TopDrug: Single Drug Selection for Individual Clusters.

In lanagarmire/Asgard: A Single-cell Guided pipeline for Accurate Repurposing of Drugs

Single Drug Selection for Individual Clusters.

Description

Select single drugs for every cell population by FDR and drug type, and summarize cell coverage for selected drugs.

Usage

TopDrug(
  SC.integrated = SC.data,
  Drug.data = Drug.ident.res,
  Drug.FDR = 0.1,
  FDA.drug.only = TRUE,
  Case = NULL
)

Arguments

SC.integrated	A Seurat object of aligned single cells.
Drug.data	Drug repurosing result from GetDrug function.
Drug.FDR	The FDR threshold to select drug. The default value is 0.1.
FDA.drug.only	logical; if TRUE, will only return FDA-approved drugs.
Case	An vector of case (diseased) samples.Only case sammples are involved in the calculation of coverage.

Details

Input raw drug repurosing result and return the top drugs with summary of cell coverage.

Value

A data frame of selected drugs with summary of cell coverage.

lanagarmire/Asgard documentation built on Jan. 25, 2024, 3:28 p.m.