sim_trial: Simulates a single trial

In labja/RollingSix: Rolling Six Design for Phase I Dose-Finding Trials

Simulates a single trial

Description

Simulates a single trial

Usage

sim_trial(
  design,
  tox_rates,
  cohortsize = 1,
  start = 1,
  parallel_recruit = TRUE,
  futime,
  accrual
)

Arguments

design	The dose-finding design which is employed. Possible options are "RollingSix" for Rolling Six.
tox_rates	Vector of true toxicity rates for each dose level in ascending order
cohortsize	Number of patients in a cohort
start	Dose level to be used at the beginning of the trial
parallel_recruit	Whether recruitment is parallel or sequential. If FALSE recruitment is sequential i.e. recruitment is suspended until all DLT results are known
futime	Follow-up time in days
accrual	Expected number of patients to be recruited in a year

Value

res_dlt Data frame with dose level and DLT result for each patient

res_time Data frame with important time points in days since trial start for each patient

labja/RollingSix documentation built on June 1, 2022, 12:58 a.m.