wmst: Comparing window mean survival time
In pauknemj/survWM2: Survival Analysis with Window Mean Survival Time

wmst	R Documentation

Comparing window mean survival time

Description

Performs two-sample comparisons using the window mean survival time (WMST) as a summary measure of the survival time distribution. Three kinds of between-group contrast metrics (i.e., the difference in WMST, the ratio of WMST and the ratio of the window mean time lost (WMTL)) are computed. The Greenwood plug-in estimator is used for the asymptotic variance.

Usage

wmst(time, status, arm, tau0 = NULL, tau1 = NULL, alternative = "two.sided", alpha = 0.05)

Arguments

`time`	The follow-up time for right censored data.
`status`	The status indicator, 1=event, and 0=right censored.
`arm`	The group indicator for comparison. The elements of this vector take either 1 or 0. Normally, 0=control group, 1=active treatment group.
`tau0`	A scaler value to specify the lower truncation time point of the window for the WMST calculation. `tau0` needs to be at least 0 and smaller than tau1. When `tau0 = NULL`, the default value 0 is used (i.e., the lower bound for restricted mean survival analysis).
`tau1`	A scaler value to specify the upper truncation time point of the window for the WMST calculation. `tau1` needs to be smaller than the minimum of the largest observed time in each of the two groups. When `tau1 = NULL`, the default value (i.e., the minimum of the largest observed time in each of the two groups) is used.
`alternative`	Determines the sidedness of the alternative hypothesis. The default is "two.sided" which performs a two-tailed hypothesis test. If set to "greater" an upper-tailed test is performed. If set to "less" a lower-tailed test is performed.
`alpha`	The default is 0.05. (1-`alpha`) confidence intervals are reported.

Details

For more details, please see the package vignette: browseVignettes(package = "survWMST")

Value

an object of class wmst.

`tau0`	the lower truncation time used in the analyses
`tau1`	the upper truncation time used in the analyses
`note`	a note regarding the truncation time
`WMST.arm1`	WMST results in arm 1.
`WMST.arm0`	WMST results in arm 0.
`result`	Results of the WMST analyses.