MAnormal: Normal Gene expression data of glioblastoma patients
In mpru/BIMEGA: BIMEGA: BIvariate Methylation and Expression GAussian mixture model

Description Usage Format References See Also

Normal gene expression data of glioblastoma patients from the TCGA project and from Noushmehr et al., 2010, and Sturm et al., 2012. A set of 13 genes that have been shown in the literature to be involved in differential methylation in glioblastoma were selected as an example to try out BIMEGA.

1	data(MAcancer)

A numeric matrix with 13 rows (genes) and 10 columns (samples).

Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008 Oct 23; 455(7216):1061-8. doi: 10.1038/nature07385. Epub 2008 Sep 4. Erratum in: Nature. 2013 Feb 28;494(7438):506. PubMed PMID: 18772890; PubMed Central PMCID: PMC2671642.

Noushmehr,H. et al. (2010) Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer cell, 17, 510-22.

Sturm,D. et al. (2012) Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma. Cancer Cell, 22, 425-437.

TCGA: The Cancer Genome Atlas: http://cancergenome.nih.gov/

mpru/BIMEGA documentation built on May 23, 2019, 6:34 a.m.