FinalEstimate: calculate de-biased estimate

In paulowhite/DelayedGSD: Planning and analysis of group sequential trial with pipeline data

calculate de-biased estimate

Description

calculate de-biased estimate

Usage

FinalEstimate(
  Info.d,
  Info.i,
  ck,
  ck.unrestricted,
  lk,
  uk,
  reason.interim,
  kMax,
  estimate,
  method,
  bindingFutility,
  cNotBelowFixedc,
  continuity.correction,
  tolerance,
  FCT.p_value
)

Arguments

Info.d	Information at all decision analyses up to stage where study was stopped (should include information at final analysis if stopped at final analysis)
Info.i	Information at all interim analyses up to stage where study was stopped
ck, ck.unrestricted	decision boundaries for all decision analyses up to stage where study was stopped (should include final boundary if stopped at final analysis). ck is possibly with restriction (when cNotBelowFixedc=TRUE) and ck.unrestricted always without.
lk	lower bounds up to stage where study was stopped
uk	upper bounds up to stage where study was stopped
reason.interim	motivation for stopping or continuing at interim. Use to handle special cases (skipped interim because reach Imax, ...)
kMax	maximum number of analyses
estimate	naive estimate (e.g. using ML or REML).
method	method 1, 2 or 3
bindingFutility	[logical] whether the futility stopping rule is binding.
cNotBelowFixedc	[logical] whether the value c at the decision analysis can be below that of a fixed sample test (H & J page 10)
continuity.correction	[logical] whether to add the probability of stopping between ck and ck.uncorrected to ensure continuity of the p-value across stages. When used the p-value will always be greater than this probability of stopping bettwen ck and ck.uncorrected.
tolerance	[numeric] acceptable discrepancy to the objective level when evaluating the confidence intervals and median unbiased estimate.

paulowhite/DelayedGSD documentation built on Nov. 1, 2023, 5:36 p.m.