pkncaControl: PKNCA estimation control

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PKNCA estimation control

Description

PKNCA estimation control

Usage

pkncaControl(
  concu = NA_character_,
  doseu = NA_character_,
  timeu = NA_character_,
  volumeu = NA_character_,
  vpMult = 2,
  qMult = 1/2,
  vp2Mult = 4,
  q2Mult = 1/4,
  dvParam = "cp",
  groups = character(),
  sparse = FALSE,
  ncaData = NULL,
  ncaResults = NULL,
  rxControl = rxode2::rxControl()
)

Arguments

concu, doseu, timeu	concentration, dose, and time units from the source data (passed to PKNCA::pknca_units_table()).
volumeu	compartment volume for the model (if NULL, simplified units from source data will be used)
vpMult, qMult, vp2Mult, q2Mult	Multipliers for vc and cl to provide initial estimates for vp, q, vp2, and q2
dvParam	The parameter name in the model that should be modified for concentration unit conversions. It must be assigned on a line by itself, separate from the residual error model line.
groups	Grouping columns for NCA summaries by group (required if sparse = TRUE)
sparse	Are the concentration-time data sparse PK (commonly used in small nonclinical species or with terminal or difficult sampling) or dense PK (commonly used in clinical studies or larger nonclinical species)?
ncaData	Data to use for calculating NCA parameters. Typical use is when a subset of the original data are informative for NCA.
ncaResults	Already computed NCA results (a PKNCAresults object) to bypass automatic calculations. At least the following parameters must be calculated in the NCA: tmax, cmax.dn, cl.last
rxControl	Control options sent to rxode2::rxControl()

Value

A list of parameters

nlmixr2/babelmixr documentation built on Jan. 21, 2025, 7:38 p.m.