R/data.R

In parsifal9/PPspectra: Energy Spectra and Coherence for Point Processes

#' Two samples of viral integration sites.
#'
#' X-linked severe combined immunodeficiency (SCID-X1) is an inherited
#' disease caused by inactivating mutations in the gene
#' encoding the interleukin 2 receptor common gamma chain (IL2RG), which is located on the X-chromosome.
#' SCID-X1 gene therapy clinical trials were conducted in Paris and London. The clinical results differed and the
#' question was raised of the effect of different transduction conditions on transduced cells.  Human peripheral blood (PB)
#' CD34+ cells were transduced with $gamma$-retroviral vectors according to the transduction protocols employed in the
#' initial clinical trials.  14 Cells cultured under London trial conditions showed relatively higher retention of CD34
#' expression at the completion of the transduction period, compared to a loss of CD34-positivity in about half the cells
#' transduced under the Paris trial conditions. Paris conditions, on the other hand, promoted higher levels of both
#' proliferation and transduction, see \cite{Hallwirth.et.al.2015}.
#'
#' @format A list with two data frames
#' \describe{
#'   \item{London}{Distance along the genome (combined chromosomes) measued in basepairs. There are 72775 integration sites}
#'   \item{Paris}{Distance along the genome (combined chromosomes) measued in basepairs. There are 308538  integration sites}
#'   ...
#' }
#' @source Supplied by the authors
"integrationSites"