fisherMethod: Fisher's method for meta-analysis

Description Usage Arguments Details Value Author(s) References See Also Examples

Description

Combine independent p-values using the minus log product

Usage

1

Arguments

x

is an array of independent p-values

Details

Considering a set of m independent significance tests, the resulted p-values are independent and uniformly distributed between 0 and 1 under the null hypothesis. Fisher's method uses the minus log product of the p-values as the summary statistic, which follows a chi-square distribution with 2m degrees of freedom. This chi-square distribution is used to calculate the combined p-value.

Value

combined p-value

Author(s)

Tin Nguyen and Sorin Draghici

References

[1] R. A. Fisher. Statistical methods for research workers. Oliver & Boyd, Edinburgh, 1925.

See Also

stoufferMethod, addCLT

Examples

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x <- rep(0,10)
fisherMethod(x)

x <- runif(10)
fisherMethod(x)

nguyentin/BLMA documentation built on May 23, 2019, 4:43 p.m.