nhejazi/biotmle: Targeted Learning with Moderated Statistics for Biomarker Discovery

This package facilitates the discovery of biomarkers from biological sequencing data (e.g., microarrays, RNA-seq) based on the associations of potential biomarkers with exposure and outcome variables by implementing an estimation procedure that combines a generalization of moderated statistics with targeted minimum loss-based estimates (TMLE) of causal parameters (e.g., Average Treatment Effect) whose estimators admit asymptotically linear representations (in terms of influence functions).

Getting started

Package details

AuthorNima Hejazi [aut, cre, cph], Alan Hubbard [aut, ths], Weixin Cai [ctb]
Bioconductor views DifferentialExpression GeneExpression ImmunoOncology Microarray RNASeq Sequencing
MaintainerNima Hejazi <[email protected]>
Licensefile LICENSE
Version1.7.2
URL https://code.nimahejazi.org/biotmle
Package repositoryView on GitHub
Installation Install the latest version of this package by entering the following in R:
install.packages("devtools")
library(devtools)
install_github("nhejazi/biotmle")
nhejazi/biotmle documentation built on Dec. 13, 2018, 5 a.m.