nca.cal: Derive Common NCA parameters using single and multiple...

Description Usage Arguments Examples

Description

nca.cal()

Usage

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nca.cal(data, n_lambda = 3, id = "id", time = "time", dv = "dv",
  sort.by = NULL, ss.variable = "ss", sd_label_in_ss = NULL,
  ss_label_in_ss = NULL, tau = NULL, dose = NULL,
  partialAUC = NULL, partialConc = NULL)

Arguments

data

datset or data frame (ex:data=PKdatat)

n_lambda

number of points for estimating the Lambda

id

unique subject identifier

time

Sampling time after dose (TAD)

dv

Concentration

tau

Dose interval. As vector or numeric.

dose

Dose administered. As vector or numeric. Required to estimate CL and Vss

partialAUC

Time interval for partial AUC. Ex: c(0,6,0,12,6,12) for AUC0-6, AUC0-12 and AUC6-12

partialConc

Concentration at particular time (Ex:c(1,4) for concentration after 1 and 4 h)

dosing.regimen

PK profile profile flag (ex: single, sd, md ,ss).As vector or numeric. Note that only one prefile per dose is to be analyzed.

label.for.sd

Label to identify sd profile used in dosing.regimen. Need to compute the effective half-life

label.for.ss

Label to identify ss profile used in dosing.regimen. Need to compute the effective half-life

Examples

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p<-nca.cal(data=data, n_lambda = 3, id = "id", time = "time", dv = "dv", 
tau="ii",dose="dose",dosing.regimen = "ss",label.for.sd="single", partialAUC = NULL, partialConc = NULL)

leonpheng/lhtool documentation built on Dec. 16, 2019, 3:52 a.m.