mutatedCopies | R Documentation |
Computes the maximum likelihood estimate of the number of mutated copies given the observed VAF
sq_hat = mutatedCopies(f_hat, n, qt, q2, alpha, e, d)
f_hat |
numeric vector of observed VAF where f_hat = 0 … 1 |
n |
integer vector of total number of reads covering mutated loci |
qt |
integer vector of total copy numbers |
q2 |
integer vector of major allele counts |
alpha |
numeric for the global cellular fraction where alpha = 0 … 1 |
e |
numeric for expected sequencing error where e = 0 … 1 |
d |
character string for the underlying distribution 'beta' or 'binomial' |
Integer vector of estimates of mutated copies
David Brown
brownd7@mskcc.org
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