facets-package: Cellular Fraction and Copy Numbers from Tumor Sequencing

In mskcc/facets: Cellular Fraction and Copy Numbers from Tumor Sequencing

Description

Algorithm to implement Fraction and Allelic Copy number Estimate from Tumor/normal Sequencing.

Details

FACETS stands for Fraction and Allelic Copy number Estimation from Tumor/normal Sequencing. It uses high coverage next generation sequencing data (whole exome or targeted) to estimate the total and integer allele specific copy numbers as well as the tumor purity and ploidy. The methodology is described in the reference paper.

Author(s)

Venkatraman E. Seshan and Ronglai Shen

Maintainer: Venkatraman E. Seshan <[e-mail]>

References

Shen, R and Seshan, VE (2016). FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing. Nucleic Acids Research https://doi.org/10.1093/nar/gkw520

mskcc/facets documentation built on Oct. 15, 2021, 3:12 p.m.