cats-package: Power calculation for a joint analysis of a two-stage case...

In nanxstats/cats: Joint Power Analysis for Non-Symmetric Two-Stage Case-Control Designs for SNP Data

Description

Power calculation for a joint analysis of a two-stage case control design for SNP data.

Author(s)

Anders Albrechtsen <[e-mail]>

References

Skol AD, Scott LJ, Abecasis GR, Boehnke M: Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat Genet 38: 209-213, 2006.

See Also

http://www.sph.umich.edu/csg/abecasis/CaTS/

Examples

# calculate the power under a multiplicative model using a
# two stage design and assuming a relative risk of 1.5
cats(
  freq = 0.2,
  ncases = 500, ncases2 = 500,
  ncontrols = 1000, ncontrols2 = 1000,
  risk = 1.5, multiplicative = 1
)

nanxstats/cats documentation built on Dec. 26, 2021, 2:17 a.m.