nlmixr2Est.pknca: Estimate starting parameters using PKNCA

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Estimate starting parameters using PKNCA

Description

Estimate starting parameters using PKNCA

Usage

## S3 method for class 'pknca'
nlmixr2Est(env, ...)

Arguments

env	Environment for the nlmixr2 estimation routines. This needs to have: - rxode2 ui object in '$ui' - data to fit in the estimation routine in '$data' - control for the estimation routine's control options in '$ui'
...	Other arguments provided to 'nlmixr2Est()' provided for flexibility but not currently used inside nlmixr

Details

Parameters are estimated as follows:

• ka 4 half-lives to Tmax but not higher than 3: log(2)/(tmax/4)

• vc Inverse of dose-normalized Cmax

• cl Estimated as the median clearance

• vp,vp22- and 4-fold the vc, respectively by default, controlled by the vpMult and vp2Mult arguments to pkncaControl

• q,q2 0.5- and 0.25-fold the cl, respectively by default, controlled by the qMult and q2Mult arguments to pkncaControl

The bounds for the parameter estimates are set to 10% of the first percentile and 10 times the 99th percentile. (For ka, the lower bound is set to the lower of 10% of the first percentile or 0.03 and the upper bound is not modified from 10 times the 99th percentile.)

Parameter estimation methods may be changed in a future version.

Value

A model with updated starting parameters. In the model a new element named "nca" will be available which includes the PKNCA results used for the calculation.

nlmixr2/babelmixr documentation built on Nov. 21, 2024, 3:16 a.m.