monolixControl: Monolix Controller for nlmixr

In nlmixrdevelopment/babelmixr:

Description

Monolix Controller for nlmixr

Usage

monolixControl(
  nbSSDoses = 7,
  stiff = FALSE,
  addProp = c("combined2", "combined1"),
  exploratoryautostop = FALSE,
  smoothingautostop = FALSE,
  simulatedannealing = TRUE,
  burniniterations = 5,
  smoothingiterations = 200,
  exploratoryiterations = 250,
  simulatedannealingiterations = 250,
  exploratoryinterval = 200,
  exploratoryalpha = 0,
  omegatau = 0.95,
  errormodeltau = 0.95,
  optimizationiterations = 20,
  optimizationtolerance = 1e-04,
  variability = c("none", "firstStage", "decreasing"),
  runCommand = getOption("babelmixr.monolix", "")
)

Arguments

nbSSDoses	Number of steady state doses (default 7)
stiff	boolean for using the stiff ODE solver
addProp	one of "combined1" and "combined2"; These are the two forms of additive+proportional errors supported by monolix/nonmem: combined1: transform(y)=transform(f)+(a+b*f^c)*eps combined2: transform(y)=transform(f)+(a^2+b^2*f^(2c))*eps
exploratoryautostop	logical to turn on or off exploratory phase auto-stop of SAEM (default 250)
exploratoryiterations	Number of iterations for exploratory phase (default 250)
simulatedannealingiterations	Number of burn in iterations
exploratoryinterval	Minimum number of interation in the exploratory phase (default 200)
runCommand	is a shell command to run monolix; You can specfy the default by options("babelmixr.monolix"="runMonolix %s") where the "%s" represents the monolix project file.

Value

A monolix control object

Author(s)

Matthew Fidler

nlmixrdevelopment/babelmixr documentation built on March 1, 2021, 10:09 p.m.