combo: Comparing window mean survival time

In pauknemj/survWM2: Survival Analysis with Window Mean Survival Time

Comparing window mean survival time

Description

Performs two-sample comparisons using the window mean survival time (WMST) as a summary measure of the survival time distribution. Three kinds of between-group contrast metrics (i.e., the difference in WMST, the ratio of WMST and the ratio of the window mean time lost (WMTL)) are computed. The Greenwood plug-in estimator is used for the asymptotic variance.

Usage

combo(time, status, arm, type = NULL, combination = FALSE, round = FALSE, method = c("maximum", "average", "chi.sq")[1], tau0 = NULL, tau1 = NULL, alternative = c("two.sided", "greater", "less")[1], alpha = 0.05)

Arguments

time	The follow-up time for right censored data.
status	The status indicator, 1=event, and 0=right censored.
arm	The group indicator for comparison. The elements of this vector take either 1 or 0. Normally, 0=control group, 1=active treatment group.
type	The type of window selection method to be applied.
combination	Determines whether the windows should be selected as every combination (TRUE) of the choices of tau0 and tau1 or not (FALSE).
round	Determines whether the choices for tau0 and tau1 will be rounded to the nearest whole number (TRUE) or will remain as chosen (FALSE).
method	Selects how the test statistics from each window will be combined.
tau0	A scaler vector to specify the lower truncation time points of the window for the WMST calculation. tau0 needs to be at least 0 and smaller than tau1. When tau0 = NULL, the default value 0 is used (i.e., the lower bound for restricted mean survival analysis).
tau1	A scaler vector to specify the upper truncation time points of the window for the WMST calculation. tau1 needs to be smaller than the minimum of the largest observed time in each of the two groups. When tau1 = NULL, the default value (i.e., the minimum of the largest observed time in each of the two groups) is used.
alternative	Determines the sidedness of the alternative hypothesis. The default is "two.sided" which performs a two-tailed hypothesis test. If set to "greater" an upper-tailed test is performed. If set to "less" a lower-tailed test is performed.
alpha	The default is 0.05. (1-alpha) confidence intervals are reported.

Details

For more details, please see the package vignette: browseVignettes(package = "survWMST")

Value

an object of class combo.

pvalue	the pvalue produced from the versatile test of multiple windows.
tau	the combination of various choices of tau0 and tau1 for windows.

Author(s)

Mitchell Paukner

References

Note to self: figure out what to place here!

pauknemj/survWM2 documentation built on March 21, 2023, 5:29 a.m.