GetDrugRef: Load and Process Drug Reference Profiles.

In lanagarmire/Asgard: A Single-cell Guided pipeline for Accurate Repurposing of Drugs

Load and Process Drug Reference Profiles.

Description

This function allows user to load in the tissue specific drug rank matrix.

Usage

GetDrugRef(drug.response.path = NULL, probe.to.genes = NULL, drug.info = NULL)

Arguments

drug.response.path	The local path and the name of the tissue specific drug rank matrix.
probe.to.genes	A data.frame contains gene IDs (the IDs used in drug rank matrix) and official gene symbol. This files was automately generated with drug rank matrix.
drug.info	A data.frame contains drug information. This file was automately generated with drug rank matrix.

Details

This function is a reverised version of get.cmap.ref from DrInsight package. The tissue specific drug rank matrix is tranformed from L1000data (GEO: GSE92742 and GSE70138) using PrepareReference function.

lanagarmire/Asgard documentation built on Jan. 25, 2024, 3:28 p.m.