 2.9549774
220 21.9 2.9467233
221 22.0 2.9385039
222 22.1 2.9303188
223 22.2 2.9221673
224 22.3 2.9140490
225 22.4 2.9059635
226 22.5 2.8979100
227 22.6 2.8898883
228 22.7 2.8818979
229 22.8 2.8739382
230 22.9 2.8660090
231 23.0 2.8581097
232 23.1 2.8502400
233 23.2 2.8423994
234 23.3 2.8345877
235 23.4 2.8268044
236 23.5 2.8190492
237 23.6 2.8113217
238 23.7 2.8036217
239 23.8 2.7959487
240 23.9 2.7883026
241 24.0 2.7806829
242 24.1 3.5612347
243 24.2 4.3186736
244 24.3 5.0538316
245 24.4 5.7675103
246 24.5 6.4604820
247 24.6 7.1334905
248 24.7 7.7872529
249 24.8 8.4224595
250 24.9 9.0397757
251 25.0 9.6398426
252 25.1 10.2232776
253 25.2 10.7906757
254 25.3 11.3426100
255 25.4 11.8796329
256 25.5 12.4022764
257 25.6 12.9110530
258 25.7 13.4064567
259 25.8 13.8889631
260 25.9 14.3590308
261 26.0 14.8171014
262 26.1 15.2636003
263 26.2 15.6989376
264 26.3 16.1235083
265 26.4 16.5376928
266 26.5 16.9418578
267 26.6 17.3363566
268 26.7 17.7215295
269 26.8 18.0977045
270 26.9 18.4651974
271 27.0 18.8243127
272 27.1 18.3871984
273 27.2 17.9654212
274 27.3 17.5584210
275 27.4 17.1656583
276 27.5 16.7866134
277 27.6 16.4207856
278 27.7 16.0676924
279 27.8 15.7268692
280 27.9 15.3978682
281 28.0 15.0802581
282 28.1 14.7736234
283 28.2 14.4775639
284 28.3 14.1916938
285 28.4 13.9156417
286 28.5 13.6490497
287 28.6 13.3915730
288 28.7 13.1428793
289 28.8 12.9026488
290 28.9 12.6705730
291 29.0 12.4463550
292 29.1 12.2297086
293 29.2 12.0203583
294 29.3 11.8180384
295 29.4 11.6224931
296 29.5 11.4334759
297 29.6 11.2507494
298 29.7 11.0740849
299 29.8 10.9032620
300 29.9 10.7380683
301 30.0 10.5782993
302 30.1 10.4237580
303 30.2 10.2742546
304 30.3 10.1296062
305 30.4 9.9896365
306 30.5 9.8541759
307 30.6 9.7230609
308 30.7 9.5961338
309 30.8 9.4732429
310 30.9 9.3542420
311 31.0 9.2389903
312 31.1 9.1273520
313 31.2 9.0191963
314 31.3 8.9143974
315 31.4 8.8128339
316 31.5 8.7143889
317 31.6 8.6189497
318 31.7 8.5264079
319 31.8 8.4366589
320 31.9 8.3496019
321 32.0 8.2651401
322 32.1 8.1831798
323 32.2 8.1036311
324 32.3 8.0264072
325 32.4 7.9514245
326 32.5 7.8786025
327 32.6 7.8078635
328 32.7 7.7391329
329 32.8 7.6723386
330 32.9 7.6074113
331 33.0 7.5442841
332 33.1 7.4828926
333 33.2 7.4231748
334 33.3 7.3650709
335 33.4 7.3085233
336 33.5 7.2534766
337 33.6 7.1998773
338 33.7 7.1476738
339 33.8 7.0968166
340 33.9 7.0472579
341 34.0 6.9989516
342 34.1 6.9518533
343 34.2 6.9059203
344 34.3 6.8611115
345 34.4 6.8173870
346 34.5 6.7747087
347 34.6 6.7330398
348 34.7 6.6923447
349 34.8 6.6525893
350 34.9 6.6137406
351 35.0 6.5757668
352 35.1 6.5386375
353 35.2 6.5023230
354 35.3 6.4667950
355 35.4 6.4320263
356 35.5 6.3979903
357 35.6 6.3646617
358 35.7 6.3320160
359 35.8 6.3000297
360 35.9 6.2686801
361 36.0 6.2379452
362 36.1 6.2078039
363 36.2 6.1782360
364 36.3 6.1492218
365 36.4 6.1207425
366 36.5 6.0927799
367 36.6 6.0653165
368 36.7 6.0383354
369 36.8 6.0118203
370 36.9 5.9857556
371 37.0 5.9601261
372 37.1 5.9349174
373 37.2 5.9101153
374 37.3 5.8857063
375 37.4 5.8616775
376 37.5 5.8380163
377 37.6 5.8147106
378 37.7 5.7917488
379 37.8 5.7691195
380 37.9 5.7468120
381 38.0 5.7248159
382 38.1 5.7031211
383 38.2 5.6817179
384 38.3 5.6605970
385 38.4 5.6397493
386 38.5 5.6191663
387 38.6 5.5988395
388 38.7 5.5787609
389 38.8 5.5589227
390 38.9 5.5393175
391 39.0 5.5199380
392 39.1 5.5007773
393 39.2 5.4818287
394 39.3 5.4630858
395 39.4 5.4445422
396 39.5 5.4261920
397 39.6 5.4080294
398 39.7 5.3900489
399 39.8 5.3722450
400 39.9 5.3546127
401 40.0 5.3371468
402 40.1 5.3198425
403 40.2 5.3026953
404 40.3 5.2857007
405 40.4 5.2688543
406 40.5 5.2521520
407 40.6 5.2355897
408 40.7 5.2191636
409 40.8 5.2028700
410 40.9 5.1867052
411 41.0 5.1706659
412 41.1 5.1547486
413 41.2 5.1389501
414 41.3 5.1232674
415 41.4 5.1076974
416 41.5 5.0922372
417 41.6 5.0768840
418 41.7 5.0616352
419 41.8 5.0464881
420 41.9 5.0314402
421 42.0 5.0164892
422 42.1 5.0016327
423 42.2 4.9868684
424 42.3 4.9721942
425 42.4 4.9576080
426 42.5 4.9431077
427 42.6 4.9286915
428 42.7 4.9143574
429 42.8 4.9001036
430 42.9 4.8859283
431 43.0 4.8718300
432 43.1 4.8578068
433 43.2 4.8438574
434 43.3 4.8299801
435 43.4 4.8161734
436 43.5 4.8024360
437 43.6 4.7887666
438 43.7 4.7751636
439 43.8 4.7616260
440 43.9 4.7481524
441 44.0 4.7347417
442 44.1 4.7213927
443 44.2 4.7081043
444 44.3 4.6948755
445 44.4 4.6817051
446 44.5 4.6685922
447 44.6 4.6555358
448 44.7 4.6425351
449 44.8 4.6295890
450 44.9 4.6166967
451 45.0 4.6038574
452 45.1 4.5910702
453 45.2 4.5783344
454 45.3 4.5656491
455 45.4 4.5530137
456 45.5 4.5404274
457 45.6 4.5278896
458 45.7 4.5153995
459 45.8 4.5029566
460 45.9 4.4905601
461 46.0 4.4782095
462 46.1 4.4659042
463 46.2 4.4536437
464 46.3 4.4414273
465 46.4 4.4292545
466 46.5 4.4171249
467 46.6 4.4050379
468 46.7 4.3929930
469 46.8 4.3809898
470 46.9 4.3690278
471 47.0 4.3571065
472 47.1 4.3452256
473 47.2 4.3333846
474 47.3 4.3215831
475 47.4 4.3098207
476 47.5 4.2980971
477 47.6 4.2864118
478 47.7 4.2747645
479 47.8 4.2631549
480 47.9 4.2515826
481 48.0 4.2400473
482 48.1 5.0166940
483 48.2 5.7702382
484 48.3 6.5015120
485 48.4 7.2113168
486 48.5 7.9004249
487 48.6 8.5695803
488 48.7 9.2194998
489 48.8 9.8508739
490 48.9 10.4643678
491 49.0 11.0606226
492 49.1 11.6402557
493 49.2 12.2038620
494 49.3 12.7520148
495 49.4 13.2852663
496 49.5 13.8041484
497 49.6 14.3091737
498 49.7 14.8008361
499 49.8 15.2796114
500 49.9 15.7459578
501 50.0 16.2003170
502 50.1 16.6431146
503 50.2 17.0747605
504 50.3 17.4956495
505 50.4 17.9061623
506 50.5 18.3066654
507 50.6 18.6975121
508 50.7 19.0790427
509 50.8 19.4515851
510 50.9 19.8154552
511 51.0 20.1709573
512 51.1 19.7302395
513 51.2 19.3048684
514 51.3 18.8942840
515 51.4 18.4979467
516 51.5 18.1153367
517 51.6 17.7459533
518 51.7 17.3893141
519 51.8 17.0449543
520 51.9 16.7124262
521 52.0 16.3912985
522 52.1 16.0811556
523 52.2 15.7815972
524 52.3 15.4922377
525 52.4 15.2127055
526 52.5 14.9426427
527 52.6 14.6817044
528 52.7 14.4295585
529 52.8 14.1858849
530 52.9 13.9503753
531 53.0 13.7227326
532 53.1 13.5026708
533 53.2 13.2899141
534 53.3 13.0841970
535 53.4 12.8852636
536 53.5 12.6928673
537 53.6 12.5067709
538 53.7 12.3267453
539 53.8 12.1525704
540 53.9 11.9840337
541 54.0 11.8209306
542 54.1 11.6630642
543 54.2 11.5102445
544 54.3 11.3622887
545 54.4 11.2190205
546 54.5 11.0802702
547 54.6 10.9458742
548 54.7 10.8156749
549 54.8 10.6895207
550 54.9 10.5672652
551 55.0 10.4487675
552 55.1 10.3338919
553 55.2 10.2225077
554 55.3 10.1144889
555 55.4 10.0097140
556 55.5 9.9080662
557 55.6 9.8094329
558 55.7 9.7137054
559 55.8 9.6207793
560 55.9 9.5305538
561 56.0 9.4429318
562 56.1 9.3578199
563 56.2 9.2751280
564 56.3 9.1947693
565 56.4 9.1166601
566 56.5 9.0407200
567 56.6 8.9668714
568 56.7 8.8950394
569 56.8 8.8251520
570 56.9 8.7571399
571 57.0 8.6909361
572 57.1 8.6264763
573 57.2 8.5636983
574 57.3 8.5025425
575 57.4 8.4429512
576 57.5 8.3848688
577 57.6 8.3282420
578 57.7 8.2730191
579 57.8 8.2191506
580 57.9 8.1665886
581 58.0 8.1152871
582 58.1 8.0652016
583 58.2 8.0162894
584 58.3 7.9685093
585 58.4 7.9218215
586 58.5 7.8761879
587 58.6 7.8315715
588 58.7 7.7879369
589 58.8 7.7452497
590 58.9 7.7034772
591 59.0 7.6625874
592 59.1 7.6225498
593 59.2 7.5833349
594 59.3 7.5449143
595 59.4 7.5072605
596 59.5 7.4703473
597 59.6 7.4341492
598 59.7 7.3986417
599 59.8 7.3638012
600 59.9 7.3296050
601 60.0 7.2960312
602 60.1 7.2630586
603 60.2 7.2306669
604 60.3 7.1988365
605 60.4 7.1675485
606 60.5 7.1367848
607 60.6 7.1065277
608 60.7 7.0767604
609 60.8 7.0474666
610 60.9 7.0186306
611 61.0 6.9902372
612 61.1 6.9622720
613 61.2 6.9347208
614 61.3 6.9075701
615 61.4 6.8808069
616 61.5 6.8544186
617 61.6 6.8283931
618 61.7 6.8027187
619 61.8 6.7773842
620 61.9 6.7523787
621 62.0 6.7276918
622 62.1 6.7033134
623 62.2 6.6792337
624 62.3 6.6554436
625 62.4 6.6319338
626 62.5 6.6086958
627 62.6 6.5857211
628 62.7 6.5630017
629 62.8 6.5405298
630 62.9 6.5182979
631 63.0 6.4962988
632 63.1 6.4745254
633 63.2 6.4529712
634 63.3 6.4316295
635 63.4 6.4104942
636 63.5 6.3895592
637 63.6 6.3688188
638 63.7 6.3482672
639 63.8 6.3278993
640 63.9 6.3077097
641 64.0 6.2876934
642 64.1 6.2678456
643 64.2 6.2481616
644 64.3 6.2286370
645 64.4 6.2092674
646 64.5 6.1900486
647 64.6 6.1709766
648 64.7 6.1520475
649 64.8 6.1332576
650 64.9 6.1146032
651 65.0 6.0960809
652 65.1 6.0776873
653 65.2 6.0594191
654 65.3 6.0412733
655 65.4 6.0232468
656 65.5 6.0053366
657 65.6 5.9875401
658 65.7 5.9698544
659 65.8 5.9522770
660 65.9 5.9348054
661 66.0 5.9174371
662 66.1 5.9001697
663 66.2 5.8830010
664 66.3 5.8659288
665 66.4 5.8489511
666 66.5 5.8320656
667 66.6 5.8152706
668 66.7 5.7985641
669 66.8 5.7819443
670 66.9 5.7654093
671 67.0 5.7489575
672 67.1 5.7325873
673 67.2 5.7162970
674 67.3 5.7000851
675 67.4 5.6839502
676 67.5 5.6678907
677 67.6 5.6519053
678 67.7 5.6359927
679 67.8 5.6201516
680 67.9 5.6043807
681 68.0 5.5886788
682 68.1 5.5730447
683 68.2 5.5574774
684 68.3 5.5419757
685 68.4 5.5265386
686 68.5 5.5111650
687 68.6 5.4958540
688 68.7 5.4806046
689 68.8 5.4654159
690 68.9 5.4502871
691 69.0 5.4352171
692 69.1 5.4202053
693 69.2 5.4052508
694 69.3 5.3903528
695 69.4 5.3755105
696 69.5 5.3607233
697 69.6 5.3459905
698 69.7 5.3313112
699 69.8 5.3166850
700 69.9 5.3021111
701 70.0 5.2875889
702 70.1 5.2731177
703 70.2 5.2586972
704 70.3 5.2443265
705 70.4 5.2300053
706 70.5 5.2157329
707 70.6 5.2015089
708 70.7 5.1873328
709 70.8 5.1732040
710 70.9 5.1591220
711 71.0 5.1450866
712 71.1 5.1310971
713 71.2 5.1171532
714 71.3 5.1032544
715 71.4 5.0894003
716 71.5 5.0755906
717 71.6 5.0618248
718 71.7 5.0481026
719 71.8 5.0344236
720 71.9 5.0207875
721 72.0 5.0071939
Code
pk_curve(t = seq(0, 72, by = 0.1), model = "3cmt_bolus", ii = 24, addl = 5,
params = list(CL = 0.25, V1 = 25, V2 = 50, V3 = 100, Q2 = 1, Q3 = 0.1))
Output
t cp
1 0.0 24.000000
2 0.1 23.870845
3 0.2 23.742577
4 0.3 23.615190
5 0.4 23.488676
6 0.5 23.363031
7 0.6 23.238248
8 0.7 23.114321
9 0.8 22.991244
10 0.9 22.869011
11 1.0 22.747617
12 1.1 22.627055
13 1.2 22.507320
14 1.3 22.388405
15 1.4 22.270306
16 1.5 22.153016
17 1.6 22.036530
18 1.7 21.920843
19 1.8 21.805948
20 1.9 21.691840
21 2.0 21.578514
22 2.1 21.465964
23 2.2 21.354185
24 2.3 21.243171
25 2.4 21.132918
26 2.5 21.023419
27 2.6 20.914670
28 2.7 20.806665
29 2.8 20.699399
30 2.9 20.592867
31 3.0 20.487064
32 3.1 20.381985
33 3.2 20.277625
34 3.3 20.173978
35 3.4 20.071040
36 3.5 19.968806
37 3.6 19.867270
38 3.7 19.766429
39 3.8 19.666277
40 3.9 19.566809
41 4.0 19.468021
42 4.1 19.369907
43 4.2 19.272464
44 4.3 19.175686
45 4.4 19.079570
46 4.5 18.984109
47 4.6 18.889300
48 4.7 18.795138
49 4.8 18.701619
50 4.9 18.608738
51 5.0 18.516491
52 5.1 18.424873
53 5.2 18.333880
54 5.3 18.243507
55 5.4 18.153750
56 5.5 18.064606
57 5.6 17.976069
58 5.7 17.888136
59 5.8 17.800801
60 5.9 17.714062
61 6.0 17.627914
62 6.1 17.542352
63 6.2 17.457373
64 6.3 17.372973
65 6.4 17.289147
66 6.5 17.205892
67 6.6 17.123204
68 6.7 17.041078
69 6.8 16.959511
70 6.9 16.878498
71 7.0 16.798037
72 7.1 16.718123
73 7.2 16.638752
74 7.3 16.559920
75 7.4 16.481625
76 7.5 16.403861
77 7.6 16.326626
78 7.7 16.249916
79 7.8 16.173726
80 7.9 16.098054
81 8.0 16.022895
82 8.1 15.948247
83 8.2 15.874105
84 8.3 15.800467
85 8.4 15.727328
86 8.5 15.654685
87 8.6 15.582535
88 8.7 15.510874
89 8.8 15.439699
90 8.9 15.369006
91 9.0 15.298792
92 9.1 15.229054
93 9.2 15.159789
94 9.3 15.090992
95 9.4 15.022662
96 9.5 14.954794
97 9.6 14.887385
98 9.7 14.820433
99 9.8 14.753933
100 9.9 14.687884
101 10.0 14.622281
102 10.1 14.557121
103 10.2 14.492403
104 10.3 14.428121
105 10.4 14.364274
106 10.5 14.300859
107 10.6 14.237872
108 10.7 14.175310
109 10.8 14.113171
110 10.9 14.051451
111 11.0 13.990147
112 11.1 13.929258
113 11.2 13.868779
114 11.3 13.808708
115 11.4 13.749042
116 11.5 13.689778
117 11.6 13.630914
118 11.7 13.572446
119 11.8 13.514373
120 11.9 13.456690
121 12.0 13.399396
122 12.1 13.342488
123 12.2 13.285962
124 12.3 13.229817
125 12.4 13.174050
126 12.5 13.118658
127 12.6 13.063638
128 12.7 13.008989
129 12.8 12.954706
130 12.9 12.900788
131 13.0 12.847233
132 13.1 12.794037
133 13.2 12.741199
134 13.3 12.688715
135 13.4 12.636583
136 13.5 12.584801
137 13.6 12.533367
138 13.7 12.482277
139 13.8 12.431530
140 13.9 12.381123
141 14.0 12.331054
142 14.1 12.281320
143 14.2 12.231919
144 14.3 12.182849
145 14.4 12.134108
146 14.5 12.085693
147 14.6 12.037601
148 14.7 11.989831
149 14.8 11.942381
150 14.9 11.895248
151 15.0 11.848430
152 15.1 11.801924
153 15.2 11.755730
154 15.3 11.709843
155 15.4 11.664263
156 15.5 11.618987
157 15.6 11.574014
158 15.7 11.529340
159 15.8 11.484964
160 15.9 11.440884
161 16.0 11.397097
162 16.1 11.353602
163 16.2 11.310397
164 16.3 11.267480
165 16.4 11.224848
166 16.5 11.182499
167 16.6 11.140433
168 16.7 11.098646
169 16.8 11.057137
170 16.9 11.015904
171 17.0 10.974944
172 17.1 10.934257
173 17.2 10.893840
174 17.3 10.853691
175 17.4 10.813808
176 17.5 10.774190
177 17.6 10.734835
178 17.7 10.695740
179 17.8 10.656905
180 17.9 10.618326
181 18.0 10.580004
182 18.1 10.541934
183 18.2 10.504117
184 18.3 10.466550
185 18.4 10.429231
186 18.5 10.392159
187 18.6 10.355332
188 18.7 10.318748
189 18.8 10.282406
190 18.9 10.246304
191 19.0 10.210439
192 19.1 10.174812
193 19.2 10.139419
194 19.3 10.104260
195 19.4 10.069332
196 19.5 10.034634
197 19.6 10.000165
198 19.7 9.965923
199 19.8 9.931906
200 19.9 9.898112
201 20.0 9.864541
202 20.1 9.831190
203 20.2 9.798059
204 20.3 9.765145
205 20.4 9.732447
206 20.5 9.699964
207 20.6 9.667693
208 20.7 9.635634
209 20.8 9.603786
210 20.9 9.572146
211 21.0 9.540713
212 21.1 9.509486
213 21.2 9.478463
214 21.3 9.447643
215 21.4 9.417025
216 21.5 9.386606
217 21.6 9.356387
218 21.7 9.326364
219 21.8 9.296538
220 21.9 9.266906
221 22.0 9.237468
222 22.1 9.208221
223 22.2 9.179165
224 22.3 9.150298
225 22.4 9.121619
226 22.5 9.093127
227 22.6 9.064820
228 22.7 9.036697
229 22.8 9.008756
230 22.9 8.980997
231 23.0 8.953419
232 23.1 8.926019
233 23.2 8.898797
234 23.3 8.871752
235 23.4 8.844881
236 23.5 8.818185
237 23.6 8.791662
238 23.7 8.765310
239 23.8 8.739129
240 23.9 8.713117
241 24.0 32.687273
242 24.1 32.532441
243 24.2 32.378662
244 24.3 32.225928
245 24.4 32.074231
246 24.5 31.923565
247 24.6 31.773922
248 24.7 31.625295
249 24.8 31.477677
250 24.9 31.331062
251 25.0 31.185441
252 25.1 31.040809
253 25.2 30.897158
254 25.3 30.754481
255 25.4 30.612772
256 25.5 30.472024
257 25.6 30.332230
258 25.7 30.193384
259 25.8 30.055478
260 25.9 29.918507
261 26.0 29.782464
262 26.1 29.647342
263 26.2 29.513135
264 26.3 29.379837
265 26.4 29.247441
266 26.5 29.115941
267 26.6 28.985331
268 26.7 28.855605
269 26.8 28.726756
270 26.9 28.598778
271 27.0 28.471665
272 27.1 28.345412
273 27.2 28.220011
274 27.3 28.095458
275 27.4 27.971747
276 27.5 27.848871
277 27.6 27.726824
278 27.7 27.605602
279 27.8 27.485197
280 27.9 27.365605
281 28.0 27.246820
282 28.1 27.128836
283 28.2 27.011648
284 28.3 26.895250
285 28.4 26.779636
286 28.5 26.664802
287 28.6 26.550741
288 28.7 26.437448
289 28.8 26.324918
290 28.9 26.213146
291 29.0 26.102127
292 29.1 25.991854
293 29.2 25.882323
294 29.3 25.773529
295 29.4 25.665467
296 29.5 25.558131
297 29.6 25.451517
298 29.7 25.345619
299 29.8 25.240432
300 29.9 25.135952
301 30.0 25.032174
302 30.1 24.929092
303 30.2 24.826702
304 30.3 24.724999
305 30.4 24.623978
306 30.5 24.523635
307 30.6 24.423964
308 30.7 24.324962
309 30.8 24.226623
310 30.9 24.128943
311 31.0 24.031917
312 31.1 23.935540
313 31.2 23.839809
314 31.3 23.744719
315 31.4 23.650264
316 31.5 23.556442
317 31.6 23.463246
318 31.7 23.370674
319 31.8 23.278721
320 31.9 23.187381
321 32.0 23.096652
322 32.1 23.006529
323 32.2 22.917007
324 32.3 22.828083
325 32.4 22.739752
326 32.5 22.652010
327 32.6 22.564853
328 32.7 22.478277
329 32.8 22.392278
330 32.9 22.306852
331 33.0 22.221995
332 33.1 22.137703
333 33.2 22.053971
334 33.3 21.970797
335 33.4 21.888176
336 33.5 21.806105
337 33.6 21.724579
338 33.7 21.643595
339 33.8 21.563149
340 33.9 21.483237
341 34.0 21.403856
342 34.1 21.325001
343 34.2 21.246670
344 34.3 21.168858
345 34.4 21.091563
346 34.5 21.014779
347 34.6 20.938505
348 34.7 20.862735
349 34.8 20.787467
350 34.9 20.712698
351 35.0 20.638423
352 35.1 20.564640
353 35.2 20.491344
354 35.3 20.418533
355 35.4 20.346204
356 35.5 20.274351
357 35.6 20.202974
358 35.7 20.132067
359 35.8 20.061629
360 35.9 19.991655
361 36.0 19.922143
362 36.1 19.853088
363 36.2 19.784489
364 36.3 19.716342
365 36.4 19.648643
366 36.5 19.581390
367 36.6 19.514579
368 36.7 19.448208
369 36.8 19.382273
370 36.9 19.316771
371 37.0 19.251700
372 37.1 19.187056
373 37.2 19.122836
374 37.3 19.059038
375 37.4 18.995658
376 37.5 18.932694
377 37.6 18.870143
378 37.7 18.808001
379 37.8 18.746266
380 37.9 18.684935
381 38.0 18.624006
382 38.1 18.563475
383 38.2 18.503340
384 38.3 18.443597
385 38.4 18.384245
386 38.5 18.325281
387 38.6 18.266702
388 38.7 18.208504
389 38.8 18.150686
390 38.9 18.093245
391 39.0 18.036179
392 39.1 17.979484
393 39.2 17.923158
394 39.3 17.867198
395 39.4 17.811603
396 39.5 17.756369
397 39.6 17.701494
398 39.7 17.646975
399 39.8 17.592810
400 39.9 17.538997
401 40.0 17.485533
402 40.1 17.432416
403 40.2 17.379642
404 40.3 17.327211
405 40.4 17.275119
406 40.5 17.223364
407 40.6 17.171944
408 40.7 17.120856
409 40.8 17.070099
410 40.9 17.019669
411 41.0 16.969565
412 41.1 16.919784
413 41.2 16.870324
414 41.3 16.821183
415 41.4 16.772358
416 41.5 16.723848
417 41.6 16.675650
418 41.7 16.627763
419 41.8 16.580183
420 41.9 16.532909
421 42.0 16.485938
422 42.1 16.439269
423 42.2 16.392900
424 42.3 16.346828
425 42.4 16.301051
426 42.5 16.255567
427 42.6 16.210375
428 42.7 16.165471
429 42.8 16.120855
430 42.9 16.076524
431 43.0 16.032477
432 43.1 15.988710
433 43.2 15.945223
434 43.3 15.902013
435 43.4 15.859079
436 43.5 15.816418
437 43.6 15.774029
438 43.7 15.731909
439 43.8 15.690058
440 43.9 15.648472
441 44.0 15.607150
442 44.1 15.566091
443 44.2 15.525293
444 44.3 15.484753
445 44.4 15.444469
446 44.5 15.404441
447 44.6 15.364667
448 44.7 15.325144
449 44.8 15.285871
450 44.9 15.246845
451 45.0 15.208067
452 45.1 15.169533
453 45.2 15.131242
454 45.3 15.093192
455 45.4 15.055382
456 45.5 15.017810
457 45.6 14.980474
458 45.7 14.943373
459 45.8 14.906505
460 45.9 14.869868
461 46.0 14.833461
462 46.1 14.797282
463 46.2 14.761330
464 46.3 14.725603
465 46.4 14.690100
466 46.5 14.654819
467 46.6 14.619758
468 46.7 14.584916
469 46.8 14.550291
470 46.9 14.515882
471 47.0 14.481688
472 47.1 14.447706
473 47.2 14.413936
474 47.3 14.380376
475 47.4 14.347025
476 47.5 14.313880
477 47.6 14.280941
478 47.7 14.248206
479 47.8 14.215675
480 47.9 14.183344
481 48.0 38.151213
482 48.1 37.990127
483 48.2 37.830124
484 48.3 37.671198
485 48.4 37.513340
486 48.5 37.356543
487 48.6 37.200801
488 48.7 37.046105
489 48.8 36.892448
490 48.9 36.739824
491 49.0 36.588224
492 49.1 36.437642
493 49.2 36.288071
494 49.3 36.139503
495 49.4 35.991932
496 49.5 35.845351
497 49.6 35.699753
498 49.7 35.555130
499 49.8 35.411477
500 49.9 35.268786
501 50.0 35.127050
502 50.1 34.986264
503 50.2 34.846420
504 50.3 34.707512
505 50.4 34.569534
506 50.5 34.432478
507 50.6 34.296339
508 50.7 34.161110
509 50.8 34.026785
510 50.9 33.893357
511 51.0 33.760821
512 51.1 33.629169
513 51.2 33.498397
514 51.3 33.368497
515 51.4 33.239463
516 51.5 33.111291
517 51.6 32.983973
518 51.7 32.857504
519 51.8 32.731877
520 51.9 32.607088
521 52.0 32.483129
522 52.1 32.359996
523 52.2 32.237682
524 52.3 32.116183
525 52.4 31.995491
526 52.5 31.875602
527 52.6 31.756510
528 52.7 31.638210
529 52.8 31.520696
530 52.9 31.403961
531 53.0 31.288002
532 53.1 31.172813
533 53.2 31.058388
534 53.3 30.944722
535 53.4 30.831810
536 53.5 30.719646
537 53.6 30.608225
538 53.7 30.497542
539 53.8 30.387593
540 53.9 30.278371
541 54.0 30.169872
542 54.1 30.062091
543 54.2 29.955022
544 54.3 29.848661
545 54.4 29.743003
546 54.5 29.638043
547 54.6 29.533777
548 54.7 29.430198
549 54.8 29.327303
550 54.9 29.225087
551 55.0 29.123545
552 55.1 29.022672
553 55.2 28.922464
554 55.3 28.822916
555 55.4 28.724023
556 55.5 28.625782
557 55.6 28.528187
558 55.7 28.431233
559 55.8 28.334917
560 55.9 28.239235
561 56.0 28.144180
562 56.1 28.049750
563 56.2 27.955940
564 56.3 27.862746
565 56.4 27.770162
566 56.5 27.678186
567 56.6 27.586813
568 56.7 27.496038
569 56.8 27.405858
570 56.9 27.316268
571 57.0 27.227264
572 57.1 27.138843
573 57.2 27.051000
574 57.3 26.963730
575 57.4 26.877031
576 57.5 26.790898
577 57.6 26.705327
578 57.7 26.620315
579 57.8 26.535857
580 57.9 26.451949
581 58.0 26.368589
582 58.1 26.285771
583 58.2 26.203492
584 58.3 26.121749
585 58.4 26.040538
586 58.5 25.959854
587 58.6 25.879695
588 58.7 25.800057
589 58.8 25.720935
590 58.9 25.642327
591 59.0 25.564229
592 59.1 25.486638
593 59.2 25.409549
594 59.3 25.332960
595 59.4 25.256866
596 59.5 25.181265
597 59.6 25.106153
598 59.7 25.031527
599 59.8 24.957383
600 59.9 24.883717
601 60.0 24.810528
602 60.1 24.737810
603 60.2 24.665562
604 60.3 24.593779
605 60.4 24.522459
606 60.5 24.451599
607 60.6 24.381194
608 60.7 24.311242
609 60.8 24.241740
610 60.9 24.172685
611 61.0 24.104073
612 61.1 24.035902
613 61.2 23.968168
614 61.3 23.900869
615 61.4 23.834000
616 61.5 23.767561
617 61.6 23.701546
618 61.7 23.635955
619 61.8 23.570782
620 61.9 23.506027
621 62.0 23.441685
622 62.1 23.377754
623 62.2 23.314230
624 62.3 23.251112
625 62.4 23.188397
626 62.5 23.126081
627 62.6 23.064161
628 62.7 23.002636
629 62.8 22.941502
630 62.9 22.880757
631 63.0 22.820397
632 63.1 22.760421
633 63.2 22.700825
634 63.3 22.641608
635 63.4 22.582765
636 63.5 22.524295
637 63.6 22.466195
638 63.7 22.408463
639 63.8 22.351096
640 63.9 22.294091
641 64.0 22.237446
642 64.1 22.181159
643 64.2 22.125226
644 64.3 22.069646
645 64.4 22.014417
646 64.5 21.959534
647 64.6 21.904997
648 64.7 21.850803
649 64.8 21.796949
650 64.9 21.743434
651 65.0 21.690254
652 65.1 21.637407
653 65.2 21.584892
654 65.3 21.532705
655 65.4 21.480845
656 65.5 21.429309
657 65.6 21.378095
658 65.7 21.327201
659 65.8 21.276625
660 65.9 21.226364
661 66.0 21.176416
662 66.1 21.126779
663 66.2 21.077451
664 66.3 21.028430
665 66.4 20.979713
666 66.5 20.931299
667 66.6 20.883185
668 66.7 20.835370
669 66.8 20.787850
670 66.9 20.740625
671 67.0 20.693692
672 67.1 20.647050
673 67.2 20.600695
674 67.3 20.554626
675 67.4 20.508842
676 67.5 20.463340
677 67.6 20.418118
678 67.7 20.373174
679 67.8 20.328507
680 67.9 20.284114
681 68.0 20.239993
682 68.1 20.196143
683 68.2 20.152563
684 68.3 20.109248
685 68.4 20.066200
686 68.5 20.023414
687 68.6 19.980889
688 68.7 19.938625
689 68.8 19.896618
690 68.9 19.854867
691 69.0 19.813370
692 69.1 19.772126
693 69.2 19.731133
694 69.3 19.690389
695 69.4 19.649892
696 69.5 19.609640
697 69.6 19.569633
698 69.7 19.529867
699 69.8 19.490342
700 69.9 19.451056
701 70.0 19.412007
702 70.1 19.373194
703 70.2 19.334615
704 70.3 19.296268
705 70.4 19.258152
706 70.5 19.220265
707 70.6 19.182605
708 70.7 19.145171
709 70.8 19.107962
710 70.9 19.070976
711 71.0 19.034211
712 71.1 18.997666
713 71.2 18.961339
714 71.3 18.925228
715 71.4 18.889333
716 71.5 18.853652
717 71.6 18.818183
718 71.7 18.782925
719 71.8 18.747876
720 71.9 18.713036
721 72.0 42.678401
Code
pk_curve(t = seq(0, 72, by = 0.1), model = "3cmt_oral", ii = 24, addl = 5,
params = list(CL = 0.25, V1 = 25, V2 = 50, V3 = 100, Q2 = 1, Q3 = 0.1, ka = 1))
Output
t cp
1 0.0 0.000000
2 0.1 2.277647
3 0.2 4.326300
4 0.3 6.167834
5 0.4 7.822042
6 0.5 9.306835
7 0.6 10.638416
8 0.7 11.831446
9 0.8 12.899193
10 0.9 13.853659
11 1.0 14.705705
12 1.1 15.465155
13 1.2 16.140901
14 1.3 16.740987
15 1.4 17.272691
16 1.5 17.742597
17 1.6 18.156662
18 1.7 18.520278
19 1.8 18.838320
20 1.9 19.115201
21 2.0 19.354913
22 2.1 19.561066
23 2.2 19.736927
24 2.3 19.885454
25 2.4 20.009318
26 2.5 20.110940
27 2.6 20.192507
28 2.7 20.256000
29 2.8 20.303208
30 2.9 20.335751
31 3.0 20.355095
32 3.1 20.362565
33 3.2 20.359359
34 3.3 20.346561
35 3.4 20.325153
36 3.5 20.296020
37 3.6 20.259964
38 3.7 20.217710
39 3.8 20.169915
40 3.9 20.117170
41 4.0 20.060012
42 4.1 19.998926
43 4.2 19.934347
44 4.3 19.866674
45 4.4 19.796263
46 4.5 19.723438
47 4.6 19.648490
48 4.7 19.571683
49 4.8 19.493256
50 4.9 19.413424
51 5.0 19.332381
52 5.1 19.250301
53 5.2 19.167345
54 5.3 19.083654
55 5.4 18.999356
56 5.5 18.914569
57 5.6 18.829397
58 5.7 18.743933
59 5.8 18.658264
60 5.9 18.572465
61 6.0 18.486605
62 6.1 18.400746
63 6.2 18.314944
64 6.3 18.229248
65 6.4 18.143703
66 6.5 18.058349
67 6.6 17.973223
68 6.7 17.888356
69 6.8 17.803776
70 6.9 17.719511
71 7.0 17.635581
72 7.1 17.552008
73 7.2 17.468810
74 7.3 17.386001
75 7.4 17.303598
76 7.5 17.221611
77 7.6 17.140051
78 7.7 17.058929
79 7.8 16.978251
80 7.9 16.898026
81 8.0 16.818259
82 8.1 16.738955
83 8.2 16.660118
84 8.3 16.581753
85 8.4 16.503862
86 8.5 16.426447
87 8.6 16.349510
88 8.7 16.273052
89 8.8 16.197075
90 8.9 16.121577
91 9.0 16.046560
92 9.1 15.972023
93 9.2 15.897966
94 9.3 15.824388
95 9.4 15.751287
96 9.5 15.678662
97 9.6 15.606512
98 9.7 15.534836
99 9.8 15.463631
100 9.9 15.392896
101 10.0 15.322628
102 10.1 15.252826
103 10.2 15.183486
104 10.3 15.114608
105 10.4 15.046188
106 10.5 14.978224
107 10.6 14.910714
108 10.7 14.843655
109 10.8 14.777044
110 10.9 14.710879
111 11.0 14.645158
112 11.1 14.579876
113 11.2 14.515033
114 11.3 14.450625
115 11.4 14.386649
116 11.5 14.323102
117 11.6 14.259983
118 11.7 14.197288
119 11.8 14.135014
120 11.9 14.073159
121 12.0 14.011719
122 12.1 13.950693
123 12.2 13.890077
124 12.3 13.829869
125 12.4 13.770066
126 12.5 13.710665
127 12.6 13.651664
128 12.7 13.593059
129 12.8 13.534849
130 12.9 13.477030
131 13.0 13.419600
132 13.1 13.362555
133 13.2 13.305895
134 13.3 13.249615
135 13.4 13.193714
136 13.5 13.138188
137 13.6 13.083036
138 13.7 13.028254
139 13.8 12.973840
140 13.9 12.919791
141 14.0 12.866105
142 14.1 12.812780
143 14.2 12.759812
144 14.3 12.707200
145 14.4 12.654941
146 14.5 12.603033
147 14.6 12.551472
148 14.7 12.500258
149 14.8 12.449386
150 14.9 12.398856
151 15.0 12.348664
152 15.1 12.298808
153 15.2 12.249286
154 15.3 12.200096
155 15.4 12.151235
156 15.5 12.102701
157 15.6 12.054492
158 15.7 12.006605
159 15.8 11.959038
160 15.9 11.911789
161 16.0 11.864856
162 16.1 11.818237
163 16.2 11.771929
164 16.3 11.725930
165 16.4 11.680238
166 16.5 11.634851
167 16.6 11.589767
168 16.7 11.544983
169 16.8 11.500499
170 16.9 11.456310
171 17.0 11.412417
172 17.1 11.368815
173 17.2 11.325504
174 17.3 11.282482
175 17.4 11.239745
176 17.5 11.197294
177 17.6 11.155124
178 17.7 11.113235
179 17.8 11.071625
180 17.9 11.030290
181 18.0 10.989231
182 18.1 10.948444
183 18.2 10.907928
184 18.3 10.867681
185 18.4 10.827702
186 18.5 10.787987
187 18.6 10.748535
188 18.7 10.709346
189 18.8 10.670415
190 18.9 10.631743
191 19.0 10.593327
192 19.1 10.555165
193 19.2 10.517256
194 19.3 10.479597
195 19.4 10.442188
196 19.5 10.405025
197 19.6 10.368109
198 19.7 10.331436
199 19.8 10.295006
200 19.9 10.258816
201 20.0 10.222864
202 20.1 10.187150
203 20.2 10.151672
204 20.3 10.116427
205 20.4 10.081415
206 20.5 10.046633
207 20.6 10.012080
208 20.7 9.977755
209 20.8 9.943656
210 20.9 9.909781
211 21.0 9.876128
212 21.1 9.842697
213 21.2 9.809485
214 21.3 9.776492
215 21.4 9.743715
216 21.5 9.711153
217 21.6 9.678805
218 21.7 9.646669
219 21.8 9.614744
220 21.9 9.583028
221 22.0 9.551519
222 22.1 9.520217
223 22.2 9.489119
224 22.3 9.458225
225 22.4 9.427533
226 22.5 9.397042
227 22.6 9.366750
228 22.7 9.336656
229 22.8 9.306758
230 22.9 9.277055
231 23.0 9.247546
232 23.1 9.218229
233 23.2 9.189103
234 23.3 9.160167
235 23.4 9.131420
236 23.5 9.102859
237 23.6 9.074485
238 23.7 9.046294
239 23.8 9.018287
240 23.9 8.990462
241 24.0 8.962818
242 24.1 11.213000
243 24.2 13.234366
244 24.3 15.048790
245 24.4 16.676064
246 24.5 18.134097
247 24.6 19.439091
248 24.7 20.605708
249 24.8 21.647211
250 24.9 22.575604
251 25.0 23.401744
252 25.1 24.135456
253 25.2 24.785631
254 25.3 25.360310
255 25.4 25.866770
256 25.5 26.311596
257 25.6 26.700743
258 25.7 27.039601
259 25.8 27.333044
260 25.9 27.585485
261 26.0 27.800913
262 26.1 27.982939
263 26.2 28.134828
264 26.3 28.259536
265 26.4 28.359735
266 26.5 28.437843
267 26.6 28.496048
268 26.7 28.536327
269 26.8 28.560470
270 26.9 28.570097
271 27.0 28.566670
272 27.1 28.551515
273 27.2 28.525829
274 27.3 28.490695
275 27.4 28.447092
276 27.5 28.395906
277 27.6 28.337938
278 27.7 28.273913
279 27.8 28.204484
280 27.9 28.130243
281 28.0 28.051725
282 28.1 27.969415
283 28.2 27.883748
284 28.3 27.795120
285 28.4 27.703887
286 28.5 27.610372
287 28.6 27.514865
288 28.7 27.417630
289 28.8 27.318904
290 28.9 27.218901
291 29.0 27.117814
292 29.1 27.015818
293 29.2 26.913071
294 29.3 26.809714
295 29.4 26.705875
296 29.5 26.601669
297 29.6 26.497200
298 29.7 26.392562
299 29.8 26.287838
300 29.9 26.183104
301 30.0 26.078429
302 30.1 25.973873
303 30.2 25.869490
304 30.3 25.765330
305 30.4 25.661438
306 30.5 25.557851
307 30.6 25.454605
308 30.7 25.351733
309 30.8 25.249260
310 30.9 25.147213
311 31.0 25.045613
312 31.1 24.944480
313 31.2 24.843830
314 31.3 24.743680
315 31.4 24.644042
316 31.5 24.544928
317 31.6 24.446348
318 31.7 24.348311
319 31.8 24.250823
320 31.9 24.153892
321 32.0 24.057523
322 32.1 23.961719
323 32.2 23.866486
324 32.3 23.771824
325 32.4 23.677738
326 32.5 23.584228
327 32.6 23.491295
328 32.7 23.398939
329 32.8 23.307162
330 32.9 23.215962
331 33.0 23.125340
332 33.1 23.035293
333 33.2 22.945821
334 33.3 22.856923
335 33.4 22.768595
336 33.5 22.680838
337 33.6 22.593648
338 33.7 22.507023
339 33.8 22.420962
340 33.9 22.335460
341 34.0 22.250516
342 34.1 22.166127
343 34.2 22.082290
344 34.3 21.999002
345 34.4 21.916260
346 34.5 21.834062
347 34.6 21.752403
348 34.7 21.671281
349 34.8 21.590693
350 34.9 21.510635
351 35.0 21.431104
352 35.1 21.352097
353 35.2 21.273612
354 35.3 21.195643
355 35.4 21.118188
356 35.5 21.041245
357 35.6 20.964809
358 35.7 20.888877
359 35.8 20.813446
360 35.9 20.738512
361 36.0 20.664073
362 36.1 20.590125
363 36.2 20.516665
364 36.3 20.443689
365 36.4 20.371194
366 36.5 20.299178
367 36.6 20.227636
368 36.7 20.156565
369 36.8 20.085963
370 36.9 20.015826
371 37.0 19.946151
372 37.1 19.876935
373 37.2 19.808174
374 37.3 19.739866
375 37.4 19.672008
376 37.5 19.604595
377 37.6 19.537626
378 37.7 19.471098
379 37.8 19.405006
380 37.9 19.339349
381 38.0 19.274122
382 38.1 19.209324
383 38.2 19.144951
384 38.3 19.081001
385 38.4 19.017470
386 38.5 18.954355
387 38.6 18.891654
388 38.7 18.829364
389 38.8 18.767481
390 38.9 18.706004
391 39.0 18.644929
392 39.1 18.584253
393 39.2 18.523974
394 39.3 18.464089
395 39.4 18.404595
396 39.5 18.345489
397 39.6 18.286770
398 39.7 18.228433
399 39.8 18.170477
400 39.9 18.112899
401 40.0 18.055696
402 40.1 17.998866
403 40.2 17.942405
404 40.3 17.886312
405 40.4 17.830584
406 40.5 17.775218
407 40.6 17.720212
408 40.7 17.665564
409 40.8 17.611270
410 40.9 17.557329
411 41.0 17.503737
412 41.1 17.450493
413 41.2 17.397595
414 41.3 17.345038
415 41.4 17.292823
416 41.5 17.240945
417 41.6 17.189403
418 41.7 17.138194
419 41.8 17.087316
420 41.9 17.036766
421 42.0 16.986543
422 42.1 16.936645
423 42.2 16.887068
424 42.3 16.837810
425 42.4 16.788870
426 42.5 16.740246
427 42.6 16.691934
428 42.7 16.643933
429 42.8 16.596241
430 42.9 16.548855
431 43.0 16.501774
432 43.1 16.454995
433 43.2 16.408516
434 43.3 16.362336
435 43.4 16.316451
436 43.5 16.270861
437 43.6 16.225562
438 43.7 16.180553
439 43.8 16.135833
440 43.9 16.091398
441 44.0 16.047247
442 44.1 16.003378
443 44.2 15.959789
444 44.3 15.916478
445 44.4 15.873443
446 44.5 15.830683
447 44.6 15.788194
448 44.7 15.745976
449 44.8 15.704027
450 44.9 15.662344
451 45.0 15.620927
452 45.1 15.579772
453 45.2 15.538878
454 45.3 15.498244
455 45.4 15.457867
456 45.5 15.417746
457 45.6 15.377879
458 45.7 15.338265
459 45.8 15.298900
460 45.9 15.259785
461 46.0 15.220916
462 46.1 15.182293
463 46.2 15.143914
464 46.3 15.105776
465 46.4 15.067879
466 46.5 15.030220
467 46.6 14.992798
468 46.7 14.955611
469 46.8 14.918658
470 46.9 14.881937
471 47.0 14.845447
472 47.1 14.809185
473 47.2 14.773150
474 47.3 14.737342
475 47.4 14.701757
476 47.5 14.666395
477 47.6 14.631253
478 47.7 14.596332
479 47.8 14.561628
480 47.9 14.527141
481 48.0 14.492868
482 48.1 16.736456
483 48.2 18.751262
484 48.3 20.559159
485 48.4 22.179940
486 48.5 23.631513
487 48.6 24.930080
488 48.7 26.090302
489 48.8 27.125443
490 48.9 28.047505
491 49.0 28.867347
492 49.1 29.594794
493 49.2 30.238733
494 49.3 30.807209
495 49.4 31.307498
496 49.5 31.746182
497 49.6 32.129218
498 49.7 32.461996
499 49.8 32.749390
500 49.9 32.995811
501 50.0 33.205249
502 50.1 33.381315
503 50.2 33.527273
504 50.3 33.646080
505 50.4 33.740407
506 50.5 33.812671
507 50.6 33.865061
508 50.7 33.899554
509 50.8 33.917939
510 50.9 33.921836
511 51.0 33.912707
512 51.1 33.891878
513 51.2 33.860545
514 51.3 33.819791
515 51.4 33.770596
516 51.5 33.713845
517 51.6 33.650339
518 51.7 33.580801
519 51.8 33.505886
520 51.9 33.426187
521 52.0 33.342236
522 52.1 33.254518
523 52.2 33.163470
524 52.3 33.069486
525 52.4 32.972922
526 52.5 32.874101
527 52.6 32.773314
528 52.7 32.670824
529 52.8 32.566867
530 52.9 32.461657
531 53.0 32.355389
532 53.1 32.248235
533 53.2 32.140354
534 53.3 32.031887
535 53.4 31.922961
536 53.5 31.813693
537 53.6 31.704185
538 53.7 31.594530
539 53.8 31.484814
540 53.9 31.375110
541 54.0 31.265487
542 54.1 31.156006
543 54.2 31.046721
544 54.3 30.937682
545 54.4 30.828931
546 54.5 30.720508
547 54.6 30.612449
548 54.7 30.504784
549 54.8 30.397541
550 54.9 30.290744
551 55.0 30.184416
552 55.1 30.078576
553 55.2 29.973241
554 55.3 29.868425
555 55.4 29.764143
556 55.5 29.660405
557 55.6 29.557221
558 55.7 29.454601
559 55.8 29.352550
560 55.9 29.251076
561 56.0 29.150183
562 56.1 29.049877
563 56.2 28.950159
564 56.3 28.851034
565 56.4 28.752502
566 56.5 28.654566
567 56.6 28.557226
568 56.7 28.460483
569 56.8 28.364337
570 56.9 28.268787
571 57.0 28.173833
572 57.1 28.079473
573 57.2 27.985706
574 57.3 27.892531
575 57.4 27.799946
576 57.5 27.707948
577 57.6 27.616535
578 57.7 27.525705
579 57.8 27.435456
580 57.9 27.345785
581 58.0 27.256688
582 58.1 27.168164
583 58.2 27.080209
584 58.3 26.992819
585 58.4 26.905993
586 58.5 26.819727
587 58.6 26.734018
588 58.7 26.648862
589 58.8 26.564256
590 58.9 26.480196
591 59.0 26.396681
592 59.1 26.313705
593 59.2 26.231266
594 59.3 26.149360
595 59.4 26.067985
596 59.5 25.987136
597 59.6 25.906810
598 59.7 25.827003
599 59.8 25.747713
600 59.9 25.668936
601 60.0 25.590668
602 60.1 25.512907
603 60.2 25.435648
604 60.3 25.358888
605 60.4 25.282625
606 60.5 25.206854
607 60.6 25.131573
608 60.7 25.056777
609 60.8 24.982465
610 60.9 24.908631
611 61.0 24.835274
612 61.1 24.762390
613 61.2 24.689976
614 61.3 24.618027
615 61.4 24.546543
616 61.5 24.475518
617 61.6 24.404950
618 61.7 24.334836
619 61.8 24.265173
620 61.9 24.195957
621 62.0 24.127186
622 62.1 24.058856
623 62.2 23.990964
624 62.3 23.923508
625 62.4 23.856484
626 62.5 23.789890
627 62.6 23.723721
628 62.7 23.657977
629 62.8 23.592652
630 62.9 23.527746
631 63.0 23.463254
632 63.1 23.399173
633 63.2 23.335502
634 63.3 23.272237
635 63.4 23.209375
636 63.5 23.146914
637 63.6 23.084851
638 63.7 23.023182
639 63.8 22.961906
640 63.9 22.901019
641 64.0 22.840519
642 64.1 22.780404
643 64.2 22.720670
644 64.3 22.661314
645 64.4 22.602335
646 64.5 22.543730
647 64.6 22.485495
648 64.7 22.427629
649 64.8 22.370129
650 64.9 22.312992
651 65.0 22.256217
652 65.1 22.199799
653 65.2 22.143737
654 65.3 22.088029
655 65.4 22.032672
656 65.5 21.977663
657 65.6 21.923000
658 65.7 21.868681
659 65.8 21.814703
660 65.9 21.761065
661 66.0 21.707763
662 66.1 21.654795
663 66.2 21.602159
664 66.3 21.549852
665 66.4 21.497873
666 66.5 21.446220
667 66.6 21.394889
668 66.7 21.343878
669 66.8 21.293186
670 66.9 21.242810
671 67.0 21.192748
672 67.1 21.142998
673 67.2 21.093558
674 67.3 21.044425
675 67.4 20.995597
676 67.5 20.947073
677 67.6 20.898850
678 67.7 20.850926
679 67.8 20.803299
680 67.9 20.755967
681 68.0 20.708928
682 68.1 20.662179
683 68.2 20.615720
684 68.3 20.569547
685 68.4 20.523659
686 68.5 20.478055
687 68.6 20.432731
688 68.7 20.387686
689 68.8 20.342918
690 68.9 20.298425
691 69.0 20.254206
692 69.1 20.210257
693 69.2 20.166579
694 69.3 20.123168
695 69.4 20.080022
696 69.5 20.037141
697 69.6 19.994522
698 69.7 19.952162
699 69.8 19.910062
700 69.9 19.868218
701 70.0 19.826629
702 70.1 19.785293
703 70.2 19.744209
704 70.3 19.703374
705 70.4 19.662787
706 70.5 19.622446
707 70.6 19.582350
708 70.7 19.542497
709 70.8 19.502884
710 70.9 19.463512
711 71.0 19.424377
712 71.1 19.385478
713 71.2 19.346814
714 71.3 19.308382
715 71.4 19.270182
716 71.5 19.232212
717 71.6 19.194470
718 71.7 19.156954
719 71.8 19.119663
720 71.9 19.082596
721 72.0 19.045751
Code
pk_curve(t = seq(0, 72, by = 0.1), model = "3cmt_infusion", ii = 24, addl = 5,
params = list(CL = 0.25, V1 = 25, V2 = 50, V3 = 100, Q2 = 1, Q3 = 0.1, tinf = 3))
Output
t cp
1 0.0 0.000000
2 0.1 0.797845
3 0.2 1.591400
4 0.3 2.380693
5 0.4 3.165755
6 0.5 3.946615
7 0.6 4.723300
8 0.7 5.495841
9 0.8 6.264264
10 0.9 7.028600
11 1.0 7.788874
12 1.1 8.545117
13 1.2 9.297354
14 1.3 10.045614
15 1.4 10.789923
16 1.5 11.530310
17 1.6 12.266800
18 1.7 12.999421
19 1.8 13.728198
20 1.9 14.453159
21 2.0 15.174330
22 2.1 15.891736
23 2.2 16.605403
24 2.3 17.315356
25 2.4 18.021622
26 2.5 18.724226
27 2.6 19.423192
28 2.7 20.118546
29 2.8 20.810311
30 2.9 21.498514
31 3.0 22.183177
32 3.1 22.066481
33 3.2 21.950585
34 3.3 21.835482
35 3.4 21.721169
36 3.5 21.607638
37 3.6 21.494885
38 3.7 21.382904
39 3.8 21.271691
40 3.9 21.161238
41 4.0 21.051542
42 4.1 20.942597
43 4.2 20.834397
44 4.3 20.726938
45 4.4 20.620214
46 4.5 20.514221
47 4.6 20.408952
48 4.7 20.304403
49 4.8 20.200570
50 4.9 20.097447
51 5.0 19.995028
52 5.1 19.893310
53 5.2 19.792287
54 5.3 19.691955
55 5.4 19.592308
56 5.5 19.493342
57 5.6 19.395052
58 5.7 19.297434
59 5.8 19.200482
60 5.9 19.104192
61 6.0 19.008560
62 6.1 18.913581
63 6.2 18.819250
64 6.3 18.725562
65 6.4 18.632515
66 6.5 18.540101
67 6.6 18.448319
68 6.7 18.357162
69 6.8 18.266627
70 6.9 18.176710
71 7.0 18.087405
72 7.1 17.998709
73 7.2 17.910618
74 7.3 17.823127
75 7.4 17.736232
76 7.5 17.649929
77 7.6 17.564214
78 7.7 17.479083
79 7.8 17.394532
80 7.9 17.310556
81 8.0 17.227151
82 8.1 17.144315
83 8.2 17.062042
84 8.3 16.980328
85 8.4 16.899171
86 8.5 16.818566
87 8.6 16.738508
88 8.7 16.658995
89 8.8 16.580023
90 8.9 16.501587
91 9.0 16.423685
92 9.1 16.346311
93 9.2 16.269463
94 9.3 16.193138
95 9.4 16.117330
96 9.5 16.042037
97 9.6 15.967256
98 9.7 15.892982
99 9.8 15.819212
100 9.9 15.745942
101 10.0 15.673169
102 10.1 15.600890
103 10.2 15.529102
104 10.3 15.457799
105 10.4 15.386980
106 10.5 15.316642
107 10.6 15.246779
108 10.7 15.177390
109 10.8 15.108471
110 10.9 15.040019
111 11.0 14.972030
112 11.1 14.904501
113 11.2 14.837429
114 11.3 14.770812
115 11.4 14.704644
116 11.5 14.638925
117 11.6 14.573650
118 11.7 14.508816
119 11.8 14.444420
120 11.9 14.380460
121 12.0 14.316931
122 12.1 14.253832
123 12.2 14.191159
124 12.3 14.128910
125 12.4 14.067080
126 12.5 14.005668
127 12.6 13.944670
128 12.7 13.884084
129 12.8 13.823906
130 12.9 13.764134
131 13.0 13.704766
132 13.1 13.645797
133 13.2 13.587226
134 13.3 13.529049
135 13.4 13.471264
136 13.5 13.413869
137 13.6 13.356860
138 13.7 13.300234
139 13.8 13.243990
140 13.9 13.188124
141 14.0 13.132634
142 14.1 13.077517
143 14.2 13.022770
144 14.3 12.968392
145 14.4 12.914379
146 14.5 12.860729
147 14.6 12.807439
148 14.7 12.754507
149 14.8 12.701931
150 14.9 12.649707
151 15.0 12.597834
152 15.1 12.546308
153 15.2 12.495129
154 15.3 12.444292
155 15.4 12.393796
156 15.5 12.343639
157 15.6 12.293817
158 15.7 12.244330
159 15.8 12.195173
160 15.9 12.146346
161 16.0 12.097846
162 16.1 12.049670
163 16.2 12.001816
164 16.3 11.954282
165 16.4 11.907066
166 16.5 11.860166
167 16.6 11.813579
168 16.7 11.767303
169 16.8 11.721336
170 16.9 11.675676
171 17.0 11.630321
172 17.1 11.585268
173 17.2 11.540516
174 17.3 11.496062
175 17.4 11.451904
176 17.5 11.408041
177 17.6 11.364470
178 17.7 11.321189
179 17.8 11.278197
180 17.9 11.235490
181 18.0 11.193068
182 18.1 11.150928
183 18.2 11.109068
184 18.3 11.067486
185 18.4 11.026181
186 18.5 10.985150
187 18.6 10.944392
188 18.7 10.903904
189 18.8 10.863685
190 18.9 10.823733
191 19.0 10.784046
192 19.1 10.744622
193 19.2 10.705459
194 19.3 10.666556
195 19.4 10.627911
196 19.5 10.589521
197 19.6 10.551386
198 19.7 10.513503
199 19.8 10.475870
200 19.9 10.438487
201 20.0 10.401350
202 20.1 10.364459
203 20.2 10.327812
204 20.3 10.291407
205 20.4 10.255242
206 20.5 10.219315
207 20.6 10.183626
208 20.7 10.148172
209 20.8 10.112952
210 20.9 10.077964
211 21.0 10.043206
212 21.1 10.008677
213 21.2 9.974375
214 21.3 9.940299
215 21.4 9.906448
216 21.5 9.872819
217 21.6 9.839410
218 21.7 9.806222
219 21.8 9.773251
220 21.9 9.740497
221 22.0 9.707957
222 22.1 9.675631
223 22.2 9.643517
224 22.3 9.611614
225 22.4 9.579919
226 22.5 9.548433
227 22.6 9.517152
228 22.7 9.486076
229 22.8 9.455203
230 22.9 9.424532
231 23.0 9.394061
232 23.1 9.363790
233 23.2 9.333716
234 23.3 9.303839
235 23.4 9.274156
236 23.5 9.244667
237 23.6 9.215371
238 23.7 9.186265
239 23.8 9.157349
240 23.9 9.128621
241 24.0 9.100080
242 24.1 9.869569
243 24.2 10.634953
244 24.3 11.396258
245 24.4 12.153514
246 24.5 12.906748
247 24.6 13.655987
248 24.7 14.401259
249 24.8 15.142592
250 24.9 15.880011
251 25.0 16.613544
252 25.1 17.343218
253 25.2 18.069059
254 25.3 18.791093
255 25.4 19.509347
256 25.5 20.223845
257 25.6 20.934615
258 25.7 21.641681
259 25.8 22.345069
260 25.9 23.044804
261 26.0 23.740911
262 26.1 24.433416
263 26.2 25.122341
264 26.3 25.807713
265 26.4 26.489555
266 26.5 27.167892
267 26.6 27.842747
268 26.7 28.514144
269 26.8 29.182107
270 26.9 29.846660
271 27.0 30.507826
272 27.1 30.367783
273 27.2 30.228688
274 27.3 30.090537
275 27.4 29.953322
276 27.5 29.817036
277 27.6 29.681673
278 27.7 29.547227
279 27.8 29.413692
280 27.9 29.281060
281 28.0 29.149326
282 28.1 29.018483
283 28.2 28.888525
284 28.3 28.759447
285 28.4 28.631241
286 28.5 28.503902
287 28.6 28.377424
288 28.7 28.251801
289 28.8 28.127027
290 28.9 28.003095
291 29.0 27.880001
292 29.1 27.757737
293 29.2 27.636300
294 29.3 27.515681
295 29.4 27.395877
296 29.5 27.276881
297 29.6 27.158688
298 29.7 27.041292
299 29.8 26.924687
300 29.9 26.808868
301 30.0 26.693830
302 30.1 26.579567
303 30.2 26.466074
304 30.3 26.353345
305 30.4 26.241375
306 30.5 26.130158
307 30.6 26.019691
308 30.7 25.909966
309 30.8 25.800980
310 30.9 25.692726
311 31.0 25.585200
312 31.1 25.478397
313 31.2 25.372312
314 31.3 25.266940
315 31.4 25.162275
316 31.5 25.058313
317 31.6 24.955050
318 31.7 24.852479
319 31.8 24.750596
320 31.9 24.649397
321 32.0 24.548877
322 32.1 24.449031
323 32.2 24.349854
324 32.3 24.251342
325 32.4 24.153489
326 32.5 24.056292
327 32.6 23.959746
328 32.7 23.863847
329 32.8 23.768589
330 32.9 23.673968
331 33.0 23.579981
332 33.1 23.486621
333 33.2 23.393886
334 33.3 23.301771
335 33.4 23.210272
336 33.5 23.119383
337 33.6 23.029102
338 33.7 22.939423
339 33.8 22.850342
340 33.9 22.761856
341 34.0 22.673961
342 34.1 22.586651
343 34.2 22.499923
344 34.3 22.413774
345 34.4 22.328198
346 34.5 22.243192
347 34.6 22.158752
348 34.7 22.074875
349 34.8 21.991555
350 34.9 21.908790
351 35.0 21.826575
352 35.1 21.744907
353 35.2 21.663781
354 35.3 21.583195
355 35.4 21.503143
356 35.5 21.423624
357 35.6 21.344632
358 35.7 21.266164
359 35.8 21.188216
360 35.9 21.110786
361 36.0 21.033869
362 36.1 20.957461
363 36.2 20.881560
364 36.3 20.806161
365 36.4 20.731262
366 36.5 20.656858
367 36.6 20.582946
368 36.7 20.509523
369 36.8 20.436586
370 36.9 20.364131
371 37.0 20.292154
372 37.1 20.220652
373 37.2 20.149623
374 37.3 20.079062
375 37.4 20.008967
376 37.5 19.939334
377 37.6 19.870160
378 37.7 19.801442
379 37.8 19.733177
380 37.9 19.665361
381 38.0 19.597992
382 38.1 19.531066
383 38.2 19.464580
384 38.3 19.398531
385 38.4 19.332916
386 38.5 19.267733
387 38.6 19.202977
388 38.7 19.138647
389 38.8 19.074739
390 38.9 19.011250
391 39.0 18.948177
392 39.1 18.885518
393 39.2 18.823269
394 39.3 18.761428
395 39.4 18.699992
396 39.5 18.638958
397 39.6 18.578323
398 39.7 18.518085
399 39.8 18.458240
400 39.9 18.398786
401 40.0 18.339721
402 40.1 18.281041
403 40.2 18.222744
404 40.3 18.164827
405 40.4 18.107288
406 40.5 18.050124
407 40.6 17.993332
408 40.7 17.936910
409 40.8 17.880855
410 40.9 17.825164
411 41.0 17.769836
412 41.1 17.714867
413 41.2 17.660256
414 41.3 17.605999
415 41.4 17.552094
416 41.5 17.498539
417 41.6 17.445331
418 41.7 17.392468
419 41.8 17.339947
420 41.9 17.287767
421 42.0 17.235924
422 42.1 17.184417
423 42.2 17.133243
424 42.3 17.082399
425 42.4 17.031884
426 42.5 16.981695
427 42.6 16.931830
428 42.7 16.882286
429 42.8 16.833062
430 42.9 16.784155
431 43.0 16.735563
432 43.1 16.687284
433 43.2 16.639315
434 43.3 16.591655
435 43.4 16.544301
436 43.5 16.497252
437 43.6 16.450504
438 43.7 16.404057
439 43.8 16.357907
440 43.9 16.312053
441 44.0 16.266493
442 44.1 16.221225
443 44.2 16.176246
444 44.3 16.131556
445 44.4 16.087150
446 44.5 16.043029
447 44.6 15.999189
448 44.7 15.955629
449 44.8 15.912347
450 44.9 15.869341
451 45.0 15.826609
452 45.1 15.784149
453 45.2 15.741959
454 45.3 15.700038
455 45.4 15.658383
456 45.5 15.616993
457 45.6 15.575865
458 45.7 15.534999
459 45.8 15.494392
460 45.9 15.454042
461 46.0 15.413947
462 46.1 15.374107
463 46.2 15.334518
464 46.3 15.295180
465 46.4 15.256090
466 46.5 15.217247
467 46.6 15.178650
468 46.7 15.140295
469 46.8 15.102183
470 46.9 15.064310
471 47.0 15.026676
472 47.1 14.989279
473 47.2 14.952117
474 47.3 14.915188
475 47.4 14.878491
476 47.5 14.842024
477 47.6 14.805786
478 47.7 14.769776
479 47.8 14.733990
480 47.9 14.698429
481 48.0 14.663090
482 48.1 15.425816
483 48.2 16.184472
484 48.3 16.939084
485 48.4 17.689681
486 48.5 18.436291
487 48.6 19.178939
488 48.7 19.917655
489 48.8 20.652464
490 48.9 21.383393
491 49.0 22.110470
492 49.1 22.833720
493 49.2 23.553169
494 49.3 24.268844
495 49.4 24.980771
496 49.5 25.688975
497 49.6 26.393482
498 49.7 27.094316
499 49.8 27.791504
500 49.9 28.485070
501 50.0 29.175039
502 50.1 29.861436
503 50.2 30.544285
504 50.3 31.223610
505 50.4 31.899435
506 50.5 32.571785
507 50.6 33.240683
508 50.7 33.906153
509 50.8 34.568218
510 50.9 35.226901
511 51.0 35.882226
512 51.1 35.736371
513 51.2 35.591493
514 51.3 35.447587
515 51.4 35.304644
516 51.5 35.162659
517 51.6 35.021625
518 51.7 34.881535
519 51.8 34.742383
520 51.9 34.604162
521 52.0 34.466865
522 52.1 34.330487
523 52.2 34.195020
524 52.3 34.060459
525 52.4 33.926796
526 52.5 33.794027
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