protein.pathology: Métricas de cuantificación proteíca de muestras

In nekrum/NeurocienciasIntroData: Paquete con Datos y Tutorales de Análisis de Datos

Description

Valores de cuantificación de proteínas por Luminex, cuantificación de isoprostano y patología inmunohistoquímica de las muestras tisulares Estos datos son proporcionados por: © 2016 Allen Institute for Cell Science. Aging, Dementia and TBI. Available from: http://aging.brain-map.org/ Mas información sobre las técnicas de colecta y métodos en la Documentación.

Usage

protein.pathology

Format

A data frame with 377 rows and 33 variables:

donor_id

Donor number ID

donor_name

Deidentified ID corresponding to a unique ACT (Adult Changes in Thought) donor.

structure_id

Structure ID

structure_acronym

Structure acrony,

ihc_a_syn

Percentage of area covered by α-synuclein immunreactivity on fresh frozen tissue (25μm); identifies Lewy bodies and Lewy neurites.

ihc_tau2_ffpe

Percentage of area covered by Tau2 immunreactivity on formalin fixed, paraffin embedded tissue (5μm); identifies mature neurofibrillary tangles and dystrophic neurites.

ihc_at8_ffpe

Percentage of area covered by AT8 immunreactivity on formalin fixed, paraffin embedded tissue (5μm); identifies immature and mature neurofibrillary tangles, formed of tau phosphorylated at S202 and T205. Also identifies neurites, glial tangles, and inclusion bodies comprised of phosphorylated tau protein.

ihc_at8

Percentage of area covered by AT8 immunreactivity on fresh frozen tissue (25μm); identifies immature and mature neurofibrillary tangles, formed of tau phosphorylated at S202 and T205. Also identifies neurites, glial tangles, and inclusion bodies comprised of phosphorylated tau protein.

ihc_ptdp_43_ffpe

Percentage of area covered by phospho-TDP43 (TAR DNA binding protein) immunreactivity on formalin fixed, paraffin embedded tissue (5μm); identifies abnormally accumulated TDP43.

ihc_a_beta_ffpe

Percentage of area covered by Aβ immunreactivity on formalin fixed, paraffin embedded tissue (5μm); identifies both Aβ40 and Aβ42.

ihc_a_beta

Percentage of area covered by Aβ immunreactivity on fresh frozen tissue (25μm); identifies both Aβ40 and Aβ42.

ihc_iba1_ffpe

Percentage of area covered by IBA1 immunreactivity on formalin fixed, paraffin embedded tissue (5μm).

ihc_gfap_ffpe

Percentage of area covered by GFAP immunreactivity on formalin fixed, paraffin embedded tissue (5μm); identifies activated astrocytes.

ptau_ng_per_mg

Tau abnormally phosphorylated at threonine 181; abnormally phosphorylated tau plays an important role in tau aggregation and the pathological process in Alzheimer's disease; neurofibrillary tangles are comprised of hyperphosphorylated tau.

vegf_pg_per_mg

A growth factor that stimulates vasculogenesis and angiogenesis.

ab42_over_ab40_ratio

Ratio of Aβ40 to Aβ42.

tnf_a_pg_per_mg

A pro-inflammatory cytokine, produced primarily by macrophages, regulates inflammatory response, especially in acute phase.

tau_ng_per_mg

Microtubule binding protein predominantly expressed in neurons in the brain.

il_10_pg_per_mg

An anti-inflammatory cytokine produced primarily via downregulation of the expression of Th1 cytokines, MHC class II antigens, and the activation of macrophages.

isoprostane_pg_per_mg

Prostaglandin-like compounds produced by the reaction of free-radicals with arachidonic acid, they are considered reliable biomarkers and mediators of oxidative stress.

il_6_pg_per_mg

A pro-inflammatory cytokine that plays an important role in acute response of inflammation and B-cell maturation.

il_1b_pg_per_mg

A pro-inflammatory cytokine protein produced in response to inflammatory stimuli, it is an important mediator of the inflammatory response. Involved in cell proliferation, differentiation and apoptosis.

ptau_over_tau_ratio

Ratio of tau phosphorylated at threonine-181 to full length tau.

il_4_pg_per_mg

A pleiotropic cytokine, produced by activated T cells and mast cells, stimulates B-cell activation and T-cell proliferation. It plays a dominant role in development of allergic inflammation.

rantes_pg_per_mg

A chemokine belonging to the CC chemokine subfamily produced by epithelial and mesodermal cells. It plays an active role in recruiting leukocytes into inflammatory sites.

ab40_pg_per_mg

40-amino acid beta-amyloid peptide derived from the amyloid precursor protein (APP); found in amyloid plaques in aging and Alzheimer's disease.

a_syn_pg_per_mg

An abundant protein in presynaptic terminals in the brain, it is a major component of Lewy bodies, the pathological hallmark of Parkinson's disease (PD). Mutant forms of α-SNCA are associated with familial PD. It may also play a role in development of sporadic PD.

ifn_g_pg_per_mg

A prototype pro-inflammatory cytokine, critical for innate and adaptive immunity against viral and some bacterial infection via activation of macrophages and induction of class II MHC expression.

mcp_1_pg_per_mg

A chemokine of the CC subfamily that displays chemotactic activity for monocytes primarily to the sites of inflammation.

bdnf_pg_per_mg

A neurotrophic factor primarily produced in the brain, it promotes the growth and differentiation of neurons and synapses.

mip_1a_pg_per_mg

A chemokine of the CC subfamily with chemotactic and pro-inflammatory effects; crucial for immune responses.

il_7_pg_per_mg

A hematopoietic growth factor that stimulates the differentiation of pluripotent hematopoietic stem cells into lymphoid progenitor cells. It is important for lymphocyte differentiation, proliferation, and survival.

ab42_pg_per_mg

42 amino-acid beta-amyloid peptide derived from the amyloid precursor protein (APP); believed to be more amyloidogenic than the 40-amino acid form; found in amyloid plaques in aging and Alzheimer's disease.

Source

http://aging.brain-map.org/

nekrum/NeurocienciasIntroData documentation built on Nov. 25, 2020, 9:34 p.m.