This package facilitates the discovery of biomarkers from biological sequencing data (e.g., microarrays, RNAseq) based on the associations of potential biomarkers with exposure and outcome variables by implementing an estimation procedure that combines a generalization of moderated statistics with asymptotically linear statistical parameters estimated via targeted minimum lossbased estimation (TMLE).
Package details 


Author  Nima Hejazi [aut, cre, cph], Alan Hubbard [aut], Weixin Cai [ctb] 
Bioconductor views  DifferentialExpression GeneExpression Microarray RNASeq Sequencing 
Maintainer  Nima Hejazi <[email protected]> 
License  file LICENSE 
Version  1.3.0 
URL  https://github.com/nhejazi/biotmle 
Package repository  View on GitHub 
Installation 
Install the latest version of this package by entering the following in R:

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