zeroRe: Set random effects and residual error to zero

In nlmixr2/rxode2: Facilities for Simulating from ODE-Based Models

Set random effects and residual error to zero

Description

Set random effects and residual error to zero

Usage

zeroRe(object, which = c("omega", "sigma"), fix = TRUE)

Arguments

object	The model to modify
which	The types of parameters to set to zero
fix	Should the parameters be fixed to the zero value?

Value

The object with some parameters set to zero

Author(s)

Bill Denney

See Also

Other Initial conditions: ini.rxUi()

Examples

one.compartment <- function() {
  ini({
    tka <- log(1.57); label("Ka")
    tcl <- log(2.72); label("Cl")
    tv <- log(31.5); label("V")
    eta.ka ~ 0.6
    eta.cl ~ 0.3
    eta.v ~ 0.1
    add.sd <- 0.7
  })
  model({
    ka <- exp(tka + eta.ka)
    cl <- exp(tcl + eta.cl)
    v <- exp(tv + eta.v)
    d/dt(depot) = -ka * depot
    d/dt(center) = ka * depot - cl / v * center
    cp = center / v
    cp ~ add(add.sd)
  })
}
zeroRe(one.compartment)

nlmixr2/rxode2 documentation built on Jan. 11, 2025, 8:48 a.m.